Immunogenicity and protective efficacy in monkeys of purified inactivated Vero-cell SARS vaccine.
Identifieur interne : 002388 ( PubMed/Curation ); précédent : 002387; suivant : 002389Immunogenicity and protective efficacy in monkeys of purified inactivated Vero-cell SARS vaccine.
Auteurs : Ede Qin [République populaire de Chine] ; Huiying Shi ; Lin Tang ; Cuie Wang ; Guohui Chang ; Zhifen Ding ; Kai Zhao ; Jian Wang ; Ze Chen ; Man Yu ; Bingyin Si ; Jianyuan Liu ; Donglai Wu ; Xiaojie Cheng ; Baoan Yang ; Wenming Peng ; Qingwen Meng ; Bohua Liu ; Weiguo Han ; Xunnan Yin ; Hongyuan Duan ; Dawei Zhan ; Long Tian ; Shuangli Li ; Jinsong Wu ; Gang Tan ; Yi Li ; Yuchuan Li ; Yonggang Liu ; Hong Liu ; Fushuang Lv ; Yu Zhang ; Xiangang Kong ; Baochang Fan ; Tao Jiang ; Shuli Xu ; Xiaomei Wang ; Changwen Li ; Xiaohong Wu ; Yongqiang Deng ; Min Zhao ; Qingyu ZhuSource :
- Vaccine [ 0264-410X ] ; 2006.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (sang), Cellules Vero, Immunisation, Macaca fascicularis, Mâle, Relation dose-réponse (immunologie), Syndrome respiratoire aigu sévère (), Vaccins antiviraux (effets indésirables), Vaccins antiviraux (immunologie), Vaccins inactivés (immunologie), Virus du SRAS (immunologie).
- MESH :
- effets indésirables : Vaccins antiviraux.
- immunologie : Vaccins antiviraux, Vaccins inactivés, Virus du SRAS.
- sang : Anticorps antiviraux.
- Animaux, Cellules Vero, Immunisation, Macaca fascicularis, Mâle, Relation dose-réponse (immunologie), Syndrome respiratoire aigu sévère.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (blood), Chlorocebus aethiops, Dose-Response Relationship, Immunologic, Immunization, Macaca fascicularis, Male, SARS Virus (immunology), Severe Acute Respiratory Syndrome (prevention & control), Vaccines, Inactivated (immunology), Vero Cells, Viral Vaccines (adverse effects), Viral Vaccines (immunology).
- MESH :
- chemical , adverse effects : Viral Vaccines.
- chemical , blood : Antibodies, Viral.
- immunology : SARS Virus, Vaccines, Inactivated, Viral Vaccines.
- prevention & control : Severe Acute Respiratory Syndrome.
- Animals, Chlorocebus aethiops, Dose-Response Relationship, Immunologic, Immunization, Macaca fascicularis, Male, Vero Cells.
Abstract
In 2003, severe acute respiratory syndrome (SARS) resulted in hundreds of infections and deaths globally. We aim to assess immunogenicity and protective efficacy of purified inactivated Vero-cell SARS vaccine in monkeys.
DOI: 10.1016/j.vaccine.2005.06.038
PubMed: 16388880
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uniqKey="Wang C" first="Cuie" last="Wang">Cuie Wang</name></author><author><name sortKey="Chang, Guohui" sort="Chang, Guohui" uniqKey="Chang G" first="Guohui" last="Chang">Guohui Chang</name></author><author><name sortKey="Ding, Zhifen" sort="Ding, Zhifen" uniqKey="Ding Z" first="Zhifen" last="Ding">Zhifen Ding</name></author><author><name sortKey="Zhao, Kai" sort="Zhao, Kai" uniqKey="Zhao K" first="Kai" last="Zhao">Kai Zhao</name></author><author><name sortKey="Wang, Jian" sort="Wang, Jian" uniqKey="Wang J" first="Jian" last="Wang">Jian Wang</name></author><author><name sortKey="Chen, Ze" sort="Chen, Ze" uniqKey="Chen Z" first="Ze" last="Chen">Ze Chen</name></author><author><name sortKey="Yu, Man" sort="Yu, Man" uniqKey="Yu M" first="Man" last="Yu">Man Yu</name></author><author><name sortKey="Si, Bingyin" sort="Si, Bingyin" uniqKey="Si B" first="Bingyin" last="Si">Bingyin Si</name></author><author><name sortKey="Liu, Jianyuan" sort="Liu, Jianyuan" uniqKey="Liu J" first="Jianyuan" 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first="Xunnan" last="Yin">Xunnan Yin</name></author><author><name sortKey="Duan, Hongyuan" sort="Duan, Hongyuan" uniqKey="Duan H" first="Hongyuan" last="Duan">Hongyuan Duan</name></author><author><name sortKey="Zhan, Dawei" sort="Zhan, Dawei" uniqKey="Zhan D" first="Dawei" last="Zhan">Dawei Zhan</name></author><author><name sortKey="Tian, Long" sort="Tian, Long" uniqKey="Tian L" first="Long" last="Tian">Long Tian</name></author><author><name sortKey="Li, Shuangli" sort="Li, Shuangli" uniqKey="Li S" first="Shuangli" last="Li">Shuangli Li</name></author><author><name sortKey="Wu, Jinsong" sort="Wu, Jinsong" uniqKey="Wu J" first="Jinsong" last="Wu">Jinsong Wu</name></author><author><name sortKey="Tan, Gang" sort="Tan, Gang" uniqKey="Tan G" first="Gang" last="Tan">Gang Tan</name></author><author><name sortKey="Li, Yi" sort="Li, Yi" uniqKey="Li Y" first="Yi" last="Li">Yi Li</name></author><author><name sortKey="Li, Yuchuan" sort="Li, Yuchuan" uniqKey="Li Y" first="Yuchuan" last="Li">Yuchuan Li</name></author><author><name sortKey="Liu, Yonggang" sort="Liu, Yonggang" uniqKey="Liu Y" first="Yonggang" last="Liu">Yonggang Liu</name></author><author><name sortKey="Liu, Hong" sort="Liu, Hong" uniqKey="Liu H" first="Hong" last="Liu">Hong Liu</name></author><author><name sortKey="Lv, Fushuang" sort="Lv, Fushuang" uniqKey="Lv F" first="Fushuang" last="Lv">Fushuang Lv</name></author><author><name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name></author><author><name sortKey="Kong, Xiangang" sort="Kong, Xiangang" uniqKey="Kong X" first="Xiangang" last="Kong">Xiangang Kong</name></author><author><name sortKey="Fan, Baochang" sort="Fan, Baochang" uniqKey="Fan B" first="Baochang" last="Fan">Baochang Fan</name></author><author><name sortKey="Jiang, Tao" sort="Jiang, Tao" uniqKey="Jiang T" first="Tao" last="Jiang">Tao Jiang</name></author><author><name sortKey="Xu, Shuli" sort="Xu, Shuli" uniqKey="Xu S" first="Shuli" last="Xu">Shuli Xu</name></author><author><name sortKey="Wang, Xiaomei" sort="Wang, Xiaomei" uniqKey="Wang X" first="Xiaomei" last="Wang">Xiaomei Wang</name></author><author><name sortKey="Li, Changwen" sort="Li, Changwen" uniqKey="Li C" first="Changwen" last="Li">Changwen Li</name></author><author><name sortKey="Wu, Xiaohong" sort="Wu, Xiaohong" uniqKey="Wu X" first="Xiaohong" last="Wu">Xiaohong Wu</name></author><author><name sortKey="Deng, Yongqiang" sort="Deng, Yongqiang" uniqKey="Deng Y" first="Yongqiang" last="Deng">Yongqiang Deng</name></author><author><name sortKey="Zhao, Min" sort="Zhao, Min" uniqKey="Zhao M" first="Min" last="Zhao">Min Zhao</name></author><author><name sortKey="Zhu, Qingyu" sort="Zhu, Qingyu" uniqKey="Zhu Q" first="Qingyu" last="Zhu">Qingyu Zhu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:16388880</idno><idno type="pmid">16388880</idno><idno type="doi">10.1016/j.vaccine.2005.06.038</idno><idno type="wicri:Area/PubMed/Corpus">002388</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002388</idno><idno type="wicri:Area/PubMed/Curation">002388</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002388</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Immunogenicity and protective efficacy in monkeys of purified inactivated Vero-cell SARS vaccine.</title><author><name sortKey="Qin, Ede" sort="Qin, Ede" uniqKey="Qin E" first="Ede" last="Qin">Ede Qin</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Fengtai District, Beijing, PR China. qinede@sohu.com</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Fengtai District, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Shi, Huiying" sort="Shi, Huiying" uniqKey="Shi H" first="Huiying" last="Shi">Huiying Shi</name></author><author><name sortKey="Tang, Lin" sort="Tang, Lin" uniqKey="Tang L" first="Lin" last="Tang">Lin Tang</name></author><author><name sortKey="Wang, Cuie" sort="Wang, Cuie" uniqKey="Wang C" first="Cuie" last="Wang">Cuie Wang</name></author><author><name sortKey="Chang, Guohui" sort="Chang, Guohui" uniqKey="Chang G" first="Guohui" last="Chang">Guohui Chang</name></author><author><name sortKey="Ding, Zhifen" sort="Ding, Zhifen" uniqKey="Ding Z" first="Zhifen" last="Ding">Zhifen Ding</name></author><author><name sortKey="Zhao, Kai" sort="Zhao, Kai" uniqKey="Zhao K" first="Kai" last="Zhao">Kai Zhao</name></author><author><name sortKey="Wang, Jian" sort="Wang, Jian" uniqKey="Wang J" first="Jian" last="Wang">Jian Wang</name></author><author><name sortKey="Chen, Ze" sort="Chen, Ze" uniqKey="Chen Z" first="Ze" last="Chen">Ze Chen</name></author><author><name sortKey="Yu, Man" sort="Yu, Man" uniqKey="Yu M" first="Man" last="Yu">Man Yu</name></author><author><name sortKey="Si, Bingyin" sort="Si, Bingyin" uniqKey="Si B" first="Bingyin" last="Si">Bingyin Si</name></author><author><name sortKey="Liu, Jianyuan" sort="Liu, Jianyuan" uniqKey="Liu J" first="Jianyuan" last="Liu">Jianyuan Liu</name></author><author><name sortKey="Wu, Donglai" sort="Wu, Donglai" uniqKey="Wu D" first="Donglai" last="Wu">Donglai Wu</name></author><author><name sortKey="Cheng, Xiaojie" sort="Cheng, Xiaojie" uniqKey="Cheng X" first="Xiaojie" last="Cheng">Xiaojie Cheng</name></author><author><name sortKey="Yang, Baoan" sort="Yang, Baoan" uniqKey="Yang B" first="Baoan" last="Yang">Baoan Yang</name></author><author><name sortKey="Peng, Wenming" sort="Peng, Wenming" uniqKey="Peng W" first="Wenming" last="Peng">Wenming Peng</name></author><author><name sortKey="Meng, Qingwen" sort="Meng, Qingwen" uniqKey="Meng Q" first="Qingwen" last="Meng">Qingwen Meng</name></author><author><name sortKey="Liu, Bohua" sort="Liu, Bohua" uniqKey="Liu B" first="Bohua" last="Liu">Bohua Liu</name></author><author><name sortKey="Han, Weiguo" sort="Han, Weiguo" uniqKey="Han W" first="Weiguo" last="Han">Weiguo Han</name></author><author><name sortKey="Yin, Xunnan" sort="Yin, Xunnan" uniqKey="Yin X" first="Xunnan" last="Yin">Xunnan Yin</name></author><author><name sortKey="Duan, Hongyuan" sort="Duan, Hongyuan" uniqKey="Duan H" first="Hongyuan" last="Duan">Hongyuan Duan</name></author><author><name sortKey="Zhan, Dawei" sort="Zhan, Dawei" uniqKey="Zhan D" first="Dawei" last="Zhan">Dawei Zhan</name></author><author><name sortKey="Tian, Long" sort="Tian, Long" uniqKey="Tian L" first="Long" last="Tian">Long Tian</name></author><author><name sortKey="Li, Shuangli" sort="Li, Shuangli" uniqKey="Li S" first="Shuangli" last="Li">Shuangli Li</name></author><author><name sortKey="Wu, Jinsong" sort="Wu, Jinsong" uniqKey="Wu J" first="Jinsong" last="Wu">Jinsong Wu</name></author><author><name sortKey="Tan, Gang" sort="Tan, Gang" uniqKey="Tan G" first="Gang" last="Tan">Gang Tan</name></author><author><name sortKey="Li, Yi" sort="Li, Yi" uniqKey="Li Y" first="Yi" last="Li">Yi Li</name></author><author><name sortKey="Li, Yuchuan" sort="Li, Yuchuan" uniqKey="Li Y" first="Yuchuan" last="Li">Yuchuan Li</name></author><author><name sortKey="Liu, Yonggang" sort="Liu, Yonggang" uniqKey="Liu Y" first="Yonggang" last="Liu">Yonggang Liu</name></author><author><name sortKey="Liu, Hong" sort="Liu, Hong" uniqKey="Liu H" first="Hong" last="Liu">Hong Liu</name></author><author><name sortKey="Lv, Fushuang" sort="Lv, Fushuang" uniqKey="Lv F" first="Fushuang" last="Lv">Fushuang