Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity.
Identifieur interne : 000E12 ( PubMed/Curation ); précédent : 000E11; suivant : 000E13Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity.
Auteurs : Hannah L. Peters [États-Unis] ; Dirk Jochmans [Belgique] ; Adriaan H. De Wilde [Pays-Bas] ; Clara C. Posthuma [Pays-Bas] ; Eric J. Snijder [Pays-Bas] ; Johan Neyts [Belgique] ; Katherine L. Seley-Radtke [États-Unis]Source :
- Bioorganic & medicinal chemistry letters [ 1464-3405 ] ; 2015.
Descripteurs français
- KwdFr :
- Aciclovir (analogues et dérivés), Aciclovir (pharmacologie), Animaux, Antiviraux (), Antiviraux (pharmacologie), Cellules Vero, Conception de médicament, Coronavirus (), Coronavirus (physiologie), Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Coronavirus humain NL63 (), Coronavirus humain NL63 (physiologie), Humains, Infections à coronavirus (traitement médicamenteux), Nucléosides (), Nucléosides (pharmacologie), Réplication virale (), Virus du SRAS (), Virus du SRAS (physiologie).
- MESH :
- analogues et dérivés : Aciclovir.
- pharmacologie : Aciclovir, Antiviraux, Nucléosides.
- physiologie : Coronavirus, Coronavirus du syndrome respiratoire du Moyen-Orient, Coronavirus humain NL63, Virus du SRAS.
- traitement médicamenteux : Infections à coronavirus.
- Animaux, Antiviraux, Cellules Vero, Conception de médicament, Coronavirus, Coronavirus du syndrome respiratoire du Moyen-Orient, Coronavirus humain NL63, Humains, Nucléosides, Réplication virale, Virus du SRAS.
English descriptors
- KwdEn :
- Acyclovir (analogs & derivatives), Acyclovir (pharmacology), Animals, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Chlorocebus aethiops, Coronavirus (drug effects), Coronavirus (physiology), Coronavirus Infections (drug therapy), Coronavirus NL63, Human (drug effects), Coronavirus NL63, Human (physiology), Drug Design, Humans, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (physiology), Nucleosides (chemistry), Nucleosides (pharmacology), SARS Virus (drug effects), SARS Virus (physiology), Vero Cells, Virus Replication (drug effects).
- MESH :
- chemical , analogs & derivatives : Acyclovir.
- chemical , chemistry : Antiviral Agents, Nucleosides.
- chemical , pharmacology : Acyclovir, Antiviral Agents, Nucleosides.
- drug effects : Coronavirus, Coronavirus NL63, Human, Middle East Respiratory Syndrome Coronavirus, SARS Virus, Virus Replication.
- drug therapy : Coronavirus Infections.
- physiology : Coronavirus, Coronavirus NL63, Human, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- Animals, Chlorocebus aethiops, Drug Design, Humans, Vero Cells.
Abstract
A series of doubly flexible nucleoside analogues were designed based on the acyclic sugar scaffold of acyclovir and the flex-base moiety found in the fleximers. The target compounds were evaluated for their antiviral potential and found to inhibit several coronaviruses. Significantly, compound 2 displayed selective antiviral activity (CC50 >3× EC50) towards human coronavirus (HCoV)-NL63 and Middle East respiratory syndrome-coronavirus, but not severe acute respiratory syndrome-coronavirus. In the case of HCoV-NL63 the activity was highly promising with an EC50 <10 μM and a CC50 >100 μM. As such, these doubly flexible nucleoside analogues are viewed as a novel new class of drug candidates with potential for potent inhibition of coronaviruses.
