SrasV1, PubMed, Curation, bibRecord, 001180

The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies.

Identifieur interne : 001180 ( PubMed/Curation ); précédent : 001179; suivant : 001181

The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies.

Auteurs : Huihui Mou [Pays-Bas] ; V Stalin Raj ; Frank J M. Van Kuppeveld ; Peter J M. Rottier ; Bart L. Haagmans ; Berend Jan Bosch

Source :

Journal of virology [ 1098-5514 ] ; 2013.

RBID : pubmed:23785207

Descripteurs français

English descriptors

KwdEn :
- Antibodies, Neutralizing (immunology), Antibodies, Viral (immunology), Binding Sites, Cell Line, Coronavirus (immunology), Coronavirus (physiology), Dipeptidyl Peptidase 4 (metabolism), Epitopes, B-Lymphocyte (genetics), Epitopes, B-Lymphocyte (immunology), Humans, Membrane Glycoproteins (immunology), Membrane Glycoproteins (metabolism), Receptors, Virus (metabolism), Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (immunology), Viral Envelope Proteins (metabolism), Virus Attachment.
MESH :
- chemical , genetics : Epitopes, B-Lymphocyte.
- chemical , immunology : Antibodies, Neutralizing, Antibodies, Viral, Epitopes, B-Lymphocyte, Membrane Glycoproteins, Viral Envelope Proteins.
- immunology : Coronavirus.
- chemical , metabolism : Dipeptidyl Peptidase 4, Membrane Glycoproteins, Receptors, Virus, Viral Envelope Proteins.
- physiology : Coronavirus.
- Binding Sites, Cell Line, Humans, Spike Glycoprotein, Coronavirus, Virus Attachment.

Abstract

The spike (S) protein of the recently emerged human Middle East respiratory syndrome coronavirus (MERS-CoV) mediates infection by binding to the cellular receptor dipeptidyl peptidase 4 (DPP4). Here we mapped the receptor binding domain in the S protein to a 231-amino-acid fragment (residues 358 to 588) by evaluating the interaction of spike truncation variants with receptor-expressing cells and soluble DPP4. Antibodies to this domain--much less so those to the preceding N-terminal region--efficiently neutralize MERS-CoV infection.

DOI: 10.1128/JVI.01277-13
PubMed: 23785207

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Le document en format XML

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<term>Coronavirus (immunology)</term>
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<term>Glycoprotéine de spicule des coronavirus</term>
<term>Glycoprotéines membranaires (immunologie)</term>
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<term>Récepteurs viraux (métabolisme)</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Epitopes, B-Lymphocyte</term>
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<term>Antibodies, Viral</term>
<term>Epitopes, B-Lymphocyte</term>
<term>Membrane Glycoproteins</term>
<term>Viral Envelope Proteins</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Déterminants antigéniques des lymphocytes B</term>
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<term>Anticorps neutralisants</term>
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<term>Glycoprotéines membranaires</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en">The spike (S) protein of the recently emerged human Middle East respiratory syndrome coronavirus (MERS-CoV) mediates infection by binding to the cellular receptor dipeptidyl peptidase 4 (DPP4). Here we mapped the receptor binding domain in the S protein to a 231-amino-acid fragment (residues 358 to 588) by evaluating the interaction of spike truncation variants with receptor-expressing cells and soluble DPP4. Antibodies to this domain--much less so those to the preceding N-terminal region--efficiently neutralize MERS-CoV infection.</div>
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<Abstract><AbstractText>The spike (S) protein of the recently emerged human Middle East respiratory syndrome coronavirus (MERS-CoV) mediates infection by binding to the cellular receptor dipeptidyl peptidase 4 (DPP4). Here we mapped the receptor binding domain in the S protein to a 231-amino-acid fragment (residues 358 to 588) by evaluating the interaction of spike truncation variants with receptor-expressing cells and soluble DPP4. Antibodies to this domain--much less so those to the preceding N-terminal region--efficiently neutralize MERS-CoV infection.</AbstractText>
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       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

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Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
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Serveur d'exploration SRAS

The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies.

The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies.

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