Prenatal exposure to radiofrequencies: Effects of WiFi signals on thymocyte development and peripheral T cell compartment in an animal model
Identifieur interne : 000676 ( Istex/Curation ); précédent : 000675; suivant : 000677Prenatal exposure to radiofrequencies: Effects of WiFi signals on thymocyte development and peripheral T cell compartment in an animal model
Auteurs : Federica Laudisi [Italie] ; Manolo Sambucci [Italie] ; Francesca Nasta [Italie] ; Rosanna Pinto [Italie] ; Rossella Lodato [Italie] ; Pierluigi Altavista [Italie] ; Giorgio Alfonso Lovisolo [Italie] ; Carmela Marino [Italie] ; Claudio Pioli [Italie]Source :
- Bioelectromagnetics [ 0197-8462 ] ; 2012-12.
English descriptors
- Teeft :
- Absorption rate, Adult life, Antibody production, Average mass, Bioelectromagnetics, Biological effects, Body mass, Cage control, Cage control group, Cage control groups, Cage control mice, Cage sham, Cell activation, Cell compartment, Cell cultures, Cell development, Cell populations, Cell proliferation, Claudio pioli, Culture supernatants, Cytokine production, Detrimental effects, Different stages, Differential effects, Differentiation process, Dramatic reduction, Early life exposure, Eld, Electromagnetic, Embryo, Exposure period, Female mice, Female offspring, Fetal, Fetal liver, Health effects, Health risks, Hematopoietic, Hematopoietic precursors, High priority, Higher susceptibility, Holladay, Immune, Immune dysfunctions, Immune response, Immune system, Immunol, International agency, International commission, Late time points, Lovisolo, Male mice, Male offspring, Marino, Mouse, Mouse embryo, Mwexposed groups, Mwexposed mice, Nasta, Newborn mice, Noxious agents, Numerical dosimetry, Numerical model, Pinto, Pioli, Possible effects, Pregnancy outcome, Pregnant mice, Pregnant mouse, Pregnant uterus, Prenatal, Prenatal exposure, Prenatal life, Present study, Proliferation, Radiat, Radiation protection, Radiofrequency, Radiofrequency electromagnetic, Radiofrequency radiation, Research agenda, Sambucci, Sham, Similar results, Spleen, Spleen cell cultures, Tcell development, Thymic atrophy, Thymocyte, Thymocyte cell number, Thymocyte number, Thymocytes, Thymus, Toxic compounds, Uterus, Whole body, Wifi, Wifi exposure, Wifi signals, World health organization, Worst case.
Abstract
Wireless local area networks are an increasing alternative to wired data networks in workplaces, homes, and public areas. Concerns about possible health effects of this type of signal, especially when exposure occurs early in life, have been raised. We examined the effects of prenatal (in utero) exposure to wireless fidelity (WiFi) signal‐associated electromagnetic fields (2450 MHz center‐frequency band) on T cell development and function. Pregnant mice were exposed whole body to a specific absorption rate of 4 W/kg, 2 h per day, starting 5 days after mating and ending 1 day before the expected delivery. Sham‐exposed and cage control groups were used as controls. No effects on cell count, phenotype, and proliferation of thymocytes were observed. Also, spleen cell count, CD4/CD8 cell frequencies, T cell proliferation, and cytokine production were not affected by the exposure. These findings were consistently observed in the male and female offspring at early (5 weeks of age) and late (26 weeks of age) time points. Nevertheless, the expected differences associated with aging and/or gender were confirmed. In conclusion, our results do not support the hypothesis that the exposure to WiFi signals during prenatal life results in detrimental effects on the immune T cell compartment. Bioelectromagnetics 33:652–661, 2012. © 2012 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/bem.21733
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Health, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Marino, Carmela" sort="Marino, Carmela" uniqKey="Marino C" first="Carmela" last="Marino">Carmela Marino</name><affiliation wicri:level="1"><mods:affiliation>ENEA (Italian Agency for New Technologies, Energy and Sustainable Economic Development), Unit of Radiation Biology and Human Health, Rome, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>ENEA (Italian Agency for New Technologies, Energy and Sustainable Economic Development), Unit of Radiation Biology and Human Health, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Pioli, Claudio" sort="Pioli, Claudio" uniqKey="Pioli C" first="Claudio" last="Pioli">Claudio Pioli</name><affiliation wicri:level="1"><mods:affiliation>ENEA (Italian Agency for New Technologies, Energy and Sustainable Economic Development), Unit of Radiation Biology and Human Health, Rome, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>ENEA (Italian Agency for New Technologies, Energy and Sustainable Economic Development), Unit of Radiation Biology and Human Health, Rome</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: claudio.pioli@enea.it</mods:affiliation><country wicri:rule="url">Italie</country></affiliation><affiliation wicri:level="1"><mods:affiliation>Correspondence address: ENEA, UTBIORAD‐RAB, Via Anguillarese, 301, 00123 Rome, Italy.</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Correspondence address: ENEA, UTBIORAD‐RAB, Via Anguillarese, 301, 00123 Rome</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Bioelectromagnetics</title><title level="j" type="alt">BIOELECTROMAGNETICS</title><idno type="ISSN">0197-8462</idno><idno type="eISSN">1521-186X</idno><imprint><biblScope unit="vol">33</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="652">652</biblScope><biblScope unit="page" to="661">661</biblScope><biblScope unit="page-count">10</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2012-12">2012-12</date></imprint><idno type="ISSN">0197-8462</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0197-8462</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Absorption rate</term><term>Adult life</term><term>Antibody production</term><term>Average mass</term><term>Bioelectromagnetics</term><term>Biological effects</term><term>Body mass</term><term>Cage control</term><term>Cage control group</term><term>Cage control groups</term><term>Cage control mice</term><term>Cage sham</term><term>Cell activation</term><term>Cell compartment</term><term>Cell cultures</term><term>Cell development</term><term>Cell populations</term><term>Cell proliferation</term><term>Claudio pioli</term><term>Culture supernatants</term><term>Cytokine production</term><term>Detrimental effects</term><term>Different stages</term><term>Differential effects</term><term>Differentiation process</term><term>Dramatic reduction</term><term>Early life exposure</term><term>Eld</term><term>Electromagnetic</term><term>Embryo</term><term>Exposure period</term><term>Female mice</term><term>Female offspring</term><term>Fetal</term><term>Fetal liver</term><term>Health effects</term><term>Health risks</term><term>Hematopoietic</term><term>Hematopoietic precursors</term><term>High priority</term><term>Higher susceptibility</term><term>Holladay</term><term>Immune</term><term>Immune dysfunctions</term><term>Immune response</term><term>Immune system</term><term>Immunol</term><term>International agency</term><term>International commission</term><term>Late time points</term><term>Lovisolo</term><term>Male mice</term><term>Male offspring</term><term>Marino</term><term>Mouse</term><term>Mouse embryo</term><term>Mwexposed groups</term><term>Mwexposed mice</term><term>Nasta</term><term>Newborn mice</term><term>Noxious agents</term><term>Numerical dosimetry</term><term>Numerical model</term><term>Pinto</term><term>Pioli</term><term>Possible effects</term><term>Pregnancy outcome</term><term>Pregnant mice</term><term>Pregnant mouse</term><term>Pregnant uterus</term><term>Prenatal</term><term>Prenatal exposure</term><term>Prenatal life</term><term>Present study</term><term>Proliferation</term><term>Radiat</term><term>Radiation protection</term><term>Radiofrequency</term><term>Radiofrequency electromagnetic</term><term>Radiofrequency radiation</term><term>Research agenda</term><term>Sambucci</term><term>Sham</term><term>Similar results</term><term>Spleen</term><term>Spleen cell cultures</term><term>Tcell development</term><term>Thymic atrophy</term><term>Thymocyte</term><term>Thymocyte cell number</term><term>Thymocyte number</term><term>Thymocytes</term><term>Thymus</term><term>Toxic compounds</term><term>Uterus</term><term>Whole body</term><term>Wifi</term><term>Wifi exposure</term><term>Wifi signals</term><term>World health organization</term><term>Worst case</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Wireless local area networks are an increasing alternative to wired data networks in workplaces, homes, and public areas. Concerns about possible health effects of this type of signal, especially when exposure occurs early in life, have been raised. We examined the effects of prenatal (in utero) exposure to wireless fidelity (WiFi) signal‐associated electromagnetic fields (2450 MHz center‐frequency band) on T cell development and function. Pregnant mice were exposed whole body to a specific absorption rate of 4 W/kg, 2 h per day, starting 5 days after mating and ending 1 day before the expected delivery. Sham‐exposed and cage control groups were used as controls. No effects on cell count, phenotype, and proliferation of thymocytes were observed. Also, spleen cell count, CD4/CD8 cell frequencies, T cell proliferation, and cytokine production were not affected by the exposure. These findings were consistently observed in the male and female offspring at early (5 weeks of age) and late (26 weeks of age) time points. Nevertheless, the expected differences associated with aging and/or gender were confirmed. In conclusion, our results do not support the hypothesis that the exposure to WiFi signals during prenatal life results in detrimental effects on the immune T cell compartment. Bioelectromagnetics 33:652–661, 2012. © 2012 Wiley Periodicals, Inc.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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