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Clinical characteristics of severe acute respiratory syndrome coronavirus 2 reactivation.

Identifieur interne : 000620 ( PubMed/Curation ); précédent : 000619; suivant : 000621

Clinical characteristics of severe acute respiratory syndrome coronavirus 2 reactivation.

Auteurs : Guangming Ye [République populaire de Chine] ; Zhenyu Pan [République populaire de Chine] ; Yunbao Pan [République populaire de Chine] ; Qiaoling Deng [République populaire de Chine] ; Liangjun Chen [République populaire de Chine] ; Jin Li [République populaire de Chine] ; Yirong Li [République populaire de Chine] ; Xinghuan Wang [République populaire de Chine]

Source :

RBID : pubmed:32171867

Abstract

Previous studies on the pneumonia outbreak caused by the 2019 novel coronavirus disease (COVID-19) were based on information from the general population. However, limited data was available for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reactivation. This study aimed to evaluate the clinical characteristics of the SARS-CoV-2 reactivation.

DOI: 10.1016/j.jinf.2020.03.001
PubMed: 32171867

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Le document en format XML

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<country xml:lang="fr">République populaire de Chine</country>
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<name sortKey="Li, Jin" sort="Li, Jin" uniqKey="Li J" first="Jin" last="Li">Jin Li</name>
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<div type="abstract" xml:lang="en">Previous studies on the pneumonia outbreak caused by the 2019 novel coronavirus disease (COVID-19) were based on information from the general population. However, limited data was available for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reactivation. This study aimed to evaluate the clinical characteristics of the SARS-CoV-2 reactivation.</div>
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<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Previous studies on the pneumonia outbreak caused by the 2019 novel coronavirus disease (COVID-19) were based on information from the general population. However, limited data was available for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reactivation. This study aimed to evaluate the clinical characteristics of the SARS-CoV-2 reactivation.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Clinical records, laboratory results, and chest CT scans were retrospectively reviewed for 55 patients with laboratory-confirmed COVID-19 pneumonia (i.e., with throat swab samples that were positive for SARS-CoV-2) who were admitted to Zhongnan Hospital of Wuhan University, Wuhan, China, from Jan. 8 to Feb. 10, 2020.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">All 55 patients had a history of epidemiological exposure to COVID-19, and 5 (9%) patients who discharged from hospital presented with SARS-CoV-2 reactivation. Among the 5 reactivated patients, other symptoms were also observed, including fever, cough, sore throat, and fatigue. One of the 5 patients had progressive lymphopenia (from 1.3 to 0.56 × 10
<sup>9</sup>
cells per L) and progressive neutrophilia (from 4.5 to 18.28 × 10
<sup>9</sup>
cells per L). All 5 reactivated patients presented normal aminotransferase levels. Throat swab samples from the 5 reactivated patients were tested for SARS-CoV-2, indicating all positive for the virus.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Findings from this small group of cases suggested that there was currently evidence for reactivation of SARS-CoV-2 and there might be no specific clinical characteristics to distinguish them.</AbstractText>
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<CoiStatement>Declaration of Competing Interest None.</CoiStatement>
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