Clinical characteristics and mechanism of liver damage in patients with severe acute respiratory syndrome.
Identifieur interne : 002878 ( PubMed/Curation ); précédent : 002877; suivant : 002879Clinical characteristics and mechanism of liver damage in patients with severe acute respiratory syndrome.
Auteurs : Zhang Yang [République populaire de Chine] ; Min Xu ; Jun-Qing Yi ; Wei-Dong JiaSource :
- Hepatobiliary & pancreatic diseases international : HBPD INT [ 1499-3872 ] ; 2005.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Alanine transaminase (analyse), Analyse de régression, Antibactériens, Association de médicaments (usage thérapeutique), Chine (épidémiologie), Comorbidité, Femelle, Humains, Immunohistochimie, Incidence, Indice de gravité médicale, Loi du khi-deux, Maladies du foie (anatomopathologie), Maladies du foie (épidémiologie), Mâle, Ponction-biopsie à l'aiguille, Répartition par sexe, Répartition par âge, Syndrome respiratoire aigu sévère (diagnostic), Syndrome respiratoire aigu sévère (traitement médicamenteux), Syndrome respiratoire aigu sévère (épidémiologie), Taux de survie, Tests de la fonction hépatique, Virus du SRAS (isolement et purification), Études rétrospectives, Évaluation des risques.
- MESH :
- analyse : Alanine transaminase.
- anatomopathologie : Maladies du foie.
- diagnostic : Syndrome respiratoire aigu sévère.
- isolement et purification : Virus du SRAS.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- usage thérapeutique : Association de médicaments.
- épidémiologie : Chine, Maladies du foie, Syndrome respiratoire aigu sévère.
- Adolescent, Adulte, Adulte d'âge moyen, Analyse de régression, Antibactériens, Comorbidité, Femelle, Humains, Immunohistochimie, Incidence, Indice de gravité médicale, Loi du khi-deux, Mâle, Ponction-biopsie à l'aiguille, Répartition par sexe, Répartition par âge, Taux de survie, Tests de la fonction hépatique, Études rétrospectives, Évaluation des risques.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Adolescent, Adult, Age Distribution, Alanine Transaminase (analysis), Anti-Bacterial Agents, Biopsy, Needle, Chi-Square Distribution, China (epidemiology), Comorbidity, Drug Therapy, Combination (therapeutic use), Female, Humans, Immunohistochemistry, Incidence, Liver Diseases (epidemiology), Liver Diseases (pathology), Liver Function Tests, Male, Middle Aged, Regression Analysis, Retrospective Studies, Risk Assessment, SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (diagnosis), Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (epidemiology), Severity of Illness Index, Sex Distribution, Survival Rate.
- MESH :
- chemical , analysis : Alanine Transaminase.
- geographic , epidemiology : China.
- diagnosis : Severe Acute Respiratory Syndrome.
- drug therapy : Severe Acute Respiratory Syndrome.
- epidemiology : Liver Diseases, Severe Acute Respiratory Syndrome.
- isolation & purification : SARS Virus.
- pathology : Liver Diseases.
- therapeutic use : Drug Therapy, Combination.
- Adolescent, Adult, Age Distribution, Anti-Bacterial Agents, Biopsy, Needle, Chi-Square Distribution, Comorbidity, Female, Humans, Immunohistochemistry, Incidence, Liver Function Tests, Male, Middle Aged, Regression Analysis, Retrospective Studies, Risk Assessment, Severity of Illness Index, Sex Distribution, Survival Rate.
Abstract
Abnormal liver function was found in patients with severe acute respiratory syndrome (SARS). This study was undertaken to explore the clinical characteristics and mechanisms of liver damage.
PubMed: 15730921
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002878
Links to Exploration step
pubmed:15730921Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical characteristics and mechanism of liver damage in patients with severe acute respiratory syndrome.</title><author><name sortKey="Yang, Zhang" sort="Yang, Zhang" uniqKey="Yang Z" first="Zhang" last="Yang">Zhang Yang</name><affiliation wicri:level="1"><nlm:affiliation>Guangzhou No.8 People's Hospital, Guangzhou 510060, China. yangzhangz@21cn.com</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou No.8 People's Hospital, Guangzhou 510060</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Min" sort="Xu, Min" uniqKey="Xu M" first="Min" last="Xu">Min Xu</name></author><author><name sortKey="Yi, Jun Qing" sort="Yi, Jun Qing" uniqKey="Yi J" first="Jun-Qing" last="Yi">Jun-Qing Yi</name></author><author><name sortKey="Jia, Wei Dong" sort="Jia, Wei Dong" uniqKey="Jia W" first="Wei-Dong" last="Jia">Wei-Dong Jia</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:15730921</idno><idno type="pmid">15730921</idno><idno type="wicri:Area/PubMed/Corpus">002878</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002878</idno><idno type="wicri:Area/PubMed/Curation">002878</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002878</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical characteristics and mechanism of liver damage in patients with severe acute respiratory syndrome.</title><author><name sortKey="Yang, Zhang" sort="Yang, Zhang" uniqKey="Yang Z" first="Zhang" last="Yang">Zhang Yang</name><affiliation wicri:level="1"><nlm:affiliation>Guangzhou No.8 People's Hospital, Guangzhou 510060, China. yangzhangz@21cn.com</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou No.8 People's Hospital, Guangzhou 510060</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Min" sort="Xu, Min" uniqKey="Xu M" first="Min" last="Xu">Min Xu</name></author><author><name sortKey="Yi, Jun Qing" sort="Yi, Jun Qing" uniqKey="Yi J" first="Jun-Qing" last="Yi">Jun-Qing Yi</name></author><author><name sortKey="Jia, Wei Dong" sort="Jia, Wei Dong" uniqKey="Jia W" first="Wei-Dong" last="Jia">Wei-Dong Jia</name></author></analytic><series><title level="j">Hepatobiliary & pancreatic diseases international : HBPD INT</title><idno type="ISSN">1499-3872</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Distribution</term><term>Alanine Transaminase (analysis)</term><term>Anti-Bacterial Agents</term><term>Biopsy, Needle</term><term>Chi-Square Distribution</term><term>China (epidemiology)</term><term>Comorbidity</term><term>Drug Therapy, Combination (therapeutic use)</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Incidence</term><term>Liver Diseases (epidemiology)</term><term>Liver Diseases (pathology)</term><term>Liver Function Tests</term><term>Male</term><term>Middle Aged</term><term>Regression Analysis</term><term>Retrospective Studies</term><term>Risk Assessment</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (diagnosis)</term><term>Severe Acute Respiratory Syndrome (drug therapy)</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severity of Illness Index</term><term>Sex Distribution</term><term>Survival Rate</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Alanine transaminase (analyse)</term><term>Analyse de régression</term><term>Antibactériens</term><term>Association de médicaments (usage thérapeutique)</term><term>Chine (épidémiologie)</term><term>Comorbidité</term><term>Femelle</term><term>Humains</term><term>Immunohistochimie</term><term>Incidence</term><term>Indice de gravité médicale</term><term>Loi du khi-deux</term><term>Maladies du foie (anatomopathologie)</term><term>Maladies du foie (épidémiologie)</term><term>Mâle</term><term>Ponction-biopsie à l'aiguille</term><term>Répartition par sexe</term><term>Répartition par âge</term><term>Syndrome respiratoire aigu sévère (diagnostic)</term><term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term><term>Syndrome respiratoire aigu sévère (épidémiologie)</term><term>Taux de survie</term><term>Tests de la fonction hépatique</term><term>Virus du SRAS (isolement et purification)</term><term>Études rétrospectives</term><term>Évaluation des risques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Alanine Transaminase</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Alanine transaminase</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Maladies du foie</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Liver Diseases</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Liver Diseases</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Drug Therapy, Combination</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Association de médicaments</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Chine</term><term>Maladies du foie</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Distribution</term><term>Anti-Bacterial Agents</term><term>Biopsy, Needle</term><term>Chi-Square Distribution</term><term>Comorbidity</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Incidence</term><term>Liver Function Tests</term><term>Male</term><term>Middle Aged</term><term>Regression Analysis</term><term>Retrospective Studies</term><term>Risk Assessment</term><term>Severity of Illness Index</term><term>Sex Distribution</term><term>Survival Rate</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de régression</term><term>Antibactériens</term><term>Comorbidité</term><term>Femelle</term><term>Humains</term><term>Immunohistochimie</term><term>Incidence</term><term>Indice de gravité médicale</term><term>Loi du khi-deux</term><term>Mâle</term><term>Ponction-biopsie à l'aiguille</term><term>Répartition par sexe</term><term>Répartition par âge</term><term>Taux de survie</term><term>Tests de la fonction hépatique</term><term>Études rétrospectives</term><term>Évaluation des risques</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abnormal liver function was found in patients with severe acute respiratory syndrome (SARS). This study was undertaken to explore the clinical characteristics and mechanisms of liver damage.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15730921</PMID><DateCompleted><Year>2005</Year><Month>04</Month><Day>06</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1499-3872</ISSN><JournalIssue CitedMedium="Print"><Volume>4</Volume><Issue>1</Issue><PubDate><Year>2005</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Hepatobiliary & pancreatic diseases international : HBPD INT</Title><ISOAbbreviation>HBPD INT</ISOAbbreviation></Journal><ArticleTitle>Clinical characteristics and mechanism of liver damage in patients with severe acute respiratory syndrome.</ArticleTitle><Pagination><MedlinePgn>60-3</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Abnormal liver function was found in patients with severe acute respiratory syndrome (SARS). This study was undertaken to explore the clinical characteristics and mechanisms of liver damage.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The serial laboratory data of liver function test and hepatic histological examination from 168 patients with SARS were retrospectively analyzed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The abnormalities of serum alanine aminotransferase (ALT) were 52.5%, 71.8%, 85.7% and 85.2%. The average levels of ALT of the patients were 56.07+/-51.57 U/L, 86.46+/-69.93 U/L, 106.69+/-102.50 U/L and 111.32+/-160.24 U/L, and the average levels of serum albumin were 37.25+/-5.37 g/L, 35.82+/-4.74 g/L, 34.49+/-5.04 g/L, and 34.26+/-4.70 g/L, at the day of admission, the first week, second week, and third week after hospitalization, respectively. Significant correlation was not shown among liver damage, blood oxygen saturation (SaO2), degree of fever, and immune functional disorder in this study. Hepatic histological examination of 4 patients demonstrated that non-specific inflammation existed in the liver.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Liver damage of patients with SARS usually occurs in the early stage of the disease with a high occurrence rate and a prolonged profile, which can be characterized by early, obvious decrease of albumin levels and slightly abnormal levels of ALT. The liver damage induced by SARS seems to be caused by SARS virus directly rather than by low SaO2 or high fever. Hepatotoxic drugs may play a role in increasing the severity of liver damage or prolonging the time of liver function recovery.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Zhang</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Guangzhou No.8 People's Hospital, Guangzhou 510060, China. yangzhangz@21cn.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Min</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Yi</LastName><ForeName>Jun-Qing</ForeName><Initials>JQ</Initials></Author><Author ValidYN="Y"><LastName>Jia</LastName><ForeName>Wei-Dong</ForeName><Initials>WD</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Singapore</Country><MedlineTA>Hepatobiliary Pancreat Dis Int</MedlineTA><NlmUniqueID>101151457</NlmUniqueID></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.6.1.2</RegistryNumber><NameOfSubstance UI="D000410">Alanine Transaminase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017677" MajorTopicYN="N">Age Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000410" MajorTopicYN="N">Alanine Transaminase</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001707" MajorTopicYN="N">Biopsy, Needle</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016009" MajorTopicYN="N">Chi-Square Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N" Type="Geographic">China</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004359" MajorTopicYN="N">Drug Therapy, Combination</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008107" MajorTopicYN="N">Liver Diseases</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008111" MajorTopicYN="N">Liver Function Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012044" MajorTopicYN="N">Regression Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017678" MajorTopicYN="N">Sex Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>2</Month><Day>26</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>4</Month><Day>7</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>2</Month><Day>26</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15730921</ArticleId><ArticleId IdType="pii">345</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002878 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 002878 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:15730921
|texte= Clinical characteristics and mechanism of liver damage in patients with severe acute respiratory syndrome.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:15730921" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |