Dissemination of MHV4 (strain JHM) infection does not require specific coronavirus receptors.
Identifieur interne : 003547 ( PubMed/Curation ); précédent : 003546; suivant : 003548Dissemination of MHV4 (strain JHM) infection does not require specific coronavirus receptors.
Auteurs : T M Gallagher [États-Unis] ; M J Buchmeier ; S. PerlmanSource :
- Advances in experimental medicine and biology [ 0065-2598 ] ; 1993.
Descripteurs français
- KwdFr :
- Animaux, Astrocytome, Cellules cancéreuses en culture (microbiologie), Cricetinae, Effet cytopathogène viral, Fusion cellulaire, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (), Glycoprotéines membranaires (physiologie), Lignée cellulaire (microbiologie), Mesocricetus, Protéines de fusion recombinantes (métabolisme), Protéines de l'enveloppe virale (), Protéines de l'enveloppe virale (physiologie), Rats, Rein, Récepteurs viraux (déficit), Récepteurs viraux (physiologie), Réplication virale, Spécificité d'espèce, Vecteurs génétiques, Virus de l'hépatite murine (physiologie).
- MESH :
- déficit : Récepteurs viraux.
- microbiologie : Cellules cancéreuses en culture, Lignée cellulaire.
- métabolisme : Protéines de fusion recombinantes.
- physiologie : Glycoprotéines membranaires, Protéines de l'enveloppe virale, Récepteurs viraux, Virus de l'hépatite murine.
- Animaux, Astrocytome, Cricetinae, Effet cytopathogène viral, Fusion cellulaire, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires, Mesocricetus, Protéines de l'enveloppe virale, Rats, Rein, Réplication virale, Spécificité d'espèce, Vecteurs génétiques.
English descriptors
- KwdEn :
- Animals, Astrocytoma, Cell Fusion, Cell Line (microbiology), Cricetinae, Cytopathogenic Effect, Viral, Genetic Vectors, Kidney, Membrane Glycoproteins (chemistry), Membrane Glycoproteins (physiology), Mesocricetus, Murine hepatitis virus (physiology), Rats, Receptors, Virus (deficiency), Receptors, Virus (physiology), Recombinant Fusion Proteins (metabolism), Species Specificity, Spike Glycoprotein, Coronavirus, Tumor Cells, Cultured (microbiology), Viral Envelope Proteins (chemistry), Viral Envelope Proteins (physiology), Virus Replication.
- MESH :
- chemical , chemistry : Membrane Glycoproteins, Viral Envelope Proteins.
- chemical , deficiency : Receptors, Virus.
- chemical , metabolism : Recombinant Fusion Proteins.
- microbiology : Cell Line, Tumor Cells, Cultured.
- chemical , physiology : Membrane Glycoproteins, Murine hepatitis virus, Receptors, Virus, Viral Envelope Proteins.
- Animals, Astrocytoma, Cell Fusion, Cricetinae, Cytopathogenic Effect, Viral, Genetic Vectors, Kidney, Mesocricetus, Rats, Species Specificity, Spike Glycoprotein, Coronavirus, Virus Replication.
Abstract
In this report, we demonstrate the syncytial spread of MHV4 (strain JHM) infection through non-murine cell cultures which lack a specific MHV4 receptor and are therefore resistant to infection by free virions. This was achieved by allowing infected murine cells to settle onto confluent monolayers of non-murine cells in a straightforward infectious center assay. Receptor-independent syncytium formation induced by cells expressing the MHV4 spike (S) from recombinant vaccinia viruses (VV) indicated that spread was mediated by this coronavirus glycoprotein. We conclude that the S protein of MHV4 is so potently fusogenic that it does not require prior binding to a virus-specific surface receptor to induce fusion of closely-opposed plasma membranes.
DOI: 10.1007/978-1-4615-2996-5_43
PubMed: 8209743
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