Post‐translational regulation of antiviral innate signaling
Identifieur interne : 000A75 ( Main/Exploration ); précédent : 000A74; suivant : 000A76Post‐translational regulation of antiviral innate signaling
Auteurs : Yilong Zhou ; Chenxi He ; Lin Wang ; Baoxue GeSource :
- European Journal of Immunology [ 0014-2980 ] ; 2017.
Abstract
The innate immune system initiates immune responses by pattern‐recognition receptors (PRR). Virus‐derived nucleic acids are sensed by the retinoic acid‐inducible gene I (RIG‐I)‐like receptor (RLR) family and the toll‐like receptor (TLR) family as well as the DNA sensor cyclic GMP‐AMP (cGAMP) synthase (cGAS). These receptors activate IRF3/7 and NF‐κB signaling pathways to induce the expression of type I interferons (IFNs) and other cytokines firing antiviral responses within the cell. However, to achieve a favorable outcome for the host, a balanced production of IFNs and activation of antiviral responses is required. Post‐translational modifications (PTMs), such as the covalent linkage of functional groups to amino acid chains, are crucial for this immune homeostasis in antiviral responses. Canonical PTMs including phosphorylation and ubiquitination have been extensively studied and other PTMs such as methylation, acetylation, SUMOylation, ADP‐ribosylation and glutamylation are being increasingly implicated in antiviral innate immunity. Here we summarize our recent understanding of the most important PTMs regulating the antiviral innate immune response, and their role in virus‐related immune pathogenesis.
Url:
DOI: 10.1002/eji.201746959
PubMed: 28744851
PubMed Central: 7163624
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000908
- to stream Pmc, to step Curation: 000908
- to stream Pmc, to step Checkpoint: 000754
- to stream Ncbi, to step Merge: 000870
- to stream Ncbi, to step Curation: 000870
- to stream Ncbi, to step Checkpoint: 000870
- to stream Main, to step Merge: 000A76
- to stream Main, to step Curation: 000A75
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Post‐translational regulation of antiviral innate signaling</title><author><name sortKey="Zhou, Yilong" sort="Zhou, Yilong" uniqKey="Zhou Y" first="Yilong" last="Zhou">Yilong Zhou</name><affiliation><nlm:aff id="eji4013-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="He, Chenxi" sort="He, Chenxi" uniqKey="He C" first="Chenxi" last="He">Chenxi He</name><affiliation><nlm:aff id="eji4013-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Wang, Lin" sort="Wang, Lin" uniqKey="Wang L" first="Lin" last="Wang">Lin Wang</name><affiliation><nlm:aff id="eji4013-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Ge, Baoxue" sort="Ge, Baoxue" uniqKey="Ge B" first="Baoxue" last="Ge">Baoxue Ge</name><affiliation><nlm:aff id="eji4013-aff-0001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28744851</idno><idno type="pmc">7163624</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163624</idno><idno type="RBID">PMC:7163624</idno><idno type="doi">10.1002/eji.201746959</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000908</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000908</idno><idno type="wicri:Area/Pmc/Curation">000908</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000908</idno><idno type="wicri:Area/Pmc/Checkpoint">000754</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000754</idno><idno type="wicri:Area/Ncbi/Merge">000870</idno><idno type="wicri:Area/Ncbi/Curation">000870</idno><idno type="wicri:Area/Ncbi/Checkpoint">000870</idno><idno type="wicri:doubleKey">0014-2980:2017:Zhou Y:post:translational:regulation</idno><idno type="wicri:Area/Main/Merge">000A76</idno><idno type="wicri:Area/Main/Curation">000A75</idno><idno type="wicri:Area/Main/Exploration">000A75</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Post‐translational regulation of antiviral innate signaling</title><author><name sortKey="Zhou, Yilong" sort="Zhou, Yilong" uniqKey="Zhou Y" first="Yilong" last="Zhou">Yilong Zhou</name><affiliation><nlm:aff id="eji4013-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="He, Chenxi" sort="He, Chenxi" uniqKey="He C" first="Chenxi" last="He">Chenxi He</name><affiliation><nlm:aff id="eji4013-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Wang, Lin" sort="Wang, Lin" uniqKey="Wang L" first="Lin" last="Wang">Lin Wang</name><affiliation><nlm:aff id="eji4013-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Ge, Baoxue" sort="Ge, Baoxue" uniqKey="Ge B" first="Baoxue" last="Ge">Baoxue Ge</name><affiliation><nlm:aff id="eji4013-aff-0001"></nlm:aff></affiliation></author></analytic><series><title level="j">European Journal of Immunology</title><idno type="ISSN">0014-2980</idno><idno type="eISSN">1521-4141</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>The innate immune system initiates immune responses by pattern‐recognition receptors (PRR). Virus‐derived nucleic acids are sensed by the retinoic acid‐inducible gene I (RIG‐I)‐like receptor (RLR) family and the toll‐like receptor (TLR) family as well as the DNA sensor cyclic GMP‐AMP (cGAMP) synthase (cGAS). These receptors activate IRF3/7 and NF‐κB signaling pathways to induce the expression of type I interferons (IFNs) and other cytokines firing antiviral responses within the cell. However, to achieve a favorable outcome for the host, a balanced production of IFNs and activation of antiviral responses is required. Post‐translational modifications (PTMs), such as the covalent linkage of functional groups to amino acid chains, are crucial for this immune homeostasis in antiviral responses. Canonical PTMs including phosphorylation and ubiquitination have been extensively studied and other PTMs such as methylation, acetylation, SUMOylation, ADP‐ribosylation and glutamylation are being increasingly implicated in antiviral innate immunity. Here we summarize our recent understanding of the most important PTMs regulating the antiviral innate immune response, and their role in virus‐related immune pathogenesis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Ge, Baoxue" sort="Ge, Baoxue" uniqKey="Ge B" first="Baoxue" last="Ge">Baoxue Ge</name><name sortKey="He, Chenxi" sort="He, Chenxi" uniqKey="He C" first="Chenxi" last="He">Chenxi He</name><name sortKey="Wang, Lin" sort="Wang, Lin" uniqKey="Wang L" first="Lin" last="Wang">Lin Wang</name><name sortKey="Zhou, Yilong" sort="Zhou, Yilong" uniqKey="Zhou Y" first="Yilong" last="Zhou">Yilong Zhou</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A75 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A75 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= StressCovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:7163624
|texte= Post‐translational regulation of antiviral innate signaling
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28744851" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a StressCovidV1
| This area was generated with Dilib version V0.6.33. |  |