SrasV1, PubMed, Curation, bibRecord, 001346

Feline infectious peritonitis virus with a large deletion in the 5'-terminal region of the spike gene retains its virulence for cats.

Identifieur interne : 001346 ( PubMed/Curation ); précédent : 001345; suivant : 001347

Feline infectious peritonitis virus with a large deletion in the 5'-terminal region of the spike gene retains its virulence for cats.

Auteurs : Yutaka Terada [Japon] ; Yuto Shiozaki [Japon] ; Hiroshi Shimoda [Japon] ; Hassan Youssef Abdel Hamid Mahmoud [Japon] ; Keita Noguchi [Japon] ; Yumiko Nagao [Japon] ; Masayuki Shimojima [Japon] ; Hiroyuki Iwata [Japon] ; Takuya Mizuno [Japon] ; Masaru Okuda [Japon] ; Masahiro Morimoto [Japon] ; Toshiharu Hayashi [Japon] ; Yoshikazu Tanaka [Japon] ; Masami Mochizuki [Japon] ; Ken Maeda [Japon]

Source :

The Journal of general virology [ 1465-2099 ] ; 2012.

RBID : pubmed:22718568

Descripteurs français

English descriptors

KwdEn :
- Amino Acid Motifs, Animals, Cats, Coronavirus, Feline (chemistry), Coronavirus, Feline (genetics), Coronavirus, Feline (metabolism), Coronavirus, Feline (pathogenicity), Feline Infectious Peritonitis (virology), Male, Membrane Glycoproteins (chemistry), Membrane Glycoproteins (genetics), Membrane Glycoproteins (metabolism), Molecular Sequence Data, Sequence Deletion, Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (chemistry), Viral Envelope Proteins (genetics), Viral Envelope Proteins (metabolism), Virulence.
MESH :
- chemical , chemistry : Membrane Glycoproteins, Viral Envelope Proteins.
- chemistry : Coronavirus, Feline.
- genetics : Coronavirus, Feline, Membrane Glycoproteins, Viral Envelope Proteins.
- metabolism : Coronavirus, Feline, Membrane Glycoproteins, Viral Envelope Proteins.
- pathogenicity : Coronavirus, Feline.
- virology : Feline Infectious Peritonitis.
- Amino Acid Motifs, Animals, Cats, Male, Molecular Sequence Data, Sequence Deletion, Spike Glycoprotein, Coronavirus, Virulence.

Abstract

In this study, the Japanese strain of type I feline infectious peritonitis virus (FIPV), C3663, was found to have a large deletion of 735 bp within the gene encoding the spike (S) protein, with a deduced loss of 245 aa of the N-terminal region of the S protein. This deletion is similar to that observed in porcine respiratory coronavirus (PRCoV) when compared to transmissible gastroenteritis virus, which correlates with reduced virulence. By analogy to PRCoV, we expected that the pathogenicity of C3663 may be attenuated in cats. However, two of four cats inoculated with C3663 died of FIP, and a third C3663-inoculated cat showed FIP lesions at 91 days after challenge. These results indicate that the 5'-terminal region of the S gene is not essential for the development of FIP.

DOI: 10.1099/vir.0.043992-0
PubMed: 22718568

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<author><name sortKey="Mizuno, Takuya" sort="Mizuno, Takuya" uniqKey="Mizuno T" first="Takuya" last="Mizuno">Takuya Mizuno</name>
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<author><name sortKey="Terada, Yutaka" sort="Terada, Yutaka" uniqKey="Terada Y" first="Yutaka" last="Terada">Yutaka Terada</name>
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<author><name sortKey="Nagao, Yumiko" sort="Nagao, Yumiko" uniqKey="Nagao Y" first="Yumiko" last="Nagao">Yumiko Nagao</name>
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<country xml:lang="fr">Japon</country>
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<author><name sortKey="Shimojima, Masayuki" sort="Shimojima, Masayuki" uniqKey="Shimojima M" first="Masayuki" last="Shimojima">Masayuki Shimojima</name>
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<country xml:lang="fr">Japon</country>
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<author><name sortKey="Iwata, Hiroyuki" sort="Iwata, Hiroyuki" uniqKey="Iwata H" first="Hiroyuki" last="Iwata">Hiroyuki Iwata</name>
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<country xml:lang="fr">Japon</country>
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<author><name sortKey="Mizuno, Takuya" sort="Mizuno, Takuya" uniqKey="Mizuno T" first="Takuya" last="Mizuno">Takuya Mizuno</name>
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<country xml:lang="fr">Japon</country>
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<author><name sortKey="Okuda, Masaru" sort="Okuda, Masaru" uniqKey="Okuda M" first="Masaru" last="Okuda">Masaru Okuda</name>
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<country xml:lang="fr">Japon</country>
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<author><name sortKey="Morimoto, Masahiro" sort="Morimoto, Masahiro" uniqKey="Morimoto M" first="Masahiro" last="Morimoto">Masahiro Morimoto</name>
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<country xml:lang="fr">Japon</country>
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<author><name sortKey="Hayashi, Toshiharu" sort="Hayashi, Toshiharu" uniqKey="Hayashi T" first="Toshiharu" last="Hayashi">Toshiharu Hayashi</name>
<affiliation wicri:level="1"><nlm:affiliation>Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515</wicri:regionArea>
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<author><name sortKey="Tanaka, Yoshikazu" sort="Tanaka, Yoshikazu" uniqKey="Tanaka Y" first="Yoshikazu" last="Tanaka">Yoshikazu Tanaka</name>
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<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Veterinary Hygiene, Veterinary School, Nippon Veterinary and Life Science University, 1-7-1 Kyounan, Musashino, Tokyo 180-8602</wicri:regionArea>
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<author><name sortKey="Mochizuki, Masami" sort="Mochizuki, Masami" uniqKey="Mochizuki M" first="Masami" last="Mochizuki">Masami Mochizuki</name>
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<country xml:lang="fr">Japon</country>
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<term>Animals</term>
<term>Cats</term>
<term>Coronavirus, Feline (chemistry)</term>
<term>Coronavirus, Feline (genetics)</term>
<term>Coronavirus, Feline (metabolism)</term>
<term>Coronavirus, Feline (pathogenicity)</term>
<term>Feline Infectious Peritonitis (virology)</term>
<term>Male</term>
<term>Membrane Glycoproteins (chemistry)</term>
<term>Membrane Glycoproteins (genetics)</term>
<term>Membrane Glycoproteins (metabolism)</term>
<term>Molecular Sequence Data</term>
<term>Sequence Deletion</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Viral Envelope Proteins (chemistry)</term>
<term>Viral Envelope Proteins (genetics)</term>
<term>Viral Envelope Proteins (metabolism)</term>
<term>Virulence</term>
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<term>Chats</term>
<term>Coronavirus félin ()</term>
<term>Coronavirus félin (génétique)</term>
<term>Coronavirus félin (métabolisme)</term>
<term>Coronavirus félin (pathogénicité)</term>
<term>Données de séquences moléculaires</term>
<term>Délétion de séquence</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Glycoprotéines membranaires ()</term>
<term>Glycoprotéines membranaires (génétique)</term>
<term>Glycoprotéines membranaires (métabolisme)</term>
<term>Motifs d'acides aminés</term>
<term>Mâle</term>
<term>Protéines de l'enveloppe virale ()</term>
<term>Protéines de l'enveloppe virale (génétique)</term>
<term>Protéines de l'enveloppe virale (métabolisme)</term>
<term>Péritonite infectieuse féline (virologie)</term>
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<term>Viral Envelope Proteins</term>
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<term>Protéines de l'enveloppe virale</term>
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<term>Viral Envelope Proteins</term>
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<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Motifs</term>
<term>Animals</term>
<term>Cats</term>
<term>Male</term>
<term>Molecular Sequence Data</term>
<term>Sequence Deletion</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Virulence</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Chats</term>
<term>Coronavirus félin</term>
<term>Données de séquences moléculaires</term>
<term>Délétion de séquence</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Glycoprotéines membranaires</term>
<term>Motifs d'acides aminés</term>
<term>Mâle</term>
<term>Protéines de l'enveloppe virale</term>
<term>Virulence</term>
</keywords>
</textClass>
</profileDesc>
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<front><div type="abstract" xml:lang="en">In this study, the Japanese strain of type I feline infectious peritonitis virus (FIPV), C3663, was found to have a large deletion of 735 bp within the gene encoding the spike (S) protein, with a deduced loss of 245 aa of the N-terminal region of the S protein. This deletion is similar to that observed in porcine respiratory coronavirus (PRCoV) when compared to transmissible gastroenteritis virus, which correlates with reduced virulence. By analogy to PRCoV, we expected that the pathogenicity of C3663 may be attenuated in cats. However, two of four cats inoculated with C3663 died of FIP, and a third C3663-inoculated cat showed FIP lesions at 91 days after challenge. These results indicate that the 5'-terminal region of the S gene is not essential for the development of FIP.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22718568</PMID>
<DateCompleted><Year>2012</Year>
<Month>10</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1465-2099</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>93</Volume>
<Issue>Pt 9</Issue>
<PubDate><Year>2012</Year>
<Month>Sep</Month>
</PubDate>
</JournalIssue>
<Title>The Journal of general virology</Title>
<ISOAbbreviation>J. Gen. Virol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Feline infectious peritonitis virus with a large deletion in the 5'-terminal region of the spike gene retains its virulence for cats.</ArticleTitle>
<Pagination><MedlinePgn>1930-1934</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1099/vir.0.043992-0</ELocationID>
<Abstract><AbstractText>In this study, the Japanese strain of type I feline infectious peritonitis virus (FIPV), C3663, was found to have a large deletion of 735 bp within the gene encoding the spike (S) protein, with a deduced loss of 245 aa of the N-terminal region of the S protein. This deletion is similar to that observed in porcine respiratory coronavirus (PRCoV) when compared to transmissible gastroenteritis virus, which correlates with reduced virulence. By analogy to PRCoV, we expected that the pathogenicity of C3663 may be attenuated in cats. However, two of four cats inoculated with C3663 died of FIP, and a third C3663-inoculated cat showed FIP lesions at 91 days after challenge. These results indicate that the 5'-terminal region of the S gene is not essential for the development of FIP.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Terada</LastName>
<ForeName>Yutaka</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shiozaki</LastName>
<ForeName>Yuto</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shimoda</LastName>
<ForeName>Hiroshi</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mahmoud</LastName>
<ForeName>Hassan Youssef Abdel Hamid</ForeName>
<Initials>HYAH</Initials>
<AffiliationInfo><Affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Noguchi</LastName>
<ForeName>Keita</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nagao</LastName>
<ForeName>Yumiko</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shimojima</LastName>
<ForeName>Masayuki</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Iwata</LastName>
<ForeName>Hiroyuki</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Veterinary Hygiene, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mizuno</LastName>
<ForeName>Takuya</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Okuda</LastName>
<ForeName>Masaru</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Morimoto</LastName>
<ForeName>Masahiro</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hayashi</LastName>
<ForeName>Toshiharu</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tanaka</LastName>
<ForeName>Yoshikazu</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Veterinary Hygiene, Veterinary School, Nippon Veterinary and Life Science University, 1-7-1 Kyounan, Musashino, Tokyo 180-8602, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mochizuki</LastName>
<ForeName>Masami</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Food Safety Commission, Cabinet Office, Government of Japan, Akasaka Park Bld. 22nd F. Akasaka 5-2-20, Minato-ku, Tokyo 107-6122, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Maeda</LastName>
<ForeName>Ken</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Laboratories of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2012</Year>
<Month>06</Month>
<Day>20</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Gen Virol</MedlineTA>
<NlmUniqueID>0077340</NlmUniqueID>
<ISSNLinking>0022-1317</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C578553">MHV surface projection glycoprotein</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008562">Membrane Glycoproteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D064370">Spike Glycoprotein, Coronavirus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014759">Viral Envelope Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C578557">spike glycoprotein, SARS-CoV</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D020816" MajorTopicYN="N">Amino Acid Motifs</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002415" MajorTopicYN="N">Cats</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016765" MajorTopicYN="N">Coronavirus, Feline</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016766" MajorTopicYN="N">Feline Infectious Peritonitis</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008562" MajorTopicYN="N">Membrane Glycoproteins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017384" MajorTopicYN="Y">Sequence Deletion</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D064370" MajorTopicYN="N">Spike Glycoprotein, Coronavirus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014759" MajorTopicYN="N">Viral Envelope Proteins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014774" MajorTopicYN="N">Virulence</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year>
<Month>6</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2012</Year>
<Month>6</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2012</Year>
<Month>10</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">22718568</ArticleId>
<ArticleId IdType="doi">10.1099/vir.0.043992-0</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
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Feline infectious peritonitis virus with a large deletion in the 5'-terminal region of the spike gene retains its virulence for cats.

Feline infectious peritonitis virus with a large deletion in the 5'-terminal region of the spike gene retains its virulence for cats.

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