Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells’ activity
Identifieur interne : 000092 ( Hal/Curation ); précédent : 000091; suivant : 000093Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells’ activity
Auteurs : C. Morel [France] ; S. Fernandez [France] ; F. Pantouli [Royaume-Uni] ; F. Meye [France] ; F. Marti [France] ; S. Tolu [France] ; S. Parnaudeau [France] ; H. Marie [France] ; F. Tronche [France] ; U. Maskos [France] ; M. Moretti [Italie] ; C. Gotti [Italie] ; M-H Han [États-Unis] ; A. Bailey [Royaume-Uni] ; M. Mameli [France] ; J. Barik [France] ; P. Faure [France]Source :
- Molecular Psychiatry [ 1359-4184 ] ; 2018.
Abstract
Epidemiological studies report strong association between mood disorders and tobacco addiction. This high comorbidity requires adequate treatment but the underlying mechanisms are unknown. We demonstrate that nicotine exposure, independent of drug withdrawal effects, increases stress sensitivity, a major risk factor in mood disorders. Nicotine and stress concur to induce long-lasting cellular adaptations within the dopamine (DA) system. This interplay is underpinned by marked remodeling of nicotinic systems, causing increased ventral tegmental area (VTA) DA neurons' activity and stress-related behaviors, such as social aversion. Blocking β2 or α7 nicotinic acetylcholine receptors (nAChRs) prevents, respectively, the development and the expression of social stress-induced neuroadaptations; conversely, facilitating α7 nAChRs activation specifically in the VTA promotes stress-induced cellular and behavioral maladaptations. Our work unravels a complex nicotine-stress bidirectional interplay and identifies α7 nAChRs as a promising therapeutic target for stress-related psychiatric disorders.
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DOI: 10.1038/mp.2017.145
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Marie</name><affiliation wicri:level="1"><hal:affiliation type="regroupinstitution" xml:id="struct-523042" status="VALID"> <orgName>Université Côte d'Azur </orgName> <orgName type="acronym">UCA</orgName> <date type="start">2015-03-01</date> <desc> <address> <addrLine>Parc Valrose, 28 avenue Valrose 06108 Nice Cedex 2 </addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Tronche, F" sort="Tronche, F" uniqKey="Tronche F" first="F." last="Tronche">F. 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Maskos</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-542131" status="VALID"> <idno type="RNSR">200718166V</idno> <orgName>Neurobiologie intégrative des Systèmes cholinergiques - Integrative Neurobiology of Cholinergic Systems</orgName> <desc> <address> <addrLine>Département de Neuroscience - 25-28, rue du docteur Roux, 75724 Paris cedex 15 </addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/fr/team/integrative-neurobiology-of-cholinergic-systems/</ref> </desc> <listRelation> <relation active="#struct-300027" type="direct"></relation> <relation active="#struct-413221" type="direct"></relation> <relation name="UMR3571" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID"> <idno type="IdRef">027936643</idno> <idno type="ISNI">0000 0001 2353 6535</idno> <orgName>Institut Pasteur [Paris]</orgName> <date type="start">1887-06-04</date> <desc> <address> <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur.fr</ref> </desc> </org></tutelle><tutelle active="#struct-413221" type="direct"><org type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName> <orgName type="acronym">SU</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-universite.fr/</ref> </desc> </org></tutelle><tutelle name="UMR3571" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Moretti, M" sort="Moretti, M" uniqKey="Moretti M" first="M" last="Moretti">M. Moretti</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300694" status="VALID"> <orgName>Università degli studi di Milano [Milano]</orgName> <desc> <address> <addrLine>Via Festa del Perdono 7 - 20122 Milano</addrLine> <country key="IT"></country> </address> <ref type="url">http://www.unimi.it/</ref> </desc> </hal:affiliation><country>Italie</country></affiliation></author><author><name sortKey="Gotti, C" sort="Gotti, C" uniqKey="Gotti C" first="C." last="Gotti">C. Gotti</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300694" status="VALID"> <orgName>Università degli studi di Milano [Milano]</orgName> <desc> <address> <addrLine>Via Festa del Perdono 7 - 20122 Milano</addrLine> <country key="IT"></country> </address> <ref type="url">http://www.unimi.it/</ref> </desc> </hal:affiliation><country>Italie</country></affiliation></author><author><name sortKey="Han, M H" sort="Han, M H" uniqKey="Han M" first="M-H" last="Han">M-H Han</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-354552" status="VALID"> <orgName>Icahn School of Medicine at Mount Sinai [New York]</orgName> <orgName type="acronym">MSSM</orgName> <desc> <address> <addrLine>1 Gustave L. Levy PlaceNew York, NY 10029-5674</addrLine> <country key="US"></country> </address> <ref type="url">http://icahn.mssm.edu/</ref> </desc> </hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Bailey, A" sort="Bailey, A" uniqKey="Bailey A" first="A" last="Bailey">A. Bailey</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-327823" status="VALID"> <orgName>St George‘s, University of London</orgName> <desc> <address> <addrLine>Cranmer Terrace, London SW17 0RE, Royaume-Uni</addrLine> <country key="GB"></country> </address> <ref type="url">https://www.sgul.ac.uk/</ref> </desc> </hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Mameli, M" sort="Mameli, M" uniqKey="Mameli M" first="M." last="Mameli">M. Mameli</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-541874" status="VALID"> <idno type="RNSR">200716490Y</idno> <orgName>Institut du Fer à Moulin</orgName> <desc> <address> <addrLine>17, rue du fer à moulin 75005 PARIS</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="U839" active="#struct-303623" type="direct"></relation> <relation active="#struct-413221" type="direct"></relation> </listRelation> <tutelles><tutelle name="U839" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-413221" type="direct"><org type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName> <orgName type="acronym">SU</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-universite.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Barik, J" sort="Barik, J" uniqKey="Barik J" first="J" last="Barik">J. Barik</name><affiliation wicri:level="1"><hal:affiliation type="regroupinstitution" xml:id="struct-523042" status="VALID"> <orgName>Université Côte d'Azur </orgName> <orgName type="acronym">UCA</orgName> <date type="start">2015-03-01</date> <desc> <address> <addrLine>Parc Valrose, 28 avenue Valrose 06108 Nice Cedex 2 </addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Faure, P" sort="Faure, P" uniqKey="Faure P" first="P." last="Faure">P. Faure</name><affiliation wicri:level="1"><hal:affiliation type="regrouplaboratory" xml:id="struct-542120" status="VALID"> <idno type="RNSR">201420879N</idno> <orgName>Institut de Biologie Paris Seine</orgName> <orgName type="acronym">IBPS</orgName> <date type="start">2014-01-01</date> <desc> <address> <addrLine>Quai Saint-Bernard75252 PARIS CEDEX 05</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ibps.upmc.fr/</ref> </desc> <listRelation> <relation active="#struct-303623" type="direct"></relation> <relation active="#struct-413221" type="direct"></relation> <relation name="FR 3631" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-413221" type="direct"><org type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName> <orgName type="acronym">SU</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-universite.fr/</ref> </desc> </org></tutelle><tutelle name="FR 3631" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></analytic><idno type="DOI">10.1038/mp.2017.145</idno><series><title level="j">Molecular Psychiatry</title><idno type="ISSN">1359-4184</idno><imprint><date type="datePub">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>Epidemiological studies report strong association between mood disorders and tobacco addiction. This high comorbidity requires adequate treatment but the underlying mechanisms are unknown. We demonstrate that nicotine exposure, independent of drug withdrawal effects, increases stress sensitivity, a major risk factor in mood disorders. Nicotine and stress concur to induce long-lasting cellular adaptations within the dopamine (DA) system. This interplay is underpinned by marked remodeling of nicotinic systems, causing increased ventral tegmental area (VTA) DA neurons' activity and stress-related behaviors, such as social aversion. Blocking β2 or α7 nicotinic acetylcholine receptors (nAChRs) prevents, respectively, the development and the expression of social stress-induced neuroadaptations; conversely, facilitating α7 nAChRs activation specifically in the VTA promotes stress-induced cellular and behavioral maladaptations. Our work unravels a complex nicotine-stress bidirectional interplay and identifies α7 nAChRs as a promising therapeutic target for stress-related psychiatric disorders.</p> </div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells’ activity</title> <author role="aut"> <persName> <forename type="first">C.</forename> <surname>Morel</surname> </persName> <idno type="halauthorid">34924</idno> <affiliation ref="#struct-542120"></affiliation> <affiliation ref="#struct-542136"></affiliation> <affiliation ref="#struct-354552"></affiliation> </author> <author role="aut"> <persName> <forename type="first">S</forename> <forename type="middle">P</forename> <surname>Fernandez</surname> </persName> <idno type="halauthorid">11533254</idno> <affiliation ref="#struct-523042"></affiliation> <affiliation ref="#struct-199361"></affiliation> </author> <author role="aut"> <persName> <forename type="first">F</forename> <surname>Pantouli</surname> </persName> <idno type="halauthorid">11533255</idno> <affiliation ref="#struct-327823"></affiliation> </author> <author role="aut"> <persName> <forename type="first">F.</forename> <forename type="middle">J</forename> <surname>Meye</surname> </persName> <idno type="halauthorid">11483909</idno> <affiliation ref="#struct-541874"></affiliation> <affiliation ref="#struct-542136"></affiliation> </author> <author role="aut"> <persName> <forename type="first">F.</forename> <surname>Marti</surname> </persName> <idno type="halauthorid">1556645</idno> <affiliation ref="#struct-542120"></affiliation> <affiliation ref="#struct-542136"></affiliation> </author> <author role="aut"> <persName> <forename type="first">S.</forename> <surname>Tolu</surname> </persName> <idno type="halauthorid">1560691</idno> <affiliation ref="#struct-542120"></affiliation> <affiliation ref="#struct-542136"></affiliation> </author> <author role="aut"> <persName> <forename type="first">S.</forename> <surname>Parnaudeau</surname> </persName> <email type="md5">846d5626bb595421f4e60bd6638ec02a</email> <email type="domain">gmail.com</email> <idno type="idhal" notation="string">sebastien-parnaudeau</idno> <idno type="idhal" notation="numeric">180489</idno> <idno type="halauthorid">11688742</idno> <affiliation ref="#struct-542136"></affiliation> </author> <author role="aut"> <persName> <forename type="first">H</forename> <surname>Marie</surname> </persName> <idno type="halauthorid">11533256</idno> <affiliation ref="#struct-523042"></affiliation> <affiliation ref="#struct-199361"></affiliation> </author> <author role="aut"> <persName> <forename type="first">F.</forename> <surname>Tronche</surname> </persName> <idno type="halauthorid">104167</idno> <affiliation ref="#struct-542136"></affiliation> </author> <author role="aut"> <persName> <forename type="first">U.</forename> <surname>Maskos</surname> </persName> <idno type="halauthorid">194527</idno> <affiliation ref="#struct-542131"></affiliation> </author> <author role="aut"> <persName> <forename type="first">M</forename> <surname>Moretti</surname> </persName> <idno type="halauthorid">1107572</idno> <affiliation ref="#struct-300694"></affiliation> </author> <author role="aut"> <persName> <forename type="first">C.</forename> <surname>Gotti</surname> </persName> <idno type="halauthorid">594049</idno> <affiliation ref="#struct-300694"></affiliation> </author> <author role="aut"> <persName> <forename type="first">M-H</forename> <surname>Han</surname> </persName> <idno type="halauthorid">11533257</idno> <affiliation ref="#struct-354552"></affiliation> </author> <author role="aut"> <persName> <forename type="first">A</forename> <surname>Bailey</surname> </persName> <idno type="halauthorid">11533258</idno> <affiliation ref="#struct-327823"></affiliation> </author> <author role="aut"> <persName> <forename type="first">M.</forename> <surname>Mameli</surname> </persName> <idno type="halauthorid">1556658</idno> <affiliation ref="#struct-541874"></affiliation> <affiliation ref="#struct-542136"></affiliation> </author> <author role="aut"> <persName> <forename type="first">J</forename> <surname>Barik</surname> </persName> <idno type="halauthorid">11533259</idno> <affiliation ref="#struct-523042"></affiliation> <affiliation ref="#struct-199361"></affiliation> </author> <author role="aut"> <persName> <forename type="first">P.