Serum hepatic enzyme manifestations in patients with severe acute respiratory syndrome: retrospective analysis.
Identifieur interne : 002D78 ( PubMed/Curation ); précédent : 002D77; suivant : 002D79Serum hepatic enzyme manifestations in patients with severe acute respiratory syndrome: retrospective analysis.
Auteurs : Hui-Juan Cui [République populaire de Chine] ; Xiao-Lin Tong ; Ping Li ; Ying-Xu Hao ; Xiao-Guang Chen ; Ai-Guo Li ; Zhi-Yuan Zhang ; Jun Duan ; Min Zhen ; Bin Zhang ; Chuan-Jin Hua ; Yue-Wen GongSource :
- World journal of gastroenterology [ 1007-9327 ] ; 2004.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Alanine transaminase (sang), Antiviraux (administration et posologie), Antiviraux (effets indésirables), Aspartate aminotransferases (sang), Enfant, Femelle, Foie (enzymologie), Humains, Incidence, L-Lactate dehydrogenase (sang), Maladies du foie (sang), Maladies du foie (épidémiologie), Mâle, Ribavirine (administration et posologie), Ribavirine (effets indésirables), Sujet âgé, Sujet âgé de 80 ans ou plus, Syndrome respiratoire aigu sévère (sang), Syndrome respiratoire aigu sévère (traitement médicamenteux), Syndrome respiratoire aigu sévère (épidémiologie), Tests de la fonction hépatique, Études rétrospectives.
- MESH :
- administration et posologie : Antiviraux, Ribavirine.
- effets indésirables : Antiviraux, Ribavirine.
- enzymologie : Foie.
- sang : Alanine transaminase, Aspartate aminotransferases, L-Lactate dehydrogenase, Maladies du foie, Syndrome respiratoire aigu sévère.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- épidémiologie : Maladies du foie, Syndrome respiratoire aigu sévère.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Femelle, Humains, Incidence, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Tests de la fonction hépatique, Études rétrospectives.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Alanine Transaminase (blood), Antiviral Agents (administration & dosage), Antiviral Agents (adverse effects), Aspartate Aminotransferases (blood), Child, Female, Humans, Incidence, L-Lactate Dehydrogenase (blood), Liver (enzymology), Liver Diseases (blood), Liver Diseases (epidemiology), Liver Function Tests, Male, Middle Aged, Retrospective Studies, Ribavirin (administration & dosage), Ribavirin (adverse effects), Severe Acute Respiratory Syndrome (blood), Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (epidemiology).
- MESH :
- chemical , administration & dosage : Antiviral Agents, Ribavirin.
- chemical , adverse effects : Antiviral Agents, Ribavirin.
- chemical , blood : Alanine Transaminase, Aspartate Aminotransferases, L-Lactate Dehydrogenase.
- blood : Liver Diseases, Severe Acute Respiratory Syndrome.
- drug therapy : Severe Acute Respiratory Syndrome.
- enzymology : Liver.
- epidemiology : Liver Diseases, Severe Acute Respiratory Syndrome.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Female, Humans, Incidence, Liver Function Tests, Male, Middle Aged, Retrospective Studies.
Abstract
To evaluate the hepatic function in patients with severe acute respiratory syndrome (SARS) and possible causes of hepatic disorder in these patients.
DOI: 10.3748/wjg.v10.i11.1652
PubMed: 15162543
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Aged</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Enfant</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tests de la fonction hépatique</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To evaluate the hepatic function in patients with severe acute respiratory syndrome (SARS) and possible causes of hepatic disorder in these patients.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15162543</PMID><DateCompleted><Year>2004</Year><Month>07</Month><Day>19</Day></DateCompleted><DateRevised><Year>2019</Year><Month>04</Month><Day>30</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1007-9327</ISSN><JournalIssue CitedMedium="Print"><Volume>10</Volume><Issue>11</Issue><PubDate><Year>2004</Year><Month>Jun</Month><Day>01</Day></PubDate></JournalIssue><Title>World journal of gastroenterology</Title><ISOAbbreviation>World J. Gastroenterol.</ISOAbbreviation></Journal><ArticleTitle>Serum hepatic enzyme manifestations in patients with severe acute respiratory syndrome: retrospective analysis.</ArticleTitle><Pagination><MedlinePgn>1652-5</MedlinePgn></Pagination><Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">To evaluate the hepatic function in patients with severe acute respiratory syndrome (SARS) and possible causes of hepatic disorder in these patients.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">One hundred and eighty-two patients with SARS were employed in a retrospective study that investigated hepatic dysfunction. Liver alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactic dehydrogenase (LDH) were analyzed in these patients. Patients with different hospital treatments were further investigated.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Of the 182 patients, 128(70.3%) had abnormal ALT activity, 57(31.3%) had abnormal AST activity and 87(47.8%) had abnormal LDH activity. The peak of elevated hepatic enzyme activities occurred between the sixth day and the tenth day after the first day of reported fever. Of the 182 patients, 160(87.9%) had been treated with antibiotics, 137(75.2%) with Ribavirin, and 115(63.2%) with methylpredisolone. There was no statistically significant correlation between the duration of Ribavirin treatment and hepatic dysfunction.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Abnormal liver functions were common in patients with SARS and could be associated with virus replication in the liver.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cui</LastName><ForeName>Hui-Juan</ForeName><Initials>HJ</Initials><AffiliationInfo><Affiliation>Chinese-Japanese Friendship Hospital, Beijing 100029, China. cuihj1963@sina.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tong</LastName><ForeName>Xiao-Lin</ForeName><Initials>XL</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Ping</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Hao</LastName><ForeName>Ying-Xu</ForeName><Initials>YX</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Xiao-Guang</ForeName><Initials>XG</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Ai-Guo</ForeName><Initials>AG</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Zhi-Yuan</ForeName><Initials>ZY</Initials></Author><Author ValidYN="Y"><LastName>Duan</LastName><ForeName>Jun</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Zhen</LastName><ForeName>Min</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Bin</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Hua</LastName><ForeName>Chuan-Jin</ForeName><Initials>CJ</Initials></Author><Author ValidYN="Y"><LastName>Gong</LastName><ForeName>Yue-Wen</ForeName><Initials>YW</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>World J Gastroenterol</MedlineTA><NlmUniqueID>100883448</NlmUniqueID><ISSNLinking>1007-9327</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>49717AWG6K</RegistryNumber><NameOfSubstance UI="D012254">Ribavirin</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.1.1.27</RegistryNumber><NameOfSubstance UI="D007770">L-Lactate Dehydrogenase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.6.1.1</RegistryNumber><NameOfSubstance UI="D001219">Aspartate Aminotransferases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.6.1.2</RegistryNumber><NameOfSubstance UI="D000410">Alanine Transaminase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000410" MajorTopicYN="N">Alanine Transaminase</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001219" MajorTopicYN="N">Aspartate Aminotransferases</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007770" MajorTopicYN="N">L-Lactate Dehydrogenase</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008107" MajorTopicYN="N">Liver Diseases</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008111" MajorTopicYN="N">Liver Function Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012254" MajorTopicYN="N">Ribavirin</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>5</Month><Day>27</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>7</Month><Day>20</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>5</Month><Day>27</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15162543</ArticleId><ArticleId IdType="pmc">PMC4572772</ArticleId><ArticleId IdType="doi">10.3748/wjg.v10.i11.1652</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1967-76</Citation><ArticleIdList><ArticleId 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