Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases
Identifieur interne : 000523 ( Main/Merge ); précédent : 000522; suivant : 000524Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases
Auteurs : Richard I. Horowitz [États-Unis] ; Phyllis R. Freeman [États-Unis] ; James Bruzzese [États-Unis]Source :
- Respiratory Medicine Case Reports [ 2213-0071 ] ; 2020.
Abstract
Infection with COVID-19 potentially can result in severe outcomes and death from “cytokine storm syndrome”, resulting in novel coronavirus pneumonia (NCP) with severe dyspnea, acute respiratory distress syndrome (ARDS), fulminant myocarditis and multiorgan dysfunction with or without disseminated intravascular coagulation. No published treatment to date has been shown to adequately control the inflammation and respiratory symptoms associated with COVID-19, apart from oxygen therapy and assisted ventilation. We evaluated the effects of using high dose oral and/or IV glutathione in the treatment of 2 patients with dyspnea secondary to COVID-19 pneumonia.
Two patients living in New York City (NYC) with a history of Lyme and tick-borne co-infections experienced a cough and dyspnea and demonstrated radiological findings consistent with novel coronavirus pneumonia (NCP). A trial of 2 g of PO or IV glutathione was used in both patients and improved their dyspnea within 1 h of use. Repeated use of both 2000 mg of PO and IV glutathione was effective in further relieving respiratory symptoms.
Oral and IV glutathione, glutathione precursors (N-acetyl-cysteine) and alpha lipoic acid may represent a novel treatment approach for blocking NF-κB and addressing “cytokine storm syndrome” and respiratory distress in patients with COVID-19 pneumonia.
Url:
DOI: 10.1016/j.rmcr.2020.101063
PubMed: 32322478
PubMed Central: 7172740
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases</title><author><name sortKey="Horowitz, Richard I" sort="Horowitz, Richard I" uniqKey="Horowitz R" first="Richard I." last="Horowitz">Richard I. Horowitz</name><affiliation wicri:level="1"><nlm:aff id="aff1">HHS Babesia and Tickborne Pathogen Subcommittee, Washington, D.C., 20201, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>HHS Babesia and Tickborne Pathogen Subcommittee, Washington, D.C., 20201</wicri:regionArea><wicri:noRegion>20201</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Hudson Valley Healing Arts Center, 4232 Albany Post Road, Hyde Park, NY, 12538, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hudson Valley Healing Arts Center, 4232 Albany Post Road, Hyde Park, NY, 12538</wicri:regionArea><wicri:noRegion>12538</wicri:noRegion></affiliation></author><author><name sortKey="Freeman, Phyllis R" sort="Freeman, Phyllis R" uniqKey="Freeman P" first="Phyllis R." last="Freeman">Phyllis R. Freeman</name><affiliation wicri:level="1"><nlm:aff id="aff2">Hudson Valley Healing Arts Center, 4232 Albany Post Road, Hyde Park, NY, 12538, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hudson Valley Healing Arts Center, 4232 Albany Post Road, Hyde Park, NY, 12538</wicri:regionArea><wicri:noRegion>12538</wicri:noRegion></affiliation></author><author><name sortKey="Bruzzese, James" sort="Bruzzese, James" uniqKey="Bruzzese J" first="James" last="Bruzzese">James Bruzzese</name><affiliation wicri:level="1"><nlm:aff id="aff3">Sophie Davis School of Biomedical Education/CUNY School of Medicine, New York, NY, 10031, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sophie Davis School of Biomedical Education/CUNY School of Medicine, New York, NY, 10031</wicri:regionArea><wicri:noRegion>10031</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32322478</idno><idno type="pmc">7172740</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172740</idno><idno type="RBID">PMC:7172740</idno><idno type="doi">10.1016/j.rmcr.2020.101063</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000214</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000214</idno><idno type="wicri:Area/Pmc/Curation">000214</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000214</idno><idno