Viral loads in clinical specimens and SARS manifestations.
Identifieur interne : 001709 ( PubMed/Curation ); précédent : 001708; suivant : 001710Viral loads in clinical specimens and SARS manifestations.
Auteurs : I F N. Hung [République populaire de Chine] ; S K P. Lau ; P C Y. Woo ; K Y YuenSource :
- Hong Kong medical journal = Xianggang yi xue za zhi [ 1024-2708 ] ; 2009.
Descripteurs français
- KwdFr :
- ARN viral (métabolisme), Antiviraux (administration et posologie), Antiviraux (usage thérapeutique), Charge virale, Excrétion virale (), Facteurs temps, Flambées de maladies, Humains, Partie nasale du pharynx (virologie), Pronostic, RT-PCR, Syndrome respiratoire aigu sévère (physiopathologie), Syndrome respiratoire aigu sévère (traitement médicamenteux), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (isolement et purification), Études rétrospectives.
- MESH :
- administration et posologie : Antiviraux.
- isolement et purification : Virus du SRAS.
- métabolisme : ARN viral.
- physiopathologie : Syndrome respiratoire aigu sévère.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- usage thérapeutique : Antiviraux.
- virologie : Partie nasale du pharynx, Syndrome respiratoire aigu sévère.
- Charge virale, Excrétion virale, Facteurs temps, Flambées de maladies, Humains, Pronostic, RT-PCR, Études rétrospectives.
English descriptors
- KwdEn :
- Antiviral Agents (administration & dosage), Antiviral Agents (therapeutic use), Disease Outbreaks, Humans, Nasopharynx (virology), Prognosis, RNA, Viral (metabolism), Retrospective Studies, Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (physiopathology), Severe Acute Respiratory Syndrome (virology), Time Factors, Viral Load, Virus Shedding (drug effects).
- MESH :
- chemical , administration & dosage : Antiviral Agents.
- chemical , metabolism : RNA, Viral.
- chemical , therapeutic use : Antiviral Agents.
- drug effects : Virus Shedding.
- drug therapy : Severe Acute Respiratory Syndrome.
- isolation & purification : SARS Virus.
- physiopathology : Severe Acute Respiratory Syndrome.
- virology : Nasopharynx, Severe Acute Respiratory Syndrome.
- Disease Outbreaks, Humans, Prognosis, Retrospective Studies, Reverse Transcriptase Polymerase Chain Reaction, Time Factors, Viral Load.
Abstract
1. A high viral load in nasopharyngeal aspirate (with or without a high viral load in serum) is a useful prognostic indicator of respiratory failure or mortality. The presence of viral RNA in multiple body sites is also indicative of poor prognosis. 2. Early treatment with an effective antiviral agent before day 10 may decrease the peak viral load, and thus ameliorate the clinical symptoms and mortality, and reduce viral shedding and the risk of transmission
PubMed: 20393220
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<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, The University of Hong Kong, Queen Mary Hospital Compound, Pokfulam Road, Hong Kong SAR, China. ivanhung@hku.hk</nlm:affiliation>
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<wicri:regionArea>Department of Microbiology, The University of Hong Kong, Queen Mary Hospital Compound, Pokfulam Road, Hong Kong SAR</wicri:regionArea>
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<author><name sortKey="Lau, S K P" sort="Lau, S K P" uniqKey="Lau S" first="S K P" last="Lau">S K P. Lau</name>
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<term>Reverse Transcriptase Polymerase Chain Reaction</term>
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<term>Flambées de maladies</term>
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<front><div type="abstract" xml:lang="en">1. A high viral load in nasopharyngeal aspirate (with or without a high viral load in serum) is a useful prognostic indicator of respiratory failure or mortality. The presence of viral RNA in multiple body sites is also indicative of poor prognosis. 2. Early treatment with an effective antiviral agent before day 10 may decrease the peak viral load, and thus ameliorate the clinical symptoms and mortality, and reduce viral shedding and the risk of transmission</div>
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