</forename> <surname>Faure</surname> </persName> <idno type="halauthorid">88780</idno> <affiliation ref="#struct-542120"></affiliation> <affiliation ref="#struct-542136"></affiliation> </author> <editor role="depositor"> <persName> <forename>Gestionnaire</forename> <surname>HAL-SU</surname> </persName> <email type="md5">7a506738bb4db17d254a4bfabd12a9f6</email> <email type="domain">sorbonne-universite.fr</email> </editor> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2019-07-12 17:19:53</date> <date type="whenModified">2020-03-17 14:40:44</date> <date type="whenReleased">2019-07-12 17:29:13</date> <date type="whenProduced">2018</date> <date type="whenEndEmbargoed">2019-07-12</date> <ref type="file" target="https://hal.sorbonne-universite.fr/hal-02182455/document"> <date notBefore="2019-07-12"></date> </ref> <ref type="file" subtype="publisherPaid" n="1" target="https://hal.sorbonne-universite.fr/hal-02182455/file/mp2017145.pdf"> <date notBefore="2019-07-12"></date> </ref> <ref type="externalLink" target="http://openaccess.sgul.ac.uk/109094/6/mp2017145a%2D1%2Dstripped.pdf"></ref> </edition> <respStmt> <resp>contributor</resp> <name key="651455"> <persName> <forename>Gestionnaire</forename> <surname>HAL-SU</surname> </persName> <email type="md5">7a506738bb4db17d254a4bfabd12a9f6</email> <email type="domain">sorbonne-universite.fr</email> </name> </respStmt> </editionStmt> <publicationStmt> <distributor>CCSD</distributor> <idno type="halId">hal-02182455</idno> <idno type="halUri">https://hal.sorbonne-universite.fr/hal-02182455</idno> <idno type="halBibtex">morel:hal-02182455</idno> <idno type="halRefHtml">Molecular Psychiatry, Nature Publishing Group, 2018, 23 (7), pp.1597-1605. ⟨10.1038/mp.2017.145⟩</idno> <idno type="halRef">Molecular Psychiatry, Nature Publishing Group, 2018, 23 (7), pp.1597-1605. ⟨10.1038/mp.2017.145⟩</idno> </publicationStmt> <seriesStmt> <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno> <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno> <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno> <idno type="stamp" n="UNICE">Université Nice Sophia Antipolis</idno> <idno type="stamp" n="UCA-TEST">UCA-TEST</idno> <idno type="stamp" n="UNIV-COTEDAZUR">Université Côte d'Azur</idno> <idno type="stamp" n="IBPS" corresp="SORBONNE-UNIVERSITE">Institut de Biologie Paris Seine</idno> <idno type="stamp" n="IFM" corresp="SORBONNE-UNIVERSITE">Institut du Fer à Moulin</idno> <idno type="stamp" n="NPS" corresp="IBPS">Neuroscience Paris Seine</idno> <idno type="stamp" n="SU-SCIENCES" corresp="SORBONNE-UNIVERSITE">Faculté des Sciences de Sorbonne Université</idno> <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno> <idno type="stamp" n="PASTEUR">Institut Pasteur</idno> <idno type="stamp" n="RIIP_PARIS">Institut Pasteur de Paris</idno> </seriesStmt> <notesStmt> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells’ activity</title> <author role="aut"> <persName> <forename type="first">C.</forename> <surname>Morel</surname> </persName> <idno type="halauthorid">34924</idno> <affiliation ref="#struct-542120"></affiliation> <affiliation ref="#struct-542136"></affiliation> <affiliation ref="#struct-354552"></affiliation> </author> <author role="aut"> <persName> <forename type="first">S</forename> <forename type="middle">P</forename> <surname>Fernandez</surname> </persName> <idno type="halauthorid">11533254</idno> <affiliation ref="#struct-523042"></affiliation> <affiliation ref="#struct-199361"></affiliation> </author> <author role="aut"> <persName> <forename type="first">F</forename> <surname>Pantouli</surname> </persName> <idno type="halauthorid">11533255</idno> <affiliation ref="#struct-327823"></affiliation> </author> <author role="aut"> <persName> <forename type="first">F.</forename> <forename type="middle">J</forename> <surname>Meye</surname> </persName> <idno type="halauthorid">11483909</idno> <affiliation ref="#struct-541874"></affiliation> <affiliation ref="#struct-542136"></affiliation> </author> <author role="aut"> <persName> <forename type="first">F.</forename> <surname>Marti</surname> </persName> <idno type="halauthorid">1556645</idno> <affiliation ref="#struct-542120"></affiliation> <affiliation ref="#struct-542136"></affiliation> </author> <author role="aut"> <persName> <forename type="first">S.</forename> <surname>Tolu</surname> </persName> <idno type="halauthorid">1560691</idno> <affiliation ref="#struct-542120"></affiliation> <affiliation ref="#struct-542136"></affiliation> </author> <author role="aut"> <persName> <forename type="first">S.</forename> <surname>Parnaudeau</surname> </persName> <email type="md5">846d5626bb595421f4e60bd6638ec02a</email> <email type="domain">gmail.com</email> <idno type="idhal" notation="string">sebastien-parnaudeau</idno> <idno type="idhal" notation="numeric">180489</idno> <idno type="halauthorid">11688742</idno> <affiliation ref="#struct-542136"></affiliation> </author> <author role="aut"> <persName> <forename type="first">H</forename> <surname>Marie</surname> </persName> <idno type="halauthorid">11533256</idno> <affiliation ref="#struct-523042"></affiliation> <affiliation ref="#struct-199361"></affiliation> </author> <author role="aut"> <persName> <forename type="first">F.</forename> <surname>Tronche</surname> </persName> <idno type="halauthorid">104167</idno> <affiliation ref="#struct-542136"></affiliation> </author> <author role="aut"> <persName> <forename type="first">U.</forename> <surname>Maskos</surname> </persName> <idno type="halauthorid">194527</idno> <affiliation ref="#struct-542131"></affiliation> </author> <author role="aut"> <persName> <forename type="first">M</forename> <surname>Moretti</surname> </persName> <idno type="halauthorid">1107572</idno> <affiliation ref="#struct-300694"></affiliation> </author> <author role="aut"> <persName> <forename type="first">C.</forename> <surname>Gotti</surname> </persName> <idno type="halauthorid">594049</idno> <affiliation ref="#struct-300694"></affiliation> </author> <author role="aut"> <persName> <forename type="first">M-H</forename> <surname>Han</surname> </persName> <idno type="halauthorid">11533257</idno> <affiliation ref="#struct-354552"></affiliation> </author> <author role="aut"> <persName> <forename type="first">A</forename> <surname>Bailey</surname> </persName> <idno type="halauthorid">11533258</idno> <affiliation ref="#struct-327823"></affiliation> </author> <author role="aut"> <persName> <forename type="first">M.</forename> <surname>Mameli</surname> </persName> <idno type="halauthorid">1556658</idno> <affiliation ref="#struct-541874"></affiliation> <affiliation ref="#struct-542136"></affiliation> </author> <author role="aut"> <persName> <forename type="first">J</forename> <surname>Barik</surname> </persName> <idno type="halauthorid">11533259</idno> <affiliation ref="#struct-523042"></affiliation> <affiliation ref="#struct-199361"></affiliation> </author> <author role="aut"> <persName> <forename type="first">P.</forename> <surname>Faure</surname> </persName> <idno type="halauthorid">88780</idno> <affiliation ref="#struct-542120"></affiliation> <affiliation ref="#struct-542136"></affiliation> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">17191</idno> <idno type="issn">1359-4184</idno> <idno type="eissn">1476-5578</idno> <title level="j">Molecular Psychiatry</title> <imprint> <publisher>Nature Publishing Group</publisher> <biblScope unit="volume">23</biblScope> <biblScope unit="issue">7</biblScope> <biblScope unit="pp">1597-1605</biblScope> <date type="datePub">2018</date> <date type="dateEpub">2017-07-25</date> </imprint> </monogr> <idno type="doi">10.1038/mp.2017.145</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <classCode scheme="halDomain" n="sdv.neu.nb">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology</classCode> <classCode scheme="halDomain" n="sdv.mhep.psm">Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en"> <p>Epidemiological studies report strong association between mood disorders and tobacco addiction. This high comorbidity requires adequate treatment but the underlying mechanisms are unknown. We demonstrate that nicotine exposure, independent of drug withdrawal effects, increases stress sensitivity, a major risk factor in mood disorders. Nicotine and stress concur to induce long-lasting cellular adaptations within the dopamine (DA) system. This interplay is underpinned by marked remodeling of nicotinic systems, causing increased ventral tegmental area (VTA) DA neurons' activity and stress-related behaviors, such as social aversion. Blocking β2 or α7 nicotinic acetylcholine receptors (nAChRs) prevents, respectively, the development and the expression of social stress-induced neuroadaptations; conversely, facilitating α7 nAChRs activation specifically in the VTA promotes stress-induced cellular and behavioral maladaptations. Our work unravels a complex nicotine-stress bidirectional interplay and identifies α7 nAChRs as a promising therapeutic target for stress-related psychiatric disorders.</p> </abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
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