Click chemistry reactions in medicinal chemistry: Applications of the 1,3‐dipolar cycloaddition between azides and alkynes
Identifieur interne : 001E45 ( Main/Exploration ); précédent : 001E44; suivant : 001E46Click chemistry reactions in medicinal chemistry: Applications of the 1,3‐dipolar cycloaddition between azides and alkynes
Auteurs : Gian Cesare Tron [Italie] ; Tracey Pirali [Italie] ; Richard A. Billington [Italie] ; Pier Luigi Canonico [Italie] ; Giovanni Sorba [Italie] ; Armando A. Genazzani [Italie]Source :
- Medicinal Research Reviews [ 0198-6325 ] ; 2008-03.
Abstract
In recent years, there has been an ever‐increasing need for rapid reactions that meet the three main criteria of an ideal synthesis: efficiency, versatility, and selectivity. Such reactions would allow medicinal chemistry to keep pace with the multitude of information derived from modern biological screening techniques. The present review describes one of these reactions, the 1,3‐dipolar cycloaddition (“click‐reaction”) between azides and alkynes catalyzed by copper (I) salts. The simplicity of this reaction and the ease of purification of the resulting products have opened new opportunities in generating vast arrays of compounds with biological potential. The present review will outline the accomplishments of this strategy achieved so far and outline some of medicinal chemistry applications in which click‐chemistry might be relevant in the future. © 2007 Wiley Periodicals, Inc. Med Res Rev, 28, No. 2, 278–308, 2008
Url:
DOI: 10.1002/med.20107
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001563
- to stream Istex, to step Curation: 001490
- to stream Istex, to step Checkpoint: 000B80
- to stream Main, to step Merge: 001E47
- to stream Main, to step Curation: 001E45
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Click chemistry reactions in medicinal chemistry: Applications of the 1,3‐dipolar cycloaddition between azides and alkynes</title><author><name sortKey="Tron, Gian Cesare" sort="Tron, Gian Cesare" uniqKey="Tron G" first="Gian Cesare" last="Tron">Gian Cesare Tron</name></author><author><name sortKey="Pirali, Tracey" sort="Pirali, Tracey" uniqKey="Pirali T" first="Tracey" last="Pirali">Tracey Pirali</name></author><author><name sortKey="Billington, Richard A" sort="Billington, Richard A" uniqKey="Billington R" first="Richard A." last="Billington">Richard A. Billington</name></author><author><name sortKey="Canonico, Pier Luigi" sort="Canonico, Pier Luigi" uniqKey="Canonico P" first="Pier Luigi" last="Canonico">Pier Luigi Canonico</name></author><author><name sortKey="Sorba, Giovanni" sort="Sorba, Giovanni" uniqKey="Sorba G" first="Giovanni" last="Sorba">Giovanni Sorba</name></author><author><name sortKey="Genazzani, Armando A" sort="Genazzani, Armando A" uniqKey="Genazzani A" first="Armando A." last="Genazzani">Armando A. Genazzani</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B7853D53492A6D252A92E9B9EB9CDC6775CB6956</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1002/med.20107</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-9W3H3LC8-S/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001563</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001563</idno><idno type="wicri:Area/Istex/Curation">001490</idno><idno type="wicri:Area/Istex/Checkpoint">000B80</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000B80</idno><idno type="wicri:doubleKey">0198-6325:2008:Tron G:click:chemistry:reactions</idno><idno type="wicri:Area/Main/Merge">001E47</idno><idno type="wicri:Area/Main/Curation">001E45</idno><idno type="wicri:Area/Main/Exploration">001E45</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Click chemistry reactions in medicinal chemistry: Applications of the 1,3‐dipolar cycloaddition between azides and alkynes</title><author><name sortKey="Tron, Gian Cesare" sort="Tron, Gian Cesare" uniqKey="Tron G" first="Gian Cesare" last="Tron">Gian Cesare Tron</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center, Università degli Studi del Piemonte Orientale “A. Avogadro”, Via Bovio 6, 28100 Novara</wicri:regionArea><wicri:noRegion>28100 Novara</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Italie</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Correspondence address: Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center, Università degli Studi del Piemonte Orientale “A. Avogadro”, Via Bovio 6, 28100 Novara</wicri:regionArea><wicri:noRegion>28100 Novara</wicri:noRegion></affiliation></author><author><name sortKey="Pirali, Tracey" sort="Pirali, Tracey" uniqKey="Pirali T" first="Tracey" last="Pirali">Tracey Pirali</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center, Università degli Studi del Piemonte Orientale “A. Avogadro”, Via Bovio 6, 28100 Novara</wicri:regionArea><wicri:noRegion>28100 Novara</wicri:noRegion></affiliation></author><author><name sortKey="Billington, Richard A" sort="Billington, Richard A" uniqKey="Billington R" first="Richard A." last="Billington">Richard A. Billington</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center, Università degli Studi del Piemonte Orientale “A. Avogadro”, Via Bovio 6, 28100 Novara</wicri:regionArea><wicri:noRegion>28100 Novara</wicri:noRegion></affiliation></author><author><name sortKey="Canonico, Pier Luigi" sort="Canonico, Pier Luigi" uniqKey="Canonico P" first="Pier Luigi" last="Canonico">Pier Luigi Canonico</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center, Università degli Studi del Piemonte Orientale “A. Avogadro”, Via Bovio 6, 28100 Novara</wicri:regionArea><wicri:noRegion>28100 Novara</wicri:noRegion></affiliation></author><author><name sortKey="Sorba, Giovanni" sort="Sorba, Giovanni" uniqKey="Sorba G" first="Giovanni" last="Sorba">Giovanni Sorba</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center, Università degli Studi del Piemonte Orientale “A. Avogadro”, Via Bovio 6, 28100 Novara</wicri:regionArea><wicri:noRegion>28100 Novara</wicri:noRegion></affiliation></author><author><name sortKey="Genazzani, Armando A" sort="Genazzani, Armando A" uniqKey="Genazzani A" first="Armando A." last="Genazzani">Armando A. Genazzani</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center, Università degli Studi del Piemonte Orientale “A. Avogadro”, Via Bovio 6, 28100 Novara</wicri:regionArea><wicri:noRegion>28100 Novara</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Medicinal Research Reviews</title><title level="j" type="alt">MEDICINAL RESEARCH REVIEWS</title><idno type="ISSN">0198-6325</idno><idno type="eISSN">1098-1128</idno><imprint><biblScope unit="vol">28</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="278">278</biblScope><biblScope unit="page" to="308">308</biblScope><biblScope unit="page-count">31</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-03">2008-03</date></imprint><idno type="ISSN">0198-6325</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0198-6325</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In recent years, there has been an ever‐increasing need for rapid reactions that meet the three main criteria of an ideal synthesis: efficiency, versatility, and selectivity. Such reactions would allow medicinal chemistry to keep pace with the multitude of information derived from modern biological screening techniques. The present review describes one of these reactions, the 1,3‐dipolar cycloaddition (“click‐reaction”) between azides and alkynes catalyzed by copper (I) salts. The simplicity of this reaction and the ease of purification of the resulting products have opened new opportunities in generating vast arrays of compounds with biological potential. The present review will outline the accomplishments of this strategy achieved so far and outline some of medicinal chemistry applications in which click‐chemistry might be relevant in the future. © 2007 Wiley Periodicals, Inc. Med Res Rev, 28, No. 2, 278–308, 2008</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Tron, Gian Cesare" sort="Tron, Gian Cesare" uniqKey="Tron G" first="Gian Cesare" last="Tron">Gian Cesare Tron</name></noRegion><name sortKey="Billington, Richard A" sort="Billington, Richard A" uniqKey="Billington R" first="Richard A." last="Billington">Richard A. Billington</name><name sortKey="Canonico, Pier Luigi" sort="Canonico, Pier Luigi" uniqKey="Canonico P" first="Pier Luigi" last="Canonico">Pier Luigi Canonico</name><name sortKey="Genazzani, Armando A" sort="Genazzani, Armando A" uniqKey="Genazzani A" first="Armando A." last="Genazzani">Armando A. Genazzani</name><name sortKey="Pirali, Tracey" sort="Pirali, Tracey" uniqKey="Pirali T" first="Tracey" last="Pirali">Tracey Pirali</name><name sortKey="Sorba, Giovanni" sort="Sorba, Giovanni" uniqKey="Sorba G" first="Giovanni" last="Sorba">Giovanni Sorba</name><name sortKey="Tron, Gian Cesare" sort="Tron, Gian Cesare" uniqKey="Tron G" first="Gian Cesare" last="Tron">Gian Cesare Tron</name><name sortKey="Tron, Gian Cesare" sort="Tron, Gian Cesare" uniqKey="Tron G" first="Gian Cesare" last="Tron">Gian Cesare Tron</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E45 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001E45 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= StressCovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:B7853D53492A6D252A92E9B9EB9CDC6775CB6956
|texte= Click chemistry reactions in medicinal chemistry: Applications of the 1,3‐dipolar cycloaddition between azides and alkynes
}}
| This area was generated with Dilib version V0.6.33. |  |