Identification of common biological pathways and drug targets across multiple respiratory viruses based on human host gene expression analysis.
Identifieur interne : 001384 ( PubMed/Curation ); précédent : 001383; suivant : 001385Identification of common biological pathways and drug targets across multiple respiratory viruses based on human host gene expression analysis.
Auteurs : Steven B. Smith [États-Unis] ; William Dampier ; Aydin Tozeren ; James R. Brown ; Michal Magid-SlavSource :
- PloS one [ 1932-6203 ] ; 2012.
Descripteurs français
- KwdFr :
- ARN messager (génétique), ARN messager (métabolisme), Analyse de profil d'expression de gènes, Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Bases de données génétiques, Contrôle de qualité, Humains, Infections à virus respiratoire syncytial (génétique), Infections à virus respiratoire syncytial (traitement médicamenteux), Infections à virus respiratoire syncytial (virologie), Interactions hôte-pathogène (), Interactions hôte-pathogène (génétique), Proteasome endopeptidase complex (métabolisme), Régulation de l'expression des gènes viraux (), Séquençage par oligonucléotides en batterie, Thérapie moléculaire ciblée, Transduction du signal (), Transduction du signal (génétique), Ubiquitin-protein ligases (métabolisme), Ubiquitine (métabolisme), Virus respiratoires syncytiaux (), Virus respiratoires syncytiaux (physiologie).
- MESH :
- génétique : ARN messager, Infections à virus respiratoire syncytial, Interactions hôte-pathogène, Transduction du signal.
- métabolisme : ARN messager, Proteasome endopeptidase complex, Ubiquitin-protein ligases, Ubiquitine.
- pharmacologie : Antiviraux.
- physiologie : Virus respiratoires syncytiaux.
- traitement médicamenteux : Infections à virus respiratoire syncytial.
- usage thérapeutique : Antiviraux.
- virologie : Infections à virus respiratoire syncytial.
- Analyse de profil d'expression de gènes, Bases de données génétiques, Contrôle de qualité, Humains, Interactions hôte-pathogène, Régulation de l'expression des gènes viraux, Séquençage par oligonucléotides en batterie, Thérapie moléculaire ciblée, Transduction du signal, Virus respiratoires syncytiaux.
English descriptors
- KwdEn :
- Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Databases, Genetic, Gene Expression Profiling, Gene Expression Regulation, Viral (drug effects), Host-Pathogen Interactions (drug effects), Host-Pathogen Interactions (genetics), Humans, Molecular Targeted Therapy, Oligonucleotide Array Sequence Analysis, Proteasome Endopeptidase Complex (metabolism), Quality Control, RNA, Messenger (genetics), RNA, Messenger (metabolism), Respiratory Syncytial Virus Infections (drug therapy), Respiratory Syncytial Virus Infections (genetics), Respiratory Syncytial Virus Infections (virology), Respiratory Syncytial Viruses (drug effects), Respiratory Syncytial Viruses (physiology), Signal Transduction (drug effects), Signal Transduction (genetics), Ubiquitin (metabolism), Ubiquitin-Protein Ligases (metabolism).
- MESH :
- chemical , genetics : RNA, Messenger.
- chemical , metabolism : Proteasome Endopeptidase Complex, RNA, Messenger, Ubiquitin, Ubiquitin-Protein Ligases.
- chemical , pharmacology : Antiviral Agents.
- chemical , therapeutic use : Antiviral Agents.
- drug effects : Gene Expression Regulation, Viral, Host-Pathogen Interactions, Respiratory Syncytial Viruses, Signal Transduction.
- drug therapy : Respiratory Syncytial Virus Infections.
- genetics : Host-Pathogen Interactions, Respiratory Syncytial Virus Infections, Signal Transduction.
- physiology : Respiratory Syncytial Viruses.
- virology : Respiratory Syncytial Virus Infections.
