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Immunohistochemical study of severe acute respiratory syndrome-associated coronavirus in tissue sections of patients.

Identifieur interne : 002799 ( PubMed/Curation ); précédent : 002798; suivant : 002800

Immunohistochemical study of severe acute respiratory syndrome-associated coronavirus in tissue sections of patients.

Auteurs : Cheng-Hsiang Hsiao [Taïwan] ; Ming-Fu Chang ; Po-Ren Hsueh ; Ih-Jen Su

Source :

Journal of the Formosan Medical Association = Taiwan yi zhi [ 0929-6646 ] ; 2005.

RBID : pubmed:15818427

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Coloration et marquage, Coronavirus (isolement et purification), Femelle, Humains, Mâle, Sujet âgé, Syndrome respiratoire aigu sévère (virologie), Techniques immunoenzymatiques.
MESH :
- isolement et purification : Coronavirus.
- virologie : Syndrome respiratoire aigu sévère.
- Adulte, Adulte d'âge moyen, Coloration et marquage, Femelle, Humains, Mâle, Sujet âgé, Techniques immunoenzymatiques.

English descriptors

KwdEn :
- Adult, Aged, Coronavirus (isolation & purification), Female, Humans, Immunoenzyme Techniques, Male, Middle Aged, Severe Acute Respiratory Syndrome (virology), Staining and Labeling.
MESH :
- isolation & purification : Coronavirus.
- virology : Severe Acute Respiratory Syndrome.
- Adult, Aged, Female, Humans, Immunoenzyme Techniques, Male, Middle Aged, Staining and Labeling.

Abstract

Severe acute respiratory syndrome (SARS) is a life-threatening and highly contagious disease caused by the novel SARS coronavirus (SARS-CoV). Immunohistochemical staining for SARS-CoV in the tissue sections of SARS patients is helpful in investigations of the biologic behavior of this virus in human tissue, and to determine the target cells of this virus in different organs.

PubMed: 15818427

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Le document en format XML

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<author><name sortKey="Hsiao, Cheng Hsiang" sort="Hsiao, Cheng Hsiang" uniqKey="Hsiao C" first="Cheng-Hsiang" last="Hsiao">Cheng-Hsiang Hsiao</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Pathology, National Taiwan University Hospital, Taipei</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chang, Ming Fu" sort="Chang, Ming Fu" uniqKey="Chang M" first="Ming-Fu" last="Chang">Ming-Fu Chang</name>
</author>
<author><name sortKey="Hsueh, Po Ren" sort="Hsueh, Po Ren" uniqKey="Hsueh P" first="Po-Ren" last="Hsueh">Po-Ren Hsueh</name>
</author>
<author><name sortKey="Su, Ih Jen" sort="Su, Ih Jen" uniqKey="Su I" first="Ih-Jen" last="Su">Ih-Jen Su</name>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Immunohistochemical study of severe acute respiratory syndrome-associated coronavirus in tissue sections of patients.</title>
<author><name sortKey="Hsiao, Cheng Hsiang" sort="Hsiao, Cheng Hsiang" uniqKey="Hsiao C" first="Cheng-Hsiang" last="Hsiao">Cheng-Hsiang Hsiao</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Pathology, National Taiwan University Hospital, Taipei</wicri:regionArea>
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<author><name sortKey="Chang, Ming Fu" sort="Chang, Ming Fu" uniqKey="Chang M" first="Ming-Fu" last="Chang">Ming-Fu Chang</name>
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<author><name sortKey="Hsueh, Po Ren" sort="Hsueh, Po Ren" uniqKey="Hsueh P" first="Po-Ren" last="Hsueh">Po-Ren Hsueh</name>
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<author><name sortKey="Su, Ih Jen" sort="Su, Ih Jen" uniqKey="Su I" first="Ih-Jen" last="Su">Ih-Jen Su</name>
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<series><title level="j">Journal of the Formosan Medical Association = Taiwan yi zhi</title>
<idno type="ISSN">0929-6646</idno>
<imprint><date when="2005" type="published">2005</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Coronavirus (isolation & purification)</term>
<term>Female</term>
<term>Humans</term>
<term>Immunoenzyme Techniques</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Staining and Labeling</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Coloration et marquage</term>
<term>Coronavirus (isolement et purification)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Techniques immunoenzymatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Immunoenzyme Techniques</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Staining and Labeling</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Coloration et marquage</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Techniques immunoenzymatiques</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a life-threatening and highly contagious disease caused by the novel SARS coronavirus (SARS-CoV). Immunohistochemical staining for SARS-CoV in the tissue sections of SARS patients is helpful in investigations of the biologic behavior of this virus in human tissue, and to determine the target cells of this virus in different organs.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15818427</PMID>
<DateCompleted><Year>2005</Year>
<Month>06</Month>
<Day>01</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>10</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0929-6646</ISSN>
<JournalIssue CitedMedium="Print"><Volume>104</Volume>
<Issue>3</Issue>
<PubDate><Year>2005</Year>
<Month>Mar</Month>
</PubDate>
</JournalIssue>
<Title>Journal of the Formosan Medical Association = Taiwan yi zhi</Title>
<ISOAbbreviation>J. Formos. Med. Assoc.</ISOAbbreviation>
</Journal>
<ArticleTitle>Immunohistochemical study of severe acute respiratory syndrome-associated coronavirus in tissue sections of patients.</ArticleTitle>
<Pagination><MedlinePgn>150-6</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="BACKGROUND AND PURPOSE" NlmCategory="OBJECTIVE">Severe acute respiratory syndrome (SARS) is a life-threatening and highly contagious disease caused by the novel SARS coronavirus (SARS-CoV). Immunohistochemical staining for SARS-CoV in the tissue sections of SARS patients is helpful in investigations of the biologic behavior of this virus in human tissue, and to determine the target cells of this virus in different organs.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We studied the pathologic specimens from 6 SARS patients by immunohistochemical staining using a specific antibody against SARS-CoV.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Positive viral staining was only found in the lung tissue taken from the patients who died in the early stage of the disease, usually less than 10 days after symptom onset. No positive staining was found in the lung tissue specimens collected in the mid-to-late stage of the disease. The SARS-CoV-infected cells had a patchy distribution and tended to be present in the periphery of the lung. Immunohistochemically, these viral-infected cells were located mainly along the alveolar space, had a cuboidal appearance, and were reactive to cytokeratin and surfactant protein C. This suggested that type II pneumocytes are the main target cell of SARS-CoV in the lung. Occasional intra-alveolar macrophages were also weakly reactive to SARS-CoV antibody. In addition to the lung, positive viral staining was also found in the mucosal epithelium of the large intestine in another patient who had the clinical symptom of diarrhea. No evidence of viral staining was found in other organs including kidney, liver, lymph node and spleen. The skeletal muscle specimens of 2 patients who had rhabdomyolysis were also negative for SARS-CoV.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">SARS-CoV is mainly present in the cytoplasm of type II pneumocytes and can only be detected in the lung tissue during the early stage of the disease. In the patient who had symptoms of diarrhea, SARS-CoV staining was also identified in the mucosal epithelium of the colon.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hsiao</LastName>
<ForeName>Cheng-Hsiang</ForeName>
<Initials>CH</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chang</LastName>
<ForeName>Ming-Fu</ForeName>
<Initials>MF</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hsueh</LastName>
<ForeName>Po-Ren</ForeName>
<Initials>PR</Initials>
</Author>
<Author ValidYN="Y"><LastName>Su</LastName>
<ForeName>Ih-Jen</ForeName>
<Initials>IJ</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>Singapore</Country>
<MedlineTA>J Formos Med Assoc</MedlineTA>
<NlmUniqueID>9214933</NlmUniqueID>
<ISSNLinking>0929-6646</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017934" MajorTopicYN="N">Coronavirus</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007124" MajorTopicYN="N">Immunoenzyme Techniques</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013194" MajorTopicYN="N">Staining and Labeling</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year>
<Month>4</Month>
<Day>9</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2005</Year>
<Month>6</Month>
<Day>2</Day>
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<PubMedPubDate PubStatus="entrez"><Year>2005</Year>
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</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">15818427</ArticleId>
</ArticleIdList>
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</pubmed>
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Immunohistochemical study of severe acute respiratory syndrome-associated coronavirus in tissue sections of patients.

Immunohistochemical study of severe acute respiratory syndrome-associated coronavirus in tissue sections of patients.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki