Altered pathogenesis of porcine respiratory coronavirus in pigs due to immunosuppressive effects of dexamethasone: implications for corticosteroid use in treatment of severe acute respiratory syndrome coronavirus.
Identifieur interne : 001D00 ( PubMed/Curation ); précédent : 001C99; suivant : 001D01Altered pathogenesis of porcine respiratory coronavirus in pigs due to immunosuppressive effects of dexamethasone: implications for corticosteroid use in treatment of severe acute respiratory syndrome coronavirus.
Auteurs : Kwonil Jung [États-Unis] ; Konstantin P. Alekseev ; Xinsheng Zhang ; Doo-Sung Cheon ; Anastasia N. Vlasova ; Linda J. SaifSource :
- Journal of virology [ 1098-5514 ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Coronavirus respiratoire porcin (), Coronavirus respiratoire porcin (génétique), Coronavirus respiratoire porcin (isolement et purification), Coronavirus respiratoire porcin (pathogénicité), Dexaméthasone (administration et posologie), Dexaméthasone (usage thérapeutique), Hormones corticosurrénaliennes (administration et posologie), Hormones corticosurrénaliennes (usage thérapeutique), Humains, Immunosuppression thérapeutique, Infections à coronavirus (anatomopathologie), Infections à coronavirus (physiopathologie), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Maladies des porcs (anatomopathologie), Maladies des porcs (physiopathologie), Maladies des porcs (traitement médicamenteux), Maladies des porcs (virologie), Modèles animaux de maladie humaine, Poumon (anatomopathologie), Poumon (immunologie), Poumon (virologie), Résultat thérapeutique, Suidae, Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (physiopathologie), Syndrome respiratoire aigu sévère (traitement médicamenteux), Syndrome respiratoire aigu sévère (virologie).
- MESH :
- administration et posologie : Dexaméthasone, Hormones corticosurrénaliennes.
- anatomopathologie : Infections à coronavirus, Maladies des porcs, Poumon, Syndrome respiratoire aigu sévère.
- génétique : Coronavirus respiratoire porcin.
- immunologie : Poumon.
- isolement et purification : Coronavirus respiratoire porcin.
- pathogénicité : Coronavirus respiratoire porcin.
- physiopathologie : Infections à coronavirus, Maladies des porcs, Syndrome respiratoire aigu sévère.
- traitement médicamenteux : Infections à coronavirus, Maladies des porcs, Syndrome respiratoire aigu sévère.
- usage thérapeutique : Dexaméthasone, Hormones corticosurrénaliennes.
- virologie : Infections à coronavirus, Maladies des porcs, Poumon, Syndrome respiratoire aigu sévère.
- Animaux, Coronavirus respiratoire porcin, Humains, Immunosuppression thérapeutique, Modèles animaux de maladie humaine, Résultat thérapeutique, Suidae.
English descriptors
- KwdEn :
- Adrenal Cortex Hormones (administration & dosage), Adrenal Cortex Hormones (therapeutic use), Animals, Coronavirus Infections (drug therapy), Coronavirus Infections (pathology), Coronavirus Infections (physiopathology), Coronavirus Infections (virology), Dexamethasone (administration & dosage), Dexamethasone (therapeutic use), Disease Models, Animal, Humans, Immunosuppression, Lung (immunology), Lung (pathology), Lung (virology), Porcine Respiratory Coronavirus (drug effects), Porcine Respiratory Coronavirus (genetics), Porcine Respiratory Coronavirus (isolation & purification), Porcine Respiratory Coronavirus (pathogenicity), Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (physiopathology), Severe Acute Respiratory Syndrome (virology), Swine, Swine Diseases (drug therapy), Swine Diseases (pathology), Swine Diseases (physiopathology), Swine Diseases (virology), Treatment Outcome.
- MESH :
- chemical , administration & dosage : Adrenal Cortex Hormones, Dexamethasone.
- chemical , therapeutic use : Adrenal Cortex Hormones, Dexamethasone.
- drug effects : Porcine Respiratory Coronavirus.
- drug therapy : Coronavirus Infections, Severe Acute Respiratory Syndrome, Swine Diseases.
- genetics : Porcine Respiratory Coronavirus.
- immunology : Lung.
- isolation & purification : Porcine Respiratory Coronavirus.
- pathogenicity : Porcine Respiratory Coronavirus.
- pathology : Coronavirus Infections, Lung, Severe Acute Respiratory Syndrome, Swine Diseases.
- physiopathology : Coronavirus Infections, Severe Acute Respiratory Syndrome, Swine Diseases.
- virology : Coronavirus Infections, Lung, Severe Acute Respiratory Syndrome, Swine Diseases.
- Animals, Disease Models, Animal, Humans, Immunosuppression, Swine, Treatment Outcome.
Abstract
The pathogenesis and optimal treatments for severe acute respiratory syndrome (SARS) are unclear, although corticosteroids were used to reduce lung and systemic inflammation. Because the pulmonary pathology of porcine respiratory coronavirus (PRCV) in pigs resembles SARS, we used PRCV as a model to clarify the effects of the corticosteroid dexamethasone (DEX) on coronavirus (CoV)-induced pneumonia. Conventional weaned pigs (n = 130) in one of four groups (PRCV/phosphate-buffered saline [PBS] [n = 41], PRCV/DEX [n = 41], mock/PBS [n = 23], and mock/DEX [n = 25]) were inoculated intranasally and intratracheally with the ISU-1 strain of PRCV (1 x 10(7) PFU) or cell culture medium. DEX was administered (once daily, 2 mg/kg of body weight/day, intramuscularly) from postinoculation day (PID) 1 to 6. In PRCV/DEX pigs, significantly milder pneumonia, fewer PRCV-positive cells, and lower viral RNA titers were present in lungs early at PID 2; however, at PID 4, 10, and 21, severe bronchointerstitial pneumonia, significantly higher numbers of PRCV-positive cells, and higher viral RNA titers were observed compared to results for PRCV/PBS pigs. Significantly lower numbers of CD2(+), CD3(+), CD4(+), and CD8(+) T cells were also observed in lungs of PRCV/DEX pigs than in those of PRCV/PBS pigs at PID 8 and 10, coincident with fewer gamma interferon (IFN-gamma)-secreting cells in the tracheobronchial lymph nodes as determined by enzyme-linked immunospot assay. Our results confirm that DEX treatment alleviates PRCV pneumonia early (PID 2) in the infection but continued use through PID 6 exacerbates later stages of infection (PID 4, 10, and 21), possibly by decreasing cellular immune responses in the lungs (IFN-gamma-secreting T cells), thereby creating an environment for more-extensive viral replication. These data have potential implications for corticosteroid use with SARS-CoV patients and suggest a precaution against prolonged use based on their unproven efficacy in humans, including possible detrimental secondary effects.
DOI: 10.1128/JVI.01702-07
PubMed: 17942563
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001D00
Links to Exploration step
pubmed:17942563Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Altered pathogenesis of porcine respiratory coronavirus in pigs due to immunosuppressive effects of dexamethasone: implications for corticosteroid use in treatment of severe acute respiratory syndrome coronavirus.</title><author><name sortKey="Jung, Kwonil" sort="Jung, Kwonil" uniqKey="Jung K" first="Kwonil" last="Jung">Kwonil Jung</name><affiliation wicri:level="1"><nlm:affiliation>Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Ave., Wooster, Ohio 44691, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Ave., Wooster, Ohio 44691</wicri:regionArea></affiliation></author><author><name sortKey="Alekseev, Konstantin P" sort="Alekseev, Konstantin P" uniqKey="Alekseev K" first="Konstantin P" last="Alekseev">Konstantin P. Alekseev</name></author><author><name sortKey="Zhang, Xinsheng" sort="Zhang, Xinsheng" uniqKey="Zhang X" first="Xinsheng" last="Zhang">Xinsheng Zhang</name></author><author><name sortKey="Cheon, Doo Sung" sort="Cheon, Doo Sung" uniqKey="Cheon D" first="Doo-Sung" last="Cheon">Doo-Sung Cheon</name></author><author><name sortKey="Vlasova, Anastasia N" sort="Vlasova, Anastasia N" uniqKey="Vlasova A" first="Anastasia N" last="Vlasova">Anastasia N. Vlasova</name></author><author><name sortKey="Saif, Linda J" sort="Saif, Linda J" uniqKey="Saif L" first="Linda J" last="Saif">Linda J. Saif</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17942563</idno><idno type="pmid">17942563</idno><idno type="doi">10.1128/JVI.01702-07</idno><idno type="wicri:Area/PubMed/Corpus">001D00</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001D00</idno><idno type="wicri:Area/PubMed/Curation">001D00</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001D00</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Altered pathogenesis of porcine respiratory coronavirus in pigs due to immunosuppressive effects of dexamethasone: implications for corticosteroid use in treatment of severe acute respiratory syndrome coronavirus.</title><author><name sortKey="Jung, Kwonil" sort="Jung, Kwonil" uniqKey="Jung K" first="Kwonil" last="Jung">Kwonil Jung</name><affiliation wicri:level="1"><nlm:affiliation>Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Ave., Wooster, Ohio 44691, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Ave., Wooster, Ohio 44691</wicri:regionArea></affiliation></author><author><name sortKey="Alekseev, Konstantin P" sort="Alekseev, Konstantin P" uniqKey="Alekseev K" first="Konstantin P" last="Alekseev">Konstantin P. Alekseev</name></author><author><name sortKey="Zhang, Xinsheng" sort="Zhang, Xinsheng" uniqKey="Zhang X" first="Xinsheng" last="Zhang">Xinsheng Zhang</name></author><author><name sortKey="Cheon, Doo Sung" sort="Cheon, Doo Sung" uniqKey="Cheon D" first="Doo-Sung" last="Cheon">Doo-Sung Cheon</name></author><author><name sortKey="Vlasova, Anastasia N" sort="Vlasova, Anastasia N" uniqKey="Vlasova A" first="Anastasia N" last="Vlasova">Anastasia N. Vlasova</name></author><author><name sortKey="Saif, Linda J" sort="Saif, Linda J" uniqKey="Saif L" first="Linda J" last="Saif">Linda J. Saif</name></author></analytic><series><title level="j">Journal of virology</title><idno type="eISSN">1098-5514</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenal Cortex Hormones (administration & dosage)</term><term>Adrenal Cortex Hormones (therapeutic use)</term><term>Animals</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (pathology)</term><term>Coronavirus Infections (physiopathology)</term><term>Coronavirus Infections (virology)</term><term>Dexamethasone (administration & dosage)</term><term>Dexamethasone (therapeutic use)</term><term>Disease Models, Animal</term><term>Humans</term><term>Immunosuppression</term><term>Lung (immunology)</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Porcine Respiratory Coronavirus (drug effects)</term><term>Porcine Respiratory Coronavirus (genetics)</term><term>Porcine Respiratory Coronavirus (isolation & purification)</term><term>Porcine Respiratory Coronavirus (pathogenicity)</term><term>Severe Acute Respiratory Syndrome (drug therapy)</term><term>Severe Acute Respiratory Syndrome (pathology)</term><term>Severe Acute Respiratory Syndrome (physiopathology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Swine</term><term>Swine Diseases (drug therapy)</term><term>Swine Diseases (pathology)</term><term>Swine Diseases (physiopathology)</term><term>Swine Diseases (virology)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Coronavirus respiratoire porcin ()</term><term>Coronavirus respiratoire porcin (génétique)</term><term>Coronavirus respiratoire porcin (isolement et purification)</term><term>Coronavirus respiratoire porcin (pathogénicité)</term><term>Dexaméthasone (administration et posologie)</term><term>Dexaméthasone (usage thérapeutique)</term><term>Hormones corticosurrénaliennes (administration et posologie)</term><term>Hormones corticosurrénaliennes (usage thérapeutique)</term><term>Humains</term><term>Immunosuppression thérapeutique</term><term>Infections à coronavirus (anatomopathologie)</term><term>Infections à coronavirus (physiopathologie)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (virologie)</term><term>Maladies des porcs (anatomopathologie)</term><term>Maladies des porcs (physiopathologie)</term><term>Maladies des porcs (traitement médicamenteux)</term><term>Maladies des porcs (virologie)</term><term>Modèles animaux de maladie humaine</term><term>Poumon (anatomopathologie)</term><term>Poumon (immunologie)</term><term>Poumon (virologie)</term><term>Résultat thérapeutique</term><term>Suidae</term><term>Syndrome respiratoire aigu sévère (anatomopathologie)</term><term>Syndrome respiratoire aigu sévère (physiopathologie)</term><term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term><term>Syndrome respiratoire aigu sévère (virologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Adrenal Cortex Hormones</term><term>Dexamethasone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adrenal Cortex Hormones</term><term>Dexamethasone</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Dexaméthasone</term><term>Hormones corticosurrénaliennes</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Maladies