SrasV1, PubMed, Curation, bibRecord, 001F65

Anti-SARS-CoV activity of nucleoside analogs having 6-chloropurine as a nucleobase.

Identifieur interne : 001F65 ( PubMed/Curation ); précédent : 001F64; suivant : 001F66

Anti-SARS-CoV activity of nucleoside analogs having 6-chloropurine as a nucleobase.

Auteurs : Masahiro Ikejiri [Japon] ; Masayuki Saijo ; Shigeru Morikawa ; Shuetsu Fukushi ; Tetsuya Mizutani ; Ichiro Kurane ; Tokumi Maruyama

Source :

Nucleic acids symposium series (2004) [ 1746-8272 ] ; 2006.

RBID : pubmed:17150843

Descripteurs français

KwdFr :
- Antiviraux (), Antiviraux (pharmacologie), Antiviraux (synthèse chimique), Méthode des plages virales, Nucléoside purique (), Nucléoside purique (pharmacologie), Nucléoside purique (synthèse chimique), Purines (), Virus du SRAS (), Virus du SRAS (croissance et développement).
MESH :
- croissance et développement : Virus du SRAS.
- pharmacologie : Antiviraux, Nucléoside purique.
- synthèse chimique : Antiviraux, Nucléoside purique.
- Antiviraux, Méthode des plages virales, Nucléoside purique, Purines, Virus du SRAS.

English descriptors

KwdEn :
- Antiviral Agents (chemical synthesis), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Purine Nucleosides (chemical synthesis), Purine Nucleosides (chemistry), Purine Nucleosides (pharmacology), Purines (chemistry), SARS Virus (drug effects), SARS Virus (growth & development), Viral Plaque Assay.
MESH :
- chemical , chemical synthesis : Antiviral Agents, Purine Nucleosides.
- chemical , chemistry : Antiviral Agents, Purine Nucleosides, Purines.
- chemical , pharmacology : Antiviral Agents, Purine Nucleosides.
- drug effects : SARS Virus.
- growth & development : SARS Virus.
- Viral Plaque Assay.

Abstract

Nucleoside analogs that have 6-chloropurine as a nucleobase were synthesized and evaluated to develop novel anti-SARS-CoV agents. Two compounds among them showed promising activity that was comparable to mizoribine and ribavirin. Moreover, one of the compounds showed a structurally unique property.

DOI: 10.1093/nass/nrl056
PubMed: 17150843

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Le document en format XML

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<affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa 769-2193, Japan.</nlm:affiliation>
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<front><div type="abstract" xml:lang="en">Nucleoside analogs that have 6-chloropurine as a nucleobase were synthesized and evaluated to develop novel anti-SARS-CoV agents. Two compounds among them showed promising activity that was comparable to mizoribine and ribavirin. Moreover, one of the compounds showed a structurally unique property.</div>
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Anti-SARS-CoV activity of nucleoside analogs having 6-chloropurine as a nucleobase.

Anti-SARS-CoV activity of nucleoside analogs having 6-chloropurine as a nucleobase.

Source :

Descripteurs français

English descriptors

Abstract

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Links to Exploration step

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