Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus.
Identifieur interne : 001D36 ( PubMed/Curation ); précédent : 001D35; suivant : 001D37Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus.
Auteurs : Santhana G. Devaraj [États-Unis] ; Nan Wang ; Zhongbin Chen ; Zihong Chen ; Monica Tseng ; Naina Barretto ; Rongtuan Lin ; Clarence J. Peters ; Chien-Te K. Tseng ; Susan C. Baker ; Kui LiSource :
- The Journal of biological chemistry [ 0021-9258 ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Bronches (cytologie), Bronches (immunologie), Bronches (virologie), Facteur-3 de régulation d'interféron (immunologie), Humains, Immunité innée, Interféron de type I (immunologie), Lignée cellulaire, Peptide hydrolases (), Peptide hydrolases (immunologie), Protéines virales (), Protéines virales (immunologie), Structure tertiaire des protéines, Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (enzymologie), Virus du SRAS (immunologie).
- MESH :
- cytologie : Bronches.
- enzymologie : Virus du SRAS.
- immunologie : Bronches, Facteur-3 de régulation d'interféron, Interféron de type I, Peptide hydrolases, Protéines virales, Syndrome respiratoire aigu sévère, Virus du SRAS.
- virologie : Bronches, Syndrome respiratoire aigu sévère.
- Animaux, Humains, Immunité innée, Lignée cellulaire, Peptide hydrolases, Protéines virales, Structure tertiaire des protéines.
English descriptors
- KwdEn :
- Animals, Bronchi (cytology), Bronchi (immunology), Bronchi (virology), Cell Line, Humans, Immunity, Innate, Interferon Regulatory Factor-3 (immunology), Interferon Type I (immunology), Peptide Hydrolases (chemistry), Peptide Hydrolases (immunology), Protein Structure, Tertiary, SARS Virus (enzymology), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology), Viral Proteins (chemistry), Viral Proteins (immunology).
- MESH :
- chemical , chemistry : Peptide Hydrolases, Viral Proteins.
- chemical , immunology : Interferon Regulatory Factor-3, Interferon Type I, Peptide Hydrolases, Viral Proteins.
- cytology : Bronchi.
- enzymology : SARS Virus.
- immunology : Bronchi, SARS Virus, Severe Acute Respiratory Syndrome.
- virology : Bronchi, Severe Acute Respiratory Syndrome.
- Animals, Cell Line, Humans, Immunity, Innate, Protein Structure, Tertiary.
Abstract
Severe acute respiratory syndrome coronavirus (SARS-CoV) is a novel coronavirus that causes a highly contagious respiratory disease, SARS, with significant mortality. Although factors contributing to the highly pathogenic nature of SARS-CoV remain poorly understood, it has been reported that SARS-CoV infection does not induce type I interferons (IFNs) in cell culture. However, it is uncertain whether SARS-CoV evades host detection or has evolved mechanisms to counteract innate host defenses. We show here that infection of SARS-CoV triggers a weak IFN response in cultured human lung/bronchial epithelial cells without inducing the phosphorylation of IFN-regulatory factor 3 (IRF-3), a latent cellular transcription factor that is pivotal for type I IFN synthesis. Furthermore, SARS-CoV infection blocked the induction of IFN antiviral activity and the up-regulation of protein expression of a subset of IFN-stimulated genes triggered by double-stranded RNA or an unrelated paramyxovirus. In searching for a SARS-CoV protein capable of counteracting innate immunity, we identified the papain-like protease (PLpro) domain as a potent IFN antagonist. The inhibition of the IFN response does not require the protease activity of PLpro. Rather, PLpro interacts with IRF-3 and inhibits the phosphorylation and nuclear translocation of IRF-3, thereby disrupting the activation of type I IFN responses through either Toll-like receptor 3 or retinoic acid-inducible gene I/melanoma differentiation-associated gene 5 pathways. Our data suggest that regulation of IRF-3-dependent innate antiviral defenses by PLpro may contribute to the establishment of SARS-CoV infection.
