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Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury.

Identifieur interne : 000086 ( Main/Exploration ); précédent : 000085; suivant : 000087

Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury.

Auteurs : Gabriel C. Motta-Ribeiro [Brésil] ; Soshi Hashimoto ; Tilo Winkler ; Rebecca M. Baron [États-Unis] ; Kira Grogg ; Luís F S C. Paula ; Arnoldo Santos [Espagne] ; Congli Zeng ; Kathryn Hibbert ; Robert S. Harris ; Ednan Bajwa ; Marcos F. Vidal Melo

Source :

RBID : pubmed:29787304

Descripteurs français

English descriptors

Abstract

RATIONALE

The contribution of aeration heterogeneity to lung injury during early mechanical ventilation of uninjured lungs is unknown.

OBJECTIVES

To test the hypotheses that a strategy consistent with clinical practice does not protect from worsening in lung strains during the first 24 hours of ventilation of initially normal lungs exposed to mild systemic endotoxemia in supine versus prone position, and that local neutrophilic inflammation is associated with local strain and blood volume at global strains below a proposed injurious threshold.

METHODS

Voxel-level aeration and tidal strain were assessed by computed tomography in sheep ventilated with low Vt and positive end-expiratory pressure while receiving intravenous endotoxin. Regional inflammation and blood volume were estimated from 2-deoxy-2-[(18)F]fluoro-d-glucose (

MEASUREMENTS AND MAIN RESULTS

Spatial heterogeneity of aeration and strain increased only in supine lungs (P < 0.001), with higher strains and atelectasis than prone at 24 hours. Absolute strains were lower than those considered globally injurious. Strains redistributed to higher aeration areas as lung injury progressed in supine lungs. At 24 hours, tissue-normalized

CONCLUSIONS

Mechanical ventilation consistent with clinical practice did not generate excessive regional strain in heterogeneously aerated supine lungs. However, it allowed worsening of spatial strain distribution in these lungs, associated with increased inflammation. Our results support the implementation of early aeration homogenization in normal lungs.


DOI: 10.1164/rccm.201710-2038OC
PubMed: 29787304
PubMed Central: PMC6173064


Affiliations:


Links toward previous steps (curation, corpus...)


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<term>Acute Lung Injury (diagnostic imaging)</term>
<term>Acute Lung Injury (etiology)</term>
<term>Acute Lung Injury (pathology)</term>
<term>Analysis of Variance (MeSH)</term>
<term>Animals (MeSH)</term>
<term>Biopsy, Needle (MeSH)</term>
<term>Blood Gas Analysis (MeSH)</term>
<term>Disease Models, Animal (MeSH)</term>
<term>Endotoxemia (etiology)</term>
<term>Endotoxemia (physiopathology)</term>
<term>Endotoxins (pharmacology)</term>
<term>Female (MeSH)</term>
<term>Fluorodeoxyglucose F18 (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immunohistochemistry (MeSH)</term>
<term>Infusions, Intravenous (MeSH)</term>
<term>Linear Models (MeSH)</term>
<term>Multivariate Analysis (MeSH)</term>
<term>Positron-Emission Tomography (methods)</term>
<term>Pulmonary Atelectasis (diagnostic imaging)</term>
<term>Pulmonary Atelectasis (etiology)</term>
<term>Random Allocation (MeSH)</term>
<term>Respiration, Artificial (adverse effects)</term>
<term>Respiration, Artificial (methods)</term>
<term>Respiratory Distress Syndrome, Adult (diagnostic imaging)</term>
<term>Respiratory Distress Syndrome, Adult (etiology)</term>
<term>Respiratory Distress Syndrome, Adult (pathology)</term>
<term>Respiratory Function Tests (MeSH)</term>
<term>Risk Factors (MeSH)</term>
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<term>Time Factors (MeSH)</term>
<term>Tomography, X-Ray Computed (methods)</term>
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<term>Analyse de variance (MeSH)</term>
<term>Analyse multifactorielle (MeSH)</term>
<term>Animaux (MeSH)</term>
<term>Atélectasie pulmonaire (imagerie diagnostique)</term>
<term>Atélectasie pulmonaire (étiologie)</term>
<term>Endotoxines (pharmacologie)</term>
<term>Endotoxémie (physiopathologie)</term>
<term>Endotoxémie (étiologie)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Facteurs temps (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Fluorodésoxyglucose F18 (MeSH)</term>
<term>Gazométrie sanguine (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Immunohistochimie (MeSH)</term>
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<term>Lésion pulmonaire aigüe (imagerie diagnostique)</term>
<term>Lésion pulmonaire aigüe (étiologie)</term>
<term>Modèles animaux de maladie humaine (MeSH)</term>
<term>Modèles linéaires (MeSH)</term>
<term>Ovis (MeSH)</term>
<term>Perfusions veineuses (MeSH)</term>
<term>Ponction-biopsie à l'aiguille (MeSH)</term>
<term>Répartition aléatoire (MeSH)</term>
<term>Syndrome de détresse respiratoire de l'adulte (anatomopathologie)</term>
<term>Syndrome de détresse respiratoire de l'adulte (imagerie diagnostique)</term>
<term>Syndrome de détresse respiratoire de l'adulte (étiologie)</term>
<term>Tests de la fonction respiratoire (MeSH)</term>
<term>Tomodensitométrie (méthodes)</term>
<term>Tomographie par émission de positons (méthodes)</term>
<term>Ventilation artificielle (effets indésirables)</term>
<term>Ventilation artificielle (méthodes)</term>
<term>Volume courant (physiologie)</term>
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<term>Endotoxins</term>
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<term>Respiration, Artificial</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr">
<term>Lésion pulmonaire aigüe</term>
<term>Syndrome de détresse respiratoire de l'adulte</term>
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<term>Acute Lung Injury</term>
<term>Pulmonary Atelectasis</term>
<term>Respiratory Distress Syndrome, Adult</term>
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<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr">
<term>Ventilation artificielle</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en">
<term>Acute Lung Injury</term>
<term>Endotoxemia</term>
<term>Pulmonary Atelectasis</term>
<term>Respiratory Distress Syndrome, Adult</term>
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<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr">
<term>Atélectasie pulmonaire</term>
<term>Lésion pulmonaire aigüe</term>
<term>Syndrome de détresse respiratoire de l'adulte</term>
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<term>Positron-Emission Tomography</term>
<term>Respiration, Artificial</term>
<term>Tomography, X-Ray Computed</term>
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<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr">
<term>Tomodensitométrie</term>
<term>Tomographie par émission de positons</term>
<term>Ventilation artificielle</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Acute Lung Injury</term>
<term>Respiratory Distress Syndrome, Adult</term>
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<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr">
<term>Endotoxines</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr">
<term>Volume courant</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en">
<term>Tidal Volume</term>
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<term>Endotoxémie</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en">
<term>Endotoxemia</term>
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<term>Atélectasie pulmonaire</term>
<term>Endotoxémie</term>
<term>Lésion pulmonaire aigüe</term>
<term>Syndrome de détresse respiratoire de l'adulte</term>
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<term>Analysis of Variance</term>
<term>Animals</term>
<term>Biopsy, Needle</term>
<term>Blood Gas Analysis</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Fluorodeoxyglucose F18</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Infusions, Intravenous</term>
<term>Linear Models</term>
<term>Multivariate Analysis</term>
<term>Random Allocation</term>
<term>Respiratory Function Tests</term>
<term>Risk Factors</term>
<term>Sheep</term>
<term>Time Factors</term>
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<keywords scheme="MESH" xml:lang="fr">
<term>Analyse de variance</term>
<term>Analyse multifactorielle</term>
<term>Animaux</term>
<term>Facteurs de risque</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Fluorodésoxyglucose F18</term>
<term>Gazométrie sanguine</term>
<term>Humains</term>
<term>Immunohistochimie</term>
<term>Modèles animaux de maladie humaine</term>
<term>Modèles linéaires</term>
<term>Ovis</term>
<term>Perfusions veineuses</term>
<term>Ponction-biopsie à l'aiguille</term>
<term>Répartition aléatoire</term>
<term>Tests de la fonction respiratoire</term>
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<front>
<div type="abstract" xml:lang="en">
<p>
<b>RATIONALE</b>
</p>
<p>The contribution of aeration heterogeneity to lung injury during early mechanical ventilation of uninjured lungs is unknown.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>OBJECTIVES</b>
</p>
<p>To test the hypotheses that a strategy consistent with clinical practice does not protect from worsening in lung strains during the first 24 hours of ventilation of initially normal lungs exposed to mild systemic endotoxemia in supine versus prone position, and that local neutrophilic inflammation is associated with local strain and blood volume at global strains below a proposed injurious threshold.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>METHODS</b>
</p>
<p>Voxel-level aeration and tidal strain were assessed by computed tomography in sheep ventilated with low Vt and positive end-expiratory pressure while receiving intravenous endotoxin. Regional inflammation and blood volume were estimated from 2-deoxy-2-[(18)F]fluoro-d-glucose (</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>MEASUREMENTS AND MAIN RESULTS</b>
</p>
<p>Spatial heterogeneity of aeration and strain increased only in supine lungs (P < 0.001), with higher strains and atelectasis than prone at 24 hours. Absolute strains were lower than those considered globally injurious. Strains redistributed to higher aeration areas as lung injury progressed in supine lungs. At 24 hours, tissue-normalized </p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSIONS</b>
</p>
<p>Mechanical ventilation consistent with clinical practice did not generate excessive regional strain in heterogeneously aerated supine lungs. However, it allowed worsening of spatial strain distribution in these lungs, associated with increased inflammation. Our results support the implementation of early aeration homogenization in normal lungs.</p>
</div>
</front>
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<DateCompleted>
<Year>2019</Year>
<Month>09</Month>
<Day>11</Day>
</DateCompleted>
<DateRevised>
<Year>2019</Year>
<Month>10</Month>
<Day>01</Day>
</DateRevised>
<Article PubModel="Print">
<Journal>
<ISSN IssnType="Electronic">1535-4970</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>198</Volume>
<Issue>7</Issue>
<PubDate>
<Year>2018</Year>
<Month>10</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>American journal of respiratory and critical care medicine</Title>
</Journal>
<ArticleTitle>Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury.</ArticleTitle>
<Pagination>
<MedlinePgn>891-902</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1164/rccm.201710-2038OC</ELocationID>
<Abstract>
<AbstractText Label="RATIONALE">The contribution of aeration heterogeneity to lung injury during early mechanical ventilation of uninjured lungs is unknown.</AbstractText>
<AbstractText Label="OBJECTIVES">To test the hypotheses that a strategy consistent with clinical practice does not protect from worsening in lung strains during the first 24 hours of ventilation of initially normal lungs exposed to mild systemic endotoxemia in supine versus prone position, and that local neutrophilic inflammation is associated with local strain and blood volume at global strains below a proposed injurious threshold.</AbstractText>
<AbstractText Label="METHODS">Voxel-level aeration and tidal strain were assessed by computed tomography in sheep ventilated with low Vt and positive end-expiratory pressure while receiving intravenous endotoxin. Regional inflammation and blood volume were estimated from 2-deoxy-2-[(18)F]fluoro-d-glucose (
<sup>18</sup>
F-FDG) positron emission tomography.</AbstractText>
<AbstractText Label="MEASUREMENTS AND MAIN RESULTS">Spatial heterogeneity of aeration and strain increased only in supine lungs (P < 0.001), with higher strains and atelectasis than prone at 24 hours. Absolute strains were lower than those considered globally injurious. Strains redistributed to higher aeration areas as lung injury progressed in supine lungs. At 24 hours, tissue-normalized
<sup>18</sup>
F-FDG uptake increased more in atelectatic and moderately high-aeration regions (>70%) than in normally aerated regions (P < 0.01), with differential mechanistically relevant regional gene expression.
<sup>18</sup>
F-FDG phosphorylation rate was associated with strain and blood volume. Imaging findings were confirmed in ventilated patients with sepsis.</AbstractText>
<AbstractText Label="CONCLUSIONS">Mechanical ventilation consistent with clinical practice did not generate excessive regional strain in heterogeneously aerated supine lungs. However, it allowed worsening of spatial strain distribution in these lungs, associated with increased inflammation. Our results support the implementation of early aeration homogenization in normal lungs.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Motta-Ribeiro</LastName>
<ForeName>Gabriel C</ForeName>
<Initials>GC</Initials>
<Identifier Source="ORCID">0000-0001-5982-8863</Identifier>
<AffiliationInfo>
<Affiliation>1 Department of Anesthesia, Critical Care and Pain Medicine.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>2 Biomedical Engineering Program, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Hashimoto</LastName>
<ForeName>Soshi</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>1 Department of Anesthesia, Critical Care and Pain Medicine.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>3 Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto, Japan; and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Winkler</LastName>
<ForeName>Tilo</ForeName>
<Initials>T</Initials>
<Identifier Source="ORCID">0000-0002-7276-5550</Identifier>
<AffiliationInfo>
<Affiliation>1 Department of Anesthesia, Critical Care and Pain Medicine.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Baron</LastName>
<ForeName>Rebecca M</ForeName>
<Initials>RM</Initials>
<AffiliationInfo>
<Affiliation>4 Department of Medicine (Pulmonary and Critical Care), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Grogg</LastName>
<ForeName>Kira</ForeName>
<Initials>K</Initials>
<AffiliationInfo>
<Affiliation>5 Department of Radiology, and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Paula</LastName>
<ForeName>Luís F S C</ForeName>
<Initials>LFSC</Initials>
<AffiliationInfo>
<Affiliation>1 Department of Anesthesia, Critical Care and Pain Medicine.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Santos</LastName>
<ForeName>Arnoldo</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>1 Department of Anesthesia, Critical Care and Pain Medicine.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>6 CIBER de Enfermedades Respiratorias, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Zeng</LastName>
<ForeName>Congli</ForeName>
<Initials>C</Initials>
<AffiliationInfo>
<Affiliation>1 Department of Anesthesia, Critical Care and Pain Medicine.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Hibbert</LastName>
<ForeName>Kathryn</ForeName>
<Initials>K</Initials>
<AffiliationInfo>
<Affiliation>7 Department of Medicine (Pulmonary and Critical Care), Massachusetts General Hospital, and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Harris</LastName>
<ForeName>Robert S</ForeName>
<Initials>RS</Initials>
<AffiliationInfo>
<Affiliation>7 Department of Medicine (Pulmonary and Critical Care), Massachusetts General Hospital, and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Bajwa</LastName>
<ForeName>Ednan</ForeName>
<Initials>E</Initials>
<AffiliationInfo>
<Affiliation>7 Department of Medicine (Pulmonary and Critical Care), Massachusetts General Hospital, and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Vidal Melo</LastName>
<ForeName>Marcos F</ForeName>
<Initials>MF</Initials>
<AffiliationInfo>
<Affiliation>1 Department of Anesthesia, Critical Care and Pain Medicine.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y">
<Grant>
<GrantID>R01 HL121228</GrantID>
<Acronym>HL</Acronym>
<Agency>NHLBI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
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<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<Country>United States</Country>
<MedlineTA>Am J Respir Crit Care Med</MedlineTA>
<NlmUniqueID>9421642</NlmUniqueID>
<ISSNLinking>1073-449X</ISSNLinking>
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<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004731">Endotoxins</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>0Z5B2CJX4D</RegistryNumber>
<NameOfSubstance UI="D019788">Fluorodeoxyglucose F18</NameOfSubstance>
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<CitationSubset>IM</CitationSubset>
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<CommentsCorrections RefType="CommentIn">
<RefSource>Am J Respir Crit Care Med. 2018 Oct 1;198(7):830-832</RefSource>
