Gene expression analysis in children with complex seizures due to influenza A(H1N1)pdm09 or rotavirus gastroenteritis.
Identifieur interne : 000F39 ( Main/Exploration ); précédent : 000F38; suivant : 000F40Gene expression analysis in children with complex seizures due to influenza A(H1N1)pdm09 or rotavirus gastroenteritis.
Auteurs : Mitsuru Tsuge [Japon] ; Takashi Oka ; Nobuko Yamashita ; Yukie Saito ; Yosuke Fujii ; Yoshiharu Nagaoka ; Masato Yashiro ; Hirokazu Tsukahara ; Tsuneo MorishimaSource :
- Journal of neurovirology [ 1538-2443 ] ; 2014.
Descripteurs français
- KwdFr :
- Analyse de regroupements, Crises épileptiques (génétique), Crises épileptiques (virologie), Enfant, Enfant d'âge préscolaire, Femelle, Gastroentérite (), Gastroentérite (génétique), Gastroentérite (virologie), Grippe humaine (), Grippe humaine (génétique), Humains, Infections à rotavirus (), Infections à rotavirus (génétique), Mâle, Nourrisson, RT-PCR, Sous-type H1N1 du virus de la grippe A, Séquençage par oligonucléotides en batterie, Transcriptome.
- MESH :
- génétique : Crises épileptiques, Gastroentérite, Grippe humaine, Infections à rotavirus.
- virologie : Crises épileptiques, Gastroentérite.
- Analyse de regroupements, Enfant, Enfant d'âge préscolaire, Femelle, Gastroentérite, Grippe humaine, Humains, Infections à rotavirus, Mâle, Nourrisson, RT-PCR, Sous-type H1N1 du virus de la grippe A, Séquençage par oligonucléotides en batterie, Transcriptome.
English descriptors
- KwdEn :
- Child, Child, Preschool, Cluster Analysis, Female, Gastroenteritis (complications), Gastroenteritis (genetics), Gastroenteritis (virology), Humans, Infant, Influenza A Virus, H1N1 Subtype, Influenza, Human (complications), Influenza, Human (genetics), Male, Oligonucleotide Array Sequence Analysis, Reverse Transcriptase Polymerase Chain Reaction, Rotavirus Infections (complications), Rotavirus Infections (genetics), Seizures (genetics), Seizures (virology), Transcriptome.
- MESH :
- complications : Gastroenteritis, Influenza, Human, Rotavirus Infections.
- genetics : Gastroenteritis, Influenza, Human, Rotavirus Infections, Seizures.
- virology : Gastroenteritis, Seizures.
- Child, Child, Preschool, Cluster Analysis, Female, Humans, Infant, Influenza A Virus, H1N1 Subtype, Male, Oligonucleotide Array Sequence Analysis, Reverse Transcriptase Polymerase Chain Reaction, Transcriptome.
Abstract
Viral infections have been implicated as a cause of complex seizures in children. The pathogenic differences in complex seizures due to influenza A(H1N1)pdm09 or rotavirus gastroenteritis remain unclear. This study analyzed the gene expression profiles in the peripheral whole blood from pediatric patients with complex seizures due to influenza A(H1N1)pdm09 or rotavirus gastroenteritis. The gene expression profiles of ten patients (five with seizures and five without) with influenza A(H1N1)pdm09 and six patients (three with seizures and three without) with rotavirus gastroenteritis were examined. Gene expression profiles in the whole blood were different in complex seizures due to influenza A(H1N1)pdm09 or rotavirus gastroenteritis. Transcripts related to the immune response were significantly differentially expressed in complex seizures with influenza A(H1N1)pdm09, and transcripts related to the stress response were significantly differentially expressed in complex seizures with rotavirus gastroenteritis. Pathway analysis showed that the mitogen-activated protein kinases in the T cell receptor signaling pathway were activated in complex seizures due to influenza A(H1N1)pdm09. Dysregulation of the genes related to immune response or stress response could contribute to the pathogenic differences of the complex seizures due to influenza A(H1N1)pdm09 or rotavirus gastroenteritis.
DOI: 10.1007/s13365-013-0231-5
PubMed: 24464411
Affiliations:
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Le document en format XML
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first="Takashi" last="Oka">Takashi Oka</name></author><author><name sortKey="Yamashita, Nobuko" sort="Yamashita, Nobuko" uniqKey="Yamashita N" first="Nobuko" last="Yamashita">Nobuko Yamashita</name></author><author><name sortKey="Saito, Yukie" sort="Saito, Yukie" uniqKey="Saito Y" first="Yukie" last="Saito">Yukie Saito</name></author><author><name sortKey="Fujii, Yosuke" sort="Fujii, Yosuke" uniqKey="Fujii Y" first="Yosuke" last="Fujii">Yosuke Fujii</name></author><author><name sortKey="Nagaoka, Yoshiharu" sort="Nagaoka, Yoshiharu" uniqKey="Nagaoka Y" first="Yoshiharu" last="Nagaoka">Yoshiharu Nagaoka</name></author><author><name sortKey="Yashiro, Masato" sort="Yashiro, Masato" uniqKey="Yashiro M" first="Masato" last="Yashiro">Masato Yashiro</name></author><author><name sortKey="Tsukahara, Hirokazu" sort="Tsukahara, Hirokazu" uniqKey="Tsukahara H" first="Hirokazu" last="Tsukahara">Hirokazu Tsukahara</name></author><author><name sortKey="Morishima, Tsuneo" sort="Morishima, Tsuneo" 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(genetics)</term><term>Seizures (virology)</term><term>Transcriptome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de regroupements</term><term>Crises épileptiques (génétique)</term><term>Crises épileptiques (virologie)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Gastroentérite ()</term><term>Gastroentérite (génétique)</term><term>Gastroentérite (virologie)</term><term>Grippe humaine ()</term><term>Grippe humaine (génétique)</term><term>Humains</term><term>Infections à rotavirus ()</term><term>Infections à rotavirus (génétique)</term><term>Mâle</term><term>Nourrisson</term><term>RT-PCR</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Séquençage par oligonucléotides en batterie</term><term>Transcriptome</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Gastroenteritis</term><term>Influenza, Human</term><term>Rotavirus Infections</term></keywords><keywords scheme="MESH" 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scheme="MESH" xml:lang="fr"><term>Analyse de regroupements</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Gastroentérite</term><term>Grippe humaine</term><term>Humains</term><term>Infections à rotavirus</term><term>Mâle</term><term>Nourrisson</term><term>RT-PCR</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Séquençage par oligonucléotides en batterie</term><term>Transcriptome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Viral infections have been implicated as a cause of complex seizures in children. The pathogenic differences in complex seizures due to influenza A(H1N1)pdm09 or rotavirus gastroenteritis remain unclear. This study analyzed the gene expression profiles in the peripheral whole blood from pediatric patients with complex seizures due to influenza A(H1N1)pdm09 or rotavirus gastroenteritis. The gene expression profiles of ten patients (five with seizures and five without) with influenza A(H1N1)pdm09 and six patients (three with seizures and three without) with rotavirus gastroenteritis were examined. Gene expression profiles in the whole blood were different in complex seizures due to influenza A(H1N1)pdm09 or rotavirus gastroenteritis. Transcripts related to the immune response were significantly differentially expressed in complex seizures with influenza A(H1N1)pdm09, and transcripts related to the stress response were significantly differentially expressed in complex seizures with rotavirus gastroenteritis. Pathway analysis showed that the mitogen-activated protein kinases in the T cell receptor signaling pathway were activated in complex seizures due to influenza A(H1N1)pdm09. Dysregulation of the genes related to immune response or stress response could contribute to the pathogenic differences of the complex seizures due to influenza A(H1N1)pdm09 or rotavirus gastroenteritis. </div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Fujii, Yosuke" sort="Fujii, Yosuke" uniqKey="Fujii Y" first="Yosuke" last="Fujii">Yosuke Fujii</name><name sortKey="Morishima, Tsuneo" sort="Morishima, Tsuneo" uniqKey="Morishima T" first="Tsuneo" last="Morishima">Tsuneo Morishima</name><name sortKey="Nagaoka, Yoshiharu" sort="Nagaoka, Yoshiharu" uniqKey="Nagaoka Y" first="Yoshiharu" last="Nagaoka">Yoshiharu Nagaoka</name><name sortKey="Oka, Takashi" sort="Oka, Takashi" uniqKey="Oka T" first="Takashi" last="Oka">Takashi Oka</name><name sortKey="Saito, Yukie" sort="Saito, Yukie" uniqKey="Saito Y" first="Yukie" last="Saito">Yukie Saito</name><name sortKey="Tsukahara, Hirokazu" sort="Tsukahara, Hirokazu" uniqKey="Tsukahara H" first="Hirokazu" last="Tsukahara">Hirokazu Tsukahara</name><name sortKey="Yamashita, Nobuko" sort="Yamashita, Nobuko" uniqKey="Yamashita N" first="Nobuko" last="Yamashita">Nobuko Yamashita</name><name sortKey="Yashiro, Masato" sort="Yashiro, Masato" uniqKey="Yashiro M" first="Masato" last="Yashiro">Masato Yashiro</name></noCountry><country name="Japon"><noRegion><name sortKey="Tsuge, Mitsuru" sort="Tsuge, Mitsuru" uniqKey="Tsuge M" first="Mitsuru" last="Tsuge">Mitsuru Tsuge</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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