- Databases, Genetic, Gene Expression Profiling, Humans, Molecular Targeted Therapy, Oligonucleotide Array Sequence Analysis, Quality Control.
Abstract
Pandemic and seasonal respiratory viruses are a major global health concern. Given the genetic diversity of respiratory viruses and the emergence of drug resistant strains, the targeted disruption of human host-virus interactions is a potential therapeutic strategy for treating multi-viral infections. The availability of large-scale genomic datasets focused on host-pathogen interactions can be used to discover novel drug targets as well as potential opportunities for drug repositioning.
DOI: 10.1371/journal.pone.0033174
PubMed: 22432004
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001384
Links to Exploration step
pubmed:22432004Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Identification of common biological pathways and drug targets across multiple respiratory viruses based on human host gene expression analysis.</title><author><name sortKey="Smith, Steven B" sort="Smith, Steven B" uniqKey="Smith S" first="Steven B" last="Smith">Steven B. Smith</name><affiliation wicri:level="1"><nlm:affiliation>Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea></affiliation></author><author><name sortKey="Dampier, William" sort="Dampier, William" uniqKey="Dampier W" first="William" last="Dampier">William Dampier</name></author><author><name sortKey="Tozeren, Aydin" sort="Tozeren, Aydin" uniqKey="Tozeren A" first="Aydin" last="Tozeren">Aydin Tozeren</name></author><author><name sortKey="Brown, James R" sort="Brown, James R" uniqKey="Brown J" first="James R" last="Brown">James R. Brown</name></author><author><name sortKey="Magid Slav, Michal" sort="Magid Slav, Michal" uniqKey="Magid Slav M" first="Michal" last="Magid-Slav">Michal Magid-Slav</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22432004</idno><idno type="pmid">22432004</idno><idno type="doi">10.1371/journal.pone.0033174</idno><idno type="wicri:Area/PubMed/Corpus">001384</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001384</idno><idno type="wicri:Area/PubMed/Curation">001384</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001384</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Identification of common biological pathways and drug targets across multiple respiratory viruses based on human host gene expression analysis.</title><author><name sortKey="Smith, Steven B" sort="Smith, Steven B" uniqKey="Smith S" first="Steven B" last="Smith">Steven B. Smith</name><affiliation wicri:level="1"><nlm:affiliation>Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea></affiliation></author><author><name sortKey="Dampier, William" sort="Dampier, William" uniqKey="Dampier W" first="William" last="Dampier">William Dampier</name></author><author><name sortKey="Tozeren, Aydin" sort="Tozeren, Aydin" uniqKey="Tozeren A" first="Aydin" last="Tozeren">Aydin Tozeren</name></author><author><name sortKey="Brown, James R" sort="Brown, James R" uniqKey="Brown J" first="James R" last="Brown">James R. Brown</name></author><author><name sortKey="Magid Slav, Michal" sort="Magid Slav, Michal" uniqKey="Magid Slav M" first="Michal" last="Magid-Slav">Michal Magid-Slav</name></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (pharmacology)</term><term>Antiviral Agents (therapeutic use)</term><term>Databases, Genetic</term><term>Gene Expression Profiling</term><term>Gene Expression Regulation, Viral (drug effects)</term><term>Host-Pathogen Interactions (drug effects)</term><term>Host-Pathogen Interactions (genetics)</term><term>Humans</term><term>Molecular Targeted Therapy</term><term>Oligonucleotide Array Sequence Analysis</term><term>Proteasome Endopeptidase Complex (metabolism)</term><term>Quality Control</term><term>RNA, Messenger (genetics)</term><term>RNA, Messenger (metabolism)</term><term>Respiratory Syncytial Virus Infections (drug therapy)</term><term>Respiratory Syncytial Virus Infections (genetics)</term><term>Respiratory Syncytial Virus Infections (virology)</term><term>Respiratory Syncytial Viruses (drug effects)</term><term>Respiratory Syncytial Viruses (physiology)</term><term>Signal Transduction (drug effects)</term><term>Signal Transduction (genetics)</term><term>Ubiquitin (metabolism)</term><term>Ubiquitin-Protein Ligases (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (génétique)</term><term>ARN messager (métabolisme)</term><term>Analyse de profil d'expression de gènes</term><term>Antiviraux (pharmacologie)</term><term>Antiviraux (usage thérapeutique)</term><term>Bases de données génétiques</term><term>Contrôle de qualité</term><term>Humains</term><term>Infections à virus respiratoire syncytial (génétique)</term><term>Infections à virus respiratoire syncytial (traitement médicamenteux)</term><term>Infections à virus respiratoire syncytial (virologie)</term><term>Interactions hôte-pathogène ()</term><term>Interactions hôte-pathogène (génétique)</term><term>Proteasome endopeptidase complex (métabolisme)</term><term>Régulation de l'expression des gènes viraux ()</term><term>Séquençage par oligonucléotides en batterie</term><term>Thérapie moléculaire ciblée</term><term>Transduction du signal ()</term><term>Transduction du signal (génétique)</term><term>Ubiquitin-protein ligases (métabolisme)</term><term>Ubiquitine (métabolisme)</term><term>Virus respiratoires syncytiaux ()</term><term>Virus respiratoires syncytiaux (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Messenger</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Proteasome Endopeptidase Complex</term><term>RNA, Messenger</term><term>Ubiquitin</term><term>Ubiquitin-Protein Ligases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gene Expression Regulation, Viral</term><term>Host-Pathogen Interactions</term><term>Respiratory Syncytial Viruses</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Respiratory Syncytial Virus Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Host-Pathogen Interactions</term><term>Respiratory Syncytial Virus Infections</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term><term>Infections à virus respiratoire syncytial</term><term>Interactions hôte-pathogène</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term><term>Proteasome endopeptidase complex</term><term>Ubiquitin-protein ligases</term><term>Ubiquitine</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus respiratoires syncytiaux</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Respiratory Syncytial Viruses</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à virus respiratoire syncytial</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à virus respiratoire syncytial</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Respiratory Syncytial Virus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Databases, Genetic</term><term>Gene Expression Profiling</term><term>Humans</term><term>Molecular Targeted Therapy</term><term>Oligonucleotide Array Sequence Analysis</term><term>Quality Control</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term><term>Bases de données génétiques</term><term>Contrôle de qualité</term><term>Humains</term><term>Interactions hôte-pathogène</term><term>Régulation de l'expression des gènes viraux</term><term>Séquençage par oligonucléotides en batterie</term><term>Thérapie moléculaire ciblée</term><term>Transduction du signal</term><term>Virus respiratoires syncytiaux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pandemic and seasonal respiratory viruses are a major global health concern. Given the genetic diversity of respiratory viruses and the emergence of drug resistant strains, the targeted disruption of human host-virus interactions is a potential therapeutic strategy for treating multi-viral infections. The availability of large-scale genomic datasets focused on host-pathogen interactions can be used to discover novel drug targets as well as potential opportunities for drug repositioning.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22432004</PMID><DateCompleted><Year>2012</Year><Month>07</Month><Day>13</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><Issue>3</Issue><PubDate><Year>2012</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Identification of common biological pathways and drug targets across multiple respiratory viruses based on human host gene expression analysis.</ArticleTitle><Pagination><MedlinePgn>e33174</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0033174</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Pandemic and seasonal respiratory viruses are a major global health concern. Given the genetic diversity of respiratory viruses and the emergence of drug resistant strains, the targeted disruption of human host-virus interactions is a potential therapeutic strategy for treating multi-viral infections. The availability of large-scale genomic datasets focused on host-pathogen interactions can be used to discover novel drug targets as well as potential opportunities for drug repositioning.</AbstractText><AbstractText Label="METHODS/RESULTS" NlmCategory="RESULTS">In this study, we performed a large-scale analysis of microarray datasets involving host response to infections by influenza A virus, respiratory syncytial virus, rhinovirus, SARS-coronavirus, metapneumonia virus, coxsackievirus and cytomegalovirus. Common genes and pathways were found through a rigorous, iterative analysis pipeline where relevant host mRNA expression datasets were identified, analyzed for quality and gene differential expression, then mapped to pathways for enrichment analysis. Possible repurposed drugs targets were found through database and literature searches. A total of 67 common biological pathways were identified among the seven different respiratory viruses analyzed, representing fifteen laboratories, nine different cell types, and seven different array platforms. A large overlap in the general immune response was observed among the top twenty of these 67 pathways, adding validation to our analysis strategy. Of the top five pathways, we found 53 differentially expressed genes affected by at least five of the seven viruses. We suggest five new therapeutic indications for existing small molecules or biological agents targeting proteins encoded by the genes F3, IL1B, TNF, CASP1 and MMP9. Pathway enrichment analysis also identified a potential novel host response, the Parkin-Ubiquitin Proteasomal System (Parkin-UPS) pathway, which is known to be involved in the progression of neurodegenerative Parkinson's disease.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our study suggests that multiple and diverse respiratory viruses invoke several common host response pathways. Further analysis of these pathways suggests potential opportunities for therapeutic intervention.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Steven B</ForeName><Initials>SB</Initials><AffiliationInfo><Affiliation>Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dampier</LastName><ForeName>William</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Tozeren</LastName><ForeName>Aydin</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Brown</LastName><ForeName>James R</ForeName><Initials>JR</Initials></Author><Author ValidYN="Y"><LastName>Magid-Slav</LastName><ForeName>Michal</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>03</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D025801">Ubiquitin</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.3.2.27</RegistryNumber><NameOfSubstance UI="D044767">Ubiquitin-Protein Ligases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.3.2.27</RegistryNumber><NameOfSubstance UI="C111567">parkin protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.25.1</RegistryNumber><NameOfSubstance UI="D046988">Proteasome Endopeptidase Complex</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D030541" MajorTopicYN="N">Databases, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020869" MajorTopicYN="Y">Gene Expression Profiling</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015967" MajorTopicYN="N">Gene Expression Regulation, Viral</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D054884" MajorTopicYN="N">Host-Pathogen Interactions</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058990" MajorTopicYN="Y">Molecular Targeted Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020411" MajorTopicYN="N">Oligonucleotide Array Sequence Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D046988" MajorTopicYN="N">Proteasome Endopeptidase Complex</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011786" MajorTopicYN="N">Quality Control</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018357" MajorTopicYN="N">Respiratory Syncytial