Proteomic analysis of serum, plasma, and lymph for the identification of biomarkers
Identifieur interne : 000515 ( Istex/Corpus ); précédent : 000514; suivant : 000516Proteomic analysis of serum, plasma, and lymph for the identification of biomarkers
Auteurs : Zhaojing Meng ; Timothy D. VeenstraSource :
- PROTEOMICS – Clinical Applications [ 1862-8346 ] ; 2007-08.
Abstract
Probably no topic has generated more excitement in the world of proteomics than the search for biomarkers. This excitement has been generated by two realities: the constant need for better biomarkers that can be used for disease diagnosis and prognosis, and the recent developments in proteomic technologies that are capable of scanning the individual proteins within varying complex clinical samples. Ideally a biomarker would be assayable from a noninvasively collected sample, therefore, much of the focus in proteomics has been on the analysis of biofluids such as serum, plasma, urine, cerebrospinal fluid, lymph, etc. While the discovery of biomarkers has been elusive, there have been many advances made in the understanding of the proteome content of various biofluids, and in the technologies used for their analysis, that continues to point the research community toward new methods for achieving the ultimate goal of identifying novel disease‐specific biomarkers. In this review, we will describe and discuss many of the proteomic approaches taken in an attempt to find novel biomarkers in serum, plasma, and lymph.
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DOI: 10.1002/prca.200700243
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ISTEX:40BDA9A670C670D32C72CFED6C558622668F5AAFLe document en format XML
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Appl.</title></titleGroup></publicationMeta><publicationMeta level="part" position="80"><doi origin="wiley" registered="yes">10.1002/prca.v1:8</doi><titleGroup><title type="specialIssueTitle">PROTEOMIC ANALYSIS OF BIOLOGICAL FLUIDS</title></titleGroup><numberingGroup><numbering type="journalVolume" number="1">1</numbering><numbering type="journalIssue">8</numbering></numberingGroup><creators><creator xml:id="sped1" creatorRole="sponsoringEditor"><personName><givenNames>Roz</givenNames><familyName>Banks</familyName></personName></creator></creators><coverDate startDate="2007-08">No. 8 August 2007</coverDate></publicationMeta><publicationMeta level="unit" type="reviewArticle" position="6" status="forIssue"><doi origin="wiley" registered="yes">10.1002/prca.200700243</doi><idGroup><id type="unit" value="PRCA200700243"></id></idGroup><countGroup><count type="pageTotal" number="11"></count></countGroup><titleGroup><title type="articleCategory">Review</title><title type="tocHeading1">Reviews</title></titleGroup><copyright ownership="publisher">Copyright © 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</copyright><eventGroup><event type="manuscriptReceived" date="2007-03-09"></event><event type="firstOnline" date="2007-07-13"></event><event type="publishedOnlineFinalForm" date="2007-08-06"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2007-07-13"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.5.2 mode:FullText source:HeaderRef result:HeaderRef" date="2011-07-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-07"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-03"></event></eventGroup><numberingGroup><numbering type="pageFirst">747</numbering><numbering type="pageLast">757</numbering></numberingGroup><correspondenceTo>SAIC‐Frederick Inc., National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, USA <b>Fax:</b> +1‐301‐846‐6037</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:PRCA.PRCA200700243.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="6"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="40"></count></countGroup><titleGroup><title type="main" xml:lang="en">Proteomic analysis of serum, plasma, and lymph for the identification of biomarkers</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#a1"><personName><givenNames>Zhaojing</givenNames><familyName>Meng</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#a1" corresponding="yes"><personName><givenNames>Timothy D.</givenNames><familyName>Veenstra</familyName><degrees>Dr.</degrees></personName><contactDetails><email>veenstra@ncifcrf.gov</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="US" type="organization"><unparsedAffiliation>Laboratory of Proteomics and Analytical Technologies, SAIC‐Frederick Inc., National Cancer Institute at Frederick, Frederick, MD, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Biomarker</keyword><keyword xml:id="kwd2">Clinical diagnostics</keyword><keyword xml:id="kwd3">Lymph</keyword><keyword xml:id="kwd4">Plasma</keyword><keyword xml:id="kwd5">Serum</keyword></keywordGroup><fundingInfo><fundingAgency>National Institutes of Health</fundingAgency><fundingNumber>NO1-CO-12400</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Probably no topic has generated more excitement in the world of proteomics than the search for biomarkers. This excitement has been generated by two realities: the constant need for better biomarkers that can be used for disease diagnosis and prognosis, and the recent developments in proteomic technologies that are capable of scanning the individual proteins within varying complex clinical samples. Ideally a biomarker would be assayable from a noninvasively collected sample, therefore, much of the focus in proteomics has been on the analysis of biofluids such as serum, plasma, urine, cerebrospinal fluid, lymph, <i>etc</i>. While the discovery of biomarkers has been elusive, there have been many advances made in the understanding of the proteome content of various biofluids, and in the technologies used for their analysis, that continues to point the research community toward new methods for achieving the ultimate goal of identifying novel disease‐specific biomarkers. In this review, we will describe and discuss many of the proteomic approaches taken in an attempt to find novel biomarkers in serum, plasma, and lymph.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Proteomic analysis of serum, plasma, and lymph for the identification of biomarkers</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Proteomic analysis of serum, plasma, and lymph for the identification of biomarkers</title></titleInfo><name type="personal"><namePart type="given">Zhaojing</namePart><namePart type="family">Meng</namePart><affiliation>Laboratory of Proteomics and Analytical Technologies, SAIC‐Frederick Inc., National Cancer Institute at Frederick, Frederick, MD, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Timothy D.</namePart><namePart type="family">Veenstra</namePart><namePart type="termsOfAddress">Dr.</namePart><affiliation>Laboratory of Proteomics and Analytical Technologies, SAIC‐Frederick Inc., National Cancer Institute at Frederick, Frederick, MD, USA</affiliation><affiliation>E-mail: veenstra@ncifcrf.gov</affiliation><affiliation>Correspondence address: SAIC‐Frederick Inc., National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, USA +1‐301‐846‐6037</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="reviewArticle" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>WILEY‐VCH Verlag</publisher><place><placeTerm type="text">Weinheim</placeTerm></place><dateIssued encoding="w3cdtf">2007-08</dateIssued><dateCaptured encoding="w3cdtf">2007-03-09</dateCaptured><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">6</extent><extent unit="tables">1</extent><extent unit="references">40</extent></physicalDescription><abstract lang="en">Probably no topic has generated more excitement in the world of proteomics than the search for biomarkers. This excitement has been generated by two realities: the constant need for better biomarkers that can be used for disease diagnosis and prognosis, and the recent developments in proteomic technologies that are capable of scanning the individual proteins within varying complex clinical samples. Ideally a biomarker would be assayable from a noninvasively collected sample, therefore, much of the focus in proteomics has been on the analysis of biofluids such as serum, plasma, urine, cerebrospinal fluid, lymph, etc. While the discovery of biomarkers has been elusive, there have been many advances made in the understanding of the proteome content of various biofluids, and in the technologies used for their analysis, that continues to point the research community toward new methods for achieving the ultimate goal of identifying novel disease‐specific biomarkers. 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|texte= Proteomic analysis of serum, plasma, and lymph for the identification of biomarkers
}}
| This area was generated with Dilib version V0.6.33. |  |