Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways.
Identifieur interne : 000D93 ( PubMed/Curation ); précédent : 000D92; suivant : 000D94Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways.
Auteurs : Hin Chu ; Jie Zhou ; Bosco Ho-Yin Wong ; Cun Li ; Jasper Fuk-Woo Chan ; Zhong-Shan Cheng ; Dong Yang ; Dong Wang ; Andrew Chak-Yiu Lee ; Chuangen Li ; Man-Lung Yeung ; Jian-Piao Cai ; Ivy Hau-Yee Chan ; Wai-Kuen Ho ; Kelvin Kai-Wang To ; Bo-Jian Zheng ; Yanfeng Yao ; Chuan Qin ; Kwok-Yung Yuen [République populaire de Chine]Source :
- The Journal of infectious diseases [ 1537-6613 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux, Apoptose (physiologie), Callithrix, Cellules cultivées, Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Dipeptidyl peptidase 4 (génétique), Dipeptidyl peptidase 4 (métabolisme), Humains, Lymphocytes T (physiologie), Lymphocytes T (virologie), Rate (cytologie), Régulation de l'expression des gènes, Tonsille palatine (cytologie), Virus du SRAS (physiologie).
- MESH :
- cytologie : Rate, Tonsille palatine.
- génétique : Dipeptidyl peptidase 4.
- métabolisme : Dipeptidyl peptidase 4.
- physiologie : Apoptose, Coronavirus du syndrome respiratoire du Moyen-Orient, Lymphocytes T, Virus du SRAS.
- virologie : Lymphocytes T.
- Animaux, Anticorps antiviraux, Callithrix, Cellules cultivées, Humains, Régulation de l'expression des gènes.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral, Apoptosis (physiology), Callithrix, Cells, Cultured, Dipeptidyl Peptidase 4 (genetics), Dipeptidyl Peptidase 4 (metabolism), Gene Expression Regulation, Humans, Middle East Respiratory Syndrome Coronavirus (physiology), Palatine Tonsil (cytology), SARS Virus (physiology), Spleen (cytology), T-Lymphocytes (physiology), T-Lymphocytes (virology).
- MESH :
- chemical , genetics : Dipeptidyl Peptidase 4.
- chemical , metabolism : Dipeptidyl Peptidase 4.
- chemical : Antibodies, Viral.
- cytology : Palatine Tonsil, Spleen.
- physiology : Apoptosis, Middle East Respiratory Syndrome Coronavirus, SARS Virus, T-Lymphocytes.
- virology : T-Lymphocytes.
- Animals, Callithrix, Cells, Cultured, Gene Expression Regulation, Humans.
Abstract
Middle East respiratory syndrome (MERS) is associated with a mortality rate of >35%. We previously showed that MERS coronavirus (MERS-CoV) could infect human macrophages and dendritic cells and induce cytokine dysregulation. Here, we further investigated the interplay between human primary T cells and MERS-CoV in disease pathogenesis. Importantly, our results suggested that MERS-CoV efficiently infected T cells from the peripheral blood and from human lymphoid organs, including the spleen and the tonsil. We further demonstrated that MERS-CoV infection induced apoptosis in T cells, which involved the activation of both the extrinsic and intrinsic apoptosis pathways. Remarkably, immunostaining of spleen sections from MERS-CoV-infected common marmosets demonstrated the presence of viral nucleoprotein in their CD3(+) T cells. Overall, our results suggested that the unusual capacity of MERS-CoV to infect T cells and induce apoptosis might partly contribute to the high pathogenicity of the virus.
DOI: 10.1093/infdis/jiv380
PubMed: 26203058
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Hin Chu<affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Surgery, University of Hong Kong, Hong Kong Special Administrative Region.</nlm:affiliation><wicri:noCountry code="subField">Hong Kong Special Administrative Region</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Surgery, University of Hong Kong, Hong Kong Special Administrative Region.</nlm:affiliation><wicri:noCountry code="subField">Hong Kong Special Administrative Region</wicri:noCountry></affiliation><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences.</nlm:affiliation><wicri:noCountry code="subField">Chinese Academy of Medical Sciences</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences.</nlm:affiliation><wicri:noCountry code="subField">Chinese Academy of Medical Sciences</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways.</title><author><name sortKey="Chu, Hin" sort="Chu, Hin" uniqKey="Chu H" first="Hin" last="Chu">Hin Chu</name><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation></author><author><name sortKey="Zhou, Jie" sort="Zhou, Jie" uniqKey="Zhou J" first="Jie" last="Zhou">Jie Zhou</name><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation></author><author><name sortKey="Wong, Bosco Ho Yin" sort="Wong, Bosco Ho Yin" uniqKey="Wong B" first="Bosco Ho-Yin" last="Wong">Bosco Ho-Yin Wong</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Li, Cun" sort="Li, Cun" uniqKey="Li C" first="Cun" last="Li">Cun Li</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Chan, Jasper Fuk Woo" sort="Chan, Jasper Fuk Woo" uniqKey="Chan J" first="Jasper Fuk-Woo" last="Chan">Jasper Fuk-Woo Chan</name><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation></author><author><name sortKey="Cheng, Zhong Shan" sort="Cheng, Zhong Shan" uniqKey="Cheng Z" first="Zhong-Shan" last="Cheng">Zhong-Shan Cheng</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Yang, Dong" sort="Yang, Dong" uniqKey="Yang D" first="Dong" last="Yang">Dong Yang</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Wang, Dong" sort="Wang, Dong" uniqKey="Wang D" first="Dong" last="Wang">Dong Wang</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Lee, Andrew Chak Yiu" sort="Lee, Andrew Chak Yiu" uniqKey="Lee A" first="Andrew Chak-Yiu" last="Lee">Andrew Chak-Yiu Lee</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Li, Chuangen" sort="Li, Chuangen" uniqKey="Li C" first="Chuangen" last="Li">Chuangen Li</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Yeung, Man Lung" sort="Yeung, Man Lung" uniqKey="Yeung M" first="Man-Lung" last="Yeung">Man-Lung Yeung</name><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation></author><author><name sortKey="Cai, Jian Piao" sort="Cai, Jian Piao" uniqKey="Cai J" first="Jian-Piao" last="Cai">Jian-Piao Cai</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Chan, Ivy Hau Yee" sort="Chan, Ivy Hau Yee" uniqKey="Chan I" first="Ivy Hau-Yee" last="Chan">Ivy Hau-Yee Chan</name><affiliation><nlm:affiliation>Department of Surgery, University of Hong Kong, Hong Kong Special Administrative Region.</nlm:affiliation><wicri:noCountry code="subField">Hong Kong Special Administrative Region</wicri:noCountry></affiliation></author><author><name sortKey="Ho, Wai Kuen" sort="Ho, Wai Kuen" uniqKey="Ho W" first="Wai-Kuen" last="Ho">Wai-Kuen Ho</name><affiliation><nlm:affiliation>Department of Surgery, University of Hong Kong, Hong Kong Special Administrative Region.</nlm:affiliation><wicri:noCountry code="subField">Hong Kong Special Administrative Region</wicri:noCountry></affiliation></author><author><name sortKey="To, Kelvin Kai Wang" sort="To, Kelvin Kai Wang" uniqKey="To K" first="Kelvin Kai-Wang" last="To">Kelvin Kai-Wang To</name><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation></author><author><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation></author><author><name sortKey="Yao, Yanfeng" sort="Yao, Yanfeng" uniqKey="Yao Y" first="Yanfeng" last="Yao">Yanfeng Yao</name><affiliation><nlm:affiliation>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences.</nlm:affiliation><wicri:noCountry code="subField">Chinese Academy of Medical Sciences</wicri:noCountry></affiliation></author><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><affiliation><nlm:affiliation>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences.</nlm:affiliation><wicri:noCountry code="subField">Chinese Academy of Medical Sciences</wicri:noCountry></affiliation></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26203058</idno><idno type="pmid">26203058</idno><idno type="doi">10.1093/infdis/jiv380</idno><idno type="wicri:Area/PubMed/Corpus">000D93</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D93</idno><idno type="wicri:Area/PubMed/Curation">000D93</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D93</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways.</title><author><name sortKey="Chu, Hin" sort="Chu, Hin" uniqKey="Chu H" first="Hin" last="Chu">Hin Chu</name><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation></author><author><name sortKey="Zhou, Jie" sort="Zhou, Jie" uniqKey="Zhou J" first="Jie" last="Zhou">Jie Zhou</name><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation></author><author><name sortKey="Wong, Bosco Ho Yin" sort="Wong, Bosco Ho Yin" uniqKey="Wong B" first="Bosco Ho-Yin" last="Wong">Bosco Ho-Yin Wong</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Li, Cun" sort="Li, Cun" uniqKey="Li C" first="Cun" last="Li">Cun Li</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Chan, Jasper Fuk Woo" sort="Chan, Jasper Fuk Woo" uniqKey="Chan J" first="Jasper Fuk-Woo" last="Chan">Jasper Fuk-Woo Chan</name><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation></author><author><name sortKey="Cheng, Zhong Shan" sort="Cheng, Zhong Shan" uniqKey="Cheng Z" first="Zhong-Shan" last="Cheng">Zhong-Shan Cheng</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Yang, Dong" sort="Yang, Dong" uniqKey="Yang D" first="Dong" last="Yang">Dong Yang</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Wang, Dong" sort="Wang, Dong" uniqKey="Wang D" first="Dong" last="Wang">Dong Wang</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Lee, Andrew Chak Yiu" sort="Lee, Andrew Chak Yiu" uniqKey="Lee A" first="Andrew Chak-Yiu" last="Lee">Andrew Chak-Yiu Lee</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Li, Chuangen" sort="Li, Chuangen" uniqKey="Li C" first="Chuangen" last="Li">Chuangen Li</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Yeung, Man Lung" sort="Yeung, Man Lung" uniqKey="Yeung M" first="Man-Lung" last="Yeung">Man-Lung Yeung</name><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation></author><author><name sortKey="Cai, Jian Piao" sort="Cai, Jian Piao" uniqKey="Cai J" first="Jian-Piao" last="Cai">Jian-Piao Cai</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Chan, Ivy Hau Yee" sort="Chan, Ivy Hau Yee" uniqKey="Chan I" first="Ivy Hau-Yee" last="Chan">Ivy Hau-Yee Chan</name><affiliation><nlm:affiliation>Department of Surgery, University of Hong Kong, Hong Kong Special Administrative Region.</nlm:affiliation><wicri:noCountry code="subField">Hong Kong Special Administrative Region</wicri:noCountry></affiliation></author><author><name sortKey="Ho, Wai Kuen" sort="Ho, Wai Kuen" uniqKey="Ho W" first="Wai-Kuen" last="Ho">Wai-Kuen Ho</name><affiliation><nlm:affiliation>Department of Surgery, University of Hong Kong, Hong Kong Special Administrative Region.</nlm:affiliation><wicri:noCountry code="subField">Hong Kong Special Administrative Region</wicri:noCountry></affiliation></author><author><name sortKey="To, Kelvin Kai Wang" sort="To, Kelvin Kai Wang" uniqKey="To K" first="Kelvin Kai-Wang" last="To">Kelvin Kai-Wang To</name><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation></author><author><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation></author><author><name sortKey="Yao, Yanfeng" sort="Yao, Yanfeng" uniqKey="Yao Y" first="Yanfeng" last="Yao">Yanfeng Yao</name><affiliation><nlm:affiliation>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences.</nlm:affiliation><wicri:noCountry code="subField">Chinese Academy of Medical Sciences</wicri:noCountry></affiliation></author><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><affiliation><nlm:affiliation>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences.</nlm:affiliation><wicri:noCountry code="subField">Chinese Academy of Medical Sciences</wicri:noCountry></affiliation></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="eISSN">1537-6613</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral</term><term>Apoptosis (physiology)</term><term>Callithrix</term><term>Cells, Cultured</term><term>Dipeptidyl Peptidase 4 (genetics)</term><term>Dipeptidyl Peptidase 4 (metabolism)</term><term>Gene Expression Regulation</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (physiology)</term><term>Palatine Tonsil (cytology)</term><term>SARS Virus (physiology)</term><term>Spleen (cytology)</term><term>T-Lymphocytes (physiology)</term><term>T-Lymphocytes (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux</term><term>Apoptose (physiologie)</term><term>Callithrix</term><term>Cellules cultivées</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term><term>Dipeptidyl peptidase 4 (génétique)</term><term>Dipeptidyl peptidase 4 (métabolisme)</term><term>Humains</term><term>Lymphocytes T (physiologie)</term><term>Lymphocytes T (virologie)</term><term>Rate (cytologie)</term><term>Régulation de l'expression des gènes</term><term>Tonsille palatine (cytologie)</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Dipeptidyl Peptidase 4</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dipeptidyl Peptidase 4</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Rate</term><term>Tonsille palatine</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Palatine Tonsil</term><term>Spleen</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Dipeptidyl peptidase 4</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Dipeptidyl peptidase 4</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Apoptose</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Lymphocytes T</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Apoptosis</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Lymphocytes T</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Callithrix</term><term>Cells, Cultured</term><term>Gene Expression Regulation</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux</term><term>Callithrix</term><term>Cellules cultivées</term><term>Humains</term><term>Régulation de l'expression des gènes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East respiratory syndrome (MERS) is associated with a mortality rate of >35%. We previously showed that MERS coronavirus (MERS-CoV) could infect human macrophages and dendritic cells and induce cytokine dysregulation. Here, we further investigated the interplay between human primary T cells and MERS-CoV in disease pathogenesis. Importantly, our results suggested that MERS-CoV efficiently infected T cells from the peripheral blood and from human lymphoid organs, including the spleen and the tonsil. We further demonstrated that MERS-CoV infection induced apoptosis in T cells, which involved the activation of both the extrinsic and intrinsic apoptosis pathways. Remarkably, immunostaining of spleen sections from MERS-CoV-infected common marmosets demonstrated the presence of viral nucleoprotein in their CD3(+) T cells. Overall, our results suggested that the unusual capacity of MERS-CoV to infect T cells and induce apoptosis might partly contribute to the high pathogenicity of the virus. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26203058</PMID><DateCompleted><Year>2016</Year><Month>07</Month><Day>06</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-6613</ISSN><JournalIssue CitedMedium="Internet"><Volume>213</Volume><Issue>6</Issue><PubDate><Year>2016</Year><Month>Mar</Month><Day>15</Day></PubDate></JournalIssue><Title>The Journal of infectious diseases</Title><ISOAbbreviation>J. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways.</ArticleTitle><Pagination><MedlinePgn>904-14</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/infdis/jiv380</ELocationID><Abstract><AbstractText>Middle East respiratory syndrome (MERS) is associated with a mortality rate of >35%. We previously showed that MERS coronavirus (MERS-CoV) could infect human macrophages and dendritic cells and induce cytokine dysregulation. Here, we further investigated the interplay between human primary T cells and MERS-CoV in disease pathogenesis. Importantly, our results suggested that MERS-CoV efficiently infected T cells from the peripheral blood and from human lymphoid organs, including the spleen and the tonsil. We further demonstrated that MERS-CoV infection induced apoptosis in T cells, which involved the activation of both the extrinsic and intrinsic apoptosis pathways. Remarkably, immunostaining of spleen sections from MERS-CoV-infected common marmosets demonstrated the presence of viral nucleoprotein in their CD3(+) T cells. Overall, our results suggested that the unusual capacity of MERS-CoV to infect T cells and induce apoptosis might partly contribute to the high pathogenicity of the virus. </AbstractText><CopyrightInformation>© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chu</LastName><ForeName>Hin</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Jie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Bosco Ho-Yin</ForeName><Initials>BH</Initials><AffiliationInfo><Affiliation>Department of Microbiology.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Cun</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Microbiology.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Jasper Fuk-Woo</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Zhong-Shan</ForeName><Initials>ZS</Initials><AffiliationInfo><Affiliation>Department of Microbiology.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Dong</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Microbiology.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Dong</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Microbiology.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Andrew Chak-Yiu</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>Department of Microbiology.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Chuangen</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Microbiology.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yeung</LastName><ForeName>Man-Lung</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cai</LastName><ForeName>Jian-Piao</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Department of Microbiology.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Ivy Hau-Yee</ForeName><Initials>IH</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Hong Kong, Hong Kong Special Administrative Region.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ho</LastName><ForeName>Wai-Kuen</ForeName><Initials>WK</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Hong Kong, Hong Kong Special Administrative Region.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>To</LastName><ForeName>Kelvin Kai-Wang</ForeName><Initials>KK</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Bo-Jian</ForeName><Initials>BJ</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yao</LastName><ForeName>Yanfeng</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qin</LastName><ForeName>Chuan</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yuen</LastName><ForeName>Kwok-Yung</ForeName><Initials>KY</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>07</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Infect Dis</MedlineTA><NlmUniqueID>0413675</NlmUniqueID><ISSNLinking>0022-1899</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.14.5</RegistryNumber><NameOfSubstance UI="C042807">DPP4 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.14.5</RegistryNumber><NameOfSubstance UI="D018819">Dipeptidyl Peptidase 4</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>J Infect Dis. 2016 Mar 15;213(6):877-9</RefSource><PMID Version="1">26203059</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002144" MajorTopicYN="N">Callithrix</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018819" MajorTopicYN="N">Dipeptidyl Peptidase 4</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005786" MajorTopicYN="N">Gene Expression Regulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014066" MajorTopicYN="N">Palatine Tonsil</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013154" MajorTopicYN="N">Spleen</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013601" MajorTopicYN="N">T-Lymphocytes</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">MERS-CoV</Keyword><Keyword MajorTopicYN="N">T lymphocytes</Keyword><Keyword MajorTopicYN="N">apoptosis</Keyword><Keyword MajorTopicYN="N">caspase</Keyword><Keyword MajorTopicYN="N">marmosets</Keyword><Keyword MajorTopicYN="N">spleen</Keyword><Keyword 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