DOI: 10.1074/jbc.M704870200
PubMed: 17761676
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Devaraj</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, Center of Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555-1019, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Center of Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555-1019</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Nan" sort="Wang, Nan" uniqKey="Wang N" first="Nan" last="Wang">Nan Wang</name></author><author><name sortKey="Chen, Zhongbin" sort="Chen, Zhongbin" uniqKey="Chen Z" first="Zhongbin" last="Chen">Zhongbin Chen</name></author><author><name sortKey="Chen, Zihong" sort="Chen, Zihong" uniqKey="Chen Z" first="Zihong" last="Chen">Zihong Chen</name></author><author><name sortKey="Tseng, Monica" sort="Tseng, Monica" uniqKey="Tseng M" first="Monica" last="Tseng">Monica Tseng</name></author><author><name sortKey="Barretto, Naina" sort="Barretto, Naina" uniqKey="Barretto N" first="Naina" last="Barretto">Naina Barretto</name></author><author><name sortKey="Lin, Rongtuan" sort="Lin, Rongtuan" uniqKey="Lin R" first="Rongtuan" last="Lin">Rongtuan Lin</name></author><author><name sortKey="Peters, Clarence J" sort="Peters, Clarence J" uniqKey="Peters C" first="Clarence J" last="Peters">Clarence J. 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Baker</name></author><author><name sortKey="Li, Kui" sort="Li, Kui" uniqKey="Li K" first="Kui" last="Li">Kui Li</name></author></analytic><series><title level="j">The Journal of biological chemistry</title><idno type="ISSN">0021-9258</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Bronchi (cytology)</term><term>Bronchi (immunology)</term><term>Bronchi (virology)</term><term>Cell Line</term><term>Humans</term><term>Immunity, Innate</term><term>Interferon Regulatory Factor-3 (immunology)</term><term>Interferon Type I (immunology)</term><term>Peptide Hydrolases (chemistry)</term><term>Peptide Hydrolases (immunology)</term><term>Protein Structure, Tertiary</term><term>SARS Virus (enzymology)</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Viral Proteins (chemistry)</term><term>Viral Proteins (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Bronches (cytologie)</term><term>Bronches (immunologie)</term><term>Bronches (virologie)</term><term>Facteur-3 de régulation d'interféron (immunologie)</term><term>Humains</term><term>Immunité innée</term><term>Interféron de type I (immunologie)</term><term>Lignée cellulaire</term><term>Peptide hydrolases ()</term><term>Peptide hydrolases (immunologie)</term><term>Protéines virales ()</term><term>Protéines virales (immunologie)</term><term>Structure tertiaire des protéines</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS (enzymologie)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Peptide Hydrolases</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Interferon Regulatory Factor-3</term><term>Interferon Type I</term><term>Peptide Hydrolases</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Bronches</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Bronchi</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Bronches</term><term>Facteur-3 de régulation d'interféron</term><term>Interféron de type I</term><term>Peptide hydrolases</term><term>Protéines virales</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Bronchi</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Bronches</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Bronchi</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Humans</term><term>Immunity, Innate</term><term>Protein Structure, Tertiary</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Immunité innée</term><term>Lignée cellulaire</term><term>Peptide hydrolases</term><term>Protéines virales</term><term>Structure tertiaire des protéines</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome coronavirus (SARS-CoV) is a novel coronavirus that causes a highly contagious respiratory disease, SARS, with significant mortality. Although factors contributing to the highly pathogenic nature of SARS-CoV remain poorly understood, it has been reported that SARS-CoV infection does not induce type I interferons (IFNs) in cell culture. However, it is uncertain whether SARS-CoV evades host detection or has evolved mechanisms to counteract innate host defenses. We show here that infection of SARS-CoV triggers a weak IFN response in cultured human lung/bronchial epithelial cells without inducing the phosphorylation of IFN-regulatory factor 3 (IRF-3), a latent cellular transcription factor that is pivotal for type I IFN synthesis. Furthermore, SARS-CoV infection blocked the induction of IFN antiviral activity and the up-regulation of protein expression of a subset of IFN-stimulated genes triggered by double-stranded RNA or an unrelated paramyxovirus. In searching for a SARS-CoV protein capable of counteracting innate immunity, we identified the papain-like protease (PLpro) domain as a potent IFN antagonist. The inhibition of the IFN response does not require the protease activity of PLpro. Rather, PLpro interacts with IRF-3 and inhibits the phosphorylation and nuclear translocation of IRF-3, thereby disrupting the activation of type I IFN responses through either Toll-like receptor 3 or retinoic acid-inducible gene I/melanoma differentiation-associated gene 5 pathways. Our data suggest that regulation of IRF-3-dependent innate antiviral defenses by PLpro may contribute to the establishment of SARS-CoV infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17761676</PMID><DateCompleted><Year>2007</Year><Month>12</Month><Day>13</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0021-9258</ISSN><JournalIssue CitedMedium="Print"><Volume>282</Volume><Issue>44</Issue><PubDate><Year>2007</Year><Month>Nov</Month><Day>02</Day></PubDate></JournalIssue><Title>The Journal of biological chemistry</Title><ISOAbbreviation>J. Biol. Chem.</ISOAbbreviation></Journal><ArticleTitle>Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus.</ArticleTitle><Pagination><MedlinePgn>32208-21</MedlinePgn></Pagination><Abstract><AbstractText>Severe acute respiratory syndrome coronavirus (SARS-CoV) is a novel coronavirus that causes a highly contagious respiratory disease, SARS, with significant mortality. Although factors contributing to the highly pathogenic nature of SARS-CoV remain poorly understood, it has been reported that SARS-CoV infection does not induce type I interferons (IFNs) in cell culture. However, it is uncertain whether SARS-CoV evades host detection or has evolved mechanisms to counteract innate host defenses. We show here that infection of SARS-CoV triggers a weak IFN response in cultured human lung/bronchial epithelial cells without inducing the phosphorylation of IFN-regulatory factor 3 (IRF-3), a latent cellular transcription factor that is pivotal for type I IFN synthesis. Furthermore, SARS-CoV infection blocked the induction of IFN antiviral activity and the up-regulation of protein expression of a subset of IFN-stimulated genes triggered by double-stranded RNA or an unrelated paramyxovirus. In searching for a SARS-CoV protein capable of counteracting innate immunity, we identified the papain-like protease (PLpro) domain as a potent IFN antagonist. The inhibition of the IFN response does not require the protease activity of PLpro. Rather, PLpro interacts with IRF-3 and inhibits the phosphorylation and nuclear translocation of IRF-3, thereby disrupting the activation of type I IFN responses through either Toll-like receptor 3 or retinoic acid-inducible gene I/melanoma differentiation-associated gene 5 pathways. Our data suggest that regulation of IRF-3-dependent innate antiviral defenses by PLpro may contribute to the establishment of SARS-CoV infection.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Devaraj</LastName><ForeName>Santhana G</ForeName><Initials>SG</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Center of Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555-1019, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Nan</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Zhongbin</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Zihong</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Tseng</LastName><ForeName>Monica</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Barretto</LastName><ForeName>Naina</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Rongtuan</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Peters</LastName><ForeName>Clarence J</ForeName><Initials>CJ</Initials></Author><Author ValidYN="Y"><LastName>Tseng</LastName><ForeName>Chien-Te K</ForeName><Initials>CT</Initials></Author><Author ValidYN="Y"><LastName>Baker</LastName><ForeName>Susan C</ForeName><Initials>SC</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Kui</ForeName><Initials>K</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>DA018054</GrantID><Acronym>DA</Acronym><Agency>NIDA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 AI060915-030001</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01AI30039</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI069285-01A2</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U54 