SrasV1, PubMed, Curation, bibRecord, 001866

Multifunctional nanoarchitectures from DNA-based ABC monomers.

Identifieur interne : 001866 ( PubMed/Curation ); précédent : 001865; suivant : 001867

Multifunctional nanoarchitectures from DNA-based ABC monomers.

Auteurs : Jong B. Lee [États-Unis] ; Young H. Roh ; Soong Ho Um ; Hisakage Funabashi ; Wenlong Cheng ; Judy J. Cha ; Pichamon Kiatwuthinon ; David A. Muller ; Dan Luo

Source :

Nature nanotechnology [ 1748-3395 ] ; 2009.

RBID : pubmed:19581895

Descripteurs français

KwdFr :
- ADN (), ADN (isolement et purification), ADN bactérien (), ADN bactérien (isolement et purification), ADN viral (), ADN viral (isolement et purification), Acrylates (), Bacillus anthracis (génétique), Boîtes quantiques, Cellules HeLa, Ebolavirus (génétique), Humains, Microscopie à force atomique, Nanocomposites (), Nanocomposites (ultrastructure), Nanotechnologie (), Polymères (), Polyéthylène glycols (), Processus photochimiques, Techniques de biocapteur (), Virus du SRAS (génétique).
MESH :
- génétique : Bacillus anthracis, Ebolavirus, Virus du SRAS.
- isolement et purification : ADN, ADN bactérien, ADN viral.
- ADN, ADN bactérien, ADN viral, Acrylates, Boîtes quantiques, Cellules HeLa, Humains, Microscopie à force atomique, Nanocomposites, Nanotechnologie, Polymères, Polyéthylène glycols, Processus photochimiques, Techniques de biocapteur.

English descriptors

KwdEn :
- Acrylates (chemistry), Bacillus anthracis (genetics), Biosensing Techniques (methods), DNA (chemistry), DNA (isolation & purification), DNA, Bacterial (chemistry), DNA, Bacterial (isolation & purification), DNA, Viral (chemistry), DNA, Viral (isolation & purification), Ebolavirus (genetics), HeLa Cells, Humans, Microscopy, Atomic Force, Nanocomposites (chemistry), Nanocomposites (ultrastructure), Nanotechnology (methods), Photochemical Processes, Polyethylene Glycols (chemistry), Polymers (chemistry), Quantum Dots, SARS Virus (genetics).
MESH :
- chemical , chemistry : Acrylates, DNA, DNA, Bacterial, DNA, Viral, Polyethylene Glycols, Polymers.
- chemistry : Nanocomposites.
- genetics : Bacillus anthracis, Ebolavirus, SARS Virus.
- chemical , isolation & purification : DNA, DNA, Bacterial, DNA, Viral.
- methods : Biosensing Techniques, Nanotechnology.
- ultrastructure : Nanocomposites.
- HeLa Cells, Humans, Microscopy, Atomic Force, Photochemical Processes, Quantum Dots.

Abstract

The ability to attach different functional moieties to a molecular building block could lead to applications in nanoelectronics, nanophotonics, intelligent sensing and drug delivery. The building unit needs to be both multivalent and anisotropic, and although many anisotropic building blocks have been created, these have not been universally applicable. Recently, DNA has been used to generate various nanostructures or hybrid systems, and as a generic building block for various applications. Here, we report the creation of anisotropic, branched and crosslinkable building blocks (ABC monomers) from which multifunctional nanoarchitectures have been assembled. In particular, we demonstrate a target-driven polymerization process in which polymers are generated only in the presence of a specific DNA molecule, leading to highly sensitive pathogen detection. Using this monomer system, we have also designed a biocompatible nanovector that delivers both drugs and tracers simultaneously. Our approach provides a general yet versatile route towards the creation of a range of multifunctional nanoarchitectures.

DOI: 10.1038/nnano.2009.93
PubMed: 19581895

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Le document en format XML

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<front><div type="abstract" xml:lang="en">The ability to attach different functional moieties to a molecular building block could lead to applications in nanoelectronics, nanophotonics, intelligent sensing and drug delivery. The building unit needs to be both multivalent and anisotropic, and although many anisotropic building blocks have been created, these have not been universally applicable. Recently, DNA has been used to generate various nanostructures or hybrid systems, and as a generic building block for various applications. Here, we report the creation of anisotropic, branched and crosslinkable building blocks (ABC monomers) from which multifunctional nanoarchitectures have been assembled. In particular, we demonstrate a target-driven polymerization process in which polymers are generated only in the presence of a specific DNA molecule, leading to highly sensitive pathogen detection. Using this monomer system, we have also designed a biocompatible nanovector that delivers both drugs and tracers simultaneously. Our approach provides a general yet versatile route towards the creation of a range of multifunctional nanoarchitectures.</div>
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Multifunctional nanoarchitectures from DNA-based ABC monomers.

Multifunctional nanoarchitectures from DNA-based ABC monomers.

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