The emergence of human coronavirus EMC: how scared should we be?
Identifieur interne : 001224 ( PubMed/Curation ); précédent : 001223; suivant : 001225The emergence of human coronavirus EMC: how scared should we be?
Auteurs : Renee W Y. Chan [Hong Kong] ; Leo L M. PoonSource :
- mBio [ 2150-7511 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- pathogénicité : Coronaviridae.
- physiologie : Coronaviridae.
- virologie : Cellules épithéliales.
- Animaux, Humains, Réplication virale.
English descriptors
- KwdEn :
- MESH :
- pathogenicity : Coronaviridae.
- physiology : Coronaviridae.
- virology : Epithelial Cells.
- Animals, Humans, Virus Replication.
Abstract
A novel betacoronavirus, human coronavirus (HCoV-EMC), has recently been detected in humans with severe respiratory disease. Further characterization of HCoV-EMC suggests that this virus is different from severe acute respiratory syndrome coronavirus (SARS-CoV) because it is able to replicate in multiple mammalian cell lines and it does not use angiotensin-converting enzyme 2 as a receptor to achieve infection. Additional research is urgently needed to better understand the pathogenicity and tissue tropism of this virus in humans. In their recent study published in mBio, Kindler et al. shed some light on these important topics (E. Kindler, H. R. Jónsdóttir, M. Muth, O. J. Hamming, R. Hartmann, R. Rodriguez, R. Geffers, R. A. Fouchier, C. Drosten, M. A. Müller, R. Dijkman, and V. Thiel, mBio 4[1]:e00611-12, 2013). These authors report the use of differentiated pseudostratified human primary airway epithelial cells, an in vitro model with high physiological relevance to the human airway epithelium, to characterize the cellular tropism of HCoV-EMC. More importantly, the authors demonstrate the potential use of type I and type III interferons (IFNs) to control viral infection.
DOI: 10.1128/mBio.00191-13
PubMed: 23572553
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Poon</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23572553</idno><idno type="pmid">23572553</idno><idno type="doi">10.1128/mBio.00191-13</idno><idno type="wicri:Area/PubMed/Corpus">001224</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001224</idno><idno type="wicri:Area/PubMed/Curation">001224</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001224</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The emergence of human coronavirus EMC: how scared should we be?</title><author><name sortKey="Chan, Renee W Y" sort="Chan, Renee W Y" uniqKey="Chan R" first="Renee W Y" last="Chan">Renee W Y. Chan</name><affiliation wicri:level="1"><nlm:affiliation>Centre of Influenza Research, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.</nlm:affiliation><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Centre of Influenza Research, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Poon, Leo L M" sort="Poon, Leo L M" uniqKey="Poon L" first="Leo L M" last="Poon">Leo L M. 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Further characterization of HCoV-EMC suggests that this virus is different from severe acute respiratory syndrome coronavirus (SARS-CoV) because it is able to replicate in multiple mammalian cell lines and it does not use angiotensin-converting enzyme 2 as a receptor to achieve infection. Additional research is urgently needed to better understand the pathogenicity and tissue tropism of this virus in humans. In their recent study published in mBio, Kindler et al. shed some light on these important topics (E. Kindler, H. R. Jónsdóttir, M. Muth, O. J. Hamming, R. Hartmann, R. Rodriguez, R. Geffers, R. A. Fouchier, C. Drosten, M. A. Müller, R. Dijkman, and V. Thiel, mBio 4[1]:e00611-12, 2013). These authors report the use of differentiated pseudostratified human primary airway epithelial cells, an in vitro model with high physiological relevance to the human airway epithelium, to characterize the cellular tropism of HCoV-EMC. More importantly, the authors demonstrate the potential use of type I and type III interferons (IFNs) to control viral infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Automated" Owner="NLM"><PMID Version="1">23572553</PMID><DateCompleted><Year>2013</Year><Month>08</Month><Day>15</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>27</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2150-7511</ISSN><JournalIssue CitedMedium="Internet"><Volume>4</Volume><Issue>2</Issue><PubDate><Year>2013</Year><Month>Apr</Month><Day>09</Day></PubDate></JournalIssue><Title>mBio</Title><ISOAbbreviation>mBio</ISOAbbreviation></Journal><ArticleTitle>The emergence of human coronavirus EMC: how scared should we be?</ArticleTitle><Pagination><MedlinePgn>e00191-13</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1128/mBio.00191-13</ELocationID><ELocationID EIdType="pii" ValidYN="Y">e00191-13</ELocationID><Abstract><AbstractText>A novel betacoronavirus, human coronavirus (HCoV-EMC), has recently been detected in humans with severe respiratory disease. Further characterization of HCoV-EMC suggests that this virus is different from severe acute respiratory syndrome coronavirus (SARS-CoV) because it is able to replicate in multiple mammalian cell lines and it does not use angiotensin-converting enzyme 2 as a receptor to achieve infection. Additional research is urgently needed to better understand the pathogenicity and tissue tropism of this virus in humans. In their recent study published in mBio, Kindler et al. shed some light on these important topics (E. Kindler, H. R. Jónsdóttir, M. Muth, O. J. Hamming, R. Hartmann, R. Rodriguez, R. Geffers, R. A. Fouchier, C. Drosten, M. A. Müller, R. Dijkman, and V. Thiel, mBio 4[1]:e00611-12, 2013). These authors report the use of differentiated pseudostratified human primary airway epithelial cells, an in vitro model with high physiological relevance to the human airway epithelium, to characterize the cellular tropism of HCoV-EMC. 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