des porcs</term><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Porcine Respiratory Coronavirus</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Severe Acute Respiratory Syndrome</term><term>Swine Diseases</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Porcine Respiratory Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus respiratoire porcin</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Porcine Respiratory Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus respiratoire porcin</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Porcine Respiratory Coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus respiratoire porcin</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term><term>Lung</term><term>Severe Acute Respiratory Syndrome</term><term>Swine Diseases</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Maladies des porcs</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Coronavirus Infections</term><term>Severe Acute Respiratory Syndrome</term><term>Swine Diseases</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Maladies des porcs</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Dexaméthasone</term><term>Hormones corticosurrénaliennes</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Maladies des porcs</term><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Lung</term><term>Severe Acute Respiratory Syndrome</term><term>Swine Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term><term>Immunosuppression</term><term>Swine</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Coronavirus respiratoire porcin</term><term>Humains</term><term>Immunosuppression thérapeutique</term><term>Modèles animaux de maladie humaine</term><term>Résultat thérapeutique</term><term>Suidae</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pathogenesis and optimal treatments for severe acute respiratory syndrome (SARS) are unclear, although corticosteroids were used to reduce lung and systemic inflammation. Because the pulmonary pathology of porcine respiratory coronavirus (PRCV) in pigs resembles SARS, we used PRCV as a model to clarify the effects of the corticosteroid dexamethasone (DEX) on coronavirus (CoV)-induced pneumonia. Conventional weaned pigs (n = 130) in one of four groups (PRCV/phosphate-buffered saline [PBS] [n = 41], PRCV/DEX [n = 41], mock/PBS [n = 23], and mock/DEX [n = 25]) were inoculated intranasally and intratracheally with the ISU-1 strain of PRCV (1 x 10(7) PFU) or cell culture medium. DEX was administered (once daily, 2 mg/kg of body weight/day, intramuscularly) from postinoculation day (PID) 1 to 6. In PRCV/DEX pigs, significantly milder pneumonia, fewer PRCV-positive cells, and lower viral RNA titers were present in lungs early at PID 2; however, at PID 4, 10, and 21, severe bronchointerstitial pneumonia, significantly higher numbers of PRCV-positive cells, and higher viral RNA titers were observed compared to results for PRCV/PBS pigs. Significantly lower numbers of CD2(+), CD3(+), CD4(+), and CD8(+) T cells were also observed in lungs of PRCV/DEX pigs than in those of PRCV/PBS pigs at PID 8 and 10, coincident with fewer gamma interferon (IFN-gamma)-secreting cells in the tracheobronchial lymph nodes as determined by enzyme-linked immunospot assay. Our results confirm that DEX treatment alleviates PRCV pneumonia early (PID 2) in the infection but continued use through PID 6 exacerbates later stages of infection (PID 4, 10, and 21), possibly by decreasing cellular immune responses in the lungs (IFN-gamma-secreting T cells), thereby creating an environment for more-extensive viral replication. These data have potential implications for corticosteroid use with SARS-CoV patients and suggest a precaution against prolonged use based on their unproven efficacy in humans, including possible detrimental secondary effects.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17942563</PMID><DateCompleted><Year>2007</Year><Month>12</Month><Day>27</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1098-5514</ISSN><JournalIssue CitedMedium="Internet"><Volume>81</Volume><Issue>24</Issue><PubDate><Year>2007</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Journal of virology</Title><ISOAbbreviation>J. Virol.</ISOAbbreviation></Journal><ArticleTitle>Altered pathogenesis of porcine respiratory coronavirus in pigs due to immunosuppressive effects of dexamethasone: implications for corticosteroid use in treatment of severe acute respiratory syndrome coronavirus.