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Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses.

Identifieur interne : 000F91 ( PubMed/Curation ); précédent : 000F90; suivant : 000F92

Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses.

Auteurs : Vineet D. Menachery [États-Unis] ; Amie J. Eisfeld [États-Unis] ; Alexandra Sch Fer [États-Unis] ; Laurence Josset [États-Unis] ; Amy C. Sims [États-Unis] ; Sean Proll [États-Unis] ; Shufang Fan [États-Unis] ; Chengjun Li [États-Unis] ; Gabriele Neumann [États-Unis] ; Susan C. Tilton [États-Unis] ; Jean Chang [États-Unis] ; Lisa E. Gralinski [États-Unis] ; Casey Long [États-Unis] ; Richard Green [États-Unis] ; Christopher M. Williams [États-Unis] ; Jeffrey Weiss [États-Unis] ; Melissa M. Matzke [États-Unis] ; Bobbie-Jo Webb-Robertson [États-Unis] ; Athena A. Schepmoes [États-Unis] ; Anil K. Shukla [États-Unis] ; Thomas O. Metz [États-Unis] ; Richard D. Smith [États-Unis] ; Katrina M. Waters [États-Unis] ; Michael G. Katze ; Yoshihiro Kawaoka ; Ralph S. Baric [États-Unis]

Source :

mBio [ 2150-7511 ] ; 2014.

RBID : pubmed:24846384

Descripteurs français

English descriptors

KwdEn :
- Animals, Cell Line, Cluster Analysis, Coronavirus (physiology), Coronavirus Infections (genetics), Coronavirus Infections (metabolism), Coronavirus Infections (virology), Gene Expression Profiling, Gene Expression Regulation (drug effects), Histones (metabolism), Host-Pathogen Interactions (genetics), Humans, Influenza A Virus, H5N1 Subtype (physiology), Influenza A virus (physiology), Influenza, Human (genetics), Influenza, Human (metabolism), Influenza, Human (virology), Interferon Type I, Interferons (metabolism), Interferons (pharmacology), Middle East Respiratory Syndrome Coronavirus (physiology), Models, Biological, Protein Binding, Proteomics, SARS Virus (physiology), Transcription Factors (metabolism), Viral Nonstructural Proteins (metabolism).
MESH :
- chemical , metabolism : Histones, Interferons, Transcription Factors, Viral Nonstructural Proteins.
- drug effects : Gene Expression Regulation.
- genetics : Coronavirus Infections, Host-Pathogen Interactions, Influenza, Human.
- metabolism : Coronavirus Infections, Influenza, Human.
- chemical , pharmacology : Interferons.
- physiology : Coronavirus, Influenza A Virus, H5N1 Subtype, Influenza A virus, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- virology : Coronavirus Infections, Influenza, Human.
- Animals, Cell Line, Cluster Analysis, Gene Expression Profiling, Humans, Interferon Type I, Models, Biological, Protein Binding, Proteomics.

Abstract

The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While successful respiratory viruses overcome individual ISG effectors, analysis of the global ISG response and subsequent viral antagonism has yet to be examined. Employing models of the human airway, transcriptomics and proteomics datasets were used to compare ISG response patterns following highly pathogenic H5N1 avian influenza (HPAI) A virus, 2009 pandemic H1N1, severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle East respiratory syndrome CoV (MERS-CoV) infection. The results illustrated distinct approaches utilized by each virus to antagonize the global ISG response. In addition, the data revealed that highly virulent HPAI virus and MERS-CoV induce repressive histone modifications, which downregulate expression of ISG subsets. Notably, influenza A virus NS1 appears to play a central role in this histone-mediated downregulation in highly pathogenic influenza strains. Together, the work demonstrates the existence of unique and common viral strategies for controlling the global ISG response and provides a novel avenue for viral antagonism via altered histone modifications.

DOI: 10.1128/mBio.01174-14
PubMed: 24846384

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<author><name sortKey="Neumann, Gabriele" sort="Neumann, Gabriele" uniqKey="Neumann G" first="Gabriele" last="Neumann">Gabriele Neumann</name>
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<author><name sortKey="Matzke, Melissa M" sort="Matzke, Melissa M" uniqKey="Matzke M" first="Melissa M" last="Matzke">Melissa M. Matzke</name>
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<author><name sortKey="Webb Robertson, Bobbie Jo" sort="Webb Robertson, Bobbie Jo" uniqKey="Webb Robertson B" first="Bobbie-Jo" last="Webb-Robertson">Bobbie-Jo Webb-Robertson</name>
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<author><name sortKey="Schepmoes, Athena A" sort="Schepmoes, Athena A" uniqKey="Schepmoes A" first="Athena A" last="Schepmoes">Athena A. Schepmoes</name>
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<author><name sortKey="Shukla, Anil K" sort="Shukla, Anil K" uniqKey="Shukla A" first="Anil K" last="Shukla">Anil K. Shukla</name>
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<author><name sortKey="Metz, Thomas O" sort="Metz, Thomas O" uniqKey="Metz T" first="Thomas O" last="Metz">Thomas O. Metz</name>
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<author><name sortKey="Smith, Richard D" sort="Smith, Richard D" uniqKey="Smith R" first="Richard D" last="Smith">Richard D. Smith</name>
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<author><name sortKey="Waters, Katrina M" sort="Waters, Katrina M" uniqKey="Waters K" first="Katrina M" last="Waters">Katrina M. Waters</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Katze, Michael G" sort="Katze, Michael G" uniqKey="Katze M" first="Michael G" last="Katze">Michael G. Katze</name>
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<author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name>
</author>
<author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses.</title>
<author><name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D" last="Menachery">Vineet D. Menachery</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eisfeld, Amie J" sort="Eisfeld, Amie J" uniqKey="Eisfeld A" first="Amie J" last="Eisfeld">Amie J. Eisfeld</name>
<affiliation wicri:level="1"><nlm:affiliation>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sch Fer, Alexandra" sort="Sch Fer, Alexandra" uniqKey="Sch Fer A" first="Alexandra" last="Sch Fer">Alexandra Sch Fer</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Josset, Laurence" sort="Josset, Laurence" uniqKey="Josset L" first="Laurence" last="Josset">Laurence Josset</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sims, Amy C" sort="Sims, Amy C" uniqKey="Sims A" first="Amy C" last="Sims">Amy C. Sims</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Proll, Sean" sort="Proll, Sean" uniqKey="Proll S" first="Sean" last="Proll">Sean Proll</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fan, Shufang" sort="Fan, Shufang" uniqKey="Fan S" first="Shufang" last="Fan">Shufang Fan</name>
<affiliation wicri:level="1"><nlm:affiliation>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Li, Chengjun" sort="Li, Chengjun" uniqKey="Li C" first="Chengjun" last="Li">Chengjun Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Neumann, Gabriele" sort="Neumann, Gabriele" uniqKey="Neumann G" first="Gabriele" last="Neumann">Gabriele Neumann</name>
<affiliation wicri:level="1"><nlm:affiliation>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tilton, Susan C" sort="Tilton, Susan C" uniqKey="Tilton S" first="Susan C" last="Tilton">Susan C. Tilton</name>
<affiliation wicri:level="1"><nlm:affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chang, Jean" sort="Chang, Jean" uniqKey="Chang J" first="Jean" last="Chang">Jean Chang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gralinski, Lisa E" sort="Gralinski, Lisa E" uniqKey="Gralinski L" first="Lisa E" last="Gralinski">Lisa E. Gralinski</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Long, Casey" sort="Long, Casey" uniqKey="Long C" first="Casey" last="Long">Casey Long</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Green, Richard" sort="Green, Richard" uniqKey="Green R" first="Richard" last="Green">Richard Green</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Williams, Christopher M" sort="Williams, Christopher M" uniqKey="Williams C" first="Christopher M" last="Williams">Christopher M. Williams</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Weiss, Jeffrey" sort="Weiss, Jeffrey" uniqKey="Weiss J" first="Jeffrey" last="Weiss">Jeffrey Weiss</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Matzke, Melissa M" sort="Matzke, Melissa M" uniqKey="Matzke M" first="Melissa M" last="Matzke">Melissa M. Matzke</name>
<affiliation wicri:level="1"><nlm:affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Webb Robertson, Bobbie Jo" sort="Webb Robertson, Bobbie Jo" uniqKey="Webb Robertson B" first="Bobbie-Jo" last="Webb-Robertson">Bobbie-Jo Webb-Robertson</name>
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<author><name sortKey="Waters, Katrina M" sort="Waters, Katrina M" uniqKey="Waters K" first="Katrina M" last="Waters">Katrina M. Waters</name>
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<author><name sortKey="Katze, Michael G" sort="Katze, Michael G" uniqKey="Katze M" first="Michael G" last="Katze">Michael G. Katze</name>
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<author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name>
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<author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name>
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<series><title level="j">mBio</title>
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<term>Cell Line</term>
<term>Cluster Analysis</term>
<term>Coronavirus (physiology)</term>
<term>Coronavirus Infections (genetics)</term>
<term>Coronavirus Infections (metabolism)</term>
<term>Coronavirus Infections (virology)</term>
<term>Gene Expression Profiling</term>
<term>Gene Expression Regulation (drug effects)</term>
<term>Histones (metabolism)</term>
<term>Host-Pathogen Interactions (genetics)</term>
<term>Humans</term>
<term>Influenza A Virus, H5N1 Subtype (physiology)</term>
<term>Influenza A virus (physiology)</term>
<term>Influenza, Human (genetics)</term>
<term>Influenza, Human (metabolism)</term>
<term>Influenza, Human (virology)</term>
<term>Interferon Type I</term>
<term>Interferons (metabolism)</term>
<term>Interferons (pharmacology)</term>
<term>Middle East Respiratory Syndrome Coronavirus (physiology)</term>
<term>Models, Biological</term>
<term>Protein Binding</term>
<term>Proteomics</term>
<term>SARS Virus (physiology)</term>
<term>Transcription Factors (metabolism)</term>
<term>Viral Nonstructural Proteins (metabolism)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
<term>Analyse de regroupements</term>
<term>Animaux</term>
<term>Coronavirus (physiologie)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Grippe humaine (génétique)</term>
<term>Grippe humaine (métabolisme)</term>
<term>Grippe humaine (virologie)</term>
<term>Histone (métabolisme)</term>
<term>Humains</term>
<term>Infections à coronavirus (génétique)</term>
<term>Infections à coronavirus (métabolisme)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Interactions hôte-pathogène (génétique)</term>
<term>Interféron de type I</term>
<term>Interférons (métabolisme)</term>
<term>Interférons (pharmacologie)</term>
<term>Liaison aux protéines</term>
<term>Lignée cellulaire</term>
<term>Modèles biologiques</term>
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<term>Sous-type H5N1 du virus de la grippe A (physiologie)</term>
<term>Virus de la grippe A (physiologie)</term>
<term>Virus du SRAS (physiologie)</term>
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<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Sous-type H5N1 du virus de la grippe A</term>
<term>Virus de la grippe A</term>
<term>Virus du SRAS</term>
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<term>Influenza A Virus, H5N1 Subtype</term>
<term>Influenza A virus</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>SARS Virus</term>
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<term>Cell Line</term>
<term>Cluster Analysis</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en">The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While successful respiratory viruses overcome individual ISG effectors, analysis of the global ISG response and subsequent viral antagonism has yet to be examined. Employing models of the human airway, transcriptomics and proteomics datasets were used to compare ISG response patterns following highly pathogenic H5N1 avian influenza (HPAI) A virus, 2009 pandemic H1N1, severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle East respiratory syndrome CoV (MERS-CoV) infection. The results illustrated distinct approaches utilized by each virus to antagonize the global ISG response. In addition, the data revealed that highly virulent HPAI virus and MERS-CoV induce repressive histone modifications, which downregulate expression of ISG subsets. Notably, influenza A virus NS1 appears to play a central role in this histone-mediated downregulation in highly pathogenic influenza strains. Together, the work demonstrates the existence of unique and common viral strategies for controlling the global ISG response and provides a novel avenue for viral antagonism via altered histone modifications.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24846384</PMID>
<DateCompleted><Year>2015</Year>
<Month>01</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>04</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2150-7511</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>5</Volume>
<Issue>3</Issue>
<PubDate><Year>2014</Year>
<Month>May</Month>
<Day>20</Day>
</PubDate>
</JournalIssue>
<Title>mBio</Title>
<ISOAbbreviation>mBio</ISOAbbreviation>
</Journal>
<ArticleTitle>Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses.</ArticleTitle>
<Pagination><MedlinePgn>e01174-14</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1128/mBio.01174-14</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">e01174-14</ELocationID>
<Abstract><AbstractText Label="UNLABELLED">The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While successful respiratory viruses overcome individual ISG effectors, analysis of the global ISG response and subsequent viral antagonism has yet to be examined. Employing models of the human airway, transcriptomics and proteomics datasets were used to compare ISG response patterns following highly pathogenic H5N1 avian influenza (HPAI) A virus, 2009 pandemic H1N1, severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle East respiratory syndrome CoV (MERS-CoV) infection. The results illustrated distinct approaches utilized by each virus to antagonize the global ISG response. In addition, the data revealed that highly virulent HPAI virus and MERS-CoV induce repressive histone modifications, which downregulate expression of ISG subsets. Notably, influenza A virus NS1 appears to play a central role in this histone-mediated downregulation in highly pathogenic influenza strains. Together, the work demonstrates the existence of unique and common viral strategies for controlling the global ISG response and provides a novel avenue for viral antagonism via altered histone modifications.</AbstractText>
<AbstractText Label="IMPORTANCE" NlmCategory="OBJECTIVE">This work combines systems biology and experimental validation to identify and confirm strategies used by viruses to control the immune response. Using a novel screening approach, specific comparison between highly pathogenic influenza viruses and coronaviruses revealed similarities and differences in strategies to control the interferon and innate immune response. These findings were subsequently confirmed and explored, revealing both a common pathway of antagonism via type I interferon (IFN) delay as well as a novel avenue for control by altered histone modification. Together, the data highlight how comparative systems biology analysis can be combined with experimental validation to derive novel insights into viral pathogenesis.</AbstractText>
<CopyrightInformation>Copyright © 2014 Menachery et al.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Menachery</LastName>
<ForeName>Vineet D</ForeName>
<Initials>VD</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Eisfeld</LastName>
<ForeName>Amie J</ForeName>
<Initials>AJ</Initials>
<AffiliationInfo><Affiliation>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schäfer</LastName>
<ForeName>Alexandra</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Josset</LastName>
<ForeName>Laurence</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sims</LastName>
<ForeName>Amy C</ForeName>
<Initials>AC</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Proll</LastName>
<ForeName>Sean</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fan</LastName>
<ForeName>Shufang</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Chengjun</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Neumann</LastName>
<ForeName>Gabriele</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tilton</LastName>
<ForeName>Susan C</ForeName>
<Initials>SC</Initials>
<AffiliationInfo><Affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chang</LastName>
<ForeName>Jean</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gralinski</LastName>
<ForeName>Lisa E</ForeName>
<Initials>LE</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Long</LastName>
<ForeName>Casey</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Green</LastName>
<ForeName>Richard</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Williams</LastName>
<ForeName>Christopher M</ForeName>
<Initials>CM</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Weiss</LastName>
<ForeName>Jeffrey</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Matzke</LastName>
<ForeName>Melissa M</ForeName>
<Initials>MM</Initials>
<AffiliationInfo><Affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Webb-Robertson</LastName>
<ForeName>Bobbie-Jo</ForeName>
<Initials>BJ</Initials>
<AffiliationInfo><Affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schepmoes</LastName>
<ForeName>Athena A</ForeName>
<Initials>AA</Initials>
<AffiliationInfo><Affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shukla</LastName>
<ForeName>Anil K</ForeName>
<Initials>AK</Initials>
<AffiliationInfo><Affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Metz</LastName>
<ForeName>Thomas O</ForeName>
<Initials>TO</Initials>
<AffiliationInfo><Affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Smith</LastName>
<ForeName>Richard D</ForeName>
<Initials>RD</Initials>
<AffiliationInfo><Affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Waters</LastName>
<ForeName>Katrina M</ForeName>
<Initials>KM</Initials>
<AffiliationInfo><Affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Katze</LastName>
<ForeName>Michael G</ForeName>
<Initials>MG</Initials>
</Author>
<Author ValidYN="Y"><LastName>Kawaoka</LastName>
<ForeName>Yoshihiro</ForeName>
<Initials>Y</Initials>
</Author>
<Author ValidYN="Y"><LastName>Baric</LastName>
<ForeName>Ralph S</ForeName>
<Initials>RS</Initials>
<AffiliationInfo><Affiliation>Rbaric@email.unc.edu.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>P41 GM103493</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>F32AI102561</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>F32 AI102561</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U19AI106772</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U19AI100625</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U19 AI106772</GrantID>
<Acronym>AI</Acronym>
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<Grant><GrantID>U19 AI100625</GrantID>
<Acronym>AI</Acronym>
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</Grant>
<Grant><GrantID>8 P41 GM103493-10</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>HHSN272200800060C</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
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<Month>05</Month>
<Day>20</Day>
</ArticleDate>
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<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>mBio</MedlineTA>
<NlmUniqueID>101519231</NlmUniqueID>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D006657">Histones</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C085820">INS1 protein, influenza virus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007370">Interferon Type I</NameOfSubstance>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
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</MeshHeading>
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Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses.

Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses.

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