Rapid Generation of Human-Like Neutralizing Monoclonal Antibodies in Urgent Preparedness for Influenza Pandemics and Virulent Infectious Diseases.
Identifieur interne : 001173 ( PubMed/Curation ); précédent : 001172; suivant : 001174Rapid Generation of Human-Like Neutralizing Monoclonal Antibodies in Urgent Preparedness for Influenza Pandemics and Virulent Infectious Diseases.
Auteurs : Weixu Meng [République populaire de Chine] ; Weiqi Pan ; Anna J X. Zhang ; Zhengfeng Li ; Guowei Wei ; Liqiang Feng ; Zhenyuan Dong ; Chufang Li ; Xiangjing Hu ; Caijun Sun ; Qinfang Luo ; Kwok-Yung Yuen ; Nanshan Zhong ; Ling ChenSource :
- PloS one [ 1932-6203 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Anticorps monoclonaux (biosynthèse), Anticorps monoclonaux (immunologie), Anticorps neutralisants (biosynthèse), Anticorps neutralisants (immunologie), Flambées de maladies, Grippe humaine (), Grippe humaine (immunologie), Grippe humaine (épidémiologie), Humains, Macaca mulatta, Maladies transmissibles émergentes (), Maladies transmissibles émergentes (immunologie), Maladies transmissibles émergentes (épidémiologie), Souris, Sous-type H5N1 du virus de la grippe A (immunologie).
- MESH :
- biosynthèse : Anticorps monoclonaux, Anticorps neutralisants.
- immunologie : Anticorps monoclonaux, Anticorps neutralisants, Grippe humaine, Maladies transmissibles émergentes, Sous-type H5N1 du virus de la grippe A.
- épidémiologie : Grippe humaine, Maladies transmissibles émergentes.
- Animaux, Flambées de maladies, Grippe humaine, Humains, Macaca mulatta, Maladies transmissibles émergentes, Souris.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (biosynthesis), Antibodies, Monoclonal (immunology), Antibodies, Neutralizing (biosynthesis), Antibodies, Neutralizing (immunology), Communicable Diseases, Emerging (epidemiology), Communicable Diseases, Emerging (immunology), Communicable Diseases, Emerging (therapy), Disease Outbreaks, Humans, Influenza A Virus, H5N1 Subtype (immunology), Influenza, Human (epidemiology), Influenza, Human (immunology), Influenza, Human (therapy), Macaca mulatta, Mice.
- MESH :
- chemical , biosynthesis : Antibodies, Monoclonal, Antibodies, Neutralizing.
- chemical , immunology : Antibodies, Monoclonal, Antibodies, Neutralizing.
- epidemiology : Communicable Diseases, Emerging, Influenza, Human.
- immunology : Communicable Diseases, Emerging, Influenza A Virus, H5N1 Subtype, Influenza, Human.
- therapy : Communicable Diseases, Emerging, Influenza, Human.
- Animals, Disease Outbreaks, Humans, Macaca mulatta, Mice.
Abstract
The outbreaks of emerging infectious diseases caused by pathogens such as SARS coronavirus, H5N1, H1N1, and recently H7N9 influenza viruses, have been associated with significant mortality and morbidity in humans. Neutralizing antibodies from individuals who have recovered from an infection confer therapeutic protection to others infected with the same pathogen. However, survivors may not always be available for providing plasma or for the cloning of monoclonal antibodies (mAbs).
DOI: 10.1371/journal.pone.0066276
PubMed: 23824680
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Zhang</name></author><author><name sortKey="Li, Zhengfeng" sort="Li, Zhengfeng" uniqKey="Li Z" first="Zhengfeng" last="Li">Zhengfeng Li</name></author><author><name sortKey="Wei, Guowei" sort="Wei, Guowei" uniqKey="Wei G" first="Guowei" last="Wei">Guowei Wei</name></author><author><name sortKey="Feng, Liqiang" sort="Feng, Liqiang" uniqKey="Feng L" first="Liqiang" last="Feng">Liqiang Feng</name></author><author><name sortKey="Dong, Zhenyuan" sort="Dong, Zhenyuan" uniqKey="Dong Z" first="Zhenyuan" last="Dong">Zhenyuan Dong</name></author><author><name sortKey="Li, Chufang" sort="Li, Chufang" uniqKey="Li C" first="Chufang" last="Li">Chufang Li</name></author><author><name sortKey="Hu, Xiangjing" sort="Hu, Xiangjing" uniqKey="Hu X" first="Xiangjing" last="Hu">Xiangjing Hu</name></author><author><name sortKey="Sun, Caijun" sort="Sun, Caijun" uniqKey="Sun C" first="Caijun" last="Sun">Caijun Sun</name></author><author><name sortKey="Luo, Qinfang" sort="Luo, Qinfang" uniqKey="Luo Q" first="Qinfang" last="Luo">Qinfang Luo</name></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name></author><author><name sortKey="Zhong, Nanshan" sort="Zhong, Nanshan" uniqKey="Zhong N" first="Nanshan" last="Zhong">Nanshan Zhong</name></author><author><name sortKey="Chen, Ling" sort="Chen, Ling" uniqKey="Chen L" first="Ling" last="Chen">Ling Chen</name></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Monoclonal (biosynthesis)</term><term>Antibodies, Monoclonal (immunology)</term><term>Antibodies, Neutralizing (biosynthesis)</term><term>Antibodies, Neutralizing (immunology)</term><term>Communicable Diseases, Emerging (epidemiology)</term><term>Communicable Diseases, Emerging (immunology)</term><term>Communicable Diseases, Emerging (therapy)</term><term>Disease Outbreaks</term><term>Humans</term><term>Influenza A Virus, H5N1 Subtype (immunology)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (therapy)</term><term>Macaca mulatta</term><term>Mice</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps monoclonaux (biosynthèse)</term><term>Anticorps monoclonaux (immunologie)</term><term>Anticorps neutralisants (biosynthèse)</term><term>Anticorps neutralisants (immunologie)</term><term>Flambées de maladies</term><term>Grippe humaine ()</term><term>Grippe humaine (immunologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Macaca mulatta</term><term>Maladies transmissibles émergentes ()</term><term>Maladies transmissibles émergentes (immunologie)</term><term>Maladies transmissibles émergentes (épidémiologie)</term><term>Souris</term><term>Sous-type H5N1 du virus de la grippe A (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antibodies, Neutralizing</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antibodies, Neutralizing</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps monoclonaux</term><term>Anticorps neutralisants</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Communicable Diseases, Emerging</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps monoclonaux</term><term>Anticorps neutralisants</term><term>Grippe humaine</term><term>Maladies transmissibles émergentes</term><term>Sous-type H5N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Communicable Diseases, Emerging</term><term>Influenza A Virus, H5N1 Subtype</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Communicable Diseases, Emerging</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term><term>Maladies transmissibles émergentes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Outbreaks</term><term>Humans</term><term>Macaca mulatta</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Flambées de maladies</term><term>Grippe humaine</term><term>Humains</term><term>Macaca mulatta</term><term>Maladies transmissibles émergentes</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The outbreaks of emerging infectious diseases caused by pathogens such as SARS coronavirus, H5N1, H1N1, and recently H7N9 influenza viruses, have been associated with significant mortality and morbidity in humans. Neutralizing antibodies from individuals who have recovered from an infection confer therapeutic protection to others infected with the same pathogen. However, survivors may not always be available for providing plasma or for the cloning of monoclonal antibodies (mAbs).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23824680</PMID><DateCompleted><Year>2017</Year><Month>10</Month><Day>13</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic-Print"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><Issue>6</Issue><PubDate><Year>2013</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Rapid Generation of Human-Like Neutralizing Monoclonal Antibodies in Urgent Preparedness for Influenza Pandemics and Virulent Infectious Diseases.</ArticleTitle><Pagination><MedlinePgn>e66276</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0066276</ELocationID><Abstract><AbstractText Label="BACKGROUND">The outbreaks of emerging infectious diseases caused by pathogens such as SARS coronavirus, H5N1, H1N1, and recently H7N9 influenza viruses, have been associated with significant mortality and morbidity in humans. Neutralizing antibodies from individuals who have recovered from an infection confer therapeutic protection to others infected with the same pathogen. However, survivors may not always be available for providing plasma or for the cloning of monoclonal antibodies (mAbs).</AbstractText><AbstractText Label="METHODOLOGY/PRINCIPAL FINDINGS">The genome and the immunoglobulin genes in rhesus macaques and humans are highly homologous; therefore, we investigated whether neutralizing mAbs that are highly homologous to those of humans (human-like) could be generated. Using the H5N1 influenza virus as a model, we first immunized rhesus macaques with recombinant adenoviruses carrying a synthetic gene encoding hemagglutinin (HA). Following screening an antibody phage display library derived from the B cells of immunized monkeys, we cloned selected macaque immunoglobulin heavy chain and light chain variable regions into the human IgG constant region, which generated human-macaque chimeric mAbs exhibiting over 97% homology to human antibodies. Selected mAbs demonstrated potent neutralizing activities against three clades (0, 1, 2) of the H5N1 influenza viruses. The in vivo protection experiments demonstrated that the mAbs effectively protected the mice even when administered up to 3 days after infection with H5N1 influenza virus. In particular, mAb 4E6 demonstrated sub-picomolar binding affinity to HA and superior in vivo protection efficacy without the loss of body weight and obvious lung damage. The analysis of the 4E6 escape mutants demonstrated that the 4E6 antibody bound to a conserved epitope region containing two amino acids on the globular head of HA.</AbstractText><AbstractText Label="CONCLUSIONS/SIGNIFICANCE">Our study demonstrated the generation of neutralizing mAbs for potential application in humans in urgent preparedness against outbreaks of new influenza infections or other virulent infectious diseases.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Meng</LastName><ForeName>Weixu</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Respiratory Disease, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China ; The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pan</LastName><ForeName>Weiqi</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Anna J X</ForeName><Initials>AJ</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Zhengfeng</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>Guowei</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Feng</LastName><ForeName>Liqiang</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Dong</LastName><ForeName>Zhenyuan</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Chufang</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Xiangjing</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Caijun</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Luo</LastName><ForeName>Qinfang</ForeName><Initials>Q</Initials></Author><Author ValidYN="Y"><LastName>Yuen</LastName><ForeName>Kwok-Yung</ForeName><Initials>KY</Initials></Author><Author ValidYN="Y"><LastName>Zhong</LastName><ForeName>Nanshan</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Ling</ForeName><Initials>L</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>06</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000911">Antibodies, Monoclonal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D057134">Antibodies, Neutralizing</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000911" MajorTopicYN="N">Antibodies, Monoclonal</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057134" MajorTopicYN="N">Antibodies, Neutralizing</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D021821" MajorTopicYN="N">Communicable Diseases, Emerging</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004196" MajorTopicYN="Y">Disease Outbreaks</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053124" MajorTopicYN="N">Influenza A Virus, H5N1 Subtype</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008253" MajorTopicYN="N">Macaca mulatta</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>12</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>05</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>7</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>7</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>7</Month><Day>5</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23824680</ArticleId><ArticleId IdType="doi">10.1371/journal.pone.0066276</ArticleId><ArticleId 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