SALIVA IS A RELIABLE TOOL TO DETECT SARS-CoV-2.
Identifieur interne : 000072 ( PubMed/Curation ); précédent : 000071; suivant : 000073SALIVA IS A RELIABLE TOOL TO DETECT SARS-CoV-2.
Auteurs : Lorenzo Azzi [Italie] ; Giulio Carcano [Italie] ; Francesco Gianfagna [Italie] ; Paolo Grossi [Italie] ; Daniela Dalla Gasperina [Italie] ; Angelo Genoni [Italie] ; Mauro Fasano [Italie] ; Fausto Sessa [Italie] ; Lucia Tettamanti [Italie] ; Francesco Carinci [Italie] ; Vittorio Maurino [Italie] ; Rossi Agostino [Italie] ; Angelo Tagliabue [Italie] ; Andreina Baj [Italie]Source :
- The Journal of infection [ 1532-2742 ] ; 2020.
Abstract
This study analyzed salivary samples of COVID-19 patients and compared the results with their clinical and laboratory data.
DOI: 10.1016/j.jinf.2020.04.005
PubMed: 32298676
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wicri:level="1"><nlm:affiliation>Unit of Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese</wicri:regionArea></affiliation></author><author><name sortKey="Tettamanti, Lucia" sort="Tettamanti, Lucia" uniqKey="Tettamanti L" first="Lucia" last="Tettamanti">Lucia Tettamanti</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese</wicri:regionArea></affiliation></author><author><name sortKey="Carinci, Francesco" sort="Carinci, Francesco" uniqKey="Carinci F" first="Francesco" last="Carinci">Francesco Carinci</name><affiliation wicri:level="1"><nlm:affiliation>Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara</wicri:regionArea></affiliation></author><author><name sortKey="Maurino, Vittorio" sort="Maurino, Vittorio" uniqKey="Maurino V" first="Vittorio" last="Maurino">Vittorio Maurino</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese</wicri:regionArea></affiliation></author><author><name sortKey="Agostino, Rossi" sort="Agostino, Rossi" uniqKey="Agostino R" first="Rossi" last="Agostino">Rossi Agostino</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Clinical Microbiology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Clinical Microbiology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese</wicri:regionArea></affiliation></author><author><name sortKey="Tagliabue, Angelo" sort="Tagliabue, Angelo" uniqKey="Tagliabue A" first="Angelo" last="Tagliabue">Angelo Tagliabue</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</nlm:affiliation><country 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Electronic address: l.azzi@uninsubria.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese</wicri:regionArea></affiliation></author><author><name sortKey="Carcano, Giulio" sort="Carcano, Giulio" uniqKey="Carcano G" first="Giulio" last="Carcano">Giulio Carcano</name><affiliation wicri:level="1"><nlm:affiliation>Unit of General, Emergency and Transplant Surgery, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of General, Emergency and Transplant Surgery, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese</wicri:regionArea></affiliation></author><author><name sortKey="Gianfagna, Francesco" sort="Gianfagna, Francesco" uniqKey="Gianfagna F" first="Francesco" last="Gianfagna">Francesco Gianfagna</name><affiliation wicri:level="1"><nlm:affiliation>Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy; Mediterranea Cardiocentro, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy; Mediterranea Cardiocentro, Naples</wicri:regionArea></affiliation></author><author><name sortKey="Grossi, Paolo" sort="Grossi, Paolo" uniqKey="Grossi P" first="Paolo" last="Grossi">Paolo Grossi</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Infectious and Tropical Diseases, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Infectious and Tropical Diseases, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese</wicri:regionArea></affiliation></author><author><name sortKey="Gasperina, Daniela Dalla" sort="Gasperina, Daniela Dalla" uniqKey="Gasperina D" first="Daniela Dalla" last="Gasperina">Daniela Dalla Gasperina</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Infectious and Tropical Diseases, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Infectious and Tropical Diseases, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese</wicri:regionArea></affiliation></author><author><name sortKey="Genoni, Angelo" sort="Genoni, Angelo" uniqKey="Genoni A" first="Angelo" last="Genoni">Angelo Genoni</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Clinical Microbiology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Clinical Microbiology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese</wicri:regionArea></affiliation></author><author><name sortKey="Fasano, Mauro" sort="Fasano, Mauro" uniqKey="Fasano M" first="Mauro" last="Fasano">Mauro Fasano</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Biochemistry and Functional Proteomics, Department of Science and High Technology, University of Insubria, Busto Arsizio (VA), Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Biochemistry and Functional Proteomics, Department of Science and High Technology, University of Insubria, Busto Arsizio (VA)</wicri:regionArea></affiliation></author><author><name sortKey="Sessa, Fausto" sort="Sessa, Fausto" uniqKey="Sessa F" first="Fausto" last="Sessa">Fausto Sessa</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese</wicri:regionArea></affiliation></author><author><name sortKey="Tettamanti, Lucia" sort="Tettamanti, Lucia" uniqKey="Tettamanti L" first="Lucia" last="Tettamanti">Lucia Tettamanti</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese</wicri:regionArea></affiliation></author><author><name sortKey="Carinci, Francesco" sort="Carinci, Francesco" uniqKey="Carinci F" first="Francesco" last="Carinci">Francesco Carinci</name><affiliation wicri:level="1"><nlm:affiliation>Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara</wicri:regionArea></affiliation></author><author><name sortKey="Maurino, Vittorio" sort="Maurino, Vittorio" uniqKey="Maurino V" first="Vittorio" last="Maurino">Vittorio Maurino</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese</wicri:regionArea></affiliation></author><author><name sortKey="Agostino, Rossi" sort="Agostino, Rossi" uniqKey="Agostino R" first="Rossi" last="Agostino">Rossi Agostino</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Clinical Microbiology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Clinical Microbiology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese</wicri:regionArea></affiliation></author><author><name sortKey="Tagliabue, Angelo" sort="Tagliabue, Angelo" uniqKey="Tagliabue A" first="Angelo" last="Tagliabue">Angelo Tagliabue</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese</wicri:regionArea></affiliation></author><author><name sortKey="Baj, Andreina" sort="Baj, Andreina" uniqKey="Baj A" first="Andreina" last="Baj">Andreina Baj</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Clinical Microbiology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Clinical Microbiology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Journal of infection</title><idno type="eISSN">1532-2742</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study analyzed salivary samples of COVID-19 patients and compared the results with their clinical and laboratory data.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32298676</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-2742</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Apr</Month><Day>13</Day></PubDate></JournalIssue><Title>The Journal of infection</Title><ISOAbbreviation>J. Infect.</ISOAbbreviation></Journal><ArticleTitle>SALIVA IS A RELIABLE TOOL TO DETECT SARS-CoV-2.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S0163-4453(20)30213-9</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jinf.2020.04.005</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">This study analyzed salivary samples of COVID-19 patients and compared the results with their clinical and laboratory data.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Salivary samples of 25 COVID-19 patients were analyzed by rRT-PCR. The following data were collected: age, sex, comorbidities, drugs. Lactate dehydrogenase (LDH) and ultrasensitive reactive C protein (usRCP) values were registered on the same day when a salivary swab was collected. Prevalence of positivity in saliva and association between clinical data and the cycle threshold as a semiquantitative indicator of viral load were considered.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Twenty-five subjects were recruited into this study, 17 males and 8 females. The mean age was 61.5 +/- 11.2 years. Cardiovascular and/or dysmetabolic disorders were observed in 65.22% of cases. All the samples tested positive for the presence of SARS-CoV-2, while there was an inverse association between LDH and Ct values. Two patients showed positive salivary results on the same days when their pharyngeal or respiratory swabs showed conversion.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Saliva is a reliable tool to detect SARS-CoV-2. The role of saliva in COVID-19 diagnosis could not be limited to a qualitative detection of the virus, but it may also provide information about the clinical evolution of the disease.</AbstractText><CopyrightInformation>Copyright © 2020. Published by Elsevier Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Azzi</LastName><ForeName>Lorenzo</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Unit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy. Electronic address: l.azzi@uninsubria.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carcano</LastName><ForeName>Giulio</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Unit of General, Emergency and Transplant Surgery, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gianfagna</LastName><ForeName>Francesco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy; Mediterranea Cardiocentro, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grossi</LastName><ForeName>Paolo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Unit of Infectious and Tropical Diseases, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gasperina</LastName><ForeName>Daniela Dalla</ForeName><Initials>DD</Initials><AffiliationInfo><Affiliation>Unit of Infectious and Tropical Diseases, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Genoni</LastName><ForeName>Angelo</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratory of Clinical Microbiology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fasano</LastName><ForeName>Mauro</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratory of Biochemistry and Functional Proteomics, Department of Science and High Technology, University of Insubria, Busto Arsizio (VA), Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sessa</LastName><ForeName>Fausto</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Unit of Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tettamanti</LastName><ForeName>Lucia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Unit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carinci</LastName><ForeName>Francesco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maurino</LastName><ForeName>Vittorio</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Unit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Agostino</LastName><ForeName>Rossi</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Laboratory of Clinical Microbiology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tagliabue</LastName><ForeName>Angelo</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Unit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>University of Insubria COVID-19 Task Force</CollectiveName></Author><Author ValidYN="Y"><LastName>Baj</LastName><ForeName>Andreina</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratory of Clinical Microbiology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Infect</MedlineTA><NlmUniqueID>7908424</NlmUniqueID><ISSNLinking>0163-4453</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Coronavirus</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">Saliva</Keyword><Keyword MajorTopicYN="N">nCoV-2019</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>04</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>04</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>4</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32298676</ArticleId><ArticleId IdType="pii">S0163-4453(20)30213-9</ArticleId><ArticleId IdType="doi">10.1016/j.jinf.2020.04.005</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |