Novel decoy cellular vaccine strategy utilizing transgenic antigen-expressing cells as immune presenter and adjuvant in vaccine prototype against SARS-CoV-2 virus.
Identifieur interne : 000166 ( PubMed/Curation ); précédent : 000165; suivant : 000167Novel decoy cellular vaccine strategy utilizing transgenic antigen-expressing cells as immune presenter and adjuvant in vaccine prototype against SARS-CoV-2 virus.
Auteurs : Henry Ji [États-Unis] ; Ying Yan [États-Unis] ; Beibei Ding [États-Unis] ; Wenzhong Guo [États-Unis] ; Mark Brunswick [États-Unis] ; Andreas Niethammer [États-Unis] ; Williams Soohoo [États-Unis] ; Robin Smith [États-Unis] ; Alexis Nahama [États-Unis] ; Yanliang Zhang [États-Unis]Source :
- Medicine in drug discovery [ 2590-0986 ] ; 2020.
Abstract
A novel approach modifying cells to express viral markers to elicit protective immunity responses (decoy cellular vaccination) in the prevention of COVID-19 disease is currently being explored. Our approach entails utilizing SARS-CoV-2 Spike antigen-expressing, non-replicating cells as carriers and presenters of immunogenic antigens, so called "I-cells". By using irradiated cells as presenting vehicles of SARS-CoV-2 viral antigens(s) in a cellular context, these presented viral proteins can be recognized by the host immune system, thus, an efficient protective immune response might be elicited. Another advantage of this strategy is that the manufacturing process is scalable and yields uniform cell products allowing for "off-the-shelf" frozen supply availability. To prevent engraftment and proliferation of the cells after administration, the cells will be irradiated post-harvesting abolishing in vivo replication potential. Specifically, immunoreactive Spike-1 proteins from SARS-CoV-2 are expressed on the surface of irradiated target I-cells. Utilizing this innovative strategy, these viral antigen-displaying decoy cells will be developed as a vaccine to protect against COVID-19 disease.
DOI: 10.1016/j.medidd.2020.100026
PubMed: 32289117
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Directors Place, San Diego, CA 92121</wicri:regionArea></affiliation></author><author><name sortKey="Brunswick, Mark" sort="Brunswick, Mark" uniqKey="Brunswick M" first="Mark" last="Brunswick">Mark Brunswick</name><affiliation wicri:level="1"><nlm:affiliation>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121</wicri:regionArea></affiliation></author><author><name sortKey="Niethammer, Andreas" sort="Niethammer, Andreas" uniqKey="Niethammer A" first="Andreas" last="Niethammer">Andreas Niethammer</name><affiliation wicri:level="1"><nlm:affiliation>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 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xml:lang="fr">États-Unis</country><wicri:regionArea>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121</wicri:regionArea></affiliation></author><author><name sortKey="Yan, Ying" sort="Yan, Ying" uniqKey="Yan Y" first="Ying" last="Yan">Ying Yan</name><affiliation wicri:level="1"><nlm:affiliation>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121</wicri:regionArea></affiliation></author><author><name sortKey="Ding, Beibei" sort="Ding, Beibei" uniqKey="Ding B" first="Beibei" last="Ding">Beibei Ding</name><affiliation wicri:level="1"><nlm:affiliation>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121</wicri:regionArea></affiliation></author><author><name sortKey="Guo, Wenzhong" sort="Guo, Wenzhong" uniqKey="Guo W" first="Wenzhong" last="Guo">Wenzhong Guo</name><affiliation wicri:level="1"><nlm:affiliation>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121</wicri:regionArea></affiliation></author><author><name sortKey="Brunswick, Mark" sort="Brunswick, Mark" uniqKey="Brunswick M" first="Mark" last="Brunswick">Mark Brunswick</name><affiliation wicri:level="1"><nlm:affiliation>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121</wicri:regionArea></affiliation></author><author><name sortKey="Niethammer, Andreas" sort="Niethammer, Andreas" uniqKey="Niethammer A" first="Andreas" last="Niethammer">Andreas Niethammer</name><affiliation wicri:level="1"><nlm:affiliation>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121</wicri:regionArea></affiliation></author><author><name sortKey="Soohoo, Williams" sort="Soohoo, Williams" uniqKey="Soohoo W" first="Williams" last="Soohoo">Williams Soohoo</name><affiliation wicri:level="1"><nlm:affiliation>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Robin" sort="Smith, Robin" uniqKey="Smith R" first="Robin" last="Smith">Robin Smith</name><affiliation wicri:level="1"><nlm:affiliation>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121</wicri:regionArea></affiliation></author><author><name sortKey="Nahama, Alexis" sort="Nahama, Alexis" uniqKey="Nahama A" first="Alexis" last="Nahama">Alexis Nahama</name><affiliation wicri:level="1"><nlm:affiliation>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Yanliang" sort="Zhang, Yanliang" uniqKey="Zhang Y" first="Yanliang" last="Zhang">Yanliang Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121</wicri:regionArea></affiliation></author></analytic><series><title level="j">Medicine in drug discovery</title><idno type="eISSN">2590-0986</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A novel approach modifying cells to express viral markers to elicit protective immunity responses (decoy cellular vaccination) in the prevention of COVID-19 disease is currently being explored. Our approach entails utilizing SARS-CoV-2 Spike antigen-expressing, non-replicating cells as carriers and presenters of immunogenic antigens, so called "I-cells". By using irradiated cells as presenting vehicles of SARS-CoV-2 viral antigens(s) in a cellular context, these presented viral proteins can be recognized by the host immune system, thus, an efficient protective immune response might be elicited. Another advantage of this strategy is that the manufacturing process is scalable and yields uniform cell products allowing for "off-the-shelf" frozen supply availability. To prevent engraftment and proliferation of the cells after administration, the cells will be irradiated post-harvesting abolishing in vivo replication potential. Specifically, immunoreactive Spike-1 proteins from SARS-CoV-2 are expressed on the surface of irradiated target I-cells. Utilizing this innovative strategy, these viral antigen-displaying decoy cells will be developed as a vaccine to protect against COVID-19 disease.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32289117</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2590-0986</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><PubDate><Year>2020</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Medicine in drug discovery</Title><ISOAbbreviation>Med Drug Discov</ISOAbbreviation></Journal><ArticleTitle>Novel decoy cellular vaccine strategy utilizing transgenic antigen-expressing cells as immune presenter and adjuvant in vaccine prototype against SARS-CoV-2 virus.</ArticleTitle><Pagination><MedlinePgn>100026</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.medidd.2020.100026</ELocationID><Abstract><AbstractText>A novel approach modifying cells to express viral markers to elicit protective immunity responses (decoy cellular vaccination) in the prevention of COVID-19 disease is currently being explored. Our approach entails utilizing SARS-CoV-2 Spike antigen-expressing, non-replicating cells as carriers and presenters of immunogenic antigens, so called "I-cells". By using irradiated cells as presenting vehicles of SARS-CoV-2 viral antigens(s) in a cellular context, these presented viral proteins can be recognized by the host immune system, thus, an efficient protective immune response might be elicited. Another advantage of this strategy is that the manufacturing process is scalable and yields uniform cell products allowing for "off-the-shelf" frozen supply availability. To prevent engraftment and proliferation of the cells after administration, the cells will be irradiated post-harvesting abolishing in vivo replication potential. Specifically, immunoreactive Spike-1 proteins from SARS-CoV-2 are expressed on the surface of irradiated target I-cells. Utilizing this innovative strategy, these viral antigen-displaying decoy cells will be developed as a vaccine to protect against COVID-19 disease.</AbstractText><CopyrightInformation>© 2020 The Authors.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ji</LastName><ForeName>Henry</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>Ying</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ding</LastName><ForeName>Beibei</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Wenzhong</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brunswick</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Niethammer</LastName><ForeName>Andreas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>SooHoo</LastName><ForeName>Williams</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Robin</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121, United States of America.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07102, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nahama</LastName><ForeName>Alexis</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yanliang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Sorrento Therapeutics, Inc., 4955 Directors Place, San Diego, CA 92121, United States of America.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Med Drug Discov</MedlineTA><NlmUniqueID>101765689</NlmUniqueID><ISSNLinking>2590-0986</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antigen</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Coronavirus</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">Transgenic cell vaccination</Keyword><Keyword MajorTopicYN="N">Vaccine</Keyword></KeywordList><CoiStatement>The authors are employed (or Directors) of Sorrento Therapeutics, Inc. The current discovery strategy is being implemented for vaccine development under the I-Cell™ label and within Sorrento's cGMP manufacturing facilities.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>03</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>03</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>03</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>4</Month><Day>15</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32289117</ArticleId><ArticleId IdType="doi">10.1016/j.medidd.2020.100026</ArticleId><ArticleId IdType="pii">S2590-0986(20)30013-0</ArticleId><ArticleId IdType="pii">100026</ArticleId><ArticleId IdType="pmc">PMC7144842</ArticleId></ArticleIdList><pmc-dir>pmcsd</pmc-dir>
<ReferenceList><Reference><Citation>PLoS One. 2012;7(4):e35421</Citation><ArticleIdList><ArticleId IdType="pubmed">22536382</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Pediatr Res. 2015 Nov;78(5):483-91</Citation><ArticleIdList><ArticleId IdType="pubmed">26267154</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Immunology. 1994 Sep;83(1):75-80</Citation><ArticleIdList><ArticleId IdType="pubmed">7821970</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Int J Cancer. 1976 Oct 15;18(4):421-31</Citation><ArticleIdList><ArticleId IdType="pubmed">789258</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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