[Detection of the mRNA expression of human angiotensin-converting enzyme 2 as a SARS coronavirus functional receptor in human femoral head].
Identifieur interne : 001B84 ( PubMed/Curation ); précédent : 001B83; suivant : 001B85[Detection of the mRNA expression of human angiotensin-converting enzyme 2 as a SARS coronavirus functional receptor in human femoral head].
Auteurs : Wei-Qiang Dong [République populaire de Chine] ; Bo Bai ; Yong-Ping Lin ; Jun Gao ; Nan-Sheng YuSource :
- Nan fang yi ke da xue xue bao = Journal of Southern Medical University [ 1673-4254 ] ; 2008.
Descripteurs français
- KwdFr :
- MESH :
- biosynthèse : ARN messager.
- génétique : ARN messager, Peptidyl-Dipeptidase A, Récepteurs viraux.
- métabolisme : Fractures du col fémoral, Tête du fémur, Virus du SRAS.
- Expression des gènes, Humains, RT-PCR.
English descriptors
- KwdEn :
- MESH :
- chemical , biosynthesis : RNA, Messenger.
- chemical , genetics : Peptidyl-Dipeptidase A, RNA, Messenger, Receptors, Virus.
- metabolism : Femoral Neck Fractures, Femur Head, SARS Virus.
- Gene Expression, Humans, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
To investigate the mRNA expression of severe acute respiratory syndrome-associated coronavirus (SARS-COV) functional receptor, angiotensin-converting enzyme 2 (ACE2), in human femoral head and conjunctiva, and explore the possible entry route of SARS-COV in human femoral head.
PubMed: 18359708
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pubmed:18359708Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Detection of the mRNA expression of human angiotensin-converting enzyme 2 as a SARS coronavirus functional receptor in human femoral head].</title><author><name sortKey="Dong, Wei Qiang" sort="Dong, Wei Qiang" uniqKey="Dong W" first="Wei-Qiang" last="Dong">Wei-Qiang Dong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Orthopedic Surgery, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Orthopedic Surgery, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120</wicri:regionArea></affiliation></author><author><name sortKey="Bai, Bo" sort="Bai, Bo" uniqKey="Bai B" first="Bo" last="Bai">Bo Bai</name></author><author><name sortKey="Lin, Yong Ping" sort="Lin, Yong Ping" uniqKey="Lin Y" first="Yong-Ping" last="Lin">Yong-Ping Lin</name></author><author><name sortKey="Gao, Jun" sort="Gao, Jun" uniqKey="Gao J" first="Jun" last="Gao">Jun Gao</name></author><author><name sortKey="Yu, Nan Sheng" sort="Yu, Nan Sheng" uniqKey="Yu N" first="Nan-Sheng" last="Yu">Nan-Sheng Yu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18359708</idno><idno type="pmid">18359708</idno><idno type="wicri:Area/PubMed/Corpus">001B84</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001B84</idno><idno type="wicri:Area/PubMed/Curation">001B84</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001B84</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Detection of the mRNA expression of human angiotensin-converting enzyme 2 as a SARS coronavirus functional receptor in human femoral head].</title><author><name sortKey="Dong, Wei Qiang" sort="Dong, Wei Qiang" uniqKey="Dong W" first="Wei-Qiang" last="Dong">Wei-Qiang Dong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Orthopedic Surgery, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Orthopedic Surgery, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120</wicri:regionArea></affiliation></author><author><name sortKey="Bai, Bo" sort="Bai, Bo" uniqKey="Bai B" first="Bo" last="Bai">Bo Bai</name></author><author><name sortKey="Lin, Yong Ping" sort="Lin, Yong Ping" uniqKey="Lin Y" first="Yong-Ping" last="Lin">Yong-Ping Lin</name></author><author><name sortKey="Gao, Jun" sort="Gao, Jun" uniqKey="Gao J" first="Jun" last="Gao">Jun Gao</name></author><author><name sortKey="Yu, Nan Sheng" sort="Yu, Nan Sheng" uniqKey="Yu N" first="Nan-Sheng" last="Yu">Nan-Sheng Yu</name></author></analytic><series><title level="j">Nan fang yi ke da xue xue bao = Journal of Southern Medical University</title><idno type="ISSN">1673-4254</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Femoral Neck Fractures (metabolism)</term><term>Femur Head (metabolism)</term><term>Gene Expression</term><term>Humans</term><term>Peptidyl-Dipeptidase A (genetics)</term><term>RNA, Messenger (biosynthesis)</term><term>RNA, Messenger (genetics)</term><term>Receptors, Virus (genetics)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>SARS Virus (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (biosynthèse)</term><term>ARN messager (génétique)</term><term>Expression des gènes</term><term>Fractures du col fémoral (métabolisme)</term><term>Humains</term><term>Peptidyl-Dipeptidase A (génétique)</term><term>RT-PCR</term><term>Récepteurs viraux (génétique)</term><term>Tête du fémur (métabolisme)</term><term>Virus du SRAS (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>RNA, Messenger</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Peptidyl-Dipeptidase A</term><term>RNA, Messenger</term><term>Receptors, Virus</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>ARN messager</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term><term>Peptidyl-Dipeptidase A</term><term>Récepteurs viraux</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Femoral Neck Fractures</term><term>Femur Head</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Fractures du col fémoral</term><term>Tête du fémur</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Gene Expression</term><term>Humans</term><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Expression des gènes</term><term>Humains</term><term>RT-PCR</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate the mRNA expression of severe acute respiratory syndrome-associated coronavirus (SARS-COV) functional receptor, angiotensin-converting enzyme 2 (ACE2), in human femoral head and conjunctiva, and explore the possible entry route of SARS-COV in human femoral head.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18359708</PMID><DateCompleted><Year>2009</Year><Month>04</Month><Day>02</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1673-4254</ISSN><JournalIssue CitedMedium="Print"><Volume>28</Volume><Issue>3</Issue><PubDate><Year>2008</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Nan fang yi ke da xue xue bao = Journal of Southern Medical University</Title><ISOAbbreviation>Nan Fang Yi Ke Da Xue Xue Bao</ISOAbbreviation></Journal><ArticleTitle>[Detection of the mRNA expression of human angiotensin-converting enzyme 2 as a SARS coronavirus functional receptor in human femoral head].</ArticleTitle><Pagination><MedlinePgn>441-3</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate the mRNA expression of severe acute respiratory syndrome-associated coronavirus (SARS-COV) functional receptor, angiotensin-converting enzyme 2 (ACE2), in human femoral head and conjunctiva, and explore the possible entry route of SARS-COV in human femoral head.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">ACE2 mRNA in human femoral head was detected by nested RT-PCR with human beta actin gene as the positive control.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The mRNA of human beta actin gene could be amplified efficiently in all the tissue samples. The mRNA of human ACE2 was expressed efficiently in the normal lung tissue, but not in the cartilage and cancellous bone under the weight-bearing area of the femoral head.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">SARS-COV can not infect the femoral head tissue and lead to avascular necrosis of the femoral head directly by the spike glycoprotein, and mechanism of the virus for causing avascular necrosis needs further investigation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dong</LastName><ForeName>Wei-qiang</ForeName><Initials>WQ</Initials><AffiliationInfo><Affiliation>Department of Orthopedic Surgery, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bai</LastName><ForeName>Bo</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Yong-ping</ForeName><Initials>YP</Initials></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Jun</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Nan-sheng</ForeName><Initials>NS</Initials></Author></AuthorList><Language>chi</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Nan Fang Yi Ke Da Xue Xue Bao</MedlineTA><NlmUniqueID>101266132</NlmUniqueID><ISSNLinking>1673-4254</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011991">Receptors, Virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C078034">coronavirus receptors</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.15.1</RegistryNumber><NameOfSubstance UI="D007703">Peptidyl-Dipeptidase A</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.17.-</RegistryNumber><NameOfSubstance UI="C413524">angiotensin converting enzyme 2</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D005265" MajorTopicYN="N">Femoral Neck Fractures</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005270" MajorTopicYN="N">Femur Head</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015870" MajorTopicYN="N">Gene Expression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007703" MajorTopicYN="N">Peptidyl-Dipeptidase A</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011991" MajorTopicYN="N">Receptors, Virus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>3</Month><Day>25</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>4</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>3</Month><Day>25</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18359708</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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