</ArticleTitle><Pagination><MedlinePgn>13681-93</MedlinePgn></Pagination><Abstract><AbstractText>The pathogenesis and optimal treatments for severe acute respiratory syndrome (SARS) are unclear, although corticosteroids were used to reduce lung and systemic inflammation. Because the pulmonary pathology of porcine respiratory coronavirus (PRCV) in pigs resembles SARS, we used PRCV as a model to clarify the effects of the corticosteroid dexamethasone (DEX) on coronavirus (CoV)-induced pneumonia. Conventional weaned pigs (n = 130) in one of four groups (PRCV/phosphate-buffered saline [PBS] [n = 41], PRCV/DEX [n = 41], mock/PBS [n = 23], and mock/DEX [n = 25]) were inoculated intranasally and intratracheally with the ISU-1 strain of PRCV (1 x 10(7) PFU) or cell culture medium. DEX was administered (once daily, 2 mg/kg of body weight/day, intramuscularly) from postinoculation day (PID) 1 to 6. In PRCV/DEX pigs, significantly milder pneumonia, fewer PRCV-positive cells, and lower viral RNA titers were present in lungs early at PID 2; however, at PID 4, 10, and 21, severe bronchointerstitial pneumonia, significantly higher numbers of PRCV-positive cells, and higher viral RNA titers were observed compared to results for PRCV/PBS pigs. Significantly lower numbers of CD2(+), CD3(+), CD4(+), and CD8(+) T cells were also observed in lungs of PRCV/DEX pigs than in those of PRCV/PBS pigs at PID 8 and 10, coincident with fewer gamma interferon (IFN-gamma)-secreting cells in the tracheobronchial lymph nodes as determined by enzyme-linked immunospot assay. Our results confirm that DEX treatment alleviates PRCV pneumonia early (PID 2) in the infection but continued use through PID 6 exacerbates later stages of infection (PID 4, 10, and 21), possibly by decreasing cellular immune responses in the lungs (IFN-gamma-secreting T cells), thereby creating an environment for more-extensive viral replication. These data have potential implications for corticosteroid use with SARS-CoV patients and suggest a precaution against prolonged use based on their unproven efficacy in humans, including possible detrimental secondary effects.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jung</LastName><ForeName>Kwonil</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Ave., Wooster, Ohio 44691, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alekseev</LastName><ForeName>Konstantin P</ForeName><Initials>KP</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Xinsheng</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Cheon</LastName><ForeName>Doo-Sung</ForeName><Initials>DS</Initials></Author><Author ValidYN="Y"><LastName>Vlasova</LastName><ForeName>Anastasia N</ForeName><Initials>AN</Initials></Author><Author ValidYN="Y"><LastName>Saif</LastName><ForeName>Linda J</ForeName><Initials>LJ</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 AI060739</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2007</Year><Month>10</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Virol</MedlineTA><NlmUniqueID>0113724</NlmUniqueID><ISSNLinking>0022-538X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000305">Adrenal Cortex Hormones</NameOfSubstance></Chemical><Chemical><RegistryNumber>7S5I7G3JQL</RegistryNumber><NameOfSubstance UI="D003907">Dexamethasone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000305" MajorTopicYN="N">Adrenal Cortex Hormones</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003907" MajorTopicYN="Y">Dexamethasone</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="Y">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007165" MajorTopicYN="Y">Immunosuppression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045722" MajorTopicYN="N">Porcine Respiratory Coronavirus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013552" MajorTopicYN="N">Swine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013553" MajorTopicYN="N">Swine Diseases</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>10</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>12</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>10</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17942563</ArticleId><ArticleId IdType="pii">JVI.01702-07</ArticleId><ArticleId IdType="doi">10.1128/JVI.01702-07</ArticleId><ArticleId IdType="pmc">PMC2168842</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>N Engl J Med. 2003 May 15;348(20):2034-5; author reply 2034-5</Citation><ArticleIdList><ArticleId IdType="pubmed">12748321</ArticleId></ArticleIdList></Reference><Reference><Citation>Virus Res. 2008 Apr;133(1):13-9</Citation><ArticleIdList><ArticleId IdType="pubmed">17374415</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2003 May 24;361(9371):1773-8</Citation><ArticleIdList><ArticleId IdType="pubmed">12781536</ArticleId></ArticleIdList></Reference><Reference><Citation>Intensive Care Med. 2003 Jun;29(6):870-5</Citation><ArticleIdList><ArticleId IdType="pubmed">12739014</ArticleId></ArticleIdList></Reference><Reference><Citation>J Pathol. 2003 Jul;200(3):282-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12845623</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2003 Jul 31;349(5):507-8</Citation><ArticleIdList><ArticleId IdType="pubmed">12890854</ArticleId></ArticleIdList></Reference><Reference><Citation>Vet Immunol Immunopathol. 2003 Aug 15;94(3-4):123-32</Citation><ArticleIdList><ArticleId IdType="pubmed">12909409</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Biol. 2003 Aug 29;331(5):991-1004</Citation><ArticleIdList><ArticleId IdType="pubmed">12927536</ArticleId></ArticleIdList></Reference><Reference><Citation>Hum Pathol. 2003 Aug;34(8):743-8</Citation><ArticleIdList><ArticleId IdType="pubmed">14506633</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2003 Oct 10;302(5643):276-8</Citation><ArticleIdList><ArticleId IdType="pubmed">12958366</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Intern Med. 2003 Nov 4;139(9):715-23</Citation><ArticleIdList><ArticleId IdType="pubmed">14597455</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Respir Crit Care Med. 2003 Dec 15;168(12):1449-56</Citation><ArticleIdList><ArticleId IdType="pubmed">12947028</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Pathol. 2004 Mar;57(3):260-5</Citation><ArticleIdList><ArticleId IdType="pubmed">14990596</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Chemother. 2004 Feb;10(1):1-7</Citation><ArticleIdList><ArticleId IdType="pubmed">14991510</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2004 Apr;10(4):368-73</Citation><ArticleIdList><ArticleId IdType="pubmed">15034574</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Clin Pathol. 2004 Apr;121(4):574-80</Citation><ArticleIdList><ArticleId IdType="pubmed">15080310</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Radiol. 2004 Jul;59(7):602-8</Citation><ArticleIdList><ArticleId IdType="pubmed">15208066</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Virol. 2004 Dec;31(4):304-9</Citation><ArticleIdList><ArticleId IdType="pubmed">15494274</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care. 2004 Apr;8(2):105-7</Citation><ArticleIdList><ArticleId IdType="pubmed">15515216</ArticleId></ArticleIdList></Reference><Reference><Citation>Infect Immun. 1972 Sep;6(3):289-301</Citation><ArticleIdList><ArticleId IdType="pubmed">4629259</ArticleId></ArticleIdList></Reference><Reference><Citation>Res Vet Sci. 1989 Jul;47(1):23-9</Citation><ArticleIdList><ArticleId IdType="pubmed">2549594</ArticleId></ArticleIdList></Reference><Reference><Citation>Res Vet Sci. 1990 Mar;48(2):165-9</Citation><ArticleIdList><ArticleId IdType="pubmed">2159175</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Vet Res. 1992 Jul;53(7):1253-8</Citation><ArticleIdList><ArticleId IdType="pubmed">1379786</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Vet Res. 1993 Feb;54(2):254-9</Citation><ArticleIdList><ArticleId IdType="pubmed">8381626</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 1993 May 1;150(9):3990-4000</Citation><ArticleIdList><ArticleId IdType="pubmed">8386204</ArticleId></ArticleIdList></Reference><Reference><Citation>J Vet Diagn Invest. 1993 Apr;5(2):184-8</Citation><ArticleIdList><ArticleId IdType="pubmed">8389599</ArticleId></ArticleIdList></Reference><Reference><Citation>Can Vet J. 1994 Feb;35(2):86-92</Citation><ArticleIdList><ArticleId IdType="pubmed">8069830</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Virol Suppl. 1996;12:153-61</Citation><ArticleIdList><ArticleId IdType="pubmed">9015112</ArticleId></ArticleIdList></Reference><Reference><Citation>Chest. 1998 Aug;114(2):426-31</Citation><ArticleIdList><ArticleId IdType="pubmed">9726725</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2000 May;81(Pt 5):1327-34</Citation><ArticleIdList><ArticleId IdType="pubmed">10769076</ArticleId></ArticleIdList></Reference><Reference><Citation>J Vet Diagn Invest. 2000 Jul;12(4):385-8</Citation><ArticleIdList><ArticleId IdType="pubmed">10907874</ArticleId></ArticleIdList></Reference><Reference><Citation>Antimicrob Agents Chemother. 2002 Jul;46(7):2299-302</Citation><ArticleIdList><ArticleId IdType="pubmed">12069994</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Pathol Lab Med. 2002 Sep;126(9):1064-70</Citation><ArticleIdList><ArticleId IdType="pubmed">12204055</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2003 Feb 20;348(8):683-93</Citation><ArticleIdList><ArticleId IdType="pubmed">12594312</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Microbiol. 2003 May;41(5):1936-41</Citation><ArticleIdList><ArticleId IdType="pubmed">12734230</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2003 May 10;361(9369):1615-7</Citation><ArticleIdList><ArticleId IdType="pubmed">12747883</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1953-66</Citation><ArticleIdList><ArticleId IdType="pubmed">12690092</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Virol. 1999;144(1):167-75</Citation><ArticleIdList><ArticleId IdType="pubmed">10076517</ArticleId></ArticleIdList></Reference><Reference><Citation>Res Vet Sci. 1999 Aug;67(1):47-52</Citation><ArticleIdList><ArticleId IdType="pubmed">10425240</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Infect Dis. 2004 Nov;4(11):663-71</Citation><ArticleIdList><ArticleId IdType="pubmed">15522678</ArticleId></ArticleIdList></Reference><Reference><Citation>Paediatr Respir Rev. 2004 Dec;5(4):270-4</Citation><ArticleIdList><ArticleId IdType="pubmed">15531250</ArticleId></ArticleIdList></Reference><Reference><Citation>Mod Pathol. 2005 Jan;18(1):1-10</Citation><ArticleIdList><ArticleId IdType="pubmed">15272286</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2005 Feb 15;191(4):503-6</Citation><ArticleIdList><ArticleId IdType="pubmed">15655772</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):797-801</Citation><ArticleIdList><ArticleId IdType="pubmed">15642942</ArticleId></ArticleIdList></Reference><Reference><Citation>Rev Sci Tech. 2004 Aug;23(2):643-60</Citation><ArticleIdList><ArticleId IdType="pubmed">15702725</ArticleId></ArticleIdList></Reference><Reference><Citation>Hematology. 2005 Apr;10(2):101-5</Citation><ArticleIdList><ArticleId IdType="pubmed">16019455</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect. 2005 Aug;51(2):98-102</Citation><ArticleIdList><ArticleId IdType="pubmed">16038758</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14040-5</Citation><ArticleIdList><ArticleId IdType="pubmed">16169905</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Clin Microbiol Infect Dis. 2005 Sep;24(9):583-91</Citation><ArticleIdList><ArticleId IdType="pubmed">16172857</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2005 Oct 28;310(5748):676-9</Citation><ArticleIdList><ArticleId IdType="pubmed">16195424</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Dec;79(23):14909-22</Citation><ArticleIdList><ArticleId IdType="pubmed">16282490</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurovirol. 2005 Oct;11(5):455-68</Citation><ArticleIdList><ArticleId IdType="pubmed">16287687</ArticleId></ArticleIdList></Reference><Reference><Citation>Hum Pathol. 2006 Apr;37(4):381-90</Citation><ArticleIdList><ArticleId IdType="pubmed">16564911</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Med. 2006 Dec;3(12):e525</Citation><ArticleIdList><ArticleId IdType="pubmed">17194199</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2007 Jan;3(1):e5</Citation><ArticleIdList><ArticleId IdType="pubmed">17222058</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2007 Aug;81(16):8692-706</Citation><ArticleIdList><ArticleId IdType="pubmed">17537853</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2003 May 30;300(5624):1394-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12730500</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D00 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 001D00 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:17942563
|texte= Altered pathogenesis of porcine respiratory coronavirus in pigs due to immunosuppressive effects of dexamethasone: implications for corticosteroid use in treatment of severe acute respiratory syndrome coronavirus.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:17942563" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |