StressCovidV1, Main, Exploration, bibRecord, 001281

Toxoplasma gondii and other risk factors for schizophrenia: an update.

Identifieur interne : 001281 ( Main/Exploration ); précédent : 001280; suivant : 001282

Toxoplasma gondii and other risk factors for schizophrenia: an update.

Auteurs : E Fuller Torrey [États-Unis] ; John J. Bartko ; Robert H. Yolken

Source :

Schizophrenia bulletin [ 1745-1701 ] ; 2012.

RBID : pubmed:22446566

Descripteurs français

KwdFr :
- Anticorps antiprotozoaires (biosynthèse), Facteurs de risque, Humains, Schizophrénie (génétique), Schizophrénie (parasitologie), Schizophrénie (étiologie), Toxoplasma (immunologie), Toxoplasma (pathogénicité), Toxoplasmose (), Toxoplasmose (génétique), Toxoplasmose (psychologie).
MESH :
- biosynthèse : Anticorps antiprotozoaires.
- génétique : Schizophrénie, Toxoplasmose.
- immunologie : Toxoplasma.
- parasitologie : Schizophrénie.
- pathogénicité : Toxoplasma.
- psychologie : Toxoplasmose.
- étiologie : Schizophrénie.
- Facteurs de risque, Humains, Toxoplasmose.

English descriptors

KwdEn :
- Antibodies, Protozoan (biosynthesis), Humans, Risk Factors, Schizophrenia (etiology), Schizophrenia (genetics), Schizophrenia (parasitology), Toxoplasma (immunology), Toxoplasma (pathogenicity), Toxoplasmosis (complications), Toxoplasmosis (genetics), Toxoplasmosis (psychology).
MESH :
- chemical , biosynthesis : Antibodies, Protozoan.
- complications : Toxoplasmosis.
- etiology : Schizophrenia.
- genetics : Schizophrenia, Toxoplasmosis.
- immunology : Toxoplasma.
- parasitology : Schizophrenia.
- pathogenicity : Toxoplasma.
- psychology : Toxoplasmosis.
- Humans, Risk Factors.

Abstract

The failure to find genes of major effect in schizophrenia has refocused attention on nongenetic, including infectious factors. In a previous study, antibodies to Toxoplasma gondii were found to be elevated in 23 studies of schizophrenia (OR 2.73; 95% CI 2.10-3.60). The current study replicates this finding with 15 additional studies (OR 2.71; 95% CI 1.93-3.80) and compares this with other identified schizophrenia risk factors. The highest risk factors are having an affected mother (relative risks [RR] 9.31; 95% CI 7.24-11.96), father (RR 7.20; 95% CI 5.10-10.16), or sibling (RR 6.99; 95% CI 5.38-9.08) or being the offspring of immigrants from selected countries (RR 4.5; 95% CI 1.5-13.1). Intermediate risk factors, in addition to infection with T. gondii, include being an immigrant from and to selected countries (RR 2.7; 95% CI 2.3-3.2), being born in (RR 2.24; 95% CI 1.92-2.61) or raised in (RR 2.75; 95% CI 2.31-3.28) an urban area, cannabis use (OR 2.10-2.93; 95% CI 1.08-6.13), having minor physical anomalies (OR 2.23; 95% CI 1.42-3.58), or having a father 55 or older (OR 2.21-5.92; 95% CI 1.46-17.02). Low-risk factors include a history of traumatic brain injury (OR 1.65; 95% CI 1.17-2.32), sex abuse in childhood (OR 1.46; 95% CI 0.84-2.52), obstetrical complications (OR 1.29-1.38; 95% CI 1.00-1.84), having a father 45 or older (OR 1.21-1.66; 95% CI 1.09-2.01), specific genetic polymorphisms (OR 1.09-1.24; 95% CI 1.06-1.45), birth seasonality (OR 1.07-1.95; 95% CI 1.05-2.91), maternal exposure to influenza (RR 1.05; 95% CI 0.98-1.12), or prenatal stress (RR 0.98-1.00; 95% CI 0.85-1.16).

DOI: 10.1093/schbul/sbs043
PubMed: 22446566

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">The failure to find genes of major effect in schizophrenia has refocused attention on nongenetic, including infectious factors. In a previous study, antibodies to Toxoplasma gondii were found to be elevated in 23 studies of schizophrenia (OR 2.73; 95% CI 2.10-3.60). The current study replicates this finding with 15 additional studies (OR 2.71; 95% CI 1.93-3.80) and compares this with other identified schizophrenia risk factors. The highest risk factors are having an affected mother (relative risks [RR] 9.31; 95% CI 7.24-11.96), father (RR 7.20; 95% CI 5.10-10.16), or sibling (RR 6.99; 95% CI 5.38-9.08) or being the offspring of immigrants from selected countries (RR 4.5; 95% CI 1.5-13.1). Intermediate risk factors, in addition to infection with T. gondii, include being an immigrant from and to selected countries (RR 2.7; 95% CI 2.3-3.2), being born in (RR 2.24; 95% CI 1.92-2.61) or raised in (RR 2.75; 95% CI 2.31-3.28) an urban area, cannabis use (OR 2.10-2.93; 95% CI 1.08-6.13), having minor physical anomalies (OR 2.23; 95% CI 1.42-3.58), or having a father 55 or older (OR 2.21-5.92; 95% CI 1.46-17.02). Low-risk factors include a history of traumatic brain injury (OR 1.65; 95% CI 1.17-2.32), sex abuse in childhood (OR 1.46; 95% CI 0.84-2.52), obstetrical complications (OR 1.29-1.38; 95% CI 1.00-1.84), having a father 45 or older (OR 1.21-1.66; 95% CI 1.09-2.01), specific genetic polymorphisms (OR 1.09-1.24; 95% CI 1.06-1.45), birth seasonality (OR 1.07-1.95; 95% CI 1.05-2.91), maternal exposure to influenza (RR 1.05; 95% CI 0.98-1.12), or prenatal stress (RR 0.98-1.00; 95% CI 0.85-1.16).</div>
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Toxoplasma gondii and other risk factors for schizophrenia: an update.

Toxoplasma gondii and other risk factors for schizophrenia: an update.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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