AI057156</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21 DA018054-01</GrantID><Acronym>DA</Acronym><Agency>NIDA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AI30039</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AI069285</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AI45798</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01 AI030039-009</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI045798</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 AI060915</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AI057156</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R56 AI069285</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U54 AI057156-05S10038</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI069285</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AI060915</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21 DA018054</GrantID><Acronym>DA</Acronym><Agency>NIDA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI045798-01A2</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2007</Year><Month>08</Month><Day>30</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Biol Chem</MedlineTA><NlmUniqueID>2985121R</NlmUniqueID><ISSNLinking>0021-9258</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D050838">Interferon Regulatory Factor-3</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007370">Interferon Type 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MajorTopicYN="Y">Immunity, Innate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D050838" MajorTopicYN="N">Interferon Regulatory Factor-3</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007370" MajorTopicYN="N">Interferon Type I</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010447" MajorTopicYN="N">Peptide Hydrolases</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017434" MajorTopicYN="N">Protein Structure, Tertiary</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName><QualifierName UI="Q000276" 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PubStatus="entrez"><Year>2007</Year><Month>9</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17761676</ArticleId><ArticleId IdType="pii">M704870200</ArticleId><ArticleId IdType="doi">10.1074/jbc.M704870200</ArticleId><ArticleId IdType="pmc">PMC2756044</ArticleId><ArticleId IdType="mid">NIHMS129989</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Nature. 2001 Oct 18;413(6857):732-8</Citation><ArticleIdList><ArticleId IdType="pubmed">11607032</ArticleId></ArticleIdList></Reference><Reference><Citation>J Interferon Cytokine Res. 2002 Jan;22(1):73-6</Citation><ArticleIdList><ArticleId IdType="pubmed">11846977</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2002 Mar 22;277(12):9976-81</Citation><ArticleIdList><ArticleId IdType="pubmed">11788588</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2002 Apr;76(8):3697-708</Citation><ArticleIdList><ArticleId IdType="pubmed">11907209</ArticleId></ArticleIdList></Reference><Reference><Citation>Hepatology. 2002 May;35(5):1237-46</Citation><ArticleIdList><ArticleId IdType="pubmed">11981774</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6322-7</Citation><ArticleIdList><ArticleId IdType="pubmed">11972054</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2002 Jun;76(11):5532-9</Citation><ArticleIdList><ArticleId IdType="pubmed">11991981</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Immunol. 2002 Sep;2(9):664-74</Citation><ArticleIdList><ArticleId IdType="pubmed">12209135</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2002 Dec 15;169(12):6668-72</Citation><ArticleIdList><ArticleId IdType="pubmed">12471095</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2003 Mar 14;278(11):9441-7</Citation><ArticleIdList><ArticleId IdType="pubmed">12524442</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Immunol. 2003 May;4(5):491-6</Citation><ArticleIdList><ArticleId IdType="pubmed">12692549</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1953-66</Citation><ArticleIdList><ArticleId IdType="pubmed">12690092</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2003 May 16;300(5622):1148-51</Citation><ArticleIdList><ArticleId IdType="pubmed">12702806</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2003 May 16;300(5622):1145-8</Citation><ArticleIdList><ArticleId IdType="pubmed">12702807</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2003 May 30;300(5624):1394-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12730500</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2003 May 30;300(5624):1399-404</Citation><ArticleIdList><ArticleId IdType="pubmed">12730501</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2004 Feb;78(4):1706-17</Citation><ArticleIdList><ArticleId IdType="pubmed">14747536</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2004 Mar 5;303(5663):1529-31</Citation><ArticleIdList><ArticleId IdType="pubmed">14976261</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2004 Mar 5;303(5663):1526-9</Citation><ArticleIdList><ArticleId IdType="pubmed">14976262</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2004 Feb;10(2):320-6</Citation><ArticleIdList><ArticleId IdType="pubmed">15030705</ArticleId></ArticleIdList></Reference><Reference><Citation>FEBS Lett. 2004 Jun 4;567(2-3):230-8</Citation><ArticleIdList><ArticleId IdType="pubmed">15178328</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Immunol. 2004 Jul;5(7):730-7</Citation><ArticleIdList><ArticleId IdType="pubmed">15208624</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2004;32(14):e115</Citation><ArticleIdList><ArticleId IdType="pubmed">15304544</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 1979 Apr;43(1):247-52</Citation><ArticleIdList><ArticleId IdType="pubmed">113494</ArticleId></ArticleIdList></Reference><Reference><Citation>Methods Enzymol. 1981;78(Pt A):339-46</Citation><ArticleIdList><ArticleId IdType="pubmed">6173610</ArticleId></ArticleIdList></Reference><Reference><Citation>Infect Immun. 1982 Jun;36(3):857-63</Citation><ArticleIdList><ArticleId IdType="pubmed">6178689</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1992 Sep 5;267(25):17971-6</Citation><ArticleIdList><ArticleId IdType="pubmed">1381359</ArticleId></ArticleIdList></Reference><Reference><Citation>EMBO J. 1998 Feb 16;17(4):1087-95</Citation><ArticleIdList><ArticleId IdType="pubmed">9463386</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 1998 Mar;18(3):1359-68</Citation><ArticleIdList><ArticleId IdType="pubmed">9488451</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 1998 May;18(5):2986-96</Citation><ArticleIdList><ArticleId IdType="pubmed">9566918</ArticleId></ArticleIdList></Reference><Reference><Citation>J Interferon Cytokine Res. 1998 Sep;18(9):773-81</Citation><ArticleIdList><ArticleId IdType="pubmed">9781817</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1999 Apr 30;274(18):12933-8</Citation><ArticleIdList><ArticleId IdType="pubmed">10212284</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2004 Dec;78(24):13600-12</Citation><ArticleIdList><ArticleId IdType="pubmed">15564471</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2004 Dec;10(12 Suppl):S88-97</Citation><ArticleIdList><ArticleId IdType="pubmed">15577937</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Top Microbiol Immunol. 2005;287:57-94</Citation><ArticleIdList><ArticleId IdType="pubmed">15609509</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Feb;79(4):2079-86</Citation><ArticleIdList><ArticleId IdType="pubmed">15681410</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2992-7</Citation><ArticleIdList><ArticleId IdType="pubmed">15710891</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Mar;79(6):3846-50</Citation><ArticleIdList><ArticleId IdType="pubmed">15731278</ArticleId></ArticleIdList></Reference><Reference><Citation>Cytokine Growth Factor Rev. 2005 Feb;16(1):1-14</Citation><ArticleIdList><ArticleId IdType="pubmed">15733829</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2005 Apr 29;280(17):16739-47</Citation><ArticleIdList><ArticleId IdType="pubmed">15737993</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Jun;79(12):7535-43</Citation><ArticleIdList><ArticleId IdType="pubmed">15919908</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Jul;79(13):8431-9</Citation><ArticleIdList><ArticleId IdType="pubmed">15956587</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Aug;79(15):9470-9</Citation><ArticleIdList><ArticleId IdType="pubmed">16014910</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Cell Biol. 2005 Aug;7(8):758-65</Citation><ArticleIdList><ArticleId IdType="pubmed">16056267</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2005 Sep 9;122(5):669-82</Citation><ArticleIdList><ArticleId IdType="pubmed">16125763</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell. 2005 Sep 16;19(6):727-40</Citation><ArticleIdList><ArticleId IdType="pubmed">16153868</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Immunol. 2005 Oct;6(10):981-8</Citation><ArticleIdList><ArticleId IdType="pubmed">16127453</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2005 Oct 20;437(7062):1167-72</Citation><ArticleIdList><ArticleId IdType="pubmed">16177806</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Dec;79(23):14909-22</Citation><ArticleIdList><ArticleId IdType="pubmed">16282490</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Dec;79(24):15189-98</Citation><ArticleIdList><ArticleId IdType="pubmed">16306590</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Dec;79(24):15199-208</Citation><ArticleIdList><ArticleId IdType="pubmed">16306591</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Immunol. 2005 Dec;5(12):941-52</Citation><ArticleIdList><ArticleId IdType="pubmed">16322747</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Immunol. 2006 Feb;7(2):131-7</Citation><ArticleIdList><ArticleId IdType="pubmed">16424890</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2006 Jan 27;281(4):2095-103</Citation><ArticleIdList><ArticleId IdType="pubmed">16306043</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Res. 2006 Feb;16(2):141-7</Citation><ArticleIdList><ArticleId IdType="pubmed">16474426</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5717-22</Citation><ArticleIdList><ArticleId IdType="pubmed">16581910</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2006 May 4;441(7089):101-5</Citation><ArticleIdList><ArticleId IdType="pubmed">16625202</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2006 May 12;312(5775):879-82</Citation><ArticleIdList><ArticleId IdType="pubmed">16690858</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Immunol. 2006 Jun;7(6):555-7</Citation><ArticleIdList><ArticleId IdType="pubmed">16715065</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2006 Jun;80(12):5927-40</Citation><ArticleIdList><ArticleId IdType="pubmed">16731931</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell. 2006 Jun 9;22(5):561-9</Citation><ArticleIdList><ArticleId IdType="pubmed">16762830</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunity. 2006 Sep;25(3):373-81</Citation><ArticleIdList><ArticleId IdType="pubmed">16979569</ArticleId></ArticleIdList></Reference><Reference><Citation>Adv Exp Med Biol. 2006;581:3-11</Citation><ArticleIdList><ArticleId IdType="pubmed">17037497</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2006 Nov;80(22):11115-23</Citation><ArticleIdList><ArticleId IdType="pubmed">16971424</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2006 Nov 10;314(5801):997-1001</Citation><ArticleIdList><ArticleId IdType="pubmed">17038589</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2006 Nov 10;314(5801):994-7</Citation><ArticleIdList><ArticleId IdType="pubmed">17038590</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2007 Jan;81(2):568-74</Citation><ArticleIdList><ArticleId IdType="pubmed">17079305</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2007 Jan;81(2):964-76</Citation><ArticleIdList><ArticleId IdType="pubmed">17093192</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2007 Jan;81(2):548-57</Citation><ArticleIdList><ArticleId IdType="pubmed">17108024</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):252-7</Citation><ArticleIdList><ArticleId IdType="pubmed">17190817</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2007 Feb 1;109(3):1131-7</Citation><ArticleIdList><ArticleId IdType="pubmed">16985170</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2007 Apr 25;361(1):18-26</Citation><ArticleIdList><ArticleId IdType="pubmed">17316733</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2007 May 10;361(2):304-15</Citation><ArticleIdList><ArticleId IdType="pubmed">17210170</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7253-8</Citation><ArticleIdList><ArticleId IdType="pubmed">17438296</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2007 Sep 30;366(2):277-92</Citation><ArticleIdList><ArticleId IdType="pubmed">17531282</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12885-90</Citation><ArticleIdList><ArticleId IdType="pubmed">16912115</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 1999 Nov 10;264(1):159-66</Citation><ArticleIdList><ArticleId IdType="pubmed">10544141</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1999 Dec 10;274(50):35535-8</Citation><ArticleIdList><ArticleId IdType="pubmed">10585427</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Cells. 2001 Apr;6(4):375-88</Citation><ArticleIdList><ArticleId IdType="pubmed">11318879</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Microbiol. 2001;55:255-81</Citation><ArticleIdList><ArticleId IdType="pubmed">11544356</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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