SrasV1, PubMed, Curation, bibRecord, 002749

Identification of natural compounds with antiviral activities against SARS-associated coronavirus.

Identifieur interne : 002749 ( PubMed/Curation ); précédent : 002748; suivant : 002750

Identification of natural compounds with antiviral activities against SARS-associated coronavirus.

Auteurs : Shi-You Li [République populaire de Chine] ; Cong Chen ; Hai-Qing Zhang ; Hai-Yan Guo ; Hui Wang ; Lin Wang ; Xiang Zhang ; Shi-Neng Hua ; Jun Yu ; Pei-Gen Xiao ; Rong-Song Li ; Xuehai Tan

Source :

Antiviral research [ 0166-3542 ] ; 2005.

RBID : pubmed:15885816

Descripteurs français

English descriptors

KwdEn :
- Amaryllidaceae Alkaloids (chemistry), Amaryllidaceae Alkaloids (pharmacology), Animals, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Cell Line, Chlorocebus aethiops, Cytopathogenic Effect, Viral, Drug Evaluation, Preclinical, Drugs, Chinese Herbal (chemistry), Drugs, Chinese Herbal (pharmacology), Humans, Liliaceae (chemistry), Microbial Sensitivity Tests, Phenanthridines (chemistry), Phenanthridines (pharmacology), Phytotherapy, SARS Virus (drug effects), Tetrazolium Salts, Vero Cells.
MESH :
- chemical , chemistry : Amaryllidaceae Alkaloids, Antiviral Agents, Drugs, Chinese Herbal, Phenanthridines.
- chemical , pharmacology : Amaryllidaceae Alkaloids, Antiviral Agents, Drugs, Chinese Herbal, Phenanthridines.
- chemistry : Liliaceae.
- drug effects : SARS Virus.
- Animals, Cell Line, Chlorocebus aethiops, Cytopathogenic Effect, Viral, Drug Evaluation, Preclinical, Humans, Microbial Sensitivity Tests, Phytotherapy, Tetrazolium Salts, Vero Cells.

Abstract

More than 200 Chinese medicinal herb extracts were screened for antiviral activities against Severe Acute Respiratory Syndrome-associated coronavirus (SARS-CoV) using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt (MTS) assay for virus-induced cytopathic effect (CPE). Four of these extracts showed moderate to potent antiviral activities against SARS-CoV with 50% effective concentration (EC50) ranging from 2.4 +/- 0.2 to 88.2 +/- 7.7 microg/ml. Out of the four, Lycoris radiata was most potent. To identify the active component, L. radiata extract was subjected to further fractionation, purification, and CPE/MTS assays. This process led to the identification of a single substance lycorine as an anti-SARS-CoV component with an EC50 value of 15.7 +/- 1.2 nM. This compound has a CC50 value of 14980.0 +/- 912.0 nM in cytotoxicity assay and a selective index (SI) greater than 900. The results suggested that four herbal extracts and the compound lycorine are candidates for the development of new anti-SARS-CoV drugs in the treatment of SARS.

DOI: 10.1016/j.antiviral.2005.02.007
PubMed: 15885816

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Le document en format XML

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<front><div type="abstract" xml:lang="en">More than 200 Chinese medicinal herb extracts were screened for antiviral activities against Severe Acute Respiratory Syndrome-associated coronavirus (SARS-CoV) using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt (MTS) assay for virus-induced cytopathic effect (CPE). Four of these extracts showed moderate to potent antiviral activities against SARS-CoV with 50% effective concentration (EC50) ranging from 2.4 +/- 0.2 to 88.2 +/- 7.7 microg/ml. Out of the four, Lycoris radiata was most potent. To identify the active component, L. radiata extract was subjected to further fractionation, purification, and CPE/MTS assays. This process led to the identification of a single substance lycorine as an anti-SARS-CoV component with an EC50 value of 15.7 +/- 1.2 nM. This compound has a CC50 value of 14980.0 +/- 912.0 nM in cytotoxicity assay and a selective index (SI) greater than 900. The results suggested that four herbal extracts and the compound lycorine are candidates for the development of new anti-SARS-CoV drugs in the treatment of SARS.</div>
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Identification of natural compounds with antiviral activities against SARS-associated coronavirus.

Identification of natural compounds with antiviral activities against SARS-associated coronavirus.

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