SrasV1, PubMed, Curation, bibRecord, 001240

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC.

Identifieur interne : 001240 ( PubMed/Curation ); précédent : 001239; suivant : 001241

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC.

Auteurs : V Stalin Raj [Pays-Bas] ; Huihui Mou ; Saskia L. Smits ; Dick H W. Dekkers ; Marcel A. Müller ; Ronald Dijkman ; Doreen Muth ; Jeroen A A. Demmers ; Ali Zaki ; Ron A M. Fouchier ; Volker Thiel ; Christian Drosten ; Peter J M. Rottier ; Albert D M E. Osterhaus ; Berend Jan Bosch ; Bart L. Haagmans

Source :

Nature [ 1476-4687 ] ; 2013.

RBID : pubmed:23486063

Descripteurs français

KwdFr :
- Animaux, Bronchioles (cytologie), Cellules COS, Cellules épithéliales (virologie), Chiroptera, Coronavirus (), Coronavirus (métabolisme), Dipeptidyl peptidase 4 (génétique), Dipeptidyl peptidase 4 (métabolisme), Données de séquences moléculaires, Humains, Infections à coronavirus (génétique), Infections à coronavirus (métabolisme), Infections à coronavirus (virologie), Infections à coronavirus (épidémiologie), Récepteurs viraux (génétique), Récepteurs viraux (métabolisme), Spécificité d'hôte.
MESH :
- cytologie : Bronchioles.
- génétique : Dipeptidyl peptidase 4, Infections à coronavirus, Récepteurs viraux.
- métabolisme : Coronavirus, Dipeptidyl peptidase 4, Infections à coronavirus, Récepteurs viraux.
- virologie : Cellules épithéliales, Infections à coronavirus.
- épidémiologie : Infections à coronavirus.
- Animaux, Cellules COS, Chiroptera, Coronavirus, Données de séquences moléculaires, Humains, Spécificité d'hôte.

English descriptors

KwdEn :
- Animals, Bronchioles (cytology), COS Cells, Chiroptera, Chlorocebus aethiops, Coronavirus (classification), Coronavirus (metabolism), Coronavirus Infections (epidemiology), Coronavirus Infections (genetics), Coronavirus Infections (metabolism), Coronavirus Infections (virology), Dipeptidyl Peptidase 4 (genetics), Dipeptidyl Peptidase 4 (metabolism), Epithelial Cells (virology), Host Specificity, Humans, Molecular Sequence Data, Receptors, Virus (genetics), Receptors, Virus (metabolism).
MESH :
- chemical , genetics : Dipeptidyl Peptidase 4, Receptors, Virus.
- classification : Coronavirus.
- cytology : Bronchioles.
- epidemiology : Coronavirus Infections.
- genetics : Coronavirus Infections.
- metabolism : Coronavirus, Coronavirus Infections, Dipeptidyl Peptidase 4, Receptors, Virus.
- virology : Coronavirus Infections, Epithelial Cells.
- Animals, COS Cells, Chiroptera, Chlorocebus aethiops, Host Specificity, Humans, Molecular Sequence Data.

Abstract

Most human coronaviruses cause mild upper respiratory tract disease but may be associated with more severe pulmonary disease in immunocompromised individuals. However, SARS coronavirus caused severe lower respiratory disease with nearly 10% mortality and evidence of systemic spread. Recently, another coronavirus (human coronavirus-Erasmus Medical Center (hCoV-EMC)) was identified in patients with severe and sometimes lethal lower respiratory tract infection. Viral genome analysis revealed close relatedness to coronaviruses found in bats. Here we identify dipeptidyl peptidase 4 (DPP4; also known as CD26) as a functional receptor for hCoV-EMC. DPP4 specifically co-purified with the receptor-binding S1 domain of the hCoV-EMC spike protein from lysates of susceptible Huh-7 cells. Antibodies directed against DPP4 inhibited hCoV-EMC infection of primary human bronchial epithelial cells and Huh-7 cells. Expression of human and bat (Pipistrellus pipistrellus) DPP4 in non-susceptible COS-7 cells enabled infection by hCoV-EMC. The use of the evolutionarily conserved DPP4 protein from different species as a functional receptor provides clues about the host range potential of hCoV-EMC. In addition, it will contribute critically to our understanding of the pathogenesis and epidemiology of this emerging human coronavirus, and may facilitate the development of intervention strategies.

DOI: 10.1038/nature12005
PubMed: 23486063

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Most human coronaviruses cause mild upper respiratory tract disease but may be associated with more severe pulmonary disease in immunocompromised individuals. However, SARS coronavirus caused severe lower respiratory disease with nearly 10% mortality and evidence of systemic spread. Recently, another coronavirus (human coronavirus-Erasmus Medical Center (hCoV-EMC)) was identified in patients with severe and sometimes lethal lower respiratory tract infection. Viral genome analysis revealed close relatedness to coronaviruses found in bats. Here we identify dipeptidyl peptidase 4 (DPP4; also known as CD26) as a functional receptor for hCoV-EMC. DPP4 specifically co-purified with the receptor-binding S1 domain of the hCoV-EMC spike protein from lysates of susceptible Huh-7 cells. Antibodies directed against DPP4 inhibited hCoV-EMC infection of primary human bronchial epithelial cells and Huh-7 cells. Expression of human and bat (Pipistrellus pipistrellus) DPP4 in non-susceptible COS-7 cells enabled infection by hCoV-EMC. The use of the evolutionarily conserved DPP4 protein from different species as a functional receptor provides clues about the host range potential of hCoV-EMC. In addition, it will contribute critically to our understanding of the pathogenesis and epidemiology of this emerging human coronavirus, and may facilitate the development of intervention strategies.</div>
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<Abstract><AbstractText>Most human coronaviruses cause mild upper respiratory tract disease but may be associated with more severe pulmonary disease in immunocompromised individuals. However, SARS coronavirus caused severe lower respiratory disease with nearly 10% mortality and evidence of systemic spread. Recently, another coronavirus (human coronavirus-Erasmus Medical Center (hCoV-EMC)) was identified in patients with severe and sometimes lethal lower respiratory tract infection. Viral genome analysis revealed close relatedness to coronaviruses found in bats. Here we identify dipeptidyl peptidase 4 (DPP4; also known as CD26) as a functional receptor for hCoV-EMC. DPP4 specifically co-purified with the receptor-binding S1 domain of the hCoV-EMC spike protein from lysates of susceptible Huh-7 cells. Antibodies directed against DPP4 inhibited hCoV-EMC infection of primary human bronchial epithelial cells and Huh-7 cells. Expression of human and bat (Pipistrellus pipistrellus) DPP4 in non-susceptible COS-7 cells enabled infection by hCoV-EMC. The use of the evolutionarily conserved DPP4 protein from different species as a functional receptor provides clues about the host range potential of hCoV-EMC. In addition, it will contribute critically to our understanding of the pathogenesis and epidemiology of this emerging human coronavirus, and may facilitate the development of intervention strategies.</AbstractText>
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<ReferenceList><Reference><Citation>J Virol. 2012 Dec;86(23):12816-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22993147</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2010 Nov;84(21):11336-49</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20686038</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2012 Nov 8;367 (19):1814-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23075143</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MBio. 2012 Dec 11;3(6):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23232719</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Cell Biol. 2003 Feb;82(2):53-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12647932</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2010 Apr;84(7):3134-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19906932</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2005 Oct 28;310(5748):676-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16195424</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2013 Jun;87(11):6081-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23427150</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2005 Jul 7;436(7047):112-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16001071</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2005 Sep 16;309(5742):1864-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16166518</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2010 Oct;84(19):10366-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20686020</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Euro Surveill. 2012 Oct 04;17(40):20290</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23078800</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1992 Jun 4;357(6377):420-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1350662</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 1992 Apr;73 ( Pt 4):901-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1321878</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2003 Nov 27;426(6965):450-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14647384</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Stem Cell. 2010 Apr 2;6(4):369-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20362541</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2005 Aug;11(8):875-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16007097</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Crit Rev Clin Lab Sci. 2003 Jun;40(3):209-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12892317</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5533-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1648219</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MBio. 2012 Nov 20;3(6):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23170002</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Microbiol Mol Biol Rev. 2005 Dec;69(4):635-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16339739</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1992 Jun 4;357(6377):417-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1350661</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2004 Dec;10(12 Suppl):S88-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15577937</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2012 Mar 16;287(12):8904-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22291007</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 2008 Apr;133(1):33-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17451829</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
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Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC.

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC.

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