| Ident. | Authors (with country if any) | Title |
|---|
| 000B30 (2017) |
Courtney M. Daczkowski [États-Unis] ; John V. Dzimianski [États-Unis] ; Jozlyn R. Clasman [États-Unis] ; Octavia Goodwin [États-Unis] ; Andrew D. Mesecar [États-Unis] ; Scott D. Pegan [États-Unis] | Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species. |
| 000C51 (2016) |
Sarah E. St John [États-Unis] ; Brandon J. Anson [États-Unis] ; Andrew D. Mesecar [États-Unis] | X-Ray Structure and Inhibition of 3C-like Protease from Porcine Epidemic Diarrhea Virus. |
| 000D97 (2015) |
Sarah E. St John [États-Unis] ; Sakshi Tomar [États-Unis] ; Shaun R. Stauffer [États-Unis] ; Andrew D. Mesecar [États-Unis] | Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4--The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS). |
| 000E10 (2015) |
Sakshi Tomar ; Melanie L. Johnston [États-Unis] ; Sarah E. St John ; Heather L. Osswald [États-Unis] ; Prasanth R. Nyalapatla [États-Unis] ; Lake N. Paul ; Arun K. Ghosh [États-Unis] ; Mark R. Denison [États-Unis] ; Andrew D. Mesecar [États-Unis] | Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS. |
| 000E81 (2015) |
Yahira M. Báez-Santos [États-Unis] ; Sarah E. St John [États-Unis] ; Andrew D. Mesecar [États-Unis] | The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds. |
| 000F42 (2014) |
Yahira M. Báez-Santos [États-Unis] ; Anna M. Mielech [États-Unis] ; Xufang Deng [États-Unis] ; Susan Baker [États-Unis] ; Andrew D. Mesecar [États-Unis] | Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus. |
| 000F49 (2014) |
Xufang Deng [États-Unis] ; Sudhakar Agnihothram [États-Unis] ; Anna M. Mielech [États-Unis] ; Daniel B. Nichols [États-Unis] ; Michael W. Wilson [États-Unis] ; Sarah E. Stjohn [États-Unis] ; Scott D. Larsen [États-Unis] ; Andrew D. Mesecar [États-Unis] ; Deborah J. Lenschow [États-Unis] ; Ralph S. Baric [États-Unis] ; Susan C. Baker [États-Unis] | A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses. |
| 000F50 (2014) |
Xufang Deng [États-Unis] ; Sarah E. Stjohn [États-Unis] ; Heather L. Osswald [États-Unis] ; Amornrat O'Brien [États-Unis] ; Bridget S. Banach [États-Unis] ; Katrina Sleeman [États-Unis] ; Arun K. Ghosh [États-Unis] ; Andrew D. Mesecar [États-Unis] ; Susan C. Baker [États-Unis] | Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance. |
| 001041 (2014) |
Yahira M. Báez-Santos [États-Unis] ; Scott J. Barraza ; Michael W. Wilson ; Michael P. Agius ; Anna M. Mielech ; Nicole M. Davis ; Susan C. Baker ; Scott D. Larsen ; Andrew D. Mesecar | X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases. |
| 001050 (2014) |
Anna M. Mielech [États-Unis] ; Yafang Chen [États-Unis] ; Andrew D. Mesecar [États-Unis] ; Susan C. Baker [États-Unis] | Nidovirus papain-like proteases: multifunctional enzymes with protease, deubiquitinating and deISGylating activities. |
| 001053 (2014) |
Anna M. Mielech [États-Unis] ; Andy Kilianski [États-Unis] ; Yahira M. Baez-Santos [États-Unis] ; Andrew D. Mesecar [États-Unis] ; Susan C. Baker [États-Unis] | MERS-CoV papain-like protease has deISGylating and deubiquitinating activities. |
| 001120 (2013) |
Mark Turlington [États-Unis] ; Aspen Chun ; Sakshi Tomar ; Aimee Eggler ; Valerie Grum-Tokars ; Jon Jacobs ; J Scott Daniels ; Eric Dawson ; Adrian Saldanha ; Peter Chase ; Yahira M. Baez-Santos ; Craig W. Lindsley ; Peter Hodder ; Andrew D. Mesecar ; Shaun R. Stauffer | Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding. |
| 001128 (2013) |
Christopher C. Stobart ; Nicole R. Sexton ; Havisha Munjal ; Xiaotao Lu ; Katrina L. Molland ; Sakshi Tomar ; Andrew D. Mesecar ; Mark R. Denison | Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activity. |
| 001686 (2010) |
Arun K. Ghosh [États-Unis] ; Jun Takayama ; Kalapala Venkateswara Rao ; Kiira Ratia ; Rima Chaudhuri ; Debbie C. Mulhearn ; Hyun Lee ; Daniel B. Nichols ; Surendranath Baliji ; Susan C. Baker ; Michael E. Johnson ; Andrew D. Mesecar | Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation. |
| 001744 (2010) |
Mark A. Clementz [États-Unis] ; Zhongbin Chen ; Bridget S. Banach ; Yanhua Wang ; Li Sun ; Kiira Ratia ; Yahira M. Baez-Santos ; Jie Wang ; Jun Takayama ; Arun K. Ghosh ; Kui Li ; Andrew D. Mesecar ; Susan C. Baker | Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases. |
| 001853 (2009) |
Arun K. Ghosh [États-Unis] ; Jun Takayama ; Yoann Aubin ; Kiira Ratia ; Rima Chaudhuri ; Yahira Baez ; Katrina Sleeman ; Melissa Coughlin ; Daniel B. Nichols ; Debbie C. Mulhearn ; Bellur S. Prabhakar ; Susan C. Baker ; Michael E. Johnson ; Andrew D. Mesecar | Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome-coronavirus papain-like protease. |
| 001927 (2009) |
Matthew Frieman [États-Unis] ; Kiira Ratia ; Robert E. Johnston ; Andrew D. Mesecar ; Ralph S. Baric | Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-kappaB signaling. |
| 001A52 (2008) |
Kiira Ratia [États-Unis] ; Scott Pegan ; Jun Takayama ; Katrina Sleeman ; Melissa Coughlin ; Surendranath Baliji ; Rima Chaudhuri ; Wentao Fu ; Bellur S. Prabhakar ; Michael E. Johnson ; Susan C. Baker ; Arun K. Ghosh ; Andrew D. Mesecar | A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. |
| 001A67 (2008) |
Arun K. Ghosh [États-Unis] ; Gangli Gong ; Valerie Grum-Tokars ; Debbie C. Mulhearn ; Susan C. Baker ; Melissa Coughlin ; Bellur S. Prabhakar ; Katrina Sleeman ; Michael E. Johnson ; Andrew D. Mesecar | Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors. |
| 001E59 (2008) |
Valerie Grum-Tokars [États-Unis] ; Kiira Ratia ; Adrian Begaye ; Susan C. Baker ; Andrew D. Mesecar | Evaluating the 3C-like protease activity of SARS-Coronavirus: recommendations for standardized assays for drug discovery. |
| 001E61 (2007) |
Zhongbin Chen [États-Unis] ; Yanhua Wang ; Kiira Ratia ; Andrew D. Mesecar ; Keith D. Wilkinson ; Susan C. Baker | Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63. |
