Humoral immune responses in rabbits induced by an experimental inactivated severe acute respiratory syndrome coronavirus vaccine prepared from F69 strain.
Identifieur interne : 002A23 ( PubMed/Curation ); précédent : 002A22; suivant : 002A24Humoral immune responses in rabbits induced by an experimental inactivated severe acute respiratory syndrome coronavirus vaccine prepared from F69 strain.
Auteurs : Chuan-Hai Zhang [République populaire de Chine] ; Zhong-Min Guo ; Huan-Ying Zheng ; Jia-Hai Lu ; Yi-Fei Wang ; Xin-Ge Yan ; Yong Zhao ; Xiong-Wei Du ; Xin Zhang ; Ling Fang ; Wen-Hua Ling ; Shu-Yuan Qi ; Xin-Bing Yu ; Nan-Shan ZhongSource :
- Chinese medical journal [ 0366-6999 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Vaccins antiviraux, Vaccins inactivés, Virus du SRAS.
- sang : Anticorps antiviraux, Immunoglobuline G.
- Animaux, Lapins, Tests de neutralisation.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin G.
- immunology : SARS Virus, Vaccines, Inactivated, Viral Vaccines.
- Animals, Neutralization Tests, Rabbits.
Abstract
The etiologic agent of severe acute respiratory syndrome (SARS) has been confirmed to be a novel coronavirus (CoV), namely SARS-CoV. Developing safe and effective SARS-CoV vaccines is essential for us to prevent the possible reemergence of its epidemic. Previous experiences indicate that inactivated vaccine is conventional and more hopeful to be successfully developed. Immunogenicity evaluation of an experimental inactivated SARS-CoV vaccine in rabbits was conducted and reported in this paper.
PubMed: 15569476
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<author><name sortKey="Zhang, Chuan Hai" sort="Zhang, Chuan Hai" uniqKey="Zhang C" first="Chuan-Hai" last="Zhang">Chuan-Hai Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>South China Institute of Botany, Graduate School of Chinese Academy of Sciences, Guangzhou 510650, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Guo, Zhong Min" sort="Guo, Zhong Min" uniqKey="Guo Z" first="Zhong-Min" last="Guo">Zhong-Min Guo</name>
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<author><name sortKey="Zheng, Huan Ying" sort="Zheng, Huan Ying" uniqKey="Zheng H" first="Huan-Ying" last="Zheng">Huan-Ying Zheng</name>
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<author><name sortKey="Zhao, Yong" sort="Zhao, Yong" uniqKey="Zhao Y" first="Yong" last="Zhao">Yong Zhao</name>
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<author><name sortKey="Zhang, Xin" sort="Zhang, Xin" uniqKey="Zhang X" first="Xin" last="Zhang">Xin Zhang</name>
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<term>Antibodies, Viral (blood)</term>
<term>Immunoglobulin G (blood)</term>
<term>Neutralization Tests</term>
<term>Rabbits</term>
<term>SARS Virus (immunology)</term>
<term>Vaccines, Inactivated (immunology)</term>
<term>Viral Vaccines (immunology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps antiviraux (sang)</term>
<term>Immunoglobuline G (sang)</term>
<term>Lapins</term>
<term>Tests de neutralisation</term>
<term>Vaccins antiviraux (immunologie)</term>
<term>Vaccins inactivés (immunologie)</term>
<term>Virus du SRAS (immunologie)</term>
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<term>Immunoglobulin G</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antiviraux</term>
<term>Vaccins inactivés</term>
<term>Virus du SRAS</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term>
<term>Vaccines, Inactivated</term>
<term>Viral Vaccines</term>
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<term>Immunoglobuline G</term>
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<term>Neutralization Tests</term>
<term>Rabbits</term>
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<front><div type="abstract" xml:lang="en">The etiologic agent of severe acute respiratory syndrome (SARS) has been confirmed to be a novel coronavirus (CoV), namely SARS-CoV. Developing safe and effective SARS-CoV vaccines is essential for us to prevent the possible reemergence of its epidemic. Previous experiences indicate that inactivated vaccine is conventional and more hopeful to be successfully developed. Immunogenicity evaluation of an experimental inactivated SARS-CoV vaccine in rabbits was conducted and reported in this paper.</div>
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<DateCompleted><Year>2004</Year>
<Month>12</Month>
<Day>30</Day>
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<DateRevised><Year>2006</Year>
<Month>11</Month>
<Day>15</Day>
</DateRevised>
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<Issue>11</Issue>
<PubDate><Year>2004</Year>
<Month>Nov</Month>
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<Title>Chinese medical journal</Title>
<ISOAbbreviation>Chin. Med. J.</ISOAbbreviation>
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<ArticleTitle>Humoral immune responses in rabbits induced by an experimental inactivated severe acute respiratory syndrome coronavirus vaccine prepared from F69 strain.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The etiologic agent of severe acute respiratory syndrome (SARS) has been confirmed to be a novel coronavirus (CoV), namely SARS-CoV. Developing safe and effective SARS-CoV vaccines is essential for us to prevent the possible reemergence of its epidemic. Previous experiences indicate that inactivated vaccine is conventional and more hopeful to be successfully developed. Immunogenicity evaluation of an experimental inactivated SARS-CoV vaccine in rabbits was conducted and reported in this paper.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The large-scale cultured SARS-CoV F69 strain was inactivated with 0.4% formaldehyde and purified, then used as the immunogen combined with Freund's adjuvant. Eight adult New Zealand rabbits were immunized four times with this experimental inactivated vaccine. Twelve sets of rabbit serum were sampled from the third day to the seventy-fourth day after the first vaccination. The titers of specific anti-SARS-CoV IgG antibody were determined by indirect enzyme-linked immunosorbent assay, and the neutralizing antibody titers were detected with micro-cytopathic effect neutralization test.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Rapid and potent humoral immune responses were induced by the inactivated SARS-CoV vaccine in all the eight test rabbits. Titers of both specific IgG antibody and neutralizing antibody peaked at about six weeks after first vaccination, with the maximum value of 1:81 920 and 1:20 480, respectively. After that, serum antibody levels remained at a plateau or had a slight decrease, though two boosters were given in the succedent 4 to 5 weeks. Cross neutralization response existed between SARS-CoV F69 strain and Z2-Y3 strain.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The inactivated SARS-CoV vaccine made from F69 strain owns strong immunogenicity, and the cross neutralization response between the two different SARS-CoV strains gives a hint of the similar neutralizing epitopes, which provide stable bases for the development of inactivated SARS-CoV vaccines.</AbstractText>
</Abstract>
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