Lv</name></author><author><name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name></author><author><name sortKey="Kong, Xiangang" sort="Kong, Xiangang" uniqKey="Kong X" first="Xiangang" last="Kong">Xiangang Kong</name></author><author><name sortKey="Fan, Baochang" sort="Fan, Baochang" uniqKey="Fan B" first="Baochang" last="Fan">Baochang Fan</name></author><author><name sortKey="Jiang, Tao" sort="Jiang, Tao" uniqKey="Jiang T" first="Tao" last="Jiang">Tao Jiang</name></author><author><name sortKey="Xu, Shuli" sort="Xu, Shuli" uniqKey="Xu S" first="Shuli" last="Xu">Shuli Xu</name></author><author><name sortKey="Wang, Xiaomei" sort="Wang, Xiaomei" uniqKey="Wang X" first="Xiaomei" last="Wang">Xiaomei Wang</name></author><author><name sortKey="Li, Changwen" sort="Li, Changwen" uniqKey="Li C" first="Changwen" last="Li">Changwen Li</name></author><author><name sortKey="Wu, Xiaohong" sort="Wu, Xiaohong" uniqKey="Wu X" first="Xiaohong" last="Wu">Xiaohong Wu</name></author><author><name sortKey="Deng, Yongqiang" sort="Deng, Yongqiang" uniqKey="Deng Y" first="Yongqiang" last="Deng">Yongqiang Deng</name></author><author><name sortKey="Zhao, Min" sort="Zhao, Min" uniqKey="Zhao M" first="Min" last="Zhao">Min Zhao</name></author><author><name sortKey="Zhu, Qingyu" sort="Zhu, Qingyu" uniqKey="Zhu Q" first="Qingyu" last="Zhu">Qingyu Zhu</name></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (blood)</term><term>Chlorocebus aethiops</term><term>Dose-Response Relationship, Immunologic</term><term>Immunization</term><term>Macaca fascicularis</term><term>Male</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (prevention & control)</term><term>Vaccines, Inactivated (immunology)</term><term>Vero Cells</term><term>Viral Vaccines (adverse effects)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Cellules Vero</term><term>Immunisation</term><term>Macaca fascicularis</term><term>Mâle</term><term>Relation dose-réponse (immunologie)</term><term>Syndrome respiratoire aigu sévère ()</term><term>Vaccins antiviraux (effets indésirables)</term><term>Vaccins antiviraux (immunologie)</term><term>Vaccins inactivés (immunologie)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Vaccins antiviraux</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antiviraux</term><term>Vaccins inactivés</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>Vaccines, Inactivated</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Dose-Response Relationship, Immunologic</term><term>Immunization</term><term>Macaca fascicularis</term><term>Male</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules Vero</term><term>Immunisation</term><term>Macaca fascicularis</term><term>Mâle</term><term>Relation dose-réponse (immunologie)</term><term>Syndrome respiratoire aigu sévère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In 2003, severe acute respiratory syndrome (SARS) resulted in hundreds of infections and deaths globally. We aim to assess immunogenicity and protective efficacy of purified inactivated Vero-cell SARS vaccine in monkeys.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16388880</PMID><DateCompleted><Year>2006</Year><Month>03</Month><Day>30</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0264-410X</ISSN><JournalIssue CitedMedium="Print"><Volume>24</Volume><Issue>7</Issue><PubDate><Year>2006</Year><Month>Feb</Month><Day>13</Day></PubDate></JournalIssue><Title>Vaccine</Title><ISOAbbreviation>Vaccine</ISOAbbreviation></Journal><ArticleTitle>Immunogenicity and protective efficacy in monkeys of purified inactivated Vero-cell SARS vaccine.</ArticleTitle><Pagination><MedlinePgn>1028-34</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">In 2003, severe acute respiratory syndrome (SARS) resulted in hundreds of infections and deaths globally. We aim to assess immunogenicity and protective efficacy of purified inactivated Vero-cell SARS vaccine in monkeys.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The cultures of SARS coronavirus (SARS-CoV) BJ-01 strain infected Vero cells were inactivated with beta-propiolactone. Sequential procedures, including ultrafiltration, gel filtration and ion exchange chromatography, were performed to obtain purified inactivated SARS vaccine. The purified SARS vaccine was analyzed with electron microscope, HPLC and Western blotting. We immunized three groups of cynomolgus macaques fascicularis with adjuvant-containing purified vaccine, purified vaccine and unpurified vaccine, respectively, and a fourth group served as a control. Antibody titers were measured by plaque reduction neutralization test. The vaccinated monkeys were challenged with SARS-CoV BJ-01 strain to observe protective efficacy. Additionally, three groups of rhesus monkeys were immunized with different doses of the purified inactivated SARS vaccine (0.5, 1 and 2mug/time/monkey) on days 0 and 7, and the monkeys were challenged with SARS-CoV GZ-01 strain. We assessed the safety of the SARS vaccine and observed whether the antibody dependent enhancement (ADE) occurred under low levels of neutralizing antibody in rhesus.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">The purity of SARS vaccine was 97.6% by HPLC identification and reacted with convalescent sera of SARS patients. The purified SARS vaccine induced high levels of neutralizing antibodies and prevented the replication of SARS-CoV in monkeys. Under low levels of neutralizing antibody, no exacerbation of clinical symptoms was observed when the immunized monkeys were challenged with SARS-CoV. In this preliminary animal trial, no side effects were detected when monkeys were immunized with purified SARS vaccine either at normal or large doses.</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">The purified inactivated SARS vaccine could induce high levels of neutralizing antibody, and protect the monkeys from the challenge of SARS-CoV. The SARS vaccine prepared in the study appeared to be safe in monkeys.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Qin</LastName><ForeName>Ede</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Fengtai District, Beijing, PR China. qinede@sohu.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Huiying</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Lin</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Cuie</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Guohui</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Ding</LastName><ForeName>Zhifen</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Kai</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jian</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Ze</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Man</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Si</LastName><ForeName>Bingyin</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Jianyuan</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Donglai</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Xiaojie</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Baoan</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Peng</LastName><ForeName>Wenming</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Meng</LastName><ForeName>Qingwen</ForeName><Initials>Q</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Bohua</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Han</LastName><ForeName>Weiguo</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Yin</LastName><ForeName>Xunnan</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Duan</LastName><ForeName>Hongyuan</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Zhan</LastName><ForeName>Dawei</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Tian</LastName><ForeName>Long</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Shuangli</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Jinsong</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Gang</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yi</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yuchuan</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yonggang</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Hong</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Lv</LastName><ForeName>Fushuang</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yu</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Kong</LastName><ForeName>Xiangang</ForeName><Initials>X</Initials></Author><Author 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