Amotosalen photochemical inactivation of severe acute respiratory syndrome coronavirus in human platelet concentrates.
Identifieur interne : 002588 ( PubMed/Curation ); précédent : 002587; suivant : 002589Amotosalen photochemical inactivation of severe acute respiratory syndrome coronavirus in human platelet concentrates.
Auteurs : D. Pinna [Italie] ; A. Sampson-Johannes ; M. Clementi ; G. Poli ; S. Rossini ; L. Lin ; E. VicenziSource :
- Transfusion medicine (Oxford, England) [ 0958-7578 ] ; 2005.
Descripteurs français
- KwdFr :
- Conservation de sang (), Furocoumarines (pharmacologie), Humains, Inactivation virale (), Inactivation virale (effets des radiations), Photolyse (), Photosensibilisants (pharmacologie), Plaquettes (virologie), Stérilisation (), Thrombocytaphérèse (), Transfusion de plaquettes (), Virus du SRAS (), Virus du SRAS (effets des radiations).
- MESH :
- effets des radiations : Inactivation virale, Virus du SRAS.
- pharmacologie : Furocoumarines, Photosensibilisants.
- virologie : Plaquettes.
- Conservation de sang, Humains, Inactivation virale, Photolyse, Stérilisation, Thrombocytaphérèse, Transfusion de plaquettes, Virus du SRAS.
English descriptors
- KwdEn :
- Blood Platelets (virology), Blood Preservation (methods), Furocoumarins (pharmacology), Humans, Photolysis (drug effects), Photosensitizing Agents (pharmacology), Platelet Transfusion (methods), Plateletpheresis (methods), SARS Virus (drug effects), SARS Virus (radiation effects), Sterilization (methods), Virus Inactivation (drug effects), Virus Inactivation (radiation effects).
- MESH :
- chemical , pharmacology : Furocoumarins, Photosensitizing Agents.
- drug effects : Photolysis, SARS Virus, Virus Inactivation.
- methods : Blood Preservation, Platelet Transfusion, Plateletpheresis, Sterilization.
- radiation effects : SARS Virus, Virus Inactivation.
- virology : Blood Platelets.
- Humans.
Abstract
A novel human coronavirus causing severe acute respiratory syndrome (SARS) emerged in epidemic form in early 2003 in China and spread worldwide in a few months. Every newly emerging human pathogen is of concern for the safety of the blood supply during and after an epidemic crisis. For this purpose, we have evaluated the inactivation of SARS-coronavirus (CoV) in platelet concentrates using an approved pathogen inactivation device, the INTERCEPT Blood System. Apheresis platelet concentrates (APCs) were inoculated with approximately 10(6) pfu mL(-1) of either Urbani or HSR1 isolates of SARS-CoV. The inoculated units were mixed with 150 microm amotosalen and illuminated with 3 J cm(-2) UV-A light. The viral titres were determined by plaque formation in Vero E6 cells. Mixing SARS-CoV with APC in the absence of any treatment decreased viral infectivity by approximately 0.5-1 log10. Following photochemical treatment, SARS-CoV was consistently inactivated to the limit of detection in seven independent APC units. No infectious virus was detected after treatment when up to one-third of the APC unit was assayed, demonstrating a mean log10-reduction of >6.2. Potent inactivation of SARS-CoV therefore extends the capability of the INTERCEPT Blood System in inactivating a broad spectrum of human pathogens including recently emerging respiratory viruses.
DOI: 10.1111/j.0958-7578.2005.00588.x
PubMed: 16101804
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Poli</name></author><author><name sortKey="Rossini, S" sort="Rossini, S" uniqKey="Rossini S" first="S" last="Rossini">S. Rossini</name></author><author><name sortKey="Lin, L" sort="Lin, L" uniqKey="Lin L" first="L" last="Lin">L. Lin</name></author><author><name sortKey="Vicenzi, E" sort="Vicenzi, E" uniqKey="Vicenzi E" first="E" last="Vicenzi">E. 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Pinna</name><affiliation wicri:level="1"><nlm:affiliation>AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Milano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Milano</wicri:regionArea></affiliation></author><author><name sortKey="Sampson Johannes, A" sort="Sampson Johannes, A" uniqKey="Sampson Johannes A" first="A" last="Sampson-Johannes">A. Sampson-Johannes</name></author><author><name sortKey="Clementi, M" sort="Clementi, M" uniqKey="Clementi M" first="M" last="Clementi">M. Clementi</name></author><author><name sortKey="Poli, G" sort="Poli, G" uniqKey="Poli G" first="G" last="Poli">G. Poli</name></author><author><name sortKey="Rossini, S" sort="Rossini, S" uniqKey="Rossini S" first="S" last="Rossini">S. Rossini</name></author><author><name sortKey="Lin, L" sort="Lin, L" uniqKey="Lin L" first="L" last="Lin">L. Lin</name></author><author><name sortKey="Vicenzi, E" sort="Vicenzi, E" uniqKey="Vicenzi E" first="E" last="Vicenzi">E. Vicenzi</name></author></analytic><series><title level="j">Transfusion medicine (Oxford, England)</title><idno type="ISSN">0958-7578</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blood Platelets (virology)</term><term>Blood Preservation (methods)</term><term>Furocoumarins (pharmacology)</term><term>Humans</term><term>Photolysis (drug effects)</term><term>Photosensitizing Agents (pharmacology)</term><term>Platelet Transfusion (methods)</term><term>Plateletpheresis (methods)</term><term>SARS Virus (drug effects)</term><term>SARS Virus (radiation effects)</term><term>Sterilization (methods)</term><term>Virus Inactivation (drug effects)</term><term>Virus Inactivation (radiation effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Conservation de sang ()</term><term>Furocoumarines (pharmacologie)</term><term>Humains</term><term>Inactivation virale ()</term><term>Inactivation virale (effets des radiations)</term><term>Photolyse ()</term><term>Photosensibilisants (pharmacologie)</term><term>Plaquettes (virologie)</term><term>Stérilisation ()</term><term>Thrombocytaphérèse ()</term><term>Transfusion de plaquettes ()</term><term>Virus du SRAS ()</term><term>Virus du SRAS (effets des radiations)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Furocoumarins</term><term>Photosensitizing Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Photolysis</term><term>SARS Virus</term><term>Virus Inactivation</term></keywords><keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Inactivation virale</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Blood Preservation</term><term>Platelet Transfusion</term><term>Plateletpheresis</term><term>Sterilization</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Furocoumarines</term><term>Photosensibilisants</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>SARS Virus</term><term>Virus Inactivation</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Plaquettes</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Blood Platelets</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Conservation de sang</term><term>Humains</term><term>Inactivation virale</term><term>Photolyse</term><term>Stérilisation</term><term>Thrombocytaphérèse</term><term>Transfusion de plaquettes</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A novel human coronavirus causing severe acute respiratory syndrome (SARS) emerged in epidemic form in early 2003 in China and spread worldwide in a few months. Every newly emerging human pathogen is of concern for the safety of the blood supply during and after an epidemic crisis. For this purpose, we have evaluated the inactivation of SARS-coronavirus (CoV) in platelet concentrates using an approved pathogen inactivation device, the INTERCEPT Blood System. Apheresis platelet concentrates (APCs) were inoculated with approximately 10(6) pfu mL(-1) of either Urbani or HSR1 isolates of SARS-CoV. The inoculated units were mixed with 150 microm amotosalen and illuminated with 3 J cm(-2) UV-A light. The viral titres were determined by plaque formation in Vero E6 cells. Mixing SARS-CoV with APC in the absence of any treatment decreased viral infectivity by approximately 0.5-1 log10. Following photochemical treatment, SARS-CoV was consistently inactivated to the limit of detection in seven independent APC units. No infectious virus was detected after treatment when up to one-third of the APC unit was assayed, demonstrating a mean log10-reduction of >6.2. Potent inactivation of SARS-CoV therefore extends the capability of the INTERCEPT Blood System in inactivating a broad spectrum of human pathogens including recently emerging respiratory viruses.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16101804</PMID><DateCompleted><Year>2005</Year><Month>11</Month><Day>07</Day></DateCompleted><DateRevised><Year>2014</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0958-7578</ISSN><JournalIssue CitedMedium="Print"><Volume>15</Volume><Issue>4</Issue><PubDate><Year>2005</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Transfusion medicine (Oxford, England)</Title><ISOAbbreviation>Transfus Med</ISOAbbreviation></Journal><ArticleTitle>Amotosalen photochemical inactivation of severe acute respiratory syndrome coronavirus in human platelet concentrates.</ArticleTitle><Pagination><MedlinePgn>269-76</MedlinePgn></Pagination><Abstract><AbstractText>A novel human coronavirus causing severe acute respiratory syndrome (SARS) emerged in epidemic form in early 2003 in China and spread worldwide in a few months. Every newly emerging human pathogen is of concern for the safety of the blood supply during and after an epidemic crisis. For this purpose, we have evaluated the inactivation of SARS-coronavirus (CoV) in platelet concentrates using an approved pathogen inactivation device, the INTERCEPT Blood System. Apheresis platelet concentrates (APCs) were inoculated with approximately 10(6) pfu mL(-1) of either Urbani or HSR1 isolates of SARS-CoV. The inoculated units were mixed with 150 microm amotosalen and illuminated with 3 J cm(-2) UV-A light. The viral titres were determined by plaque formation in Vero E6 cells. Mixing SARS-CoV with APC in the absence of any treatment decreased viral infectivity by approximately 0.5-1 log10. Following photochemical treatment, SARS-CoV was consistently inactivated to the limit of detection in seven independent APC units. No infectious virus was detected after treatment when up to one-third of the APC unit was assayed, demonstrating a mean log10-reduction of >6.2. Potent inactivation of SARS-CoV therefore extends the capability of the INTERCEPT Blood System in inactivating a broad spectrum of human pathogens including recently emerging respiratory viruses.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pinna</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Milano, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sampson-Johannes</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Clementi</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Poli</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Rossini</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Vicenzi</LastName><ForeName>E</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Transfus Med</MedlineTA><NlmUniqueID>9301182</NlmUniqueID><ISSNLinking>0958-7578</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011564">Furocoumarins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017319">Photosensitizing Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>K1LDZ0VBC0</RegistryNumber><NameOfSubstance UI="C118577">amotosalen</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001792" MajorTopicYN="N">Blood Platelets</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001793" MajorTopicYN="N">Blood Preservation</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011564" MajorTopicYN="N">Furocoumarins</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010782" MajorTopicYN="N">Photolysis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017319" MajorTopicYN="N">Photosensitizing Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017713" MajorTopicYN="N">Platelet Transfusion</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010983" MajorTopicYN="N">Plateletpheresis</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000528" MajorTopicYN="Y">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013242" MajorTopicYN="N">Sterilization</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D038301" MajorTopicYN="N">Virus Inactivation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>8</Month><Day>17</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>11</Month><Day>8</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>8</Month><Day>17</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16101804</ArticleId><ArticleId IdType="pii">TME588</ArticleId><ArticleId IdType="doi">10.1111/j.0958-7578.2005.00588.x</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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