SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects
Identifieur interne : 000193 ( Main/Exploration ); précédent : 000192; suivant : 000194SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects
Auteurs : Konstantinos Michalakis [Grèce] ; Ioannis Ilias [Grèce]Source :
- Diabetes & Metabolic Syndrome [ 1871-4021 ] ; 2020.
Abstract
According to the World Obesity Federation, “obesity-related conditions seem to worsen the effect of Covid-19 (SARS-CoV-2)”; additionally the Centres for Disease Control and Prevention reported that “people with heart disease and diabetes are at higher risk of SARS-CoV-2 complications and that severe obesity poses a higher risk for severe illness”. Recent reports have shown elevated levels of cytokines due to increased inflammation in patients with SARS-CoV-2 disease. On the other hand, obesity represents a state of low-grade inflammation, with various inflammatory products directly excreted by adipose tissue. In this concise report we aimed to assess common elements of obesity and SARS-CoV-2 infection.
Literature search on obesity and SARS-CoV-2 infection.
We present “mechanistic” obesity-related problems that aggravate SARS-CoV-2 infection as well as tentative inflammatory/metabolic links between these diseases.
Obesity and SARS-CoV-2 share common elements of the inflammatory process (and possibly also metabolic disturbances), exacerbating SARS-CoV-2 infection in the obese.
Url:
DOI: 10.1016/j.dsx.2020.04.033
PubMed: NONE
PubMed Central: 7189186
Affiliations:
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Le document en format XML
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<author><name sortKey="Michalakis, Konstantinos" sort="Michalakis, Konstantinos" uniqKey="Michalakis K" first="Konstantinos" last="Michalakis">Konstantinos Michalakis</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects</title>
<author><name sortKey="Michalakis, Konstantinos" sort="Michalakis, Konstantinos" uniqKey="Michalakis K" first="Konstantinos" last="Michalakis">Konstantinos Michalakis</name>
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<author><name sortKey="Ilias, Ioannis" sort="Ilias, Ioannis" uniqKey="Ilias I" first="Ioannis" last="Ilias">Ioannis Ilias</name>
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<series><title level="j">Diabetes & Metabolic Syndrome</title>
<idno type="ISSN">1871-4021</idno>
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<front><div type="abstract" xml:lang="en"><sec><title>Backround and aims</title>
<p>According to the World Obesity Federation, “obesity-related conditions seem to worsen the effect of Covid-19 (SARS-CoV-2)”; additionally the Centres for Disease Control and Prevention reported that “people with heart disease and diabetes are at higher risk of SARS-CoV-2 complications and that severe obesity poses a higher risk for severe illness”. Recent reports have shown elevated levels of cytokines due to increased inflammation in patients with SARS-CoV-2 disease. On the other hand, obesity represents a state of low-grade inflammation, with various inflammatory products directly excreted by adipose tissue. In this concise report we aimed to assess common elements of obesity and SARS-CoV-2 infection.</p>
</sec>
<sec><title>Methods</title>
<p>Literature search on obesity and SARS-CoV-2 infection.</p>
</sec>
<sec><title>Results</title>
<p>We present “mechanistic” obesity-related problems that aggravate SARS-CoV-2 infection as well as tentative inflammatory/metabolic links between these diseases.</p>
</sec>
<sec><title>Conclusion</title>
<p>Obesity and SARS-CoV-2 share common elements of the inflammatory process (and possibly also metabolic disturbances), exacerbating SARS-CoV-2 infection in the obese.</p>
</sec>
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