type="wicri:Area/Pmc/Checkpoint">000440</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000440</idno><idno type="wicri:Area/Ncbi/Merge">000F71</idno><idno type="wicri:Area/Ncbi/Curation">000F71</idno><idno type="wicri:Area/Ncbi/Checkpoint">000F71</idno><idno type="wicri:Area/Main/Merge">000523</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases</title><author><name sortKey="Horowitz, Richard I" sort="Horowitz, Richard I" uniqKey="Horowitz R" first="Richard I." last="Horowitz">Richard I. Horowitz</name><affiliation wicri:level="1"><nlm:aff id="aff1">HHS Babesia and Tickborne Pathogen Subcommittee, Washington, D.C., 20201, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>HHS Babesia and Tickborne Pathogen Subcommittee, Washington, D.C., 20201</wicri:regionArea><wicri:noRegion>20201</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Hudson Valley Healing Arts Center, 4232 Albany Post Road, Hyde Park, NY, 12538, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hudson Valley Healing Arts Center, 4232 Albany Post Road, Hyde Park, NY, 12538</wicri:regionArea><wicri:noRegion>12538</wicri:noRegion></affiliation></author><author><name sortKey="Freeman, Phyllis R" sort="Freeman, Phyllis R" uniqKey="Freeman P" first="Phyllis R." last="Freeman">Phyllis R. Freeman</name><affiliation wicri:level="1"><nlm:aff id="aff2">Hudson Valley Healing Arts Center, 4232 Albany Post Road, Hyde Park, NY, 12538, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hudson Valley Healing Arts Center, 4232 Albany Post Road, Hyde Park, NY, 12538</wicri:regionArea><wicri:noRegion>12538</wicri:noRegion></affiliation></author><author><name sortKey="Bruzzese, James" sort="Bruzzese, James" uniqKey="Bruzzese J" first="James" last="Bruzzese">James Bruzzese</name><affiliation wicri:level="1"><nlm:aff id="aff3">Sophie Davis School of Biomedical Education/CUNY School of Medicine, New York, NY, 10031, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sophie Davis School of Biomedical Education/CUNY School of Medicine, New York, NY, 10031</wicri:regionArea><wicri:noRegion>10031</wicri:noRegion></affiliation></author></analytic><series><title level="j">Respiratory Medicine Case Reports</title><idno type="eISSN">2213-0071</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>Infection with COVID-19 potentially can result in severe outcomes and death from “cytokine storm syndrome”, resulting in novel coronavirus pneumonia (NCP) with severe dyspnea, acute respiratory distress syndrome (ARDS), fulminant myocarditis and multiorgan dysfunction with or without disseminated intravascular coagulation. No published treatment to date has been shown to adequately control the inflammation and respiratory symptoms associated with COVID-19, apart from oxygen therapy and assisted ventilation. We evaluated the effects of using high dose oral and/or IV glutathione in the treatment of 2 patients with dyspnea secondary to COVID-19 pneumonia.</p></sec><sec><title>Methods</title><p>Two patients living in New York City (NYC) with a history of Lyme and tick-borne co-infections experienced a cough and dyspnea and demonstrated radiological findings consistent with novel coronavirus pneumonia (NCP). A trial of 2 g of PO or IV glutathione was used in both patients and improved their dyspnea within 1 h of use. Repeated use of both 2000 mg of PO and IV glutathione was effective in further relieving respiratory symptoms.</p></sec><sec><title>Conclusion</title><p>Oral and IV glutathione, glutathione precursors (N-acetyl-cysteine) and alpha lipoic acid may represent a novel treatment approach for blocking NF-κB and addressing “cytokine storm syndrome” and respiratory distress in patients with COVID-19 pneumonia.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Valencia" uniqKey="Valencia">Valencia</name></author><author><name sortKey="Damian, N" uniqKey="Damian N">N. Damian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Who" uniqKey="Who">WHO</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. 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