<PMID Version="1">29787308</PMID>
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<MeshHeadingList>
<MeshHeading>
<DescriptorName UI="D055371" MajorTopicYN="N">Acute Lung Injury</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D001707" MajorTopicYN="N">Biopsy, Needle</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D001784" MajorTopicYN="N">Blood Gas Analysis</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D019446" MajorTopicYN="N">Endotoxemia</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D004731" MajorTopicYN="N">Endotoxins</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D019788" MajorTopicYN="N">Fluorodeoxyglucose F18</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D007262" MajorTopicYN="N">Infusions, Intravenous</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D016014" MajorTopicYN="N">Linear Models</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D015999" MajorTopicYN="N">Multivariate Analysis</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D049268" MajorTopicYN="N">Positron-Emission Tomography</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D001261" MajorTopicYN="N">Pulmonary Atelectasis</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
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<MeshHeading>
<DescriptorName UI="D011897" MajorTopicYN="N">Random Allocation</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D012121" MajorTopicYN="N">Respiration, Artificial</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
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<MeshHeading>
<DescriptorName UI="D012128" MajorTopicYN="N">Respiratory Distress Syndrome, Adult</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
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<MeshHeading>
<DescriptorName UI="D012129" MajorTopicYN="N">Respiratory Function Tests</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D012756" MajorTopicYN="N">Sheep</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D013990" MajorTopicYN="N">Tidal Volume</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
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<DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D014057" MajorTopicYN="N">Tomography, X-Ray Computed</DescriptorName>
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<Keyword MajorTopicYN="Y">acute respiratory distress syndrome</Keyword>
<Keyword MajorTopicYN="Y">endotoxemia</Keyword>
<Keyword MajorTopicYN="Y">mechanical ventilation</Keyword>
<Keyword MajorTopicYN="Y">positron emission tomography computed tomography</Keyword>
<Keyword MajorTopicYN="Y">ventilator-induced lung injury</Keyword>
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<li>Brésil</li>
<li>Espagne</li>
<li>États-Unis</li>
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<li>Communauté de Madrid</li>
<li>Massachusetts</li>
<li>État de Rio de Janeiro</li>
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<li>Madrid</li>
<li>Rio de Janeiro</li>
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<name sortKey="Bajwa, Ednan" sort="Bajwa, Ednan" uniqKey="Bajwa E" first="Ednan" last="Bajwa">Ednan Bajwa</name>
<name sortKey="Grogg, Kira" sort="Grogg, Kira" uniqKey="Grogg K" first="Kira" last="Grogg">Kira Grogg</name>
<name sortKey="Harris, Robert S" sort="Harris, Robert S" uniqKey="Harris R" first="Robert S" last="Harris">Robert S. Harris</name>
<name sortKey="Hashimoto, Soshi" sort="Hashimoto, Soshi" uniqKey="Hashimoto S" first="Soshi" last="Hashimoto">Soshi Hashimoto</name>
<name sortKey="Hibbert, Kathryn" sort="Hibbert, Kathryn" uniqKey="Hibbert K" first="Kathryn" last="Hibbert">Kathryn Hibbert</name>
<name sortKey="Paula, Luis F S C" sort="Paula, Luis F S C" uniqKey="Paula L" first="Luís F S C" last="Paula">Luís F S C. Paula</name>
<name sortKey="Vidal Melo, Marcos F" sort="Vidal Melo, Marcos F" uniqKey="Vidal Melo M" first="Marcos F" last="Vidal Melo">Marcos F. Vidal Melo</name>
<name sortKey="Winkler, Tilo" sort="Winkler, Tilo" uniqKey="Winkler T" first="Tilo" last="Winkler">Tilo Winkler</name>
<name sortKey="Zeng, Congli" sort="Zeng, Congli" uniqKey="Zeng C" first="Congli" last="Zeng">Congli Zeng</name>
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<country name="Brésil">
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<name sortKey="Motta Ribeiro, Gabriel C" sort="Motta Ribeiro, Gabriel C" uniqKey="Motta Ribeiro G" first="Gabriel C" last="Motta-Ribeiro">Gabriel C. Motta-Ribeiro</name>
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<country name="États-Unis">
<region name="Massachusetts">
<name sortKey="Baron, Rebecca M" sort="Baron, Rebecca M" uniqKey="Baron R" first="Rebecca M" last="Baron">Rebecca M. Baron</name>
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<country name="Espagne">
<region name="Communauté de Madrid">
<name sortKey="Santos, Arnoldo" sort="Santos, Arnoldo" uniqKey="Santos A" first="Arnoldo" last="Santos">Arnoldo Santos</name>
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</country>
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</record>

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