DOI: 10.1016/j.bmcl.2015.05.039
PubMed: 26048809
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000E12
Links to Exploration step
pubmed:26048809Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity.</title>
<author><name sortKey="Peters, Hannah L" sort="Peters, Hannah L" uniqKey="Peters H" first="Hannah L" last="Peters">Hannah L. Peters</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Maryland, Baltimore County, Department of Chemistry & Biochemistry, 1000 Hilltop Circle, Baltimore, MD 21250, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Maryland, Baltimore County, Department of Chemistry & Biochemistry, 1000 Hilltop Circle, Baltimore, MD 21250</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jochmans, Dirk" sort="Jochmans, Dirk" uniqKey="Jochmans D" first="Dirk" last="Jochmans">Dirk Jochmans</name>
<affiliation wicri:level="1"><nlm:affiliation>Rega Institute, University of Leuven (KULeuven), Minderbroederstraat 10, Leuven BE-3000, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Rega Institute, University of Leuven (KULeuven), Minderbroederstraat 10, Leuven BE-3000</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Wilde, Adriaan H" sort="De Wilde, Adriaan H" uniqKey="De Wilde A" first="Adriaan H" last="De Wilde">Adriaan H. De Wilde</name>
<affiliation wicri:level="1"><nlm:affiliation>Leiden University Medical Center, Department of Medical Microbiology, PO Box 9600, 2300 RC Leiden, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Leiden University Medical Center, Department of Medical Microbiology, PO Box 9600, 2300 RC Leiden</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Posthuma, Clara C" sort="Posthuma, Clara C" uniqKey="Posthuma C" first="Clara C" last="Posthuma">Clara C. Posthuma</name>
<affiliation wicri:level="1"><nlm:affiliation>Leiden University Medical Center, Department of Medical Microbiology, PO Box 9600, 2300 RC Leiden, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Leiden University Medical Center, Department of Medical Microbiology, PO Box 9600, 2300 RC Leiden</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Snijder, Eric J" sort="Snijder, Eric J" uniqKey="Snijder E" first="Eric J" last="Snijder">Eric J. Snijder</name>
<affiliation wicri:level="1"><nlm:affiliation>Leiden University Medical Center, Department of Medical Microbiology, PO Box 9600, 2300 RC Leiden, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Leiden University Medical Center, Department of Medical Microbiology, PO Box 9600, 2300 RC Leiden</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Neyts, Johan" sort="Neyts, Johan" uniqKey="Neyts J" first="Johan" last="Neyts">Johan Neyts</name>
<affiliation wicri:level="1"><nlm:affiliation>Rega Institute, University of Leuven (KULeuven), Minderbroederstraat 10, Leuven BE-3000, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Rega Institute, University of Leuven (KULeuven), Minderbroederstraat 10, Leuven BE-3000</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Seley Radtke, Katherine L" sort="Seley Radtke, Katherine L" uniqKey="Seley Radtke K" first="Katherine L" last="Seley-Radtke">Katherine L. Seley-Radtke</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Maryland, Baltimore County, Department of Chemistry & Biochemistry, 1000 Hilltop Circle, Baltimore, MD 21250, USA. Electronic address: kseley@umbc.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Maryland, Baltimore County, Department of Chemistry & Biochemistry, 1000 Hilltop Circle, Baltimore, MD 21250</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2015">2015</date>
<idno type="RBID">pubmed:26048809</idno>
<idno type="pmid">26048809</idno>
<idno type="doi">10.1016/j.bmcl.2015.05.039</idno>
<idno type="wicri:Area/PubMed/Corpus">000E12</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E12</idno>
<idno type="wicri:Area/PubMed/Curation">000E12</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E12</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity.</title>
<author><name sortKey="Peters, Hannah L" sort="Peters, Hannah L" uniqKey="Peters H" first="Hannah L" last="Peters">Hannah L. Peters</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Maryland, Baltimore County, Department of Chemistry & Biochemistry, 1000 Hilltop Circle, Baltimore, MD 21250, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Maryland, Baltimore County, Department of Chemistry & Biochemistry, 1000 Hilltop Circle, Baltimore, MD 21250</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jochmans, Dirk" sort="Jochmans, Dirk" uniqKey="Jochmans D" first="Dirk" last="Jochmans">Dirk Jochmans</name>
<affiliation wicri:level="1"><nlm:affiliation>Rega Institute, University of Leuven (KULeuven), Minderbroederstraat 10, Leuven BE-3000, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Rega Institute, University of Leuven (KULeuven), Minderbroederstraat 10, Leuven BE-3000</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Wilde, Adriaan H" sort="De Wilde, Adriaan H" uniqKey="De Wilde A" first="Adriaan H" last="De Wilde">Adriaan H. De Wilde</name>
<affiliation wicri:level="1"><nlm:affiliation>Leiden University Medical Center, Department of Medical Microbiology, PO Box 9600, 2300 RC Leiden, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Leiden University Medical Center, Department of Medical Microbiology, PO Box 9600, 2300 RC Leiden</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Posthuma, Clara C" sort="Posthuma, Clara C" uniqKey="Posthuma C" first="Clara C" last="Posthuma">Clara C. Posthuma</name>
<affiliation wicri:level="1"><nlm:affiliation>Leiden University Medical Center, Department of Medical Microbiology, PO Box 9600, 2300 RC Leiden, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Leiden University Medical Center, Department of Medical Microbiology, PO Box 9600, 2300 RC Leiden</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Snijder, Eric J" sort="Snijder, Eric J" uniqKey="Snijder E" first="Eric J" last="Snijder">Eric J. Snijder</name>
<affiliation wicri:level="1"><nlm:affiliation>Leiden University Medical Center, Department of Medical Microbiology, PO Box 9600, 2300 RC Leiden, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Leiden University Medical Center, Department of Medical Microbiology, PO Box 9600, 2300 RC Leiden</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Neyts, Johan" sort="Neyts, Johan" uniqKey="Neyts J" first="Johan" last="Neyts">Johan Neyts</name>
<affiliation wicri:level="1"><nlm:affiliation>Rega Institute, University of Leuven (KULeuven), Minderbroederstraat 10, Leuven BE-3000, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Rega Institute, University of Leuven (KULeuven), Minderbroederstraat 10, Leuven BE-3000</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Seley Radtke, Katherine L" sort="Seley Radtke, Katherine L" uniqKey="Seley Radtke K" first="Katherine L" last="Seley-Radtke">Katherine L. Seley-Radtke</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Maryland, Baltimore County, Department of Chemistry & Biochemistry, 1000 Hilltop Circle, Baltimore, MD 21250, USA. Electronic address: kseley@umbc.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Maryland, Baltimore County, Department of Chemistry & Biochemistry, 1000 Hilltop Circle, Baltimore, MD 21250</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Bioorganic & medicinal chemistry letters</title>
<idno type="eISSN">1464-3405</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acyclovir (analogs & derivatives)</term>
<term>Acyclovir (pharmacology)</term>
<term>Animals</term>
<term>Antiviral Agents (chemistry)</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Chlorocebus aethiops</term>
<term>Coronavirus (drug effects)</term>
<term>Coronavirus (physiology)</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Coronavirus NL63, Human (drug effects)</term>
<term>Coronavirus NL63, Human (physiology)</term>
<term>Drug Design</term>
<term>Humans</term>
<term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term>
<term>Middle East Respiratory Syndrome Coronavirus (physiology)</term>
<term>Nucleosides (chemistry)</term>
<term>Nucleosides (pharmacology)</term>
<term>SARS Virus (drug effects)</term>
<term>SARS Virus (physiology)</term>
<term>Vero Cells</term>
<term>Virus Replication (drug effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Aciclovir (analogues et dérivés)</term>
<term>Aciclovir (pharmacologie)</term>
<term>Animaux</term>
<term>Antiviraux ()</term>
<term>Antiviraux (pharmacologie)</term>
<term>Cellules Vero</term>
<term>Conception de médicament</term>
<term>Coronavirus ()</term>
<term>Coronavirus (physiologie)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term>
<term>Coronavirus humain NL63 ()</term>
<term>Coronavirus humain NL63 (physiologie)</term>
<term>Humains</term>
<term>Infections à coronavirus (traitement médicamenteux)</term>
<term>Nucléosides ()</term>
<term>Nucléosides (pharmacologie)</term>
<term>Réplication virale ()</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (physiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Acyclovir</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term>
<term>Nucleosides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Acyclovir</term>
<term>Antiviral Agents</term>
<term>Nucleosides</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Aciclovir</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Coronavirus</term>
<term>Coronavirus NL63, Human</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>SARS Virus</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Aciclovir</term>
<term>Antiviraux</term>
<term>Nucléosides</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Coronavirus humain NL63</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term>
<term>Coronavirus NL63, Human</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Chlorocebus aethiops</term>
<term>Drug Design</term>
<term>Humans</term>
<term>Vero Cells</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Antiviraux</term>
<term>Cellules Vero</term>
<term>Conception de médicament</term>
<term>Coronavirus</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Coronavirus humain NL63</term>
<term>Humains</term>
<term>Nucléosides</term>
<term>Réplication virale</term>
<term>Virus du SRAS</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">A series of doubly flexible nucleoside analogues were designed based on the acyclic sugar scaffold of acyclovir and the flex-base moiety found in the fleximers. The target compounds were evaluated for their antiviral potential and found to inhibit several coronaviruses. Significantly, compound 2 displayed selective antiviral activity (CC50 >3× EC50) towards human coronavirus (HCoV)-NL63 and Middle East respiratory syndrome-coronavirus, but not severe acute respiratory syndrome-coronavirus. In the case of HCoV-NL63 the activity was highly promising with an EC50 <10 μM and a CC50 >100 μM. As such, these doubly flexible nucleoside analogues are viewed as a novel new class of drug candidates with potential for potent inhibition of coronaviruses.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26048809</PMID>
<DateCompleted><Year>2016</Year>
<Month>03</Month>
<Day>08</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1464-3405</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>25</Volume>
<Issue>15</Issue>
<PubDate><Year>2015</Year>
<Month>Aug</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>Bioorganic & medicinal chemistry letters</Title>
<ISOAbbreviation>Bioorg. Med. Chem. Lett.</ISOAbbreviation>
</Journal>
<ArticleTitle>Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity.</ArticleTitle>
<Pagination><MedlinePgn>2923-6</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bmcl.2015.05.039</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S0960-894X(15)00501-6</ELocationID>
<Abstract><AbstractText>A series of doubly flexible nucleoside analogues were designed based on the acyclic sugar scaffold of acyclovir and the flex-base moiety found in the fleximers. The target compounds were evaluated for their antiviral potential and found to inhibit several coronaviruses. Significantly, compound 2 displayed selective antiviral activity (CC50 >3× EC50) towards human coronavirus (HCoV)-NL63 and Middle East respiratory syndrome-coronavirus, but not severe acute respiratory syndrome-coronavirus. In the case of HCoV-NL63 the activity was highly promising with an EC50 <10 μM and a CC50 >100 μM. As such, these doubly flexible nucleoside analogues are viewed as a novel new class of drug candidates with potential for potent inhibition of coronaviruses.</AbstractText>
<CopyrightInformation>Copyright © 2015 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Peters</LastName>
<ForeName>Hannah L</ForeName>
<Initials>HL</Initials>
<AffiliationInfo><Affiliation>University of Maryland, Baltimore County, Department of Chemistry & Biochemistry, 1000 Hilltop Circle, Baltimore, MD 21250, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jochmans</LastName>
<ForeName>Dirk</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Rega Institute, University of Leuven (KULeuven), Minderbroederstraat 10, Leuven BE-3000, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de Wilde</LastName>
<ForeName>Adriaan H</ForeName>
<Initials>AH</Initials>
<AffiliationInfo><Affiliation>Leiden University Medical Center, Department of Medical Microbiology, PO Box 9600, 2300 RC Leiden, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Posthuma</LastName>
<ForeName>Clara C</ForeName>
<Initials>CC</Initials>
<AffiliationInfo><Affiliation>Leiden University Medical Center, Department of Medical Microbiology, PO Box 9600, 2300 RC Leiden, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Snijder</LastName>
<ForeName>Eric J</ForeName>
<Initials>EJ</Initials>
<AffiliationInfo><Affiliation>Leiden University Medical Center, Department of Medical Microbiology, PO Box 9600, 2300 RC Leiden, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Neyts</LastName>
<ForeName>Johan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Rega Institute, University of Leuven (KULeuven), Minderbroederstraat 10, Leuven BE-3000, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Seley-Radtke</LastName>
<ForeName>Katherine L</ForeName>
<Initials>KL</Initials>
<AffiliationInfo><Affiliation>University of Maryland, Baltimore County, Department of Chemistry & Biochemistry, 1000 Hilltop Circle, Baltimore, MD 21250, USA. Electronic address: kseley@umbc.edu.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R21 AI097685</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>T32 GM066706</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R21AI097685</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>T32GM066706</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>05</Month>
<Day>23</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Bioorg Med Chem Lett</MedlineTA>
<NlmUniqueID>9107377</NlmUniqueID>
<ISSNLinking>0960-894X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D009705">Nucleosides</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>X4HES1O11F</RegistryNumber>
<NameOfSubstance UI="D000212">Acyclovir</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000212" MajorTopicYN="N">Acyclovir</DescriptorName>
<QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002522" MajorTopicYN="N">Chlorocebus aethiops</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017934" MajorTopicYN="N">Coronavirus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058957" MajorTopicYN="N">Coronavirus NL63, Human</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015195" MajorTopicYN="N">Drug Design</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009705" MajorTopicYN="N">Nucleosides</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014709" MajorTopicYN="N">Vero Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Acyclovir</Keyword>
<Keyword MajorTopicYN="N">Antiviral</Keyword>
<Keyword MajorTopicYN="N">Coronaviruses</Keyword>
<Keyword MajorTopicYN="N">Fleximers</Keyword>
<Keyword MajorTopicYN="N">MERS-CoV</Keyword>
<Keyword MajorTopicYN="N">Nucleosides</Keyword>
<Keyword MajorTopicYN="N">SARS</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year>
<Month>04</Month>
<Day>10</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2015</Year>
<Month>05</Month>
<Day>16</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2015</Year>
<Month>05</Month>
<Day>19</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2015</Year>
<Month>6</Month>
<Day>7</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2015</Year>
<Month>6</Month>
<Day>7</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>3</Month>
<Day>10</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">26048809</ArticleId>
<ArticleId IdType="pii">S0960-894X(15)00501-6</ArticleId>
<ArticleId IdType="doi">10.1016/j.bmcl.2015.05.039</ArticleId>
<ArticleId IdType="pmc">PMC4466200</ArticleId>
<ArticleId IdType="mid">NIHMS697060</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Bioorg Med Chem Lett. 2010 Aug 15;20(16):4850-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20637609</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Infect Dis. 2010 Feb 15;201(4):635-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20085496</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Chemistry. 2005 May 20;11(11):3294-308</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15786503</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Synthesis (Stuttg). 2012;44(22):3496-3504</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24465059</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Med. 2013 Oct;19(10):1313-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24013700</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 1984 Aug 10;259(15):9575-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6086640</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Expert Rev Anti Infect Ther. 2007 Apr;5(2):245-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17402839</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Med. 1982 Jul 20;73(1A):67-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6285735</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Int J Infect Dis. 2014 Mar;20:42-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24406736</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Org Lett. 2005 Jan 6;7(1):63-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15624978</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Int J Infect Dis. 2013 Oct;17(10):e792-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23993766</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Org Chem. 2002 May 17;67(10):3365-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12003548</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem Biophys Res Commun. 2005 Jan 28;326(4):905-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15607755</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Antimicrob Agents Chemother. 2014 Aug;58(8):4875-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24841269</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochemistry. 2005 Oct 4;44(39):13172-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16185085</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Gen Virol. 2013 Aug;94(Pt 8):1749-1760</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23620378</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Emerg Infect Dis. 2004 Apr;10(4):581-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15200845</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS Pathog. 2013 Aug;9(8):e1003565</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23966862</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochemistry. 2005 Aug 16;44(32):10854-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16086588</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Org Lett. 2001 Oct 4;3(20):3209-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11574032</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2003 Apr 19;361(9366):1319-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12711465</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Clin Virol. 2004 Sep;31(1):69-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15288617</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E12 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 000E12 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= PubMed |étape= Curation |type= RBID |clé= pubmed:26048809 |texte= Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:26048809" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |