StressCovidV1, Main, Curation, bibRecord, 000A90

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication.

Identifieur interne : 000A90 ( Main/Curation ); précédent : 000A89; suivant : 000A91

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication.

Auteurs : Sharon K. Kuss-Duerkop [États-Unis] ; Juan Wang [États-Unis] ; Ignacio Mena [États-Unis] ; Kris White [États-Unis] ; Giorgi Metreveli [États-Unis] ; Ramanavelan Sakthivel [États-Unis] ; Miguel A. Mata [États-Unis] ; Raquel Mu Oz-Moreno [États-Unis] ; Xiang Chen [États-Unis] ; Florian Krammer [États-Unis] ; Michael S. Diamond [États-Unis] ; Zhijian J. Chen [États-Unis] ; Adolfo García-Sastre [États-Unis] ; Beatriz M A. Fontoura [États-Unis]

Source :

PLoS pathogens [ 1553-7374 ] ; 2017.

RBID : pubmed:28953980

Descripteurs français

English descriptors

KwdEn :
- Carrier Proteins (metabolism), Cell Movement (physiology), DNA Replication, Down-Regulation (drug effects), Humans, Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, Multiprotein Complexes (metabolism), Orthomyxoviridae (physiology), Phosphorylation (drug effects), Proto-Oncogene Proteins c-akt (metabolism), Signal Transduction (physiology), TOR Serine-Threonine Kinases (metabolism), Transcription Factors (metabolism), Virus Replication.
MESH :
- chemical , metabolism : Carrier Proteins, Multiprotein Complexes, Proto-Oncogene Proteins c-akt, TOR Serine-Threonine Kinases, Transcription Factors.
- drug effects : Down-Regulation, Phosphorylation.
- physiology : Cell Movement, Orthomyxoviridae, Signal Transduction.
- DNA Replication, Humans, Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, Virus Replication.

Abstract

Influenza A virus usurps host signaling factors to regulate its replication. One example is mTOR, a cellular regulator of protein synthesis, growth and motility. While the role of mTORC1 in viral infection has been studied, the mechanisms that induce mTORC1 activation and the substrates regulated by mTORC1 during influenza virus infection have not been established. In addition, the role of mTORC2 during influenza virus infection remains unknown. Here we show that mTORC2 and PDPK1 differentially phosphorylate AKT upon influenza virus infection. PDPK1-mediated phoshorylation of AKT at a distinct site is required for mTORC1 activation by influenza virus. On the other hand, the viral NS1 protein promotes phosphorylation of AKT at a different site via mTORC2, which is an activity dispensable for mTORC1 stimulation but known to regulate apoptosis. Influenza virus HA protein and down-regulation of the mTORC1 inhibitor REDD1 by the virus M2 protein promote mTORC1 activity. Systematic phosphoproteomics analysis performed in cells lacking the mTORC2 component Rictor in the absence or presence of Torin, an inhibitor of both mTORC1 and mTORC2, revealed mTORC1-dependent substrates regulated during infection. Members of pathways that regulate mTORC1 or are regulated by mTORC1 were identified, including constituents of the translation machinery that once activated can promote translation. mTORC1 activation supports viral protein expression and replication. As mTORC1 activation is optimal midway through the virus life cycle, the observed effects on viral protein expression likely support the late stages of influenza virus replication when infected cells undergo significant stress.

DOI: 10.1371/journal.ppat.1006635
PubMed: 28953980

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000306
to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000305
to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000322
to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000881
to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000881
to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000881
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :000A91

Links to Exploration step

pubmed:28953980

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication.</title>
<author><name sortKey="Kuss Duerkop, Sharon K" sort="Kuss Duerkop, Sharon K" uniqKey="Kuss Duerkop S" first="Sharon K" last="Kuss-Duerkop">Sharon K. Kuss-Duerkop</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Juan" sort="Wang, Juan" uniqKey="Wang J" first="Juan" last="Wang">Juan Wang</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mena, Ignacio" sort="Mena, Ignacio" uniqKey="Mena I" first="Ignacio" last="Mena">Ignacio Mena</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="White, Kris" sort="White, Kris" uniqKey="White K" first="Kris" last="White">Kris White</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Metreveli, Giorgi" sort="Metreveli, Giorgi" uniqKey="Metreveli G" first="Giorgi" last="Metreveli">Giorgi Metreveli</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sakthivel, Ramanavelan" sort="Sakthivel, Ramanavelan" uniqKey="Sakthivel R" first="Ramanavelan" last="Sakthivel">Ramanavelan Sakthivel</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mata, Miguel A" sort="Mata, Miguel A" uniqKey="Mata M" first="Miguel A" last="Mata">Miguel A. Mata</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mu Oz Moreno, Raquel" sort="Mu Oz Moreno, Raquel" uniqKey="Mu Oz Moreno R" first="Raquel" last="Mu Oz-Moreno">Raquel Mu Oz-Moreno</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Xiang" sort="Chen, Xiang" uniqKey="Chen X" first="Xiang" last="Chen">Xiang Chen</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krammer, Florian" sort="Krammer, Florian" uniqKey="Krammer F" first="Florian" last="Krammer">Florian Krammer</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Diamond, Michael S" sort="Diamond, Michael S" uniqKey="Diamond M" first="Michael S" last="Diamond">Michael S. Diamond</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Chen, Zhijian J" sort="Chen, Zhijian J" uniqKey="Chen Z" first="Zhijian J" last="Chen">Zhijian J. Chen</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fontoura, Beatriz M A" sort="Fontoura, Beatriz M A" uniqKey="Fontoura B" first="Beatriz M A" last="Fontoura">Beatriz M A. Fontoura</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:28953980</idno>
<idno type="pmid">28953980</idno>
<idno type="doi">10.1371/journal.ppat.1006635</idno>
<idno type="wicri:Area/PubMed/Corpus">000306</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000306</idno>
<idno type="wicri:Area/PubMed/Curation">000305</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000305</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000322</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000322</idno>
<idno type="wicri:Area/Ncbi/Merge">000881</idno>
<idno type="wicri:Area/Ncbi/Curation">000881</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000881</idno>
<idno type="wicri:Area/Main/Merge">000A91</idno>
<idno type="wicri:Area/Main/Curation">000A90</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication.</title>
<author><name sortKey="Kuss Duerkop, Sharon K" sort="Kuss Duerkop, Sharon K" uniqKey="Kuss Duerkop S" first="Sharon K" last="Kuss-Duerkop">Sharon K. Kuss-Duerkop</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Juan" sort="Wang, Juan" uniqKey="Wang J" first="Juan" last="Wang">Juan Wang</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mena, Ignacio" sort="Mena, Ignacio" uniqKey="Mena I" first="Ignacio" last="Mena">Ignacio Mena</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="White, Kris" sort="White, Kris" uniqKey="White K" first="Kris" last="White">Kris White</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Metreveli, Giorgi" sort="Metreveli, Giorgi" uniqKey="Metreveli G" first="Giorgi" last="Metreveli">Giorgi Metreveli</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sakthivel, Ramanavelan" sort="Sakthivel, Ramanavelan" uniqKey="Sakthivel R" first="Ramanavelan" last="Sakthivel">Ramanavelan Sakthivel</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mata, Miguel A" sort="Mata, Miguel A" uniqKey="Mata M" first="Miguel A" last="Mata">Miguel A. Mata</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mu Oz Moreno, Raquel" sort="Mu Oz Moreno, Raquel" uniqKey="Mu Oz Moreno R" first="Raquel" last="Mu Oz-Moreno">Raquel Mu Oz-Moreno</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Xiang" sort="Chen, Xiang" uniqKey="Chen X" first="Xiang" last="Chen">Xiang Chen</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krammer, Florian" sort="Krammer, Florian" uniqKey="Krammer F" first="Florian" last="Krammer">Florian Krammer</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Diamond, Michael S" sort="Diamond, Michael S" uniqKey="Diamond M" first="Michael S" last="Diamond">Michael S. Diamond</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Chen, Zhijian J" sort="Chen, Zhijian J" uniqKey="Chen Z" first="Zhijian J" last="Chen">Zhijian J. Chen</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fontoura, Beatriz M A" sort="Fontoura, Beatriz M A" uniqKey="Fontoura B" first="Beatriz M A" last="Fontoura">Beatriz M A. Fontoura</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS pathogens</title>
<idno type="eISSN">1553-7374</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Carrier Proteins (metabolism)</term>
<term>Cell Movement (physiology)</term>
<term>DNA Replication</term>
<term>Down-Regulation (drug effects)</term>
<term>Humans</term>
<term>Mechanistic Target of Rapamycin Complex 1</term>
<term>Mechanistic Target of Rapamycin Complex 2</term>
<term>Multiprotein Complexes (metabolism)</term>
<term>Orthomyxoviridae (physiology)</term>
<term>Phosphorylation (drug effects)</term>
<term>Proto-Oncogene Proteins c-akt (metabolism)</term>
<term>Signal Transduction (physiology)</term>
<term>TOR Serine-Threonine Kinases (metabolism)</term>
<term>Transcription Factors (metabolism)</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Complexes multiprotéiques (métabolisme)</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Humains</term>
<term>Mouvement cellulaire (physiologie)</term>
<term>Orthomyxoviridae (physiologie)</term>
<term>Phosphorylation ()</term>
<term>Protéines de transport (métabolisme)</term>
<term>Protéines proto-oncogènes c-akt (métabolisme)</term>
<term>Régulation négative ()</term>
<term>Réplication de l'ADN</term>
<term>Réplication virale</term>
<term>Sérine-thréonine kinases TOR (métabolisme)</term>
<term>Transduction du signal (physiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Carrier Proteins</term>
<term>Multiprotein Complexes</term>
<term>Proto-Oncogene Proteins c-akt</term>
<term>TOR Serine-Threonine Kinases</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Down-Regulation</term>
<term>Phosphorylation</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Complexes multiprotéiques</term>
<term>Facteurs de transcription</term>
<term>Protéines de transport</term>
<term>Protéines proto-oncogènes c-akt</term>
<term>Sérine-thréonine kinases TOR</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Mouvement cellulaire</term>
<term>Orthomyxoviridae</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Movement</term>
<term>Orthomyxoviridae</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>DNA Replication</term>
<term>Humans</term>
<term>Mechanistic Target of Rapamycin Complex 1</term>
<term>Mechanistic Target of Rapamycin Complex 2</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Humains</term>
<term>Phosphorylation</term>
<term>Régulation négative</term>
<term>Réplication de l'ADN</term>
<term>Réplication virale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Influenza A virus usurps host signaling factors to regulate its replication. One example is mTOR, a cellular regulator of protein synthesis, growth and motility. While the role of mTORC1 in viral infection has been studied, the mechanisms that induce mTORC1 activation and the substrates regulated by mTORC1 during influenza virus infection have not been established. In addition, the role of mTORC2 during influenza virus infection remains unknown. Here we show that mTORC2 and PDPK1 differentially phosphorylate AKT upon influenza virus infection. PDPK1-mediated phoshorylation of AKT at a distinct site is required for mTORC1 activation by influenza virus. On the other hand, the viral NS1 protein promotes phosphorylation of AKT at a different site via mTORC2, which is an activity dispensable for mTORC1 stimulation but known to regulate apoptosis. Influenza virus HA protein and down-regulation of the mTORC1 inhibitor REDD1 by the virus M2 protein promote mTORC1 activity. Systematic phosphoproteomics analysis performed in cells lacking the mTORC2 component Rictor in the absence or presence of Torin, an inhibitor of both mTORC1 and mTORC2, revealed mTORC1-dependent substrates regulated during infection. Members of pathways that regulate mTORC1 or are regulated by mTORC1 were identified, including constituents of the translation machinery that once activated can promote translation. mTORC1 activation supports viral protein expression and replication. As mTORC1 activation is optimal midway through the virus life cycle, the observed effects on viral protein expression likely support the late stages of influenza virus replication when infected cells undergo significant stress.</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Main/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A90 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 000A90 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    StressCovidV1
   |flux=    Main
   |étape=   Curation
   |type=    RBID
   |clé=     pubmed:28953980
   |texte=   Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i   -Sk "pubmed:28953980" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a StressCovidV1

This area was generated with Dilib version V0.6.33.
Data generation: Wed May 6 16:44:09 2020. Site generation: Sun Mar 28 08:26:57 2021

	Serveur d'exploration Stress et Covid
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Stress et Covid

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication.

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki