Cytokine storm intervention in the early stages of COVID-19 pneumonia
Identifieur interne : 000570 ( Main/Merge ); précédent : 000569; suivant : 000571Cytokine storm intervention in the early stages of COVID-19 pneumonia
Auteurs : Xinjuan Sun [République populaire de Chine] ; Tianyuan Wang [République populaire de Chine] ; Dayong Cai [République populaire de Chine] ; Zhiwei Hu [République populaire de Chine] ; Jin N Chen [République populaire de Chine] ; Hui Liao [République populaire de Chine] ; Liming Zhi [République populaire de Chine] ; Hongxia Wei [République populaire de Chine] ; Zhihong Zhang [République populaire de Chine] ; Yuying Qiu [République populaire de Chine] ; Jing Wang [République populaire de Chine] ; Aiping Wang [République populaire de Chine]Source :
- Cytokine & Growth Factor Reviews [ 1359-6101 ] ; 2020.
Abstract
COVID-19 infection can lead to the development of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome MODS within a few days of disease onset. A powerful cytokine storm accompanies COVID-19 pneumonia. The capacity to accurately predict and intervene in the cytokine storm during COVID-19 pneumonia, as well as the ability to design effective specific strategies to block excessive inflammation, is critical for patient survival.
Url:
DOI: 10.1016/j.cytogfr.2020.04.002
PubMed: NONE
PubMed Central: 7182527
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populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name><affiliation wicri:level="1"><nlm:aff id="aff0020">Translational Medicine Center, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Translational Medicine Center, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Aiping" sort="Wang, Aiping" uniqKey="Wang A" first="Aiping" last="Wang">Aiping Wang</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Endocrinology, Air Force Hospital 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Nephrology, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Zhiwei" sort="Hu, Zhiwei" uniqKey="Hu Z" first="Zhiwei" last="Hu">Zhiwei Hu</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Endocrinology, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Endocrinology, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0010">Department of Nephrology, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Nephrology, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0015">Department of Hematology, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Hematology, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0020">Translational Medicine Center, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Translational Medicine Center, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0025">Department of Infectious Disease, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine. Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine. Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0030">Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0035">Department of Respiratory Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Jin N" sort="Chen, Jin N" uniqKey="Chen J" first="Jin N" last="Chen">Jin N Chen</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Endocrinology, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Endocrinology, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0010">Department of Nephrology, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Nephrology, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0015">Department of Hematology, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Hematology, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0020">Translational Medicine Center, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Translational Medicine Center, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0025">Department of Infectious Disease, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine. Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine. Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0030">Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0035">Department of Respiratory Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Liao, Hui" sort="Liao, Hui" uniqKey="Liao H" first="Hui" last="Liao">Hui Liao</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Department of Hematology, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Hematology, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Zhi, Liming" sort="Zhi, Liming" uniqKey="Zhi L" first="Liming" last="Zhi">Liming Zhi</name><affiliation wicri:level="1"><nlm:aff id="aff0020">Translational Medicine Center, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Translational Medicine Center, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Wei, Hongxia" sort="Wei, Hongxia" uniqKey="Wei H" first="Hongxia" last="Wei">Hongxia Wei</name><affiliation wicri:level="1"><nlm:aff id="aff0025">Department of Infectious Disease, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine. Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine. Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Zhihong" sort="Zhang, Zhihong" uniqKey="Zhang Z" first="Zhihong" last="Zhang">Zhihong Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff0030">Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Qiu, Yuying" sort="Qiu, Yuying" uniqKey="Qiu Y" first="Yuying" last="Qiu">Yuying Qiu</name><affiliation wicri:level="1"><nlm:aff id="aff0035">Department of Respiratory Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name><affiliation wicri:level="1"><nlm:aff id="aff0020">Translational Medicine Center, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Translational Medicine Center, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Aiping" sort="Wang, Aiping" uniqKey="Wang A" first="Aiping" last="Wang">Aiping Wang</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Endocrinology, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Endocrinology, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cytokine & Growth Factor Reviews</title><idno type="ISSN">1359-6101</idno><idno type="eISSN">1879-0305</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">COVID-19 infection can lead to the development of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome MODS within a few days of disease onset.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">A powerful cytokine storm accompanies COVID-19 pneumonia.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">The capacity to accurately predict and intervene in the cytokine storm during COVID-19 pneumonia, as well as the ability to design effective specific strategies to block excessive inflammation, is critical for patient survival.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Wu, J T" uniqKey="Wu J">J.T. 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Darwish</name></author><author><name sortKey="Mubareka, S" uniqKey="Mubareka S">S. Mubareka</name></author><author><name sortKey="Liles, W C" uniqKey="Liles W">W.C. Liles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcdermott, J E" uniqKey="Mcdermott J">J.E. McDermott</name></author><author><name sortKey="Mitchell, H D" uniqKey="Mitchell H">H.D. Mitchell</name></author><author><name sortKey="Gralinski, L E" uniqKey="Gralinski L">L.E. Gralinski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Silvester, W" uniqKey="Silvester W">W. Silvester</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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