Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brain.
Identifieur interne : 001303 ( PubMed/Curation ); précédent : 001302; suivant : 001304Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brain.
Auteurs : Byoung-Shik Shim [Corée du Sud] ; Konrad Stadler ; Huan Huu Nguyen ; Cheol-Heui Yun ; Dong Wook Kim ; Jun Chang ; Cecil Czerkinsky ; Man Ki SongSource :
- Virology journal [ 1743-422X ] ; 2012.
Descripteurs français
- KwdFr :
- Administration par voie sublinguale, Animaux, Anticorps antiviraux (immunologie), Encéphale (immunologie), Encéphale (virologie), Femelle, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (administration et posologie), Glycoprotéines membranaires (génétique), Glycoprotéines membranaires (immunologie), Humains, Immunisation, Immunité muqueuse, Protéines de l'enveloppe virale (administration et posologie), Protéines de l'enveloppe virale (génétique), Protéines de l'enveloppe virale (immunologie), Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Vaccins antiviraux (administration et posologie), Vaccins antiviraux (génétique), Vaccins antiviraux (immunologie), Virus du SRAS (génétique), Virus du SRAS (immunologie).
- MESH :
- administration et posologie : Glycoprotéines membranaires, Protéines de l'enveloppe virale, Vaccins antiviraux.
- génétique : Glycoprotéines membranaires, Protéines de l'enveloppe virale, Vaccins antiviraux, Virus du SRAS.
- immunologie : Anticorps antiviraux, Encéphale, Glycoprotéines membranaires, Protéines de l'enveloppe virale, Syndrome respiratoire aigu sévère, Vaccins antiviraux, Virus du SRAS.
- virologie : Encéphale, Syndrome respiratoire aigu sévère.
- Administration par voie sublinguale, Animaux, Femelle, Glycoprotéine de spicule des coronavirus, Humains, Immunisation, Immunité muqueuse, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Administration, Sublingual, Animals, Antibodies, Viral (immunology), Brain (immunology), Brain (virology), Female, Humans, Immunity, Mucosal, Immunization, Membrane Glycoproteins (administration & dosage), Membrane Glycoproteins (genetics), Membrane Glycoproteins (immunology), Mice, Mice, Inbred BALB C, SARS Virus (genetics), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology), Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (administration & dosage), Viral Envelope Proteins (genetics), Viral Envelope Proteins (immunology), Viral Vaccines (administration & dosage), Viral Vaccines (genetics), Viral Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Membrane Glycoproteins, Viral Envelope Proteins, Viral Vaccines.
- chemical , genetics : Membrane Glycoproteins, Viral Envelope Proteins, Viral Vaccines.
- chemical , immunology : Antibodies, Viral, Membrane Glycoproteins, Viral Envelope Proteins, Viral Vaccines.
- genetics : SARS Virus.
- immunology : Brain, SARS Virus, Severe Acute Respiratory Syndrome.
- virology : Brain, Severe Acute Respiratory Syndrome.
- Administration, Sublingual, Animals, Female, Humans, Immunity, Mucosal, Immunization, Mice, Mice, Inbred BALB C, Spike Glycoprotein, Coronavirus.
Abstract
Sublingual (s.l.) administration of soluble protein antigens, inactivated viruses, or virus-like particles has been shown to induce broad immune responses in mucosal and extra-mucosal tissues. Recombinant replication-defective adenovirus vectors (rADVs) infect mucosa surface and therefore can serve as a mucosal antigen delivery vehicle. In this study we examined whether s.l. immunization with rADV encoding spike protein (S) (rADV-S) of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) induces protective immunity against SARS-CoV and could serve as a safe mucosal route for delivery of rADV.
DOI: 10.1186/1743-422X-9-215
PubMed: 22995185
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qualifier="virologie" xml:lang="fr"><term>Encéphale</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Brain</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Sublingual</term><term>Animals</term><term>Female</term><term>Humans</term><term>Immunity, Mucosal</term><term>Immunization</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie sublinguale</term><term>Animaux</term><term>Femelle</term><term>Glycoprotéine de spicule des coronavirus</term><term>Humains</term><term>Immunisation</term><term>Immunité muqueuse</term><term>Souris</term><term>Souris de lignée BALB C</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sublingual (s.l.) administration of soluble protein antigens, inactivated viruses, or virus-like particles has been shown to induce broad immune responses in mucosal and extra-mucosal tissues. Recombinant replication-defective adenovirus vectors (rADVs) infect mucosa surface and therefore can serve as a mucosal antigen delivery vehicle. In this study we examined whether s.l. immunization with rADV encoding spike protein (S) (rADV-S) of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) induces protective immunity against SARS-CoV and could serve as a safe mucosal route for delivery of rADV.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22995185</PMID><DateCompleted><Year>2013</Year><Month>03</Month><Day>26</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1743-422X</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><PubDate><Year>2012</Year><Month>Sep</Month><Day>21</Day></PubDate></JournalIssue><Title>Virology journal</Title><ISOAbbreviation>Virol. J.</ISOAbbreviation></Journal><ArticleTitle>Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brain.</ArticleTitle><Pagination><MedlinePgn>215</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/1743-422X-9-215</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Sublingual (s.l.) administration of soluble protein antigens, inactivated viruses, or virus-like particles has been shown to induce broad immune responses in mucosal and extra-mucosal tissues. Recombinant replication-defective adenovirus vectors (rADVs) infect mucosa surface and therefore can serve as a mucosal antigen delivery vehicle. In this study we examined whether s.l. immunization with rADV encoding spike protein (S) (rADV-S) of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) induces protective immunity against SARS-CoV and could serve as a safe mucosal route for delivery of rADV.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Here, we show that s.l. administration of rADV-S induced serum SARS-CoV neutralizing and airway IgA antibodies in mice. These antibody responses are comparable to those induced by intranasal (i.n.) administration. In addition, s.l. immunization induced antigen-specific CD8+ T cell responses in the lungs that are superior to those induced by intramuscular immunization. Importantly, unlike i.n. administration, s.l. immunization with rADV did not redirect the rADV vector to the olfactory bulb.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Our study indicates that s.l. immunization with rADV-S is safe and effective in induction of a broad spectrum of immune responses and presumably protection against infection with SARS-CoV.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shim</LastName><ForeName>Byoung-Shik</ForeName><Initials>BS</Initials><AffiliationInfo><Affiliation>Laboratory Sciences Division, International Vaccine Institute, Seoul, 151-919, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stadler</LastName><ForeName>Konrad</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Nguyen</LastName><ForeName>Huan Huu</ForeName><Initials>HH</Initials></Author><Author ValidYN="Y"><LastName>Yun</LastName><ForeName>Cheol-Heui</ForeName><Initials>CH</Initials></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Dong Wook</ForeName><Initials>DW</Initials></Author><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Jun</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Czerkinsky</LastName><ForeName>Cecil</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>Man Ki</ForeName><Initials>MK</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>09</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Virol J</MedlineTA><NlmUniqueID>101231645</NlmUniqueID><ISSNLinking>1743-422X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008562">Membrane Glycoproteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D064370">Spike Glycoprotein, Coronavirus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014759">Viral Envelope Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014765">Viral Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000286" MajorTopicYN="N">Administration, Sublingual</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018928" MajorTopicYN="N">Immunity, Mucosal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007114" MajorTopicYN="N">Immunization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008562" MajorTopicYN="N">Membrane Glycoproteins</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D064370" MajorTopicYN="N">Spike Glycoprotein, Coronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014759" MajorTopicYN="N">Viral Envelope Proteins</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014765" MajorTopicYN="N">Viral Vaccines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>03</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>09</Month><Day>19</Day></PubMedPubDate><PubMedPubDate 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IdType="pubmed">11117750</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Allergy Asthma Immunol. 2008 Apr;100(4):343-50</Citation><ArticleIdList><ArticleId IdType="pubmed">18450120</ArticleId></ArticleIdList></Reference><Reference><Citation>Infect Immun. 1972 Mar;5(3):300-4</Citation><ArticleIdList><ArticleId IdType="pubmed">4629075</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2007 Dec 12;25(51):8598-610</Citation><ArticleIdList><ArticleId IdType="pubmed">17996991</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Genet. 1993 Mar;3(3):219-23</Citation><ArticleIdList><ArticleId IdType="pubmed">8387378</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1987 Jul;84(13):4626-30</Citation><ArticleIdList><ArticleId IdType="pubmed">2955413</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2003 Sep;77(18):10078-87</Citation><ArticleIdList><ArticleId IdType="pubmed">12941918</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2009;4(9):e6999</Citation><ArticleIdList><ArticleId IdType="pubmed">19756141</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2007 Jul 9;25(28):5220-31</Citation><ArticleIdList><ArticleId IdType="pubmed">17559989</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Allergy Immunol. 2008;21:71-86</Citation><ArticleIdList><ArticleId IdType="pubmed">18828499</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2004 Aug;10(8):871-5</Citation><ArticleIdList><ArticleId IdType="pubmed">15247913</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2004 Apr 1;428(6982):561-4</Citation><ArticleIdList><ArticleId IdType="pubmed">15024391</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2000 Nov 1;165(9):4778-82</Citation><ArticleIdList><ArticleId IdType="pubmed">11045998</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2005 Apr 25;335(1):34-45</Citation><ArticleIdList><ArticleId IdType="pubmed">15823604</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2005 Nov 1;192(9):1628-33</Citation><ArticleIdList><ArticleId IdType="pubmed">16206078</ArticleId></ArticleIdList></Reference><Reference><Citation>Postepy Hig Med Dosw. 1995;49(4):469-86</Citation><ArticleIdList><ArticleId IdType="pubmed">8657643</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Microbiol. 2009 Mar;7(3):226-36</Citation><ArticleIdList><ArticleId IdType="pubmed">19198616</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Immunol. 2006 Feb;6(2):148-58</Citation><ArticleIdList><ArticleId IdType="pubmed">16491139</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2005 Apr;11(4 Suppl):S45-53</Citation><ArticleIdList><ArticleId IdType="pubmed">15812489</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2011 Sep 16;29(40):7080-9</Citation><ArticleIdList><ArticleId IdType="pubmed">21801777</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2000 Jun 15;18(25):2804-7</Citation><ArticleIdList><ArticleId IdType="pubmed">10812222</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Vaccine Immunol. 2011 Jan;18(1):150-60</Citation><ArticleIdList><ArticleId IdType="pubmed">21084461</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2009 Dec 15;183(12):7851-9</Citation><ArticleIdList><ArticleId IdType="pubmed">19933861</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 1990 Sep;64(9):4589-92</Citation><ArticleIdList><ArticleId IdType="pubmed">2166833</ArticleId></ArticleIdList></Reference><Reference><Citation>Virus Res. 2005 Sep;112(1-2):24-31</Citation><ArticleIdList><ArticleId IdType="pubmed">16022898</ArticleId></ArticleIdList></Reference><Reference><Citation>Expert Rev Vaccines. 2003 Jun;2(3):399-406</Citation><ArticleIdList><ArticleId IdType="pubmed">12903805</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2010 Mar 19;28(14):2598-606</Citation><ArticleIdList><ArticleId IdType="pubmed">20116467</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2006 Apr;80(8):4079-87</Citation><ArticleIdList><ArticleId IdType="pubmed">16571824</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Immunopathol Pharmacol. 2003 Jan-Apr;16(1):73-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12578735</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2008 Sep;89(Pt 9):2136-46</Citation><ArticleIdList><ArticleId IdType="pubmed">18753223</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 1994 May;12(7):607-12</Citation><ArticleIdList><ArticleId IdType="pubmed">8085377</ArticleId></ArticleIdList></Reference><Reference><Citation>Microbes Infect. 2005 Mar;7(3):427-36</Citation><ArticleIdList><ArticleId IdType="pubmed">15784184</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2010 Aug 2;28(34):5582-90</Citation><ArticleIdList><ArticleId IdType="pubmed">20600505</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6641-6</Citation><ArticleIdList><ArticleId IdType="pubmed">15096611</ArticleId></ArticleIdList></Reference><Reference><Citation>Expert Rev Vaccines. 2007 Jun;6(3):347-56</Citation><ArticleIdList><ArticleId IdType="pubmed">17542750</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2002 Jun 7;20(19-20):2431-8</Citation><ArticleIdList><ArticleId IdType="pubmed">12057597</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Immunol. 2005 Dec;5(12):905-16</Citation><ArticleIdList><ArticleId IdType="pubmed">16239901</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2006 Mar;87(Pt 3):641-50</Citation><ArticleIdList><ArticleId IdType="pubmed">16476986</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunity. 1998 Mar;8(3):353-62</Citation><ArticleIdList><ArticleId IdType="pubmed">9529152</ArticleId></ArticleIdList></Reference><Reference><Citation>J Allergy Clin Immunol. 2007 Sep;120(3):707-13</Citation><ArticleIdList><ArticleId IdType="pubmed">17681368</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1644-9</Citation><ArticleIdList><ArticleId IdType="pubmed">18227512</ArticleId></ArticleIdList></Reference><Reference><Citation>Genet Vaccines Ther. 2008 Feb 08;6:5</Citation><ArticleIdList><ArticleId IdType="pubmed">18261231</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2005 Jan 11;23(8):996-1003</Citation><ArticleIdList><ArticleId IdType="pubmed">15620472</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 1997 Nov;71(11):8531-41</Citation><ArticleIdList><ArticleId IdType="pubmed">9343211</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2003 Aug;77(16):8729-35</Citation><ArticleIdList><ArticleId IdType="pubmed">12885892</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2003 Oct 15;171(8):4287-93</Citation><ArticleIdList><ArticleId IdType="pubmed">14530353</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 1988 Aug;62(8):2718-27</Citation><ArticleIdList><ArticleId IdType="pubmed">3292790</ArticleId></ArticleIdList></Reference><Reference><Citation>Expert Rev Vaccines. 2008 Feb;7(1):25-31</Citation><ArticleIdList><ArticleId IdType="pubmed">18251691</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2007 Nov 15;196 Suppl 2:S413-20</Citation><ArticleIdList><ArticleId IdType="pubmed">17940978</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 1996 May 1;219(1):220-7</Citation><ArticleIdList><ArticleId IdType="pubmed">8623532</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2004 Apr;78(7):3572-7</Citation><ArticleIdList><ArticleId IdType="pubmed">15016880</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2001 Dec;75(23):11474-82</Citation><ArticleIdList><ArticleId IdType="pubmed">11689629</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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