Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition.
Identifieur interne : 001E91 ( PubMed/Curation ); précédent : 001E90; suivant : 001E92Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition.
Auteurs : Gijs A. Versteeg [Pays-Bas] ; Peter J. Bredenbeek ; Sjoerd H E. Van Den Worm ; Willy J M. SpaanSource :
- Virology [ 0042-6822 ] ; 2007.
Descripteurs français
- KwdFr :
- ARN viral (physiologie), Animaux, Cellules Vero, Facteur-3 de régulation d'interféron (métabolisme), Interféron alpha (métabolisme), Souris, Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Transport biologique, Virus Sendai (immunologie), Virus de l'hépatite murine (immunologie), Virus du SRAS (génétique), Virus du SRAS (immunologie).
- MESH :
- génétique : Virus du SRAS.
- immunologie : Syndrome respiratoire aigu sévère, Virus Sendai, Virus de l'hépatite murine, Virus du SRAS.
- métabolisme : Facteur-3 de régulation d'interféron, Interféron alpha.
- physiologie : ARN viral.
- virologie : Syndrome respiratoire aigu sévère.
- Animaux, Cellules Vero, Souris, Transport biologique.
English descriptors
- KwdEn :
- Animals, Biological Transport, Chlorocebus aethiops, Interferon Regulatory Factor-3 (metabolism), Interferon-alpha (metabolism), L Cells, Mice, Murine hepatitis virus (immunology), RNA, Viral (physiology), SARS Virus (genetics), SARS Virus (immunology), Sendai virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology), Vero Cells.
- MESH :
- chemical , metabolism : Interferon Regulatory Factor-3, Interferon-alpha.
- genetics : SARS Virus.
- immunology : Murine hepatitis virus, SARS Virus, Sendai virus, Severe Acute Respiratory Syndrome.
- chemical , physiology : RNA, Viral.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Biological Transport, Chlorocebus aethiops, L Cells, Mice, Vero Cells.
Abstract
Many viruses encode antagonists to prevent interferon (IFN) induction. Infection of fibroblasts with the murine hepatitis coronavirus (MHV) and SARS-coronavirus (SARS-CoV) did not result in nuclear translocation of interferon-regulatory factor 3 (IRF3), a key transcription factor involved in IFN induction, and induction of IFN mRNA transcription. Furthermore, MHV and SARS-CoV infection could not prevent IFN induction by poly (I:C) or Sendai virus, suggesting that these CoVs do not inactivate IRF3-mediated transcription regulation, but apparently prevent detection of replicative RNA by cellular sensory molecules. Our data indicate that shielding of viral RNA to host cell sensors might be the main general mechanism for coronaviruses to prevent IFN induction.
DOI: 10.1016/j.virol.2007.01.020
PubMed: 17316733
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Bredenbeek</name></author><author><name sortKey="Van Den Worm, Sjoerd H E" sort="Van Den Worm, Sjoerd H E" uniqKey="Van Den Worm S" first="Sjoerd H E" last="Van Den Worm">Sjoerd H E. Van Den Worm</name></author><author><name sortKey="Spaan, Willy J M" sort="Spaan, Willy J M" uniqKey="Spaan W" first="Willy J M" last="Spaan">Willy J M. 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Versteeg</name><affiliation wicri:level="1"><nlm:affiliation>Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, LUMC E4-P, P.O. Box 9600, 2300 RC Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, LUMC E4-P, P.O. Box 9600, 2300 RC Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Bredenbeek, Peter J" sort="Bredenbeek, Peter J" uniqKey="Bredenbeek P" first="Peter J" last="Bredenbeek">Peter J. Bredenbeek</name></author><author><name sortKey="Van Den Worm, Sjoerd H E" sort="Van Den Worm, Sjoerd H E" uniqKey="Van Den Worm S" first="Sjoerd H E" last="Van Den Worm">Sjoerd H E. Van Den Worm</name></author><author><name sortKey="Spaan, Willy J M" sort="Spaan, Willy J M" uniqKey="Spaan W" first="Willy J M" last="Spaan">Willy J M. 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Infection of fibroblasts with the murine hepatitis coronavirus (MHV) and SARS-coronavirus (SARS-CoV) did not result in nuclear translocation of interferon-regulatory factor 3 (IRF3), a key transcription factor involved in IFN induction, and induction of IFN mRNA transcription. Furthermore, MHV and SARS-CoV infection could not prevent IFN induction by poly (I:C) or Sendai virus, suggesting that these CoVs do not inactivate IRF3-mediated transcription regulation, but apparently prevent detection of replicative RNA by cellular sensory molecules. Our data indicate that shielding of viral RNA to host cell sensors might be the main general mechanism for coronaviruses to prevent IFN induction.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17316733</PMID><DateCompleted><Year>2007</Year><Month>06</Month><Day>22</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0042-6822</ISSN><JournalIssue CitedMedium="Print"><Volume>361</Volume><Issue>1</Issue><PubDate><Year>2007</Year><Month>Apr</Month><Day>25</Day></PubDate></JournalIssue><Title>Virology</Title><ISOAbbreviation>Virology</ISOAbbreviation></Journal><ArticleTitle>Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition.</ArticleTitle><Pagination><MedlinePgn>18-26</MedlinePgn></Pagination><Abstract><AbstractText>Many viruses encode antagonists to prevent interferon (IFN) induction. Infection of fibroblasts with the murine hepatitis coronavirus (MHV) and SARS-coronavirus (SARS-CoV) did not result in nuclear translocation of interferon-regulatory factor 3 (IRF3), a key transcription factor involved in IFN induction, and induction of IFN mRNA transcription. Furthermore, MHV and SARS-CoV infection could not prevent IFN induction by poly (I:C) or Sendai virus, suggesting that these CoVs do not inactivate IRF3-mediated transcription regulation, but apparently prevent detection of replicative RNA by cellular sensory molecules. Our data indicate that shielding of viral RNA to host cell sensors might be the main general mechanism for coronaviruses to prevent IFN induction.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Versteeg</LastName><ForeName>Gijs A</ForeName><Initials>GA</Initials><AffiliationInfo><Affiliation>Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, LUMC E4-P, P.O. 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Factor-3</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016898">Interferon-alpha</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001692" MajorTopicYN="N">Biological Transport</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002522" MajorTopicYN="N">Chlorocebus aethiops</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D050838" MajorTopicYN="N">Interferon Regulatory Factor-3</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016898" MajorTopicYN="N">Interferon-alpha</DescriptorName><QualifierName UI="Q000378" 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