The large 386-nt deletion in SARS-associated coronavirus: evidence for quasispecies?
Identifieur interne : 002109 ( PubMed/Curation ); précédent : 002108; suivant : 002110The large 386-nt deletion in SARS-associated coronavirus: evidence for quasispecies?
Auteurs : Julian W. Tang [République populaire de Chine] ; Jo L K. Cheung ; Ida M T. Chu ; Joseph J Y. Sung ; Malik Peiris ; Paul K S. ChanSource :
- The Journal of infectious diseases [ 0022-1899 ] ; 2006.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Cadres ouverts de lecture (génétique), Données de séquences moléculaires, Délétion de séquence (génétique), Facteurs temps, Femelle, Flambées de maladies, Hong Kong (épidémiologie), Humains, Mâle, Ordre des gènes, Réaction de polymérisation en chaîne, Sujet âgé, Sujet âgé de 80 ans ou plus, Syndrome respiratoire aigu sévère (physiopathologie), Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Séquence nucléotidique, Virus du SRAS (), Virus du SRAS (génétique), Virus du SRAS (isolement et purification), Virus du SRAS (pathogénicité).
- MESH :
- génétique : Cadres ouverts de lecture, Délétion de séquence, Virus du SRAS.
- isolement et purification : Virus du SRAS.
- pathogénicité : Virus du SRAS.
- physiopathologie : Syndrome respiratoire aigu sévère.
- virologie : Syndrome respiratoire aigu sévère.
- épidémiologie : Hong Kong, Syndrome respiratoire aigu sévère.
- Adolescent, Adulte, Adulte d'âge moyen, Données de séquences moléculaires, Facteurs temps, Femelle, Flambées de maladies, Humains, Mâle, Ordre des gènes, Réaction de polymérisation en chaîne, Sujet âgé, Sujet âgé de 80 ans ou plus, Séquence nucléotidique, Virus du SRAS.
- Wicri :
- geographic : Hong Kong.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Base Sequence, Disease Outbreaks, Female, Gene Order, Hong Kong (epidemiology), Humans, Male, Middle Aged, Molecular Sequence Data, Open Reading Frames (genetics), Polymerase Chain Reaction, SARS Virus (classification), SARS Virus (genetics), SARS Virus (isolation & purification), SARS Virus (pathogenicity), Sequence Deletion (genetics), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (physiopathology), Severe Acute Respiratory Syndrome (virology), Time Factors.
- MESH :
- geographic , epidemiology : Hong Kong.
- classification : SARS Virus.
- epidemiology : Severe Acute Respiratory Syndrome.
- genetics : Open Reading Frames, SARS Virus, Sequence Deletion.
- isolation & purification : SARS Virus.
- pathogenicity : SARS Virus.
- physiopathology : Severe Acute Respiratory Syndrome.
- virology : Severe Acute Respiratory Syndrome.
- Adolescent, Adult, Aged, Aged, 80 and over, Base Sequence, Disease Outbreaks, Female, Gene Order, Humans, Male, Middle Aged, Molecular Sequence Data, Polymerase Chain Reaction, Time Factors.
Abstract
The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is reported to have deletions of various sizes. Recently, the large 386-nucleotide deletion (L386del) comprising nucleotide positions 27719-28104 and spanning open reading frames 9-11 has been reported in the genomes of some human isolates from Hong Kong. In this study, archived specimens from 71 patients with SARS who were admitted to the New Territory East Cluster Hospitals in Hong Kong were analyzed to determine whether the L386del variant of SARS-CoV was present. There was no clear relationship between the presence of the L386del variant and SARS clinical severity as defined either by the need for intensive-care therapy and/or ventilation or by death. One patient had evidence of both the L386del variant and the wild-type variant in the same clinical specimen, supporting the idea that SARS-CoV exists as a quasispecies in some patients, although the clinical significance of these quasispecies remains unclear.
DOI: 10.1086/507044
PubMed: 16941348
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Recently, the large 386-nucleotide deletion (L386del) comprising nucleotide positions 27719-28104 and spanning open reading frames 9-11 has been reported in the genomes of some human isolates from Hong Kong. In this study, archived specimens from 71 patients with SARS who were admitted to the New Territory East Cluster Hospitals in Hong Kong were analyzed to determine whether the L386del variant of SARS-CoV was present. There was no clear relationship between the presence of the L386del variant and SARS clinical severity as defined either by the need for intensive-care therapy and/or ventilation or by death. One patient had evidence of both the L386del variant and the wild-type variant in the same clinical specimen, supporting the idea that SARS-CoV exists as a quasispecies in some patients, although the clinical significance of these quasispecies remains unclear.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16941348</PMID><DateCompleted><Year>2006</Year><Month>10</Month><Day>19</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0022-1899</ISSN><JournalIssue CitedMedium="Print"><Volume>194</Volume><Issue>6</Issue><PubDate><Year>2006</Year><Month>Sep</Month><Day>15</Day></PubDate></JournalIssue><Title>The Journal of infectious diseases</Title><ISOAbbreviation>J. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>The large 386-nt deletion in SARS-associated coronavirus: evidence for quasispecies?</ArticleTitle><Pagination><MedlinePgn>808-13</MedlinePgn></Pagination><Abstract><AbstractText>The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is reported to have deletions of various sizes. Recently, the large 386-nucleotide deletion (L386del) comprising nucleotide positions 27719-28104 and spanning open reading frames 9-11 has been reported in the genomes of some human isolates from Hong Kong. In this study, archived specimens from 71 patients with SARS who were admitted to the New Territory East Cluster Hospitals in Hong Kong were analyzed to determine whether the L386del variant of SARS-CoV was present. There was no clear relationship between the presence of the L386del variant and SARS clinical severity as defined either by the need for intensive-care therapy and/or ventilation or by death. One patient had evidence of both the L386del variant and the wild-type variant in the same clinical specimen, supporting the idea that SARS-CoV exists as a quasispecies in some patients, although the clinical significance of these quasispecies remains unclear.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Julian W</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cheung</LastName><ForeName>Jo L K</ForeName><Initials>JL</Initials></Author><Author ValidYN="Y"><LastName>Chu</LastName><ForeName>Ida M T</ForeName><Initials>IM</Initials></Author><Author ValidYN="Y"><LastName>Sung</LastName><ForeName>Joseph J Y</ForeName><Initials>JJ</Initials></Author><Author 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