Involvement of CD91 and scavenger receptors in Hsp70-facilitated activation of human antigen-specific CD4+ memory T cells.
Identifieur interne : 001781 ( Main/Curation ); précédent : 001780; suivant : 001782Involvement of CD91 and scavenger receptors in Hsp70-facilitated activation of human antigen-specific CD4+ memory T cells.
Auteurs : Nadja Fischer [Allemagne] ; Markus Haug ; William W. Kwok ; Hubert Kalbacher ; Dorothee Wernet ; Guenther E. Dannecker ; Ursula HolzerSource :
- European journal of immunology [ 1521-4141 ] ; 2010.
Descripteurs français
- KwdFr :
- Activation des lymphocytes (immunologie), Antigènes CD (génétique), Antigènes CD (immunologie), Antigènes HLA-DR (immunologie), Antigènes d'histocompatibilité de classe II (immunologie), Antigènes de différenciation des lymphocytes B (immunologie), Antigènes viraux (immunologie), Chaines HLA-DRB1, Données de séquences moléculaires, Fragments peptidiques (immunologie), Glycoprotéine hémagglutinine du virus influenza (immunologie), Humains, Lymphocytes T CD4+ (immunologie), Lymphokines (biosynthèse), Lymphokines (génétique), Monocytes (immunologie), Mémoire immunologique (immunologie), Petit ARN interférent (pharmacologie), Polyosides (pharmacologie), Protéine-1 apparentée au récepteur des LDL, Protéines du choc thermique HSP70 (immunologie), Récepteurs éboueurs (immunologie), Récepteurs éboueurs de classe E (immunologie), Récepteurs éboueurs de classe F (immunologie), Sous-populations de lymphocytes (immunologie), Séquence d'acides aminés, Techniques de knock-down de gènes, Toxine tétanique (immunologie).
- MESH :
- biosynthèse : Lymphokines.
- génétique : Antigènes CD, Lymphokines.
- immunologie : Activation des lymphocytes, Antigènes CD, Antigènes HLA-DR, Antigènes d'histocompatibilité de classe II, Antigènes de différenciation des lymphocytes B, Antigènes viraux, Fragments peptidiques, Glycoprotéine hémagglutinine du virus influenza, Lymphocytes T CD4+, Monocytes, Mémoire immunologique, Protéines du choc thermique HSP70, Récepteurs éboueurs, Récepteurs éboueurs de classe E, Récepteurs éboueurs de classe F, Sous-populations de lymphocytes, Toxine tétanique.
- pharmacologie : Petit ARN interférent, Polyosides.
- Chaines HLA-DRB1, Données de séquences moléculaires, Humains, Protéine-1 apparentée au récepteur des LDL, Séquence d'acides aminés, Techniques de knock-down de gènes.
English descriptors
- KwdEn :
- Amino Acid Sequence, Antigens, CD (genetics), Antigens, CD (immunology), Antigens, Differentiation, B-Lymphocyte (immunology), Antigens, Viral (immunology), CD36 Antigens (immunology), CD4-Positive T-Lymphocytes (immunology), Gene Knockdown Techniques, HLA-DR Antigens (immunology), HLA-DRB1 Chains, HSP70 Heat-Shock Proteins (immunology), Hemagglutinin Glycoproteins, Influenza Virus (immunology), Histocompatibility Antigens Class II (immunology), Humans, Immunologic Memory (immunology), Low Density Lipoprotein Receptor-Related Protein-1, Lymphocyte Activation (immunology), Lymphocyte Subsets (immunology), Lymphokines (biosynthesis), Lymphokines (genetics), Molecular Sequence Data, Monocytes (immunology), Peptide Fragments (immunology), Polysaccharides (pharmacology), RNA, Small Interfering (pharmacology), Receptors, Scavenger (immunology), Scavenger Receptors, Class E (immunology), Scavenger Receptors, Class F (immunology), Tetanus Toxin (immunology).
- MESH :
- chemical , biosynthesis : Lymphokines.
- chemical , genetics : Antigens, CD, Lymphokines.
- chemical , immunology : Antigens, CD, Antigens, Differentiation, B-Lymphocyte, Antigens, Viral, CD36 Antigens, HLA-DR Antigens, HSP70 Heat-Shock Proteins, Hemagglutinin Glycoproteins, Influenza Virus, Histocompatibility Antigens Class II, Peptide Fragments, Receptors, Scavenger, Scavenger Receptors, Class E, Scavenger Receptors, Class F, Tetanus Toxin.
- immunology : CD4-Positive T-Lymphocytes, Immunologic Memory, Lymphocyte Activation, Lymphocyte Subsets, Monocytes.
- chemical , pharmacology : Polysaccharides, RNA, Small Interfering.
- Amino Acid Sequence, Gene Knockdown Techniques, HLA-DRB1 Chains, Humans, Low Density Lipoprotein Receptor-Related Protein-1, Molecular Sequence Data.
Abstract
Hsp70 plays several roles in the adaptive immune response. Based on the ability to interact with diverse peptides, extracellular Hsp70:peptide complexes exert profound effects both in autoimmunity and in tumor rejection by evoking potent T cell responses to the chaperoned peptide. The interaction with receptors on APC represents the basis for the immunological functions of Hsp70 and a critical point where the immune response can be regulated. Various surface proteins (e.g. CD91, scavenger receptors (SR)) have been implicated in binding of Hsp70. In this study, antigenic peptides from tetanus toxin and influenza hemagglutinin complexed to human stress-inducible Hsp70 were found to enhance the proliferation and cytokine production of human antigen-specific CD4(+) T cells. This was demonstrated in proliferation experiments using human monocytes as APC. Proliferated antigen-specific cells were detected combining HLA-DRB1*0401 or HLA-DRB1*1101 tetramer and CFSE staining. Treating monocytes with CD91 siRNA diminished these effects. Additional blocking of SR by the SR ligand fucoidan completely abolished enhanced proliferation and production of Th1 and Th2 cytokines. Taken together, our data indicate that in the human system, CD91 and members of the SR family efficiently direct Hsp70:peptide complexes into the MHC class II presentation pathway and thus enhance antigen-specific CD4(+) T cell responses.
DOI: 10.1002/eji.200939738
PubMed: 20101615
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pubmed:20101615Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Antigens, CD (genetics)</term>
<term>Antigens, CD (immunology)</term>
<term>Antigens, Differentiation, B-Lymphocyte (immunology)</term>
<term>Antigens, Viral (immunology)</term>
<term>CD36 Antigens (immunology)</term>
<term>CD4-Positive T-Lymphocytes (immunology)</term>
<term>Gene Knockdown Techniques</term>
<term>HLA-DR Antigens (immunology)</term>
<term>HLA-DRB1 Chains</term>
<term>HSP70 Heat-Shock Proteins (immunology)</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term>
<term>Histocompatibility Antigens Class II (immunology)</term>
<term>Humans</term>
<term>Immunologic Memory (immunology)</term>
<term>Low Density Lipoprotein Receptor-Related Protein-1</term>
<term>Lymphocyte Activation (immunology)</term>
<term>Lymphocyte Subsets (immunology)</term>
<term>Lymphokines (biosynthesis)</term>
<term>Lymphokines (genetics)</term>
<term>Molecular Sequence Data</term>
<term>Monocytes (immunology)</term>
<term>Peptide Fragments (immunology)</term>
<term>Polysaccharides (pharmacology)</term>
<term>RNA, Small Interfering (pharmacology)</term>
<term>Receptors, Scavenger (immunology)</term>
<term>Scavenger Receptors, Class E (immunology)</term>
<term>Scavenger Receptors, Class F (immunology)</term>
<term>Tetanus Toxin (immunology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes (immunologie)</term>
<term>Antigènes CD (génétique)</term>
<term>Antigènes CD (immunologie)</term>
<term>Antigènes HLA-DR (immunologie)</term>
<term>Antigènes d'histocompatibilité de classe II (immunologie)</term>
<term>Antigènes de différenciation des lymphocytes B (immunologie)</term>
<term>Antigènes viraux (immunologie)</term>
<term>Chaines HLA-DRB1</term>
<term>Données de séquences moléculaires</term>
<term>Fragments peptidiques (immunologie)</term>
<term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term>
<term>Humains</term>
<term>Lymphocytes T CD4+ (immunologie)</term>
<term>Lymphokines (biosynthèse)</term>
<term>Lymphokines (génétique)</term>
<term>Monocytes (immunologie)</term>
<term>Mémoire immunologique (immunologie)</term>
<term>Petit ARN interférent (pharmacologie)</term>
<term>Polyosides (pharmacologie)</term>
<term>Protéine-1 apparentée au récepteur des LDL</term>
<term>Protéines du choc thermique HSP70 (immunologie)</term>
<term>Récepteurs éboueurs (immunologie)</term>
<term>Récepteurs éboueurs de classe E (immunologie)</term>
<term>Récepteurs éboueurs de classe F (immunologie)</term>
<term>Sous-populations de lymphocytes (immunologie)</term>
<term>Séquence d'acides aminés</term>
<term>Techniques de knock-down de gènes</term>
<term>Toxine tétanique (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Lymphokines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, CD</term>
<term>Lymphokines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, CD</term>
<term>Antigens, Differentiation, B-Lymphocyte</term>
<term>Antigens, Viral</term>
<term>CD36 Antigens</term>
<term>HLA-DR Antigens</term>
<term>HSP70 Heat-Shock Proteins</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
<term>Histocompatibility Antigens Class II</term>
<term>Peptide Fragments</term>
<term>Receptors, Scavenger</term>
<term>Scavenger Receptors, Class E</term>
<term>Scavenger Receptors, Class F</term>
<term>Tetanus Toxin</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Lymphokines</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes CD</term>
<term>Lymphokines</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Antigènes CD</term>
<term>Antigènes HLA-DR</term>
<term>Antigènes d'histocompatibilité de classe II</term>
<term>Antigènes de différenciation des lymphocytes B</term>
<term>Antigènes viraux</term>
<term>Fragments peptidiques</term>
<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Lymphocytes T CD4+</term>
<term>Monocytes</term>
<term>Mémoire immunologique</term>
<term>Protéines du choc thermique HSP70</term>
<term>Récepteurs éboueurs</term>
<term>Récepteurs éboueurs de classe E</term>
<term>Récepteurs éboueurs de classe F</term>
<term>Sous-populations de lymphocytes</term>
<term>Toxine tétanique</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term>
<term>Immunologic Memory</term>
<term>Lymphocyte Activation</term>
<term>Lymphocyte Subsets</term>
<term>Monocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Petit ARN interférent</term>
<term>Polyosides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Polysaccharides</term>
<term>RNA, Small Interfering</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Gene Knockdown Techniques</term>
<term>HLA-DRB1 Chains</term>
<term>Humans</term>
<term>Low Density Lipoprotein Receptor-Related Protein-1</term>
<term>Molecular Sequence Data</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Chaines HLA-DRB1</term>
<term>Données de séquences moléculaires</term>
<term>Humains</term>
<term>Protéine-1 apparentée au récepteur des LDL</term>
<term>Séquence d'acides aminés</term>
<term>Techniques de knock-down de gènes</term>
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<front><div type="abstract" xml:lang="en">Hsp70 plays several roles in the adaptive immune response. Based on the ability to interact with diverse peptides, extracellular Hsp70:peptide complexes exert profound effects both in autoimmunity and in tumor rejection by evoking potent T cell responses to the chaperoned peptide. The interaction with receptors on APC represents the basis for the immunological functions of Hsp70 and a critical point where the immune response can be regulated. Various surface proteins (e.g. CD91, scavenger receptors (SR)) have been implicated in binding of Hsp70. In this study, antigenic peptides from tetanus toxin and influenza hemagglutinin complexed to human stress-inducible Hsp70 were found to enhance the proliferation and cytokine production of human antigen-specific CD4(+) T cells. This was demonstrated in proliferation experiments using human monocytes as APC. Proliferated antigen-specific cells were detected combining HLA-DRB1*0401 or HLA-DRB1*1101 tetramer and CFSE staining. Treating monocytes with CD91 siRNA diminished these effects. Additional blocking of SR by the SR ligand fucoidan completely abolished enhanced proliferation and production of Th1 and Th2 cytokines. Taken together, our data indicate that in the human system, CD91 and members of the SR family efficiently direct Hsp70:peptide complexes into the MHC class II presentation pathway and thus enhance antigen-specific CD4(+) T cell responses.</div>
</front>
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