Corticosteroid treatment of patients with coronavirus disease 2019 (COVID-19).
Identifieur interne : 000294 ( PubMed/Curation ); précédent : 000293; suivant : 000295Corticosteroid treatment of patients with coronavirus disease 2019 (COVID-19).
Auteurs : Lei Zha [République populaire de Chine] ; Shirong Li [République populaire de Chine] ; Lingling Pan [République populaire de Chine] ; Boris Tefsen [République populaire de Chine] ; Yeshan Li [République populaire de Chine] ; Neil French [Royaume-Uni] ; Liyun Chen [République populaire de Chine] ; Gang Yang [République populaire de Chine] ; Elmer V. Villanueva [République populaire de Chine]Source :
- The Medical journal of Australia [ 1326-5377 ] ; 2020.
Abstract
To assess the efficacy of corticosteroid treatment of patients with coronavirus disease 2019 (COVID-19).
DOI: 10.5694/mja2.50577
PubMed: 32266987
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Corticosteroid treatment of patients with coronavirus disease 2019 (COVID-19).</title><author><name sortKey="Zha, Lei" sort="Zha, Lei" uniqKey="Zha L" first="Lei" last="Zha">Lei Zha</name><affiliation wicri:level="1"><nlm:affiliation>Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu</wicri:regionArea></affiliation></author><author><name sortKey="Li, Shirong" sort="Li, Shirong" uniqKey="Li S" first="Shirong" last="Li">Shirong Li</name><affiliation wicri:level="1"><nlm:affiliation>The Second People's Hospital of Wuhu, Wuhu, Anhui, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Second People's Hospital of Wuhu, Wuhu, Anhui</wicri:regionArea></affiliation></author><author><name sortKey="Pan, Lingling" sort="Pan, Lingling" uniqKey="Pan L" first="Lingling" last="Pan">Lingling Pan</name><affiliation wicri:level="1"><nlm:affiliation>Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Yijishan Hospital of Wannan Medical College, Wuhu, Anhui</wicri:regionArea></affiliation></author><author><name sortKey="Tefsen, Boris" sort="Tefsen, Boris" uniqKey="Tefsen B" first="Boris" last="Tefsen">Boris Tefsen</name><affiliation wicri:level="1"><nlm:affiliation>Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu</wicri:regionArea></affiliation></author><author><name sortKey="Li, Yeshan" sort="Li, Yeshan" uniqKey="Li Y" first="Yeshan" last="Li">Yeshan Li</name><affiliation wicri:level="1"><nlm:affiliation>The Second People's Hospital of Wuhu, Wuhu, Anhui, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Second People's Hospital of Wuhu, Wuhu, Anhui</wicri:regionArea></affiliation></author><author><name sortKey="French, Neil" sort="French, Neil" uniqKey="French N" first="Neil" last="French">Neil French</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Infection and Global Health, University of Liverpool, Liverpool</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Liyun" sort="Chen, Liyun" uniqKey="Chen L" first="Liyun" last="Chen">Liyun Chen</name><affiliation wicri:level="1"><nlm:affiliation>The Third People's Hospital of Wuhu, Wuhu, Anhui, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Third People's Hospital of Wuhu, Wuhu, Anhui</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Gang" sort="Yang, Gang" uniqKey="Yang G" first="Gang" last="Yang">Gang Yang</name><affiliation wicri:level="1"><nlm:affiliation>The Second People's Hospital of Wuhu, Wuhu, Anhui, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Second People's Hospital of Wuhu, Wuhu, Anhui</wicri:regionArea></affiliation></author><author><name sortKey="Villanueva, Elmer V" sort="Villanueva, Elmer V" uniqKey="Villanueva E" first="Elmer V" last="Villanueva">Elmer V. Villanueva</name><affiliation wicri:level="1"><nlm:affiliation>Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32266987</idno><idno type="pmid">32266987</idno><idno type="doi">10.5694/mja2.50577</idno><idno type="wicri:Area/PubMed/Corpus">000294</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000294</idno><idno type="wicri:Area/PubMed/Curation">000294</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000294</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Corticosteroid treatment of patients with coronavirus disease 2019 (COVID-19).</title><author><name sortKey="Zha, Lei" sort="Zha, Lei" uniqKey="Zha L" first="Lei" last="Zha">Lei Zha</name><affiliation wicri:level="1"><nlm:affiliation>Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu</wicri:regionArea></affiliation></author><author><name sortKey="Li, Shirong" sort="Li, Shirong" uniqKey="Li S" first="Shirong" last="Li">Shirong Li</name><affiliation wicri:level="1"><nlm:affiliation>The Second People's Hospital of Wuhu, Wuhu, Anhui, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Second People's Hospital of Wuhu, Wuhu, Anhui</wicri:regionArea></affiliation></author><author><name sortKey="Pan, Lingling" sort="Pan, Lingling" uniqKey="Pan L" first="Lingling" last="Pan">Lingling Pan</name><affiliation wicri:level="1"><nlm:affiliation>Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Yijishan Hospital of Wannan Medical College, Wuhu, Anhui</wicri:regionArea></affiliation></author><author><name sortKey="Tefsen, Boris" sort="Tefsen, Boris" uniqKey="Tefsen B" first="Boris" last="Tefsen">Boris Tefsen</name><affiliation wicri:level="1"><nlm:affiliation>Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu</wicri:regionArea></affiliation></author><author><name sortKey="Li, Yeshan" sort="Li, Yeshan" uniqKey="Li Y" first="Yeshan" last="Li">Yeshan Li</name><affiliation wicri:level="1"><nlm:affiliation>The Second People's Hospital of Wuhu, Wuhu, Anhui, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Second People's Hospital of Wuhu, Wuhu, Anhui</wicri:regionArea></affiliation></author><author><name sortKey="French, Neil" sort="French, Neil" uniqKey="French N" first="Neil" last="French">Neil French</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Infection and Global Health, University of Liverpool, Liverpool</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Liyun" sort="Chen, Liyun" uniqKey="Chen L" first="Liyun" last="Chen">Liyun Chen</name><affiliation wicri:level="1"><nlm:affiliation>The Third People's Hospital of Wuhu, Wuhu, Anhui, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Third People's Hospital of Wuhu, Wuhu, Anhui</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Gang" sort="Yang, Gang" uniqKey="Yang G" first="Gang" last="Yang">Gang Yang</name><affiliation wicri:level="1"><nlm:affiliation>The Second People's Hospital of Wuhu, Wuhu, Anhui, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Second People's Hospital of Wuhu, Wuhu, Anhui</wicri:regionArea></affiliation></author><author><name sortKey="Villanueva, Elmer V" sort="Villanueva, Elmer V" uniqKey="Villanueva E" first="Elmer V" last="Villanueva">Elmer V. Villanueva</name><affiliation wicri:level="1"><nlm:affiliation>Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Medical journal of Australia</title><idno type="eISSN">1326-5377</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To assess the efficacy of corticosteroid treatment of patients with coronavirus disease 2019 (COVID-19).</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32266987</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1326-5377</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Apr</Month><Day>08</Day></PubDate></JournalIssue><Title>The Medical journal of Australia</Title><ISOAbbreviation>Med. J. Aust.</ISOAbbreviation></Journal><ArticleTitle>Corticosteroid treatment of patients with coronavirus disease 2019 (COVID-19).</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.5694/mja2.50577</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To assess the efficacy of corticosteroid treatment of patients with coronavirus disease 2019 (COVID-19).</AbstractText><AbstractText Label="DESIGN, SETTING" NlmCategory="UNASSIGNED">Observational study in the two COVID-19-designated hospitals in Wuhu, Anhui province, China, 24 January - 24 February 2020.</AbstractText><AbstractText Label="PARTICIPANTS" NlmCategory="METHODS">Thirty-one patients infected with the severe acute respiratory coronavirus 2 (SARS-CoV-2) treated at the two designated hospitals.</AbstractText><AbstractText Label="MAIN OUTCOME MEASURES" NlmCategory="METHODS">Virus clearance time, length of hospital stay, and duration of symptoms, by treatment type (including or not including corticosteroid therapy).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Eleven of 31 patients with COVID-19 received corticosteroid treatment. Cox proportional hazards regression analysis indicated no association between corticosteroid treatment and virus clearance time (hazard ratio [HR], 1.26; 95% CI, 0.58-2.74), hospital length of stay (HR, 0.77; 95% CI, 0.33-1.78), or duration of symptoms (HR, 0.86; 95% CI, 0.40-1.83). Univariate analysis indicated that virus clearance was slower in two patients with chronic hepatitis B infections (mean difference, 10.6 days; 95% CI, 6.2-15.1 days).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Corticosteroids are widely used when treating patients with COVID-19, but we found no association between therapy and outcomes in patients without acute respiratory distress syndrome. An existing HBV infection may delay SARS-CoV-2 clearance, and this association should be further investigated.</AbstractText><CopyrightInformation>© 2020 AMPCo Pty Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zha</LastName><ForeName>Lei</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Shirong</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>The Second People's Hospital of Wuhu, Wuhu, Anhui, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pan</LastName><ForeName>Lingling</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tefsen</LastName><ForeName>Boris</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yeshan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>The Second People's Hospital of Wuhu, Wuhu, Anhui, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>French</LastName><ForeName>Neil</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Liyun</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>The Third People's Hospital of Wuhu, Wuhu, Anhui, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Gang</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>The Second People's Hospital of Wuhu, Wuhu, Anhui, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Villanueva</LastName><ForeName>Elmer V</ForeName><Initials>EV</Initials><AffiliationInfo><Affiliation>Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>Australia</Country><MedlineTA>Med J Aust</MedlineTA><NlmUniqueID>0400714</NlmUniqueID><ISSNLinking>0025-729X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Corticosteroids</Keyword><Keyword MajorTopicYN="N">Epidemics</Keyword><Keyword MajorTopicYN="N">Pneumonia, viral</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>03</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32266987</ArticleId><ArticleId IdType="doi">10.5694/mja2.50577</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Zhu N, Zhang D, Wang W, et al. 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