Increases in a marker of immune system reconstitution are predated by decreases in 24-h urinary cortisol output and depressed mood during a 10-week stress management intervention in symptomatic HIV-infected men
Identifieur interne : 002678 ( Main/Exploration ); précédent : 002677; suivant : 002679Increases in a marker of immune system reconstitution are predated by decreases in 24-h urinary cortisol output and depressed mood during a 10-week stress management intervention in symptomatic HIV-infected men
Auteurs : Michael H. Antoni [États-Unis] ; Dean G. Cruess [États-Unis] ; Nancy Klimas [États-Unis] ; Adam W. Carrico [États-Unis] ; Kevin Maher [États-Unis] ; Stacy Cruess [États-Unis] ; Suzanne C. Lechner [États-Unis] ; Mahendra Kumar [États-Unis] ; Susan Lutgendorf [États-Unis] ; Gail Ironson [États-Unis] ; Mary Ann Fletcher [États-Unis] ; Neil Schneiderman [États-Unis]Source :
- Journal of psychosomatic research [ 0022-3999 ] ; 2005.
Descripteurs français
- Pascal (Inist)
- SIDA, Maladie, Association morbide, Etat dépressif, Traitement, Thérapie cognitive, Thérapie comportementale, Stress, Coping, Etude comparative, Evolution, Marqueur biologique, Hydrocortisone, Système immunitaire, Symptomatologie, Efficacité traitement, Etude longitudinale, Mâle, Adulte jeune, Adulte.
- Wicri :
English descriptors
- KwdEn :
Abstract
Background: Stress management interventions reduce distress symptoms and hypothalamic-pituitary-adrenal (HPA) axis hormones such as cortisol, which has been related to a down-regulation of immune system components relevant to the human immunodeficiency virus (HIV) infection. We previously showed that HIV+ men assigned to a 10-week cognitive behavioral stress management (CBSM) intervention showed more CD4+CD45RA+CD29+ lymphocytes, an indicator of immune system reconstitution, at a 6- to 12-month follow-up compared with controls. Here, we tested whether reductions in urinary cortisol output and depressed mood during the 10-week CBSM intervention period mediated its effects on this immune system reconstitution marker at follow-up. Methods: Twenty-five HIV-infected men randomized to either a 10-week CBSM intervention or a wait-list control provided 24-h urine samples and psychological responses pre- to postintervention, which were related to changes in immune status over a 6- to 12-month follow-up period. Results: Greater reductions in cortisol output and depressed mood during CBSM appeared to mediate the effects of this intervention on this indicator of immune system reconstitution over the 6- to 12-month follow-up period. Changes in mood were maintained over the follow-up period, although these did not add explanatory information beyond the cortisol and mood changes that were observed during the 10-week intervention period. These findings were not explained by the changes in medications or health behaviors during follow-up. Conclusion: A time-limited CBSM intervention may affect the rate of immune system reconstitution in HIV-infected men by modifying the stress of symptomatic disease. This intervention may work by decreasing depressed mood and normalizing HPA axis functioning.
Affiliations:
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men</title><author><name sortKey="Antoni, Michael H" sort="Antoni, Michael H" uniqKey="Antoni M" first="Michael H." last="Antoni">Michael H. Antoni</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Psychology, University of Miami, 5665 Ponce Deleon Boulevard</s1><s2>Coral Gables, FL 33146</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Psychiatry and Behavioral Sciences, University of Miami, 5665 Ponce Deleon Boulevard</s1><s2>Coral Gables, FL 33146</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Cruess, Dean G" sort="Cruess, Dean G" uniqKey="Cruess D" first="Dean G." last="Cruess">Dean G. Cruess</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Psychology, University of Pennsylvania</s1><s2>Philadelphia, PA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Klimas, Nancy" sort="Klimas, Nancy" uniqKey="Klimas N" first="Nancy" last="Klimas">Nancy Klimas</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Medicine, University of Miami, 5665 Ponce Deleon Boulevard</s1><s2>Coral Gables, FL 33146</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Carrico, Adam W" sort="Carrico, Adam W" uniqKey="Carrico A" first="Adam W." last="Carrico">Adam W. Carrico</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Psychology, University of Miami, 5665 Ponce Deleon Boulevard</s1><s2>Coral Gables, FL 33146</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Maher, Kevin" sort="Maher, Kevin" uniqKey="Maher K" first="Kevin" last="Maher">Kevin Maher</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Medicine, University of Miami, 5665 Ponce Deleon Boulevard</s1><s2>Coral Gables, FL 33146</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Cruess, Stacy" sort="Cruess, Stacy" uniqKey="Cruess S" first="Stacy" last="Cruess">Stacy Cruess</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Psychology, University of Pennsylvania</s1><s2>Philadelphia, PA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Lechner, Suzanne C" sort="Lechner, Suzanne C" uniqKey="Lechner S" first="Suzanne C." last="Lechner">Suzanne C. Lechner</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Psychology, University of Miami, 5665 Ponce Deleon Boulevard</s1><s2>Coral Gables, FL 33146</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Kumar, Mahendra" sort="Kumar, Mahendra" uniqKey="Kumar M" first="Mahendra" last="Kumar">Mahendra Kumar</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Psychology, University of Miami, 5665 Ponce Deleon Boulevard</s1><s2>Coral Gables, FL 33146</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Psychiatry and Behavioral Sciences, University of Miami, 5665 Ponce Deleon Boulevard</s1><s2>Coral Gables, FL 33146</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Lutgendorf, Susan" sort="Lutgendorf, Susan" uniqKey="Lutgendorf S" first="Susan" last="Lutgendorf">Susan Lutgendorf</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Psychology, University of Pennsylvania</s1><s2>Philadelphia, PA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Ironson, Gail" sort="Ironson, Gail" uniqKey="Ironson G" first="Gail" last="Ironson">Gail Ironson</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Psychology, University of Miami, 5665 Ponce Deleon Boulevard</s1><s2>Coral Gables, FL 33146</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Psychiatry and Behavioral Sciences, University of Miami, 5665 Ponce Deleon Boulevard</s1><s2>Coral Gables, FL 33146</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Fletcher, Mary Ann" sort="Fletcher, Mary Ann" uniqKey="Fletcher M" first="Mary Ann" last="Fletcher">Mary Ann Fletcher</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Psychology, University of Miami, 5665 Ponce Deleon Boulevard</s1><s2>Coral Gables, FL 33146</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Medicine, University of Miami, 5665 Ponce Deleon Boulevard</s1><s2>Coral Gables, FL 33146</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Schneiderman, Neil" sort="Schneiderman, Neil" uniqKey="Schneiderman N" first="Neil" last="Schneiderman">Neil Schneiderman</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Psychology, University of Miami, 5665 Ponce Deleon Boulevard</s1><s2>Coral Gables, FL 33146</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Psychiatry and Behavioral Sciences, University of Miami, 5665 Ponce Deleon Boulevard</s1><s2>Coral Gables, FL 33146</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Medicine, University of Miami, 5665 Ponce Deleon Boulevard</s1><s2>Coral Gables, FL 33146</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of psychosomatic research</title><title level="j" type="abbreviated">J. psychosom. res.</title><idno type="ISSN">0022-3999</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of psychosomatic research</title><title level="j" type="abbreviated">J. psychosom. res.</title><idno type="ISSN">0022-3999</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term><term>Adult</term><term>Behavior therapy</term><term>Biological marker</term><term>Cognitive therapy</term><term>Comparative study</term><term>Concomitant disease</term><term>Coping</term><term>Depression</term><term>Disease</term><term>Evolution</term><term>Follow up study</term><term>Hydrocortisone</term><term>Immune system</term><term>Male</term><term>Stress</term><term>Symptomatology</term><term>Treatment</term><term>Treatment efficiency</term><term>Young adult</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>SIDA</term><term>Maladie</term><term>Association morbide</term><term>Etat dépressif</term><term>Traitement</term><term>Thérapie cognitive</term><term>Thérapie comportementale</term><term>Stress</term><term>Coping</term><term>Etude comparative</term><term>Evolution</term><term>Marqueur biologique</term><term>Hydrocortisone</term><term>Système immunitaire</term><term>Symptomatologie</term><term>Efficacité traitement</term><term>Etude longitudinale</term><term>Mâle</term><term>Adulte jeune</term><term>Adulte</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Maladie</term><term>Adulte</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Stress management interventions reduce distress symptoms and hypothalamic-pituitary-adrenal (HPA) axis hormones such as cortisol, which has been related to a down-regulation of immune system components relevant to the human immunodeficiency virus (HIV) infection. We previously showed that HIV+ men assigned to a 10-week cognitive behavioral stress management (CBSM) intervention showed more CD4+CD45RA+CD29+ lymphocytes, an indicator of immune system reconstitution, at a 6- to 12-month follow-up compared with controls. Here, we tested whether reductions in urinary cortisol output and depressed mood during the 10-week CBSM intervention period mediated its effects on this immune system reconstitution marker at follow-up. Methods: Twenty-five HIV-infected men randomized to either a 10-week CBSM intervention or a wait-list control provided 24-h urine samples and psychological responses pre- to postintervention, which were related to changes in immune status over a 6- to 12-month follow-up period. Results: Greater reductions in cortisol output and depressed mood during CBSM appeared to mediate the effects of this intervention on this indicator of immune system reconstitution over the 6- to 12-month follow-up period. Changes in mood were maintained over the follow-up period, although these did not add explanatory information beyond the cortisol and mood changes that were observed during the 10-week intervention period. These findings were not explained by the changes in medications or health behaviors during follow-up. Conclusion: A time-limited CBSM intervention may affect the rate of immune system reconstitution in HIV-infected men by modifying the stress of symptomatic disease. This intervention may work by decreasing depressed mood and normalizing HPA axis functioning.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Floride"><name sortKey="Antoni, Michael H" sort="Antoni, Michael H" uniqKey="Antoni M" first="Michael H." last="Antoni">Michael H. Antoni</name></region><name sortKey="Antoni, Michael H" sort="Antoni, Michael H" uniqKey="Antoni M" first="Michael H." last="Antoni">Michael H. Antoni</name><name sortKey="Carrico, Adam W" sort="Carrico, Adam W" uniqKey="Carrico A" first="Adam W." last="Carrico">Adam W. Carrico</name><name sortKey="Cruess, Dean G" sort="Cruess, Dean G" uniqKey="Cruess D" first="Dean G." last="Cruess">Dean G. Cruess</name><name sortKey="Cruess, Stacy" sort="Cruess, Stacy" uniqKey="Cruess S" first="Stacy" last="Cruess">Stacy Cruess</name><name sortKey="Fletcher, Mary Ann" sort="Fletcher, Mary Ann" uniqKey="Fletcher M" first="Mary Ann" last="Fletcher">Mary Ann Fletcher</name><name sortKey="Fletcher, Mary Ann" sort="Fletcher, Mary Ann" uniqKey="Fletcher M" first="Mary Ann" last="Fletcher">Mary Ann Fletcher</name><name sortKey="Ironson, Gail" sort="Ironson, Gail" uniqKey="Ironson G" first="Gail" last="Ironson">Gail Ironson</name><name sortKey="Ironson, Gail" sort="Ironson, Gail" uniqKey="Ironson G" first="Gail" last="Ironson">Gail Ironson</name><name sortKey="Klimas, Nancy" sort="Klimas, Nancy" uniqKey="Klimas N" first="Nancy" last="Klimas">Nancy Klimas</name><name sortKey="Kumar, Mahendra" sort="Kumar, Mahendra" uniqKey="Kumar M" first="Mahendra" last="Kumar">Mahendra Kumar</name><name sortKey="Kumar, Mahendra" sort="Kumar, Mahendra" uniqKey="Kumar M" first="Mahendra" last="Kumar">Mahendra Kumar</name><name sortKey="Lechner, Suzanne C" sort="Lechner, Suzanne C" uniqKey="Lechner S" first="Suzanne C." last="Lechner">Suzanne C. Lechner</name><name sortKey="Lutgendorf, Susan" sort="Lutgendorf, Susan" uniqKey="Lutgendorf S" first="Susan" last="Lutgendorf">Susan Lutgendorf</name><name sortKey="Maher, Kevin" sort="Maher, Kevin" uniqKey="Maher K" first="Kevin" last="Maher">Kevin Maher</name><name sortKey="Schneiderman, Neil" sort="Schneiderman, Neil" uniqKey="Schneiderman N" first="Neil" last="Schneiderman">Neil Schneiderman</name><name sortKey="Schneiderman, Neil" sort="Schneiderman, Neil" uniqKey="Schneiderman N" first="Neil" last="Schneiderman">Neil Schneiderman</name><name sortKey="Schneiderman, Neil" sort="Schneiderman, Neil" uniqKey="Schneiderman N" first="Neil" last="Schneiderman">Neil Schneiderman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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