Virus Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012136" MajorTopicYN="N">Respiratory Syncytial Viruses</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D025801" MajorTopicYN="N">Ubiquitin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044767" MajorTopicYN="N">Ubiquitin-Protein Ligases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>10</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>02</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>3</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>3</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>7</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22432004</ArticleId><ArticleId IdType="doi">10.1371/journal.pone.0033174</ArticleId><ArticleId IdType="pii">PONE-D-11-20371</ArticleId><ArticleId IdType="pmc">PMC3303816</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>PLoS One. 2010;5(1):e8729</Citation><ArticleIdList><ArticleId IdType="pubmed">20090954</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurol. 2003 Oct;250 Suppl 3:III25-9</Citation><ArticleIdList><ArticleId IdType="pubmed">14579121</ArticleId></ArticleIdList></Reference><Reference><Citation>Drug Discov Today. 2011 Mar;16(5-6):229-36</Citation><ArticleIdList><ArticleId IdType="pubmed">21277381</ArticleId></ArticleIdList></Reference><Reference><Citation>Mucosal Immunol. 2010 Jan;3(1):69-80</Citation><ArticleIdList><ArticleId IdType="pubmed">19710636</ArticleId></ArticleIdList></Reference><Reference><Citation>FEBS Lett. 2011 Jan 3;585(1):128-32</Citation><ArticleIdList><ArticleId IdType="pubmed">21094644</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Biotechnol. 2007 Dec;25(12):1383-9</Citation><ArticleIdList><ArticleId IdType="pubmed">18066032</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cell Biochem. 2011 Feb;112(2):559-70</Citation><ArticleIdList><ArticleId IdType="pubmed">21268077</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurochem. 2005 Apr;93(2):422-31</Citation><ArticleIdList><ArticleId IdType="pubmed">15816865</ArticleId></ArticleIdList></Reference><Reference><Citation>Braz J Med Biol Res. 2011 Nov;44(11):1134-40</Citation><ArticleIdList><ArticleId IdType="pubmed">22011961</ArticleId></ArticleIdList></Reference><Reference><Citation>Genomics. 2003 Feb;81(2):98-104</Citation><ArticleIdList><ArticleId IdType="pubmed">12620386</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Infect Dis. 2011;11:178</Citation><ArticleIdList><ArticleId IdType="pubmed">21696601</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2009;4(12):e8072</Citation><ArticleIdList><ArticleId IdType="pubmed">20011590</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2011 Feb;85(3):1360-9</Citation><ArticleIdList><ArticleId IdType="pubmed">21084488</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2006 Jan 1;34(Database issue):D668-72</Citation><ArticleIdList><ArticleId IdType="pubmed">16381955</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2010 Apr;84(7):3528-41</Citation><ArticleIdList><ArticleId IdType="pubmed">20071566</ArticleId></ArticleIdList></Reference><Reference><Citation>Infect Immun. 2011 Apr;79(4):1407-17</Citation><ArticleIdList><ArticleId IdType="pubmed">21245275</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cell Physiol. 2011 Dec;226(12):3316-29</Citation><ArticleIdList><ArticleId IdType="pubmed">21321939</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Exp Allergy. 2007 Apr;37(4):608-14</Citation><ArticleIdList><ArticleId IdType="pubmed">17430359</ArticleId></ArticleIdList></Reference><Reference><Citation>Neuron. 2003 Mar 6;37(5):735-49</Citation><ArticleIdList><ArticleId IdType="pubmed">12628165</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2007 Mar 1;178(5):3134-42</Citation><ArticleIdList><ArticleId IdType="pubmed">17312161</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurosci. 2003 Apr 15;23(8):3316-24</Citation><ArticleIdList><ArticleId IdType="pubmed">12716939</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Immunol. 2012 Feb;12(2):125-35</Citation><ArticleIdList><ArticleId IdType="pubmed">22222875</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2003 Jun 27;278(26):23376-80</Citation><ArticleIdList><ArticleId IdType="pubmed">12692130</ArticleId></ArticleIdList></Reference><Reference><Citation>Intern Med. 2011;50(15):1605-9</Citation><ArticleIdList><ArticleId IdType="pubmed">21804290</ArticleId></ArticleIdList></Reference><Reference><Citation>J Exp Med. 1997 Feb 3;185(3):461-9</Citation><ArticleIdList><ArticleId IdType="pubmed">9053446</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunology. 1992 Jan;75(1):189-95</Citation><ArticleIdList><ArticleId IdType="pubmed">1537596</ArticleId></ArticleIdList></Reference><Reference><Citation>Viral Immunol. 2009 Dec;22(6):343-51</Citation><ArticleIdList><ArticleId IdType="pubmed">19951172</ArticleId></ArticleIdList></Reference><Reference><Citation>Inflamm Allergy Drug Targets. 2011 Jun;10(3):171-9</Citation><ArticleIdList><ArticleId IdType="pubmed">21428909</ArticleId></ArticleIdList></Reference><Reference><Citation>EMBO J. 2011 Jul 20;30(14):2853-67</Citation><ArticleIdList><ArticleId IdType="pubmed">21694720</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2010;5(6):e11275</Citation><ArticleIdList><ArticleId IdType="pubmed">20585657</ArticleId></ArticleIdList></Reference><Reference><Citation>J Comput Aided Mol Des. 2009 Apr;23(4):195-8</Citation><ArticleIdList><ArticleId IdType="pubmed">19194660</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2009;4(9):e7162</Citation><ArticleIdList><ArticleId IdType="pubmed">19779614</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2008 Apr 25;374(1):114-27</Citation><ArticleIdList><ArticleId IdType="pubmed">18234263</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2001 Oct;7(10):1144-50</Citation><ArticleIdList><ArticleId IdType="pubmed">11590439</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6739-44</Citation><ArticleIdList><ArticleId IdType="pubmed">21502533</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2011 Jan 1;52 Suppl 1:S75-82</Citation><ArticleIdList><ArticleId IdType="pubmed">21342903</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2011 Mar 1;203(5):674-82</Citation><ArticleIdList><ArticleId IdType="pubmed">21208913</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Exp Immunol. 2011 Oct;166(1):1-15</Citation><ArticleIdList><ArticleId IdType="pubmed">21762124</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Microbiol. 2012 Feb;10(2):137-49</Citation><ArticleIdList><ArticleId IdType="pubmed">22183253</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Med. 2007 May;4(5):e176</Citation><ArticleIdList><ArticleId IdType="pubmed">17488182</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6</Citation><ArticleIdList><ArticleId IdType="pubmed">18048412</ArticleId></ArticleIdList></Reference><Reference><Citation>Wkly Epidemiol Rec. 2011 Mar 4;86(10):86-90</Citation><ArticleIdList><ArticleId IdType="pubmed">21395187</ArticleId></ArticleIdList></Reference><Reference><Citation>Respir Res. 2010;11:147</Citation><ArticleIdList><ArticleId IdType="pubmed">21029402</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2001 Jul 13;293(5528):263-9</Citation><ArticleIdList><ArticleId IdType="pubmed">11431533</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Respir Cell Mol Biol. 2011 Jun;44(6):906-13</Citation><ArticleIdList><ArticleId IdType="pubmed">20705938</ArticleId></ArticleIdList></Reference><Reference><Citation>Methods Mol Biol. 2009;563:177-96</Citation><ArticleIdList><ArticleId IdType="pubmed">19597786</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Biophys Res Commun. 2002 Oct 25;298(2):251-6</Citation><ArticleIdList><ArticleId IdType="pubmed">12387824</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2010 Dec;84(24):12895-902</Citation><ArticleIdList><ArticleId IdType="pubmed">20926560</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Immunol. 2003 Jun;107(3):178-85</Citation><ArticleIdList><ArticleId IdType="pubmed">12804531</ArticleId></ArticleIdList></Reference><Reference><Citation>J Allergy Clin Immunol. 1997 Jan;99(1 Pt 1):28-37</Citation><ArticleIdList><ArticleId IdType="pubmed">9003208</ArticleId></ArticleIdList></Reference><Reference><Citation>Circ Shock. 1992 Mar;36(3):200-7</Citation><ArticleIdList><ArticleId IdType="pubmed">1611705</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Med Chem. 2007;14(18):1966-77</Citation><ArticleIdList><ArticleId IdType="pubmed">17691939</ArticleId></ArticleIdList></Reference><Reference><Citation>Methods Mol Biol. 2007;356:319-50</Citation><ArticleIdList><ArticleId IdType="pubmed">16988414</ArticleId></ArticleIdList></Reference><Reference><Citation>J Interferon Cytokine Res. 2011 Jan;31(1):5-11</Citation><ArticleIdList><ArticleId IdType="pubmed">21226606</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2009 Apr;83(7):3039-48</Citation><ArticleIdList><ArticleId IdType="pubmed">19004938</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Immunol. 2010 Feb;22(1):55-62</Citation><ArticleIdList><ArticleId IdType="pubmed">20137905</ArticleId></ArticleIdList></Reference><Reference><Citation>J Thromb Haemost. 2011 Jul;9 Suppl 1:182-8</Citation><ArticleIdList><ArticleId IdType="pubmed">21781254</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2011 Jun;85(12):5718-32</Citation><ArticleIdList><ArticleId IdType="pubmed">21471247</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Respir Crit Care Med. 2008 Nov 1;178(9):962-8</Citation><ArticleIdList><ArticleId IdType="pubmed">18658112</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2004 Feb 12;427(6975):636-40</Citation><ArticleIdList><ArticleId IdType="pubmed">14737177</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Bioinformatics. 2010;11:483</Citation><ArticleIdList><ArticleId IdType="pubmed">20875095</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunopharmacology. 1996 Mar;31(2-3):223-35</Citation><ArticleIdList><ArticleId IdType="pubmed">8861748</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Immunol. 2005;6:2</Citation><ArticleIdList><ArticleId IdType="pubmed">15655079</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Host Microbe. 2009 Sep 17;6(3):207-17</Citation><ArticleIdList><ArticleId IdType="pubmed">19664979</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Cardiol. 1997 Dec 1;62 Suppl 1:S3-12</Citation><ArticleIdList><ArticleId IdType="pubmed">9464576</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Cancer. 2011 Jun 15;128(12):2881-91</Citation><ArticleIdList><ArticleId IdType="pubmed">21165954</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochim Biophys Acta. 2009 Jul;1792(7):714-21</Citation><ArticleIdList><ArticleId IdType="pubmed">18760350</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2010;6(9):e1001099</Citation><ArticleIdList><ArticleId IdType="pubmed">20844577</ArticleId></ArticleIdList></Reference><Reference><Citation>Chin Med J (Engl). 2007 Jan 5;120(1):5-11</Citation><ArticleIdList><ArticleId IdType="pubmed">17254480</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2010 Mar 15;184(6):3213-22</Citation><ArticleIdList><ArticleId IdType="pubmed">20173022</ArticleId></ArticleIdList></Reference><Reference><Citation>Neurobiol Dis. 2003 Dec;14(3):357-64</Citation><ArticleIdList><ArticleId IdType="pubmed">14678753</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13354-9</Citation><ArticleIdList><ArticleId IdType="pubmed">11078524</ArticleId></ArticleIdList></Reference><Reference><Citation>Expert Opin Biol Ther. 2009 Sep;9(9):1177-88</Citation><ArticleIdList><ArticleId IdType="pubmed">19604125</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Microbiol. 2008;62:171-92</Citation><ArticleIdList><ArticleId IdType="pubmed">18729734</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 1996 Feb 15;97(4):915-24</Citation><ArticleIdList><ArticleId IdType="pubmed">8613544</ArticleId></ArticleIdList></Reference><Reference><Citation>Hum Mol Genet. 2003 Nov 15;12(22):2957-65</Citation><ArticleIdList><ArticleId IdType="pubmed">14519684</ArticleId></ArticleIdList></Reference><Reference><Citation>Future Virol. 2011 Aug;6(8):951-962</Citation><ArticleIdList><ArticleId IdType="pubmed">21909336</ArticleId></ArticleIdList></Reference><Reference><Citation>Genomic Med. 2008 Dec;2(3-4):113-25</Citation><ArticleIdList><ArticleId IdType="pubmed">19459069</ArticleId></ArticleIdList></Reference><Reference><Citation>J Postgrad Med. 2011 Apr-Jun;57(2):153-60</Citation><ArticleIdList><ArticleId IdType="pubmed">21654146</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Respir Cell Mol Biol. 2010 Apr;42(4):404-14</Citation><ArticleIdList><ArticleId IdType="pubmed">19502390</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Exp Immunol. 2006 Jun;144(3):425-31</Citation><ArticleIdList><ArticleId IdType="pubmed">16734611</ArticleId></ArticleIdList></Reference><Reference><Citation>Pediatrics. 2009 Dec;124(6):1676-9</Citation><ArticleIdList><ArticleId IdType="pubmed">19948632</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Dev Immunol. 2011;2011:103917</Citation><ArticleIdList><ArticleId IdType="pubmed">21234380</ArticleId></ArticleIdList></Reference><Reference><Citation>J Pharmacol Exp Ther. 1995 Mar;272(3):1313-20</Citation><ArticleIdList><ArticleId IdType="pubmed">7891349</ArticleId></ArticleIdList></Reference><Reference><Citation>Vet J. 2011 Jan;187(1):48-53</Citation><ArticleIdList><ArticleId IdType="pubmed">20097110</ArticleId></ArticleIdList></Reference><Reference><Citation>Retrovirology. 2005;2:24</Citation><ArticleIdList><ArticleId IdType="pubmed">15813969</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Pharmacol. 1997 Nov 27;339(2-3):215-21</Citation><ArticleIdList><ArticleId IdType="pubmed">9473138</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2011;6(4):e18928</Citation><ArticleIdList><ArticleId IdType="pubmed">21533115</ArticleId></ArticleIdList></Reference><Reference><Citation>J Pharmacol Exp Ther. 2000 Aug;294(2):701-6</Citation><ArticleIdList><ArticleId IdType="pubmed">10900250</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Immunol. 1994;12:881-922</Citation><ArticleIdList><ArticleId IdType="pubmed">7516669</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14063-8</Citation><ArticleIdList><ArticleId IdType="pubmed">19667183</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Signal. 2008;1(29):re8</Citation><ArticleIdList><ArticleId IdType="pubmed">18648074</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 1995 Jul;96(1):549-57</Citation><ArticleIdList><ArticleId IdType="pubmed">7615827</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Immunol. 2012 Jan;12(1):35-48</Citation><ArticleIdList><ArticleId IdType="pubmed">22158412</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Exp Allergy. 2003 Jun;33(6):795-801</Citation><ArticleIdList><ArticleId IdType="pubmed">12801315</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Microbiol Rev. 2008 Apr;21(2):274-90, table of contents</Citation><ArticleIdList><ArticleId IdType="pubmed">18400797</ArticleId></ArticleIdList></Reference><Reference><Citation>Travel Med Infect Dis. 2008 May;6(3):114-24</Citation><ArticleIdList><ArticleId IdType="pubmed">18486065</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 2001 Jun;17(6):520-5</Citation><ArticleIdList><ArticleId IdType="pubmed">11395428</ArticleId></ArticleIdList></Reference><Reference><Citation>J Interferon Cytokine Res. 2011 Jan;31(1):119-30</Citation><ArticleIdList><ArticleId IdType="pubmed">21190487</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2011 Apr;7(4):e1002016</Citation><ArticleIdList><ArticleId IdType="pubmed">21533215</ArticleId></ArticleIdList></Reference><Reference><Citation>Pediatr Neurol. 2011 Jan;44(1):47-51</Citation><ArticleIdList><ArticleId IdType="pubmed">21147387</ArticleId></ArticleIdList></Reference><Reference><Citation>Pharmacol Rep. 2010 Nov-Dec;62(6):1148-58</Citation><ArticleIdList><ArticleId IdType="pubmed">21273672</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2001 Dec;75(24):12319-30</Citation><ArticleIdList><ArticleId IdType="pubmed">11711622</ArticleId></ArticleIdList></Reference><Reference><Citation>Genomics. 2010 Mar;95(3):138-42</Citation><ArticleIdList><ArticleId IdType="pubmed">20079422</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncologist. 2001;6(1):34-55</Citation><ArticleIdList><ArticleId IdType="pubmed">11161227</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2011;6(5):e20495</Citation><ArticleIdList><ArticleId IdType="pubmed">21655265</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001384 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 001384 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:22432004
|texte= Identification of common biological pathways and drug targets across multiple respiratory viruses based on human host gene expression analysis.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:22432004" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |