Humoral immune responses in rabbits induced by an experimental inactivated severe acute respiratory syndrome coronavirus vaccine prepared from F69 strain.
Identifieur interne : 002A23 ( PubMed/Curation ); précédent : 002A22; suivant : 002A24Humoral immune responses in rabbits induced by an experimental inactivated severe acute respiratory syndrome coronavirus vaccine prepared from F69 strain.
Auteurs : Chuan-Hai Zhang [République populaire de Chine] ; Zhong-Min Guo ; Huan-Ying Zheng ; Jia-Hai Lu ; Yi-Fei Wang ; Xin-Ge Yan ; Yong Zhao ; Xiong-Wei Du ; Xin Zhang ; Ling Fang ; Wen-Hua Ling ; Shu-Yuan Qi ; Xin-Bing Yu ; Nan-Shan ZhongSource :
- Chinese medical journal [ 0366-6999 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Vaccins antiviraux, Vaccins inactivés, Virus du SRAS.
- sang : Anticorps antiviraux, Immunoglobuline G.
- Animaux, Lapins, Tests de neutralisation.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin G.
- immunology : SARS Virus, Vaccines, Inactivated, Viral Vaccines.
- Animals, Neutralization Tests, Rabbits.
Abstract
The etiologic agent of severe acute respiratory syndrome (SARS) has been confirmed to be a novel coronavirus (CoV), namely SARS-CoV. Developing safe and effective SARS-CoV vaccines is essential for us to prevent the possible reemergence of its epidemic. Previous experiences indicate that inactivated vaccine is conventional and more hopeful to be successfully developed. Immunogenicity evaluation of an experimental inactivated SARS-CoV vaccine in rabbits was conducted and reported in this paper.
PubMed: 15569476
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last="Zheng">Huan-Ying Zheng</name></author><author><name sortKey="Lu, Jia Hai" sort="Lu, Jia Hai" uniqKey="Lu J" first="Jia-Hai" last="Lu">Jia-Hai Lu</name></author><author><name sortKey="Wang, Yi Fei" sort="Wang, Yi Fei" uniqKey="Wang Y" first="Yi-Fei" last="Wang">Yi-Fei Wang</name></author><author><name sortKey="Yan, Xin Ge" sort="Yan, Xin Ge" uniqKey="Yan X" first="Xin-Ge" last="Yan">Xin-Ge Yan</name></author><author><name sortKey="Zhao, Yong" sort="Zhao, Yong" uniqKey="Zhao Y" first="Yong" last="Zhao">Yong Zhao</name></author><author><name sortKey="Du, Xiong Wei" sort="Du, Xiong Wei" uniqKey="Du X" first="Xiong-Wei" last="Du">Xiong-Wei Du</name></author><author><name sortKey="Zhang, Xin" sort="Zhang, Xin" uniqKey="Zhang X" first="Xin" last="Zhang">Xin Zhang</name></author><author><name sortKey="Fang, Ling" sort="Fang, Ling" uniqKey="Fang L" first="Ling" last="Fang">Ling Fang</name></author><author><name sortKey="Ling, Wen Hua" sort="Ling, Wen Hua" uniqKey="Ling W" first="Wen-Hua" last="Ling">Wen-Hua Ling</name></author><author><name sortKey="Qi, Shu Yuan" sort="Qi, Shu Yuan" uniqKey="Qi S" first="Shu-Yuan" last="Qi">Shu-Yuan Qi</name></author><author><name sortKey="Yu, Xin Bing" sort="Yu, Xin Bing" uniqKey="Yu X" first="Xin-Bing" last="Yu">Xin-Bing Yu</name></author><author><name sortKey="Zhong, Nan Shan" sort="Zhong, Nan Shan" uniqKey="Zhong N" first="Nan-Shan" last="Zhong">Nan-Shan Zhong</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15569476</idno><idno type="pmid">15569476</idno><idno type="wicri:Area/PubMed/Corpus">002A23</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002A23</idno><idno type="wicri:Area/PubMed/Curation">002A23</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002A23</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Humoral immune responses in rabbits induced by an experimental inactivated severe acute respiratory syndrome coronavirus vaccine prepared from F69 strain.</title><author><name sortKey="Zhang, Chuan Hai" sort="Zhang, Chuan Hai" uniqKey="Zhang C" first="Chuan-Hai" last="Zhang">Chuan-Hai Zhang</name><affiliation wicri:level="1"><nlm:affiliation>South China Institute of Botany, Graduate School of Chinese Academy of Sciences, Guangzhou 510650, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>South China Institute of Botany, Graduate School of Chinese Academy of Sciences, Guangzhou 510650</wicri:regionArea></affiliation></author><author><name sortKey="Guo, Zhong Min" sort="Guo, Zhong Min" uniqKey="Guo Z" first="Zhong-Min" last="Guo">Zhong-Min Guo</name></author><author><name sortKey="Zheng, Huan Ying" sort="Zheng, Huan Ying" uniqKey="Zheng H" first="Huan-Ying" last="Zheng">Huan-Ying Zheng</name></author><author><name sortKey="Lu, Jia Hai" sort="Lu, Jia Hai" uniqKey="Lu J" first="Jia-Hai" last="Lu">Jia-Hai Lu</name></author><author><name sortKey="Wang, Yi Fei" sort="Wang, Yi Fei" uniqKey="Wang Y" first="Yi-Fei" last="Wang">Yi-Fei Wang</name></author><author><name sortKey="Yan, Xin Ge" sort="Yan, Xin Ge" uniqKey="Yan X" first="Xin-Ge" last="Yan">Xin-Ge Yan</name></author><author><name sortKey="Zhao, Yong" sort="Zhao, Yong" uniqKey="Zhao Y" first="Yong" last="Zhao">Yong Zhao</name></author><author><name sortKey="Du, Xiong Wei" sort="Du, Xiong Wei" uniqKey="Du X" first="Xiong-Wei" last="Du">Xiong-Wei Du</name></author><author><name sortKey="Zhang, Xin" sort="Zhang, Xin" uniqKey="Zhang X" first="Xin" last="Zhang">Xin Zhang</name></author><author><name sortKey="Fang, Ling" sort="Fang, Ling" uniqKey="Fang L" first="Ling" last="Fang">Ling Fang</name></author><author><name sortKey="Ling, Wen Hua" sort="Ling, Wen Hua" uniqKey="Ling W" first="Wen-Hua" last="Ling">Wen-Hua Ling</name></author><author><name sortKey="Qi, Shu Yuan" sort="Qi, Shu Yuan" uniqKey="Qi S" first="Shu-Yuan" last="Qi">Shu-Yuan Qi</name></author><author><name sortKey="Yu, Xin Bing" sort="Yu, Xin Bing" uniqKey="Yu X" first="Xin-Bing" last="Yu">Xin-Bing Yu</name></author><author><name sortKey="Zhong, Nan Shan" sort="Zhong, Nan Shan" uniqKey="Zhong N" first="Nan-Shan" last="Zhong">Nan-Shan Zhong</name></author></analytic><series><title level="j">Chinese medical journal</title><idno type="ISSN">0366-6999</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (blood)</term><term>Immunoglobulin G (blood)</term><term>Neutralization Tests</term><term>Rabbits</term><term>SARS Virus (immunology)</term><term>Vaccines, Inactivated (immunology)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Immunoglobuline G (sang)</term><term>Lapins</term><term>Tests de neutralisation</term><term>Vaccins antiviraux (immunologie)</term><term>Vaccins inactivés (immunologie)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antiviraux</term><term>Vaccins inactivés</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>Vaccines, Inactivated</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Neutralization Tests</term><term>Rabbits</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Lapins</term><term>Tests de neutralisation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The etiologic agent of severe acute respiratory syndrome (SARS) has been confirmed to be a novel coronavirus (CoV), namely SARS-CoV. Developing safe and effective SARS-CoV vaccines is essential for us to prevent the possible reemergence of its epidemic. Previous experiences indicate that inactivated vaccine is conventional and more hopeful to be successfully developed. Immunogenicity evaluation of an experimental inactivated SARS-CoV vaccine in rabbits was conducted and reported in this paper.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15569476</PMID><DateCompleted><Year>2004</Year><Month>12</Month><Day>30</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0366-6999</ISSN><JournalIssue CitedMedium="Print"><Volume>117</Volume><Issue>11</Issue><PubDate><Year>2004</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Chinese medical journal</Title><ISOAbbreviation>Chin. Med. J.</ISOAbbreviation></Journal><ArticleTitle>Humoral immune responses in rabbits induced by an experimental inactivated severe acute respiratory syndrome coronavirus vaccine prepared from F69 strain.</ArticleTitle><Pagination><MedlinePgn>1625-9</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The etiologic agent of severe acute respiratory syndrome (SARS) has been confirmed to be a novel coronavirus (CoV), namely SARS-CoV. Developing safe and effective SARS-CoV vaccines is essential for us to prevent the possible reemergence of its epidemic. Previous experiences indicate that inactivated vaccine is conventional and more hopeful to be successfully developed. Immunogenicity evaluation of an experimental inactivated SARS-CoV vaccine in rabbits was conducted and reported in this paper.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The large-scale cultured SARS-CoV F69 strain was inactivated with 0.4% formaldehyde and purified, then used as the immunogen combined with Freund's adjuvant. Eight adult New Zealand rabbits were immunized four times with this experimental inactivated vaccine. Twelve sets of rabbit serum were sampled from the third day to the seventy-fourth day after the first vaccination. The titers of specific anti-SARS-CoV IgG antibody were determined by indirect enzyme-linked immunosorbent assay, and the neutralizing antibody titers were detected with micro-cytopathic effect neutralization test.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Rapid and potent humoral immune responses were induced by the inactivated SARS-CoV vaccine in all the eight test rabbits. Titers of both specific IgG antibody and neutralizing antibody peaked at about six weeks after first vaccination, with the maximum value of 1:81 920 and 1:20 480, respectively. After that, serum antibody levels remained at a plateau or had a slight decrease, though two boosters were given in the succedent 4 to 5 weeks. Cross neutralization response existed between SARS-CoV F69 strain and Z2-Y3 strain.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The inactivated SARS-CoV vaccine made from F69 strain owns strong immunogenicity, and the cross neutralization response between the two different SARS-CoV strains gives a hint of the similar neutralizing epitopes, which provide stable bases for the development of inactivated SARS-CoV vaccines.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Chuan-Hai</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>South China Institute of Botany, Graduate School of Chinese Academy of Sciences, Guangzhou 510650, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Zhong-Min</ForeName><Initials>ZM</Initials></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Huan-Ying</ForeName><Initials>HY</Initials></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Jia-Hai</ForeName><Initials>JH</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yi-Fei</ForeName><Initials>YF</Initials></Author><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>Xin-Ge</ForeName><Initials>XG</Initials></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Yong</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>DU</LastName><ForeName>Xiong-Wei</ForeName><Initials>XW</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Xin</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Fang</LastName><ForeName>Ling</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Ling</LastName><ForeName>Wen-Hua</ForeName><Initials>WH</Initials></Author><Author ValidYN="Y"><LastName>Qi</LastName><ForeName>Shu-Yuan</ForeName><Initials>SY</Initials></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Xin-Bing</ForeName><Initials>XB</Initials></Author><Author ValidYN="Y"><LastName>Zhong</LastName><ForeName>Nan-Shan</ForeName><Initials>NS</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Chin Med J (Engl)</MedlineTA><NlmUniqueID>7513795</NlmUniqueID><ISSNLinking>0366-6999</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015164">Vaccines, Inactivated</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014765">Viral Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009500" MajorTopicYN="N">Neutralization Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011817" MajorTopicYN="N">Rabbits</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015164" MajorTopicYN="N">Vaccines, Inactivated</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014765" MajorTopicYN="N">Viral Vaccines</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>12</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>12</Month><Day>31</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>12</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15569476</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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