Genomic organization of microRNAs
Identifieur interne : 001950 ( Main/Merge ); précédent : 001949; suivant : 001951Genomic organization of microRNAs
Auteurs : Abigail F. Olena [États-Unis] ; James G. Patton [États-Unis]Source :
- Journal of Cellular Physiology [ 0021-9541 ] ; 2010-03.
English descriptors
- Teeft :
- Biogenesis, Biol, Black arrowhead, Caenorhabditis elegans, Cellular physiology, Cleavage, Dicer, Drosophila, Elegans, Family members, Gene, Gene clusters, Genome, Genomic, Genomic organization, Genomics, Host gene, Host genes, Intron, Intronic, Intronic mirnas, Maternal mrnas, Microrna, Micrornas, Mirna, Mirna biogenesis, Mirna genes, Mirnas, Mrna, Multiple copies, Noncoding, Noncoding rnas, Nucleic acids, Online issue, Plo, Polycistronic, Polymerase, Precursor, Proc natl acad, Promoter, Rna, Small rnas, Special case, Target mrnas, Teleost, Thatcher, Transcript, Transcription, Transcription units, Tuschl, Vertebrate.
Abstract
microRNAs (miRNAs) are small (∼22 nt) noncoding RNAs that have been shown to regulate gene expression post‐transcriptionally. They function by pairing with the 3′ UTR of target mRNAs and repressing translation or by targeting the mRNA for degradation. miRNAs are involved in diverse aspects of development, maintenance, and disease, and are largely evolutionarily conserved in metazoans. Searching the genomes of organisms from viruses to worms to humans has revealed potentially thousands of miRNA genes. Understanding the patterns of genomic organization between species cannot only help to refine tools to identify new miRNAs, but also provide insight into miRNA biogenesis and function. J. Cell. Physiol. 222: 540–545, 2010. © 2009 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jcp.21993
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Olena</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Biological Sciences, Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Patton, James G" sort="Patton, James G" uniqKey="Patton J" first="James G." last="Patton">James G. Patton</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Biological Sciences, Vanderbilt University, Nashville</wicri:cityArea></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Cellular Physiology</title><title level="j" type="alt">JOURNAL OF CELLULAR PHYSIOLOGY</title><idno type="ISSN">0021-9541</idno><idno type="eISSN">1097-4652</idno><imprint><biblScope unit="vol">222</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="540">540</biblScope><biblScope unit="page" to="545">545</biblScope><biblScope unit="page-count">6</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-03">2010-03</date></imprint><idno type="ISSN">0021-9541</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0021-9541</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Biogenesis</term><term>Biol</term><term>Black arrowhead</term><term>Caenorhabditis elegans</term><term>Cellular physiology</term><term>Cleavage</term><term>Dicer</term><term>Drosophila</term><term>Elegans</term><term>Family members</term><term>Gene</term><term>Gene clusters</term><term>Genome</term><term>Genomic</term><term>Genomic organization</term><term>Genomics</term><term>Host gene</term><term>Host genes</term><term>Intron</term><term>Intronic</term><term>Intronic mirnas</term><term>Maternal mrnas</term><term>Microrna</term><term>Micrornas</term><term>Mirna</term><term>Mirna biogenesis</term><term>Mirna genes</term><term>Mirnas</term><term>Mrna</term><term>Multiple copies</term><term>Noncoding</term><term>Noncoding rnas</term><term>Nucleic acids</term><term>Online issue</term><term>Plo</term><term>Polycistronic</term><term>Polymerase</term><term>Precursor</term><term>Proc natl acad</term><term>Promoter</term><term>Rna</term><term>Small rnas</term><term>Special case</term><term>Target mrnas</term><term>Teleost</term><term>Thatcher</term><term>Transcript</term><term>Transcription</term><term>Transcription units</term><term>Tuschl</term><term>Vertebrate</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">microRNAs (miRNAs) are small (∼22 nt) noncoding RNAs that have been shown to regulate gene expression post‐transcriptionally. They function by pairing with the 3′ UTR of target mRNAs and repressing translation or by targeting the mRNA for degradation. miRNAs are involved in diverse aspects of development, maintenance, and disease, and are largely evolutionarily conserved in metazoans. Searching the genomes of organisms from viruses to worms to humans has revealed potentially thousands of miRNA genes. Understanding the patterns of genomic organization between species cannot only help to refine tools to identify new miRNAs, but also provide insight into miRNA biogenesis and function. J. Cell. Physiol. 222: 540–545, 2010. © 2009 Wiley‐Liss, Inc.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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