The SARS coronavirus nucleocapsid protein induces actin reorganization and apoptosis in COS-1 cells in the absence of growth factors.
Identifieur interne : 002C36 ( PubMed/Curation ); précédent : 002C35; suivant : 002C37The SARS coronavirus nucleocapsid protein induces actin reorganization and apoptosis in COS-1 cells in the absence of growth factors.
Auteurs : Milan Surjit [Inde] ; Boping Liu ; Shahid Jameel ; Vincent T K. Chow ; Sunil K. LalSource :
- The Biochemical journal [ 1470-8728 ] ; 2004.
Descripteurs français
- KwdFr :
- Actines (métabolisme), Animaux, Apoptose (physiologie), Caspases (métabolisme), Cellules COS, Fibronectines (métabolisme), Focal adhesion protein-tyrosine kinases, Intégrines (physiologie), Lignée cellulaire tumorale, Milieux de culture sans sérum, Mitogen-Activated Protein Kinases (métabolisme), Protein-Serine-Threonine Kinases (métabolisme), Protein-tyrosine kinases (métabolisme), Protéines nucléocapside (physiologie), Protéines proto-oncogènes (métabolisme), Protéines proto-oncogènes c-akt, Régulation négative, Régulation positive, Substances de croissance (physiologie), Transfection, Virus du SRAS (physiologie).
- MESH :
- métabolisme : Actines, Caspases, Fibronectines, Mitogen-Activated Protein Kinases, Protein-Serine-Threonine Kinases, Protein-tyrosine kinases, Protéines proto-oncogènes.
- physiologie : Apoptose, Intégrines, Protéines nucléocapside, Substances de croissance, Virus du SRAS.
- Animaux, Cellules COS, Focal adhesion protein-tyrosine kinases, Lignée cellulaire tumorale, Milieux de culture sans sérum, Protéines proto-oncogènes c-akt, Régulation négative, Régulation positive, Transfection.
English descriptors
- KwdEn :
- Actins (metabolism), Animals, Apoptosis (physiology), COS Cells, Caspases (metabolism), Cell Line, Tumor, Chlorocebus aethiops, Culture Media, Serum-Free, Down-Regulation, Fibronectins (metabolism), Focal Adhesion Protein-Tyrosine Kinases, Growth Substances (physiology), Integrins (physiology), Mitogen-Activated Protein Kinases (metabolism), Nucleocapsid Proteins (physiology), Protein-Serine-Threonine Kinases (metabolism), Protein-Tyrosine Kinases (metabolism), Proto-Oncogene Proteins (metabolism), Proto-Oncogene Proteins c-akt, SARS Virus (physiology), Transfection, Up-Regulation.
- MESH :
- chemical , metabolism : Actins, Caspases, Fibronectins, Mitogen-Activated Protein Kinases, Protein-Serine-Threonine Kinases, Protein-Tyrosine Kinases, Proto-Oncogene Proteins.
- physiology : Apoptosis, Growth Substances, Integrins, Nucleocapsid Proteins, SARS Virus.
- Animals, COS Cells, Cell Line, Tumor, Chlorocebus aethiops, Culture Media, Serum-Free, Down-Regulation, Focal Adhesion Protein-Tyrosine Kinases, Proto-Oncogene Proteins c-akt, Transfection, Up-Regulation.
Abstract
In March 2003, a novel coronavirus was isolated from patients exhibiting atypical pneumonia, and was subsequently proven to be the causative agent of the disease now referred to as SARS (severe acute respiratory syndrome). The complete genome of the SARS-CoV (SARS coronavirus) has since been sequenced. The SARS-CoV nucleocapsid (SARS-CoV N) protein shares little homology with other members of the coronavirus family. In the present paper, we show that SARS-CoV N is capable of inducing apoptosis of COS-1 monkey kidney cells in the absence of growth factors by down-regulating ERK (extracellular-signal-regulated kinase), up-regulating JNK (c-Jun N-terminal kinase) and p38 MAPK (mitogen-activated protein kinase) pathways, and affecting their downstream effectors. SARS-CoV N expression also down-regulated phospho-Akt and Bcl-2 levels, and activated caspases 3 and 7. However, apoptosis was independent of the p53 and Fas signalling pathways. Furthermore, activation of the p38 MAPK pathway was found to induce actin reorganization in cells devoid of growth factors. At the cytoskeletal level, SARS-CoV N down-regulated FAK (focal adhesion kinase) activity and also down-regulated fibronectin expression. This is the first report showing the ability of the N protein of SARS-CoV to induce apoptosis and actin reorganization in mammalian cells under stressed conditions.
DOI: 10.1042/BJ20040984
PubMed: 15294014
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002C36
Links to Exploration step
pubmed:15294014Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The SARS coronavirus nucleocapsid protein induces actin reorganization and apoptosis in COS-1 cells in the absence of growth factors.</title><author><name sortKey="Surjit, Milan" sort="Surjit, Milan" uniqKey="Surjit M" first="Milan" last="Surjit">Milan Surjit</name><affiliation wicri:level="1"><nlm:affiliation>Virology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Road, New Delhi 110067, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Virology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Road, New Delhi 110067</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Boping" sort="Liu, Boping" uniqKey="Liu B" first="Boping" last="Liu">Boping Liu</name></author><author><name sortKey="Jameel, Shahid" sort="Jameel, Shahid" uniqKey="Jameel S" first="Shahid" last="Jameel">Shahid Jameel</name></author><author><name sortKey="Chow, Vincent T K" sort="Chow, Vincent T K" uniqKey="Chow V" first="Vincent T K" last="Chow">Vincent T K. Chow</name></author><author><name sortKey="Lal, Sunil K" sort="Lal, Sunil K" uniqKey="Lal S" first="Sunil K" last="Lal">Sunil K. Lal</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15294014</idno><idno type="pmid">15294014</idno><idno type="doi">10.1042/BJ20040984</idno><idno type="wicri:Area/PubMed/Corpus">002C36</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002C36</idno><idno type="wicri:Area/PubMed/Curation">002C36</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002C36</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The SARS coronavirus nucleocapsid protein induces actin reorganization and apoptosis in COS-1 cells in the absence of growth factors.</title><author><name sortKey="Surjit, Milan" sort="Surjit, Milan" uniqKey="Surjit M" first="Milan" last="Surjit">Milan Surjit</name><affiliation wicri:level="1"><nlm:affiliation>Virology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Road, New Delhi 110067, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Virology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Road, New Delhi 110067</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Boping" sort="Liu, Boping" uniqKey="Liu B" first="Boping" last="Liu">Boping Liu</name></author><author><name sortKey="Jameel, Shahid" sort="Jameel, Shahid" uniqKey="Jameel S" first="Shahid" last="Jameel">Shahid Jameel</name></author><author><name sortKey="Chow, Vincent T K" sort="Chow, Vincent T K" uniqKey="Chow V" first="Vincent T K" last="Chow">Vincent T K. Chow</name></author><author><name sortKey="Lal, Sunil K" sort="Lal, Sunil K" uniqKey="Lal S" first="Sunil K" last="Lal">Sunil K. Lal</name></author></analytic><series><title level="j">The Biochemical journal</title><idno type="eISSN">1470-8728</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Actins (metabolism)</term><term>Animals</term><term>Apoptosis (physiology)</term><term>COS Cells</term><term>Caspases (metabolism)</term><term>Cell Line, Tumor</term><term>Chlorocebus aethiops</term><term>Culture Media, Serum-Free</term><term>Down-Regulation</term><term>Fibronectins (metabolism)</term><term>Focal Adhesion Protein-Tyrosine Kinases</term><term>Growth Substances (physiology)</term><term>Integrins (physiology)</term><term>Mitogen-Activated Protein Kinases (metabolism)</term><term>Nucleocapsid Proteins (physiology)</term><term>Protein-Serine-Threonine Kinases (metabolism)</term><term>Protein-Tyrosine Kinases (metabolism)</term><term>Proto-Oncogene Proteins (metabolism)</term><term>Proto-Oncogene Proteins c-akt</term><term>SARS Virus (physiology)</term><term>Transfection</term><term>Up-Regulation</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Actines (métabolisme)</term><term>Animaux</term><term>Apoptose (physiologie)</term><term>Caspases (métabolisme)</term><term>Cellules COS</term><term>Fibronectines (métabolisme)</term><term>Focal adhesion protein-tyrosine kinases</term><term>Intégrines (physiologie)</term><term>Lignée cellulaire tumorale</term><term>Milieux de culture sans sérum</term><term>Mitogen-Activated Protein Kinases (métabolisme)</term><term>Protein-Serine-Threonine Kinases (métabolisme)</term><term>Protein-tyrosine kinases (métabolisme)</term><term>Protéines nucléocapside (physiologie)</term><term>Protéines proto-oncogènes (métabolisme)</term><term>Protéines proto-oncogènes c-akt</term><term>Régulation négative</term><term>Régulation positive</term><term>Substances de croissance (physiologie)</term><term>Transfection</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Actins</term><term>Caspases</term><term>Fibronectins</term><term>Mitogen-Activated Protein Kinases</term><term>Protein-Serine-Threonine Kinases</term><term>Protein-Tyrosine Kinases</term><term>Proto-Oncogene Proteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Actines</term><term>Caspases</term><term>Fibronectines</term><term>Mitogen-Activated Protein Kinases</term><term>Protein-Serine-Threonine Kinases</term><term>Protein-tyrosine kinases</term><term>Protéines proto-oncogènes</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Apoptose</term><term>Intégrines</term><term>Protéines nucléocapside</term><term>Substances de croissance</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Apoptosis</term><term>Growth Substances</term><term>Integrins</term><term>Nucleocapsid Proteins</term><term>SARS Virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>COS Cells</term><term>Cell Line, Tumor</term><term>Chlorocebus aethiops</term><term>Culture Media, Serum-Free</term><term>Down-Regulation</term><term>Focal Adhesion Protein-Tyrosine Kinases</term><term>Proto-Oncogene Proteins c-akt</term><term>Transfection</term><term>Up-Regulation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules COS</term><term>Focal adhesion protein-tyrosine kinases</term><term>Lignée cellulaire tumorale</term><term>Milieux de culture sans sérum</term><term>Protéines proto-oncogènes c-akt</term><term>Régulation négative</term><term>Régulation positive</term><term>Transfection</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In March 2003, a novel coronavirus was isolated from patients exhibiting atypical pneumonia, and was subsequently proven to be the causative agent of the disease now referred to as SARS (severe acute respiratory syndrome). The complete genome of the SARS-CoV (SARS coronavirus) has since been sequenced. The SARS-CoV nucleocapsid (SARS-CoV N) protein shares little homology with other members of the coronavirus family. In the present paper, we show that SARS-CoV N is capable of inducing apoptosis of COS-1 monkey kidney cells in the absence of growth factors by down-regulating ERK (extracellular-signal-regulated kinase), up-regulating JNK (c-Jun N-terminal kinase) and p38 MAPK (mitogen-activated protein kinase) pathways, and affecting their downstream effectors. SARS-CoV N expression also down-regulated phospho-Akt and Bcl-2 levels, and activated caspases 3 and 7. However, apoptosis was independent of the p53 and Fas signalling pathways. Furthermore, activation of the p38 MAPK pathway was found to induce actin reorganization in cells devoid of growth factors. At the cytoskeletal level, SARS-CoV N down-regulated FAK (focal adhesion kinase) activity and also down-regulated fibronectin expression. This is the first report showing the ability of the N protein of SARS-CoV to induce apoptosis and actin reorganization in mammalian cells under stressed conditions.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15294014</PMID><DateCompleted><Year>2005</Year><Month>03</Month><Day>03</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1470-8728</ISSN><JournalIssue CitedMedium="Internet"><Volume>383</Volume><Issue>Pt 1</Issue><PubDate><Year>2004</Year><Month>Oct</Month><Day>01</Day></PubDate></JournalIssue><Title>The Biochemical journal</Title><ISOAbbreviation>Biochem. J.</ISOAbbreviation></Journal><ArticleTitle>The SARS coronavirus nucleocapsid protein induces actin reorganization and apoptosis in COS-1 cells in the absence of growth factors.</ArticleTitle><Pagination><MedlinePgn>13-8</MedlinePgn></Pagination><Abstract><AbstractText>In March 2003, a novel coronavirus was isolated from patients exhibiting atypical pneumonia, and was subsequently proven to be the causative agent of the disease now referred to as SARS (severe acute respiratory syndrome). The complete genome of the SARS-CoV (SARS coronavirus) has since been sequenced. The SARS-CoV nucleocapsid (SARS-CoV N) protein shares little homology with other members of the coronavirus family. In the present paper, we show that SARS-CoV N is capable of inducing apoptosis of COS-1 monkey kidney cells in the absence of growth factors by down-regulating ERK (extracellular-signal-regulated kinase), up-regulating JNK (c-Jun N-terminal kinase) and p38 MAPK (mitogen-activated protein kinase) pathways, and affecting their downstream effectors. SARS-CoV N expression also down-regulated phospho-Akt and Bcl-2 levels, and activated caspases 3 and 7. However, apoptosis was independent of the p53 and Fas signalling pathways. Furthermore, activation of the p38 MAPK pathway was found to induce actin reorganization in cells devoid of growth factors. At the cytoskeletal level, SARS-CoV N down-regulated FAK (focal adhesion kinase) activity and also down-regulated fibronectin expression. This is the first report showing the ability of the N protein of SARS-CoV to induce apoptosis and actin reorganization in mammalian cells under stressed conditions.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Surjit</LastName><ForeName>Milan</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Virology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Road, New Delhi 110067, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Boping</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Jameel</LastName><ForeName>Shahid</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Chow</LastName><ForeName>Vincent T K</ForeName><Initials>VT</Initials></Author><Author ValidYN="Y"><LastName>Lal</LastName><ForeName>Sunil K</ForeName><Initials>SK</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Biochem J</MedlineTA><NlmUniqueID>2984726R</NlmUniqueID><ISSNLinking>0264-6021</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000199">Actins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016895">Culture Media, Serum-Free</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005353">Fibronectins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006133">Growth Substances</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016023">Integrins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019590">Nucleocapsid Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011518">Proto-Oncogene Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber><NameOfSubstance UI="D011505">Protein-Tyrosine Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.10.2</RegistryNumber><NameOfSubstance UI="D051416">Focal Adhesion Protein-Tyrosine Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D017346">Protein-Serine-Threonine Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D051057">Proto-Oncogene Proteins c-akt</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.24</RegistryNumber><NameOfSubstance UI="D020928">Mitogen-Activated Protein Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.22.-</RegistryNumber><NameOfSubstance UI="D020169">Caspases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000199" MajorTopicYN="N">Actins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019556" MajorTopicYN="N">COS Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020169" MajorTopicYN="N">Caspases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002522" MajorTopicYN="N">Chlorocebus aethiops</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016895" MajorTopicYN="N">Culture Media, Serum-Free</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015536" MajorTopicYN="N">Down-Regulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005353" MajorTopicYN="N">Fibronectins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051416" MajorTopicYN="N">Focal Adhesion Protein-Tyrosine Kinases</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006133" MajorTopicYN="N">Growth Substances</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016023" MajorTopicYN="N">Integrins</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020928" MajorTopicYN="N">Mitogen-Activated Protein Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019590" MajorTopicYN="N">Nucleocapsid Proteins</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017346" MajorTopicYN="N">Protein-Serine-Threonine Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011505" MajorTopicYN="N">Protein-Tyrosine Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011518" MajorTopicYN="N">Proto-Oncogene Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051057" MajorTopicYN="N">Proto-Oncogene Proteins c-akt</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014162" MajorTopicYN="N">Transfection</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015854" MajorTopicYN="N">Up-Regulation</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2004</Year><Month>08</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2004</Year><Month>08</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="received"><Year>2004</Year><Month>06</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>8</Month><Day>6</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>3</Month><Day>4</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>8</Month><Day>6</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15294014</ArticleId><ArticleId IdType="doi">10.1042/BJ20040984</ArticleId><ArticleId IdType="pii">BJ20040984</ArticleId><ArticleId IdType="pmc">PMC1134038</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Genes Dev. 1999 Nov 15;13(22):2905-27</Citation><ArticleIdList><ArticleId IdType="pubmed">10579998</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cell Biol. 2002 Feb 18;156(4):737-50</Citation><ArticleIdList><ArticleId IdType="pubmed">11839767</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1967-76</Citation><ArticleIdList><ArticleId IdType="pubmed">12690091</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1953-66</Citation><ArticleIdList><ArticleId IdType="pubmed">12690092</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2003 May 30;300(5624):1394-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12730500</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2003 May 30;300(5624):1399-404</Citation><ArticleIdList><ArticleId IdType="pubmed">12730501</ArticleId></ArticleIdList></Reference><Reference><Citation>Pharmacol Rev. 1998 Jun;50(2):197-263</Citation><ArticleIdList><ArticleId IdType="pubmed">9647866</ArticleId></ArticleIdList></Reference><Reference><Citation>Pathology. 2003 Dec;35(6):526-31</Citation><ArticleIdList><ArticleId IdType="pubmed">14660106</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Pathol. 2004 Mar;57(3):260-5</Citation><ArticleIdList><ArticleId IdType="pubmed">14990596</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Biophys Res Commun. 2004 May 14;317(4):1030-6</Citation><ArticleIdList><ArticleId IdType="pubmed">15094372</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Virol. 2004 Jul;73(3):323-31</Citation><ArticleIdList><ArticleId IdType="pubmed">15170624</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2004 Jul 15;190(2):379-86</Citation><ArticleIdList><ArticleId IdType="pubmed">15216476</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Biophys Res Commun. 2003 Nov 28;311(4):870-6</Citation><ArticleIdList><ArticleId IdType="pubmed">14623261</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002C36 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 002C36 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:15294014
|texte= The SARS coronavirus nucleocapsid protein induces actin reorganization and apoptosis in COS-1 cells in the absence of growth factors.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:15294014" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |