SrasV1, PubMed, Curation, bibRecord, 000E88

Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates.

Identifieur interne : 000E88 ( PubMed/Curation ); précédent : 000E87; suivant : 000E89

Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates.

Auteurs : Christian Selinger [États-Unis] ; Jennifer Tisoncik-Go [États-Unis] ; Vineet D. Menachery [États-Unis] ; Sudhakar Agnihothram [États-Unis] ; G Lynn Law [États-Unis] ; Jean Chang [États-Unis] ; Sara M. Kelly [États-Unis] ; Pavel Sova [États-Unis] ; Ralph S. Baric [États-Unis] ; Michael G. Katze [États-Unis]

Source :

BMC genomics [ 1471-2164 ] ; 2014.

RBID : pubmed:25534508

Descripteurs français

KwdFr :
- Analyse de profil d'expression de gènes, Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Cytokines (pharmacologie), Facteur de transcription STAT-3 (métabolisme), Facteurs temps, Génomique, Humains, Immunité innée (), Inflammation (virologie), Interactions hôte-pathogène (immunologie), Lignée cellulaire.
MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient.
- immunologie : Interactions hôte-pathogène.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- métabolisme : Facteur de transcription STAT-3.
- pharmacologie : Cytokines.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Inflammation.
- Analyse de profil d'expression de gènes, Facteurs temps, Génomique, Humains, Immunité innée, Lignée cellulaire.

English descriptors

KwdEn :
- Cell Line, Cytokines (pharmacology), Gene Expression Profiling, Genomics, Host-Pathogen Interactions (immunology), Humans, Immunity, Innate (drug effects), Inflammation (virology), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Middle East Respiratory Syndrome Coronavirus (physiology), STAT3 Transcription Factor (metabolism), Time Factors.
MESH :
- chemical , metabolism : STAT3 Transcription Factor.
- chemical , pharmacology : Cytokines.
- drug effects : Immunity, Innate.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- immunology : Host-Pathogen Interactions.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- virology : Inflammation.
- Cell Line, Gene Expression Profiling, Genomics, Humans, Time Factors.

Abstract

The recent emergence of a novel coronavirus in the Middle East (designated MERS-CoV) is a reminder of the zoonotic and pathogenic potential of emerging coronaviruses in humans. Clinical features of Middle East respiratory syndrome (MERS) include atypical pneumonia and progressive respiratory failure that is highly reminiscent of severe acute respiratory syndrome (SARS) caused by SARS-CoV. The host response is a key component of highly pathogenic respiratory virus infection. Here, we computationally analyzed gene expression changes in a human airway epithelial cell line infected with two genetically distinct MERS-CoV strains obtained from human patients, MERS-CoV SA 1 and MERS-CoV Eng 1.

DOI: 10.1186/1471-2164-15-1161
PubMed: 25534508

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Le document en format XML

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<front><div type="abstract" xml:lang="en">The recent emergence of a novel coronavirus in the Middle East (designated MERS-CoV) is a reminder of the zoonotic and pathogenic potential of emerging coronaviruses in humans. Clinical features of Middle East respiratory syndrome (MERS) include atypical pneumonia and progressive respiratory failure that is highly reminiscent of severe acute respiratory syndrome (SARS) caused by SARS-CoV. The host response is a key component of highly pathogenic respiratory virus infection. Here, we computationally analyzed gene expression changes in a human airway epithelial cell line infected with two genetically distinct MERS-CoV strains obtained from human patients, MERS-CoV SA 1 and MERS-CoV Eng 1.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25534508</PMID>
<DateCompleted><Year>2016</Year>
<Month>01</Month>
<Day>04</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>04</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2164</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>15</Volume>
<PubDate><Year>2014</Year>
<Month>Dec</Month>
<Day>22</Day>
</PubDate>
</JournalIssue>
<Title>BMC genomics</Title>
<ISOAbbreviation>BMC Genomics</ISOAbbreviation>
</Journal>
<ArticleTitle>Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates.</ArticleTitle>
<Pagination><MedlinePgn>1161</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/1471-2164-15-1161</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The recent emergence of a novel coronavirus in the Middle East (designated MERS-CoV) is a reminder of the zoonotic and pathogenic potential of emerging coronaviruses in humans. Clinical features of Middle East respiratory syndrome (MERS) include atypical pneumonia and progressive respiratory failure that is highly reminiscent of severe acute respiratory syndrome (SARS) caused by SARS-CoV. The host response is a key component of highly pathogenic respiratory virus infection. Here, we computationally analyzed gene expression changes in a human airway epithelial cell line infected with two genetically distinct MERS-CoV strains obtained from human patients, MERS-CoV SA 1 and MERS-CoV Eng 1.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Using topological techniques, including persistence homology and filtered clustering, we performed a comparative transcriptional analysis of human Calu-3 cell host responses to the different MERS-CoV strains, with MERS-CoV Eng 1 inducing early kinetic changes, between 3 and 12 hours post infection, compared to MERS-CoV SA 1. Robust transcriptional changes distinguished the two MERS-CoV strains predominantly at the late time points. Combining statistical analysis of infection and cytokine-stimulated Calu-3 transcriptomics, we identified differential innate responses, including up-regulation of extracellular remodeling genes following MERS-CoV Eng 1 infection and differential pro-inflammatory responses.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Through our genomics-based approach, we found topological differences in the kinetics and magnitude of the host response to MERS-CoV SA 1 and MERS-CoV Eng 1, with differential expression of innate immune and pro-inflammatory responsive genes as a result of IFN, TNF and IL-1α signaling. Predicted activation for STAT3 mediating gene expression relevant for epithelial cell-to-cell adherens and junction signaling in MERS-CoV Eng 1 infection suggest that these transcriptional differences may be the result of amino acid differences in viral proteins known to modulate innate immunity during MERS-CoV infection.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Selinger</LastName>
<ForeName>Christian</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA. csel@uw.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tisoncik-Go</LastName>
<ForeName>Jennifer</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA. tisoncik@uw.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Menachery</LastName>
<ForeName>Vineet D</ForeName>
<Initials>VD</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA. vineet@email.unc.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Agnihothram</LastName>
<ForeName>Sudhakar</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA. agniss@email.unc.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Law</LastName>
<ForeName>G Lynn</ForeName>
<Initials>GL</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA. gllaw@uw.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chang</LastName>
<ForeName>Jean</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA. mspiggy1@uw.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kelly</LastName>
<ForeName>Sara M</ForeName>
<Initials>SM</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA. smkelly@uw.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sova</LastName>
<ForeName>Pavel</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA. ps44@uw.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Baric</LastName>
<ForeName>Ralph S</ForeName>
<Initials>RS</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA. rbaric@email.unc.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Katze</LastName>
<ForeName>Michael G</ForeName>
<Initials>MG</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA. honey@uw.edu.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
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<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
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<Acronym>OD</Acronym>
<Agency>NIH HHS</Agency>
<Country>United States</Country>
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<Grant><GrantID>HHSN272200800060C</GrantID>
<Acronym>AI</Acronym>
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<ReferenceList><Reference><Citation>Methods Mol Biol. 2000;132:365-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10547847</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Exp Hematol. 1999 Nov;27(11):1583-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10560905</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Methods. 2001 Dec;25(4):402-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11846609</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncogene. 2002 Mar 7;21(11):1685-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11896600</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Biophys Res Commun. 1999 Jul 14;260(3):686-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10403827</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2004 Nov 24;329(2):251-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15518805</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS Lett. 2004 Nov 5;577(1-2):187-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15527783</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2005 Nov;6(11):1133-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16200068</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2671-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16478804</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biostatistics. 2007 Jan;8(1):118-27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16632515</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2007 Nov;81(21):11620-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17715225</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2009 Jul;37(Web Server issue):W247-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19487240</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 2011 Jan;121(1):265-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21157041</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mod Pathol. 2011 Feb;24(2):175-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21057457</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Exp Allergy. 2011 Nov;41(11):1568-78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21801248</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Virol. 2012 Jun;2(3):264-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22572391</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Euro Surveill. 2012;17(40):20290</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23078800</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2012 Nov 8;367(19):1814-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23075143</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MBio. 2013;4(1):e00611-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23422412</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2013 Apr;87(7):3885-902</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23365422</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2013 Mar 14;495(7440):251-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23486063</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Bioinformatics. 2013;14:128</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23586463</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MBio. 2013;4(3):e00165-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23631916</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2013 Jun;87(12):6604-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23552422</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Biochem Cell Biol. 2013 Jul;45(7):1366-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23583295</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2013 Sep;87(17):9953-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23824802</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16157-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24043791</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2013 Oct;19(10):1313-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24013700</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2013 Nov;87(22):12489-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24027320</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Immunol. 2013 Oct;25(5):588-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24011665</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2013 Dec;94(Pt 12):2679-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24077366</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2013 Dec 14;382(9909):1993-2002</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24055451</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2014 Feb;450-451:64-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24503068</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2014;9(2):e88716</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24551142</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2014 Apr 1;209(7):995-1006</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24253287</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MBio. 2014;5(2):e00047-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24667706</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2014 May;88(9):4866-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24522921</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4970-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24599590</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MBio. 2014;5(3):e01174-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24846384</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2014 Aug;10(8):e1004250</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25144235</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
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Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates.

Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates.

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