AVNP2 protects against cognitive impairments induced by C6 glioma by suppressing tumour associated inflammation in rats.
Identifieur interne : 000750 ( PubMed/Curation ); précédent : 000749; suivant : 000751AVNP2 protects against cognitive impairments induced by C6 glioma by suppressing tumour associated inflammation in rats.
Auteurs : Junyang Li [République populaire de Chine] ; Meicen Liu [République populaire de Chine] ; Jin Gao [République populaire de Chine] ; Yu Jiang [République populaire de Chine] ; Limin Wu [République populaire de Chine] ; Yuen-Ki Cheong [Royaume-Uni] ; Guogang Ren [Royaume-Uni] ; Zhuo Yang [République populaire de Chine]Source :
- Brain, behavior, and immunity [ 1090-2139 ] ; 2020.
Abstract
Glioblastoma is a kind of malignant tumour and originates from the central nervous system. In the last century, some researchers and clinician have noticed that the psychosocial and neurocognitive functioning of patients with malignant gliomas can be impaired. Many clinical studies have demonstrated that part of patients, adults or children, diagnosed with glioblastoma will suffer from cognitive deficiency during their clinical course, especially in long-term survivors. Many nanoparticles (NPs) can inhibit the biological functions of tumours by modulating tumour-associated inflammation, which provokes angiogenesis and tumour growth. As one of the best antiviral nanoparticles (AVNPs), AVNP2 is the 2nd generation of AVNP2 that have been conjugated to graphite-graphene for improving physiochemical performance and reducing toxicity. AVNP2 inactivates viruses, such as the H1N1 and H5N1influenza viruses and even the SARS coronavirus, while it inhibits bacteria, such as MRSA and E. coli. As antimicrobials, nanoparticles are considered to be one of the vectors for the administration of therapeutic compounds. Yet, little is known about their potential functionalities and toxicities to the neurotoxic effects of cancer. Herein, we explored the functionality of AVNP2 on inhibiting C6 in glioma-bearing rats. The novel object-recognition test and open-field test showed that AVNP2 significantly improved the neuro-behaviour affected by C6 glioma. AVNP2 also alleviated the decline of long-term potentiation (LTP) and the decreased density of dendritic spines in the CA1 region induced by C6. Western blot assay and immunofluorescence staining showed that the expressions of synaptic-related proteins (PSD-95 and SYP) were increased, and these findings were in accordance with the results mentioned above. It revealed that the sizes of tumours in C6 glioma-bearing rats were smaller after treatment with AVNP2. The decreased expression of inflammatory factors (IL-1β, IL-6 and TNF-α) by Western blotting assay and ELISA, angiogenesis protein (VEGF) by Western blotting assay and other related proteins (BDNF, NF-ĸB, iNOS and COX-2) by Western blotting assay in peri-tumour tissue indicated that AVNP2 could control tumour-associated inflammation, thus efficiently ameliorating the local inflammatory condition and, to some extent, inhibiting angiogenesis in C6-bearing rats. In conclusion, our results suggested that AVNP2 could have an effect on the peri-tumor environment, obviously restraining the growth progress of gliomas, and eventually improving cognitive levels in C6-bearing rats.
DOI: 10.1016/j.bbi.2020.02.009
PubMed: 32097763
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">AVNP2 protects against cognitive impairments induced by C6 glioma by suppressing tumour associated inflammation in rats.</title><author><name sortKey="Li, Junyang" sort="Li, Junyang" uniqKey="Li J" first="Junyang" last="Li">Junyang Li</name><affiliation wicri:level="1"><nlm:affiliation>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Meicen" sort="Liu, Meicen" uniqKey="Liu M" first="Meicen" last="Liu">Meicen Liu</name><affiliation wicri:level="1"><nlm:affiliation>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071</wicri:regionArea></affiliation></author><author><name sortKey="Gao, Jin" sort="Gao, Jin" uniqKey="Gao J" first="Jin" last="Gao">Jin Gao</name><affiliation wicri:level="1"><nlm:affiliation>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071</wicri:regionArea></affiliation></author><author><name sortKey="Jiang, Yu" sort="Jiang, Yu" uniqKey="Jiang Y" first="Yu" last="Jiang">Yu Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Limin" sort="Wu, Limin" uniqKey="Wu L" first="Limin" last="Wu">Limin Wu</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Laser and Optoelectronics, School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Laser and Optoelectronics, School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072</wicri:regionArea></affiliation></author><author><name sortKey="Cheong, Yuen Ki" sort="Cheong, Yuen Ki" uniqKey="Cheong Y" first="Yuen-Ki" last="Cheong">Yuen-Ki Cheong</name><affiliation wicri:level="1"><nlm:affiliation>Science and Technology Research Institute, University of Hertfordshire, Hatfield, Herts AL10 9AB, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Science and Technology Research Institute, University of Hertfordshire, Hatfield, Herts AL10 9AB</wicri:regionArea></affiliation></author><author><name sortKey="Ren, Guogang" sort="Ren, Guogang" uniqKey="Ren G" first="Guogang" last="Ren">Guogang Ren</name><affiliation wicri:level="1"><nlm:affiliation>Science and Technology Research Institute, University of Hertfordshire, Hatfield, Herts AL10 9AB, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Science and Technology Research Institute, University of Hertfordshire, Hatfield, Herts AL10 9AB</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Zhuo" sort="Yang, Zhuo" uniqKey="Yang Z" first="Zhuo" last="Yang">Zhuo Yang</name><affiliation wicri:level="1"><nlm:affiliation>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071, China. Electronic address: zhuoyang@nankai.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32097763</idno><idno type="pmid">32097763</idno><idno type="doi">10.1016/j.bbi.2020.02.009</idno><idno type="wicri:Area/PubMed/Corpus">000750</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000750</idno><idno type="wicri:Area/PubMed/Curation">000750</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000750</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">AVNP2 protects against cognitive impairments induced by C6 glioma by suppressing tumour associated inflammation in rats.</title><author><name sortKey="Li, Junyang" sort="Li, Junyang" uniqKey="Li J" first="Junyang" last="Li">Junyang Li</name><affiliation wicri:level="1"><nlm:affiliation>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Meicen" sort="Liu, Meicen" uniqKey="Liu M" first="Meicen" last="Liu">Meicen Liu</name><affiliation wicri:level="1"><nlm:affiliation>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071</wicri:regionArea></affiliation></author><author><name sortKey="Gao, Jin" sort="Gao, Jin" uniqKey="Gao J" first="Jin" last="Gao">Jin Gao</name><affiliation wicri:level="1"><nlm:affiliation>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071</wicri:regionArea></affiliation></author><author><name sortKey="Jiang, Yu" sort="Jiang, Yu" uniqKey="Jiang Y" first="Yu" last="Jiang">Yu Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Limin" sort="Wu, Limin" uniqKey="Wu L" first="Limin" last="Wu">Limin Wu</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Laser and Optoelectronics, School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Laser and Optoelectronics, School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072</wicri:regionArea></affiliation></author><author><name sortKey="Cheong, Yuen Ki" sort="Cheong, Yuen Ki" uniqKey="Cheong Y" first="Yuen-Ki" last="Cheong">Yuen-Ki Cheong</name><affiliation wicri:level="1"><nlm:affiliation>Science and Technology Research Institute, University of Hertfordshire, Hatfield, Herts AL10 9AB, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Science and Technology Research Institute, University of Hertfordshire, Hatfield, Herts AL10 9AB</wicri:regionArea></affiliation></author><author><name sortKey="Ren, Guogang" sort="Ren, Guogang" uniqKey="Ren G" first="Guogang" last="Ren">Guogang Ren</name><affiliation wicri:level="1"><nlm:affiliation>Science and Technology Research Institute, University of Hertfordshire, Hatfield, Herts AL10 9AB, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Science and Technology Research Institute, University of Hertfordshire, Hatfield, Herts AL10 9AB</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Zhuo" sort="Yang, Zhuo" uniqKey="Yang Z" first="Zhuo" last="Yang">Zhuo Yang</name><affiliation wicri:level="1"><nlm:affiliation>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071, China. Electronic address: zhuoyang@nankai.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071</wicri:regionArea></affiliation></author></analytic><series><title level="j">Brain, behavior, and immunity</title><idno type="eISSN">1090-2139</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Glioblastoma is a kind of malignant tumour and originates from the central nervous system. In the last century, some researchers and clinician have noticed that the psychosocial and neurocognitive functioning of patients with malignant gliomas can be impaired. Many clinical studies have demonstrated that part of patients, adults or children, diagnosed with glioblastoma will suffer from cognitive deficiency during their clinical course, especially in long-term survivors. Many nanoparticles (NPs) can inhibit the biological functions of tumours by modulating tumour-associated inflammation, which provokes angiogenesis and tumour growth. As one of the best antiviral nanoparticles (AVNPs), AVNP2 is the 2nd generation of AVNP2 that have been conjugated to graphite-graphene for improving physiochemical performance and reducing toxicity. AVNP2 inactivates viruses, such as the H1N1 and H5N1influenza viruses and even the SARS coronavirus, while it inhibits bacteria, such as MRSA and E. coli. As antimicrobials, nanoparticles are considered to be one of the vectors for the administration of therapeutic compounds. Yet, little is known about their potential functionalities and toxicities to the neurotoxic effects of cancer. Herein, we explored the functionality of AVNP2 on inhibiting C6 in glioma-bearing rats. The novel object-recognition test and open-field test showed that AVNP2 significantly improved the neuro-behaviour affected by C6 glioma. AVNP2 also alleviated the decline of long-term potentiation (LTP) and the decreased density of dendritic spines in the CA1 region induced by C6. Western blot assay and immunofluorescence staining showed that the expressions of synaptic-related proteins (PSD-95 and SYP) were increased, and these findings were in accordance with the results mentioned above. It revealed that the sizes of tumours in C6 glioma-bearing rats were smaller after treatment with AVNP2. The decreased expression of inflammatory factors (IL-1β, IL-6 and TNF-α) by Western blotting assay and ELISA, angiogenesis protein (VEGF) by Western blotting assay and other related proteins (BDNF, NF-ĸB, iNOS and COX-2) by Western blotting assay in peri-tumour tissue indicated that AVNP2 could control tumour-associated inflammation, thus efficiently ameliorating the local inflammatory condition and, to some extent, inhibiting angiogenesis in C6-bearing rats. In conclusion, our results suggested that AVNP2 could have an effect on the peri-tumor environment, obviously restraining the growth progress of gliomas, and eventually improving cognitive levels in C6-bearing rats.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32097763</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1090-2139</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Feb</Month><Day>22</Day></PubDate></JournalIssue><Title>Brain, behavior, and immunity</Title><ISOAbbreviation>Brain Behav. Immun.</ISOAbbreviation></Journal><ArticleTitle>AVNP2 protects against cognitive impairments induced by C6 glioma by suppressing tumour associated inflammation in rats.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S0889-1591(19)31417-5</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbi.2020.02.009</ELocationID><Abstract><AbstractText>Glioblastoma is a kind of malignant tumour and originates from the central nervous system. In the last century, some researchers and clinician have noticed that the psychosocial and neurocognitive functioning of patients with malignant gliomas can be impaired. Many clinical studies have demonstrated that part of patients, adults or children, diagnosed with glioblastoma will suffer from cognitive deficiency during their clinical course, especially in long-term survivors. Many nanoparticles (NPs) can inhibit the biological functions of tumours by modulating tumour-associated inflammation, which provokes angiogenesis and tumour growth. As one of the best antiviral nanoparticles (AVNPs), AVNP2 is the 2nd generation of AVNP2 that have been conjugated to graphite-graphene for improving physiochemical performance and reducing toxicity. AVNP2 inactivates viruses, such as the H1N1 and H5N1influenza viruses and even the SARS coronavirus, while it inhibits bacteria, such as MRSA and E. coli. As antimicrobials, nanoparticles are considered to be one of the vectors for the administration of therapeutic compounds. Yet, little is known about their potential functionalities and toxicities to the neurotoxic effects of cancer. Herein, we explored the functionality of AVNP2 on inhibiting C6 in glioma-bearing rats. The novel object-recognition test and open-field test showed that AVNP2 significantly improved the neuro-behaviour affected by C6 glioma. AVNP2 also alleviated the decline of long-term potentiation (LTP) and the decreased density of dendritic spines in the CA1 region induced by C6. Western blot assay and immunofluorescence staining showed that the expressions of synaptic-related proteins (PSD-95 and SYP) were increased, and these findings were in accordance with the results mentioned above. It revealed that the sizes of tumours in C6 glioma-bearing rats were smaller after treatment with AVNP2. The decreased expression of inflammatory factors (IL-1β, IL-6 and TNF-α) by Western blotting assay and ELISA, angiogenesis protein (VEGF) by Western blotting assay and other related proteins (BDNF, NF-ĸB, iNOS and COX-2) by Western blotting assay in peri-tumour tissue indicated that AVNP2 could control tumour-associated inflammation, thus efficiently ameliorating the local inflammatory condition and, to some extent, inhibiting angiogenesis in C6-bearing rats. In conclusion, our results suggested that AVNP2 could have an effect on the peri-tumor environment, obviously restraining the growth progress of gliomas, and eventually improving cognitive levels in C6-bearing rats.</AbstractText><CopyrightInformation>Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Junyang</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Meicen</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Jin</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Yu</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Limin</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute of Laser and Optoelectronics, School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cheong</LastName><ForeName>Yuen-Ki</ForeName><Initials>YK</Initials><AffiliationInfo><Affiliation>Science and Technology Research Institute, University of Hertfordshire, Hatfield, Herts AL10 9AB, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ren</LastName><ForeName>Guogang</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Science and Technology Research Institute, University of Hertfordshire, Hatfield, Herts AL10 9AB, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Zhuo</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin 300071, China. Electronic address: zhuoyang@nankai.edu.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>02</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Brain Behav Immun</MedlineTA><NlmUniqueID>8800478</NlmUniqueID><ISSNLinking>0889-1591</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">AVNP2</Keyword><Keyword MajorTopicYN="N">C6 glioma</Keyword><Keyword MajorTopicYN="N">Cognitive function</Keyword><Keyword MajorTopicYN="N">Inflammation</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>11</Month><Day>12</Day></PubMedPubDate><PubMedPubDate 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