Severe COVID-19 during Pregnancy and Possible Vertical Transmission.
Identifieur interne : 000036 ( PubMed/Curation ); précédent : 000035; suivant : 000037Severe COVID-19 during Pregnancy and Possible Vertical Transmission.
Auteurs : Maria Claudia Alzamora [Pérou] ; Tania Paredes [Pérou] ; David Caceres [Pérou] ; Camille M. Webb [États-Unis] ; Luis M. Valdez [Pérou] ; Mauricio La Rosa [Pérou]Source :
- American journal of perinatology [ 1098-8785 ] ; 2020.
Abstract
There are few cases of pregnant women with novel corona virus 2019 (COVID-19) in the literature, most of them with a mild illness course. There is limited evidence about in utero infection and early positive neonatal testing. A 41-year-old G3P2 with a history of previous cesarean deliveries and diabetes mellitus presented with a 4-day history of malaise, low-grade fever, and progressive shortness of breath. A nasopharyngeal swab was positive for COVID-19, COVID-19 serology was negative. The patient developed respiratory failure requiring mechanical ventilation on day 5 of disease onset. The patient underwent a cesarean delivery, and neonatal isolation was implemented immediately after birth, without delayed cord clamping or skin-to-skin contact. The neonatal nasopharyngeal swab, 16 hours after delivery, was positive for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) real-time polymerase chain reaction (RT-PCR), and immunoglobulin (Ig)-M and IgG for SARS-CoV-2 were negative. Maternal IgM and IgG were positive on postpartum day 4 (day 9 after symptom onset). We report a severe presentation of COVID-19 during pregnancy. To our knowledge, this is the earliest reported positive PCR in the neonate, raising the concern for vertical transmission. We suggest pregnant women should be considered as a high-risk group and minimize exposures for these reasons. KEY POINTS: · We report a severe presentation of COVID-19 in pregnancy requiring invasive ventilatory support.. · This is a case of positive RT-PCR in first day of life, suggesting possible vertical transmission.. · There were no detectable maternal antibodies for COVID-19 until after delivery..
DOI: 10.1055/s-0040-1710050
PubMed: 32305046
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Webb</name><affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Disease, University of Texas Medical Branch, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Division of Infectious Disease, University of Texas Medical Branch</wicri:cityArea></affiliation></author><author><name sortKey="Valdez, Luis M" sort="Valdez, Luis M" uniqKey="Valdez L" first="Luis M" last="Valdez">Luis M. Valdez</name><affiliation wicri:level="1"><nlm:affiliation>Tropical Medicine Institute "Alexander von Humbolt," Universidad Peruana Cayetano Heredia, Lima, Peru.</nlm:affiliation><country xml:lang="fr">Pérou</country><wicri:regionArea>Tropical Medicine Institute "Alexander von Humbolt," Universidad Peruana Cayetano Heredia, Lima</wicri:regionArea></affiliation></author><author><name sortKey="La Rosa, Mauricio" sort="La Rosa, Mauricio" uniqKey="La Rosa M" first="Mauricio" last="La Rosa">Mauricio La Rosa</name><affiliation wicri:level="1"><nlm:affiliation>Division of Maternal Fetal Medicine, British American Hospital, Lima, Peru.</nlm:affiliation><country xml:lang="fr">Pérou</country><wicri:regionArea>Division of Maternal Fetal Medicine, British American Hospital, Lima</wicri:regionArea></affiliation></author></analytic><series><title level="j">American journal of perinatology</title><idno type="eISSN">1098-8785</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There are few cases of pregnant women with novel corona virus 2019 (COVID-19) in the literature, most of them with a mild illness course. There is limited evidence about in utero infection and early positive neonatal testing. A 41-year-old G3P2 with a history of previous cesarean deliveries and diabetes mellitus presented with a 4-day history of malaise, low-grade fever, and progressive shortness of breath. A nasopharyngeal swab was positive for COVID-19, COVID-19 serology was negative. The patient developed respiratory failure requiring mechanical ventilation on day 5 of disease onset. The patient underwent a cesarean delivery, and neonatal isolation was implemented immediately after birth, without delayed cord clamping or skin-to-skin contact. The neonatal nasopharyngeal swab, 16 hours after delivery, was positive for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) real-time polymerase chain reaction (RT-PCR), and immunoglobulin (Ig)-M and IgG for SARS-CoV-2 were negative. Maternal IgM and IgG were positive on postpartum day 4 (day 9 after symptom onset). We report a severe presentation of COVID-19 during pregnancy. To our knowledge, this is the earliest reported positive PCR in the neonate, raising the concern for vertical transmission. We suggest pregnant women should be considered as a high-risk group and minimize exposures for these reasons. KEY POINTS: · We report a severe presentation of COVID-19 in pregnancy requiring invasive ventilatory support.. · This is a case of positive RT-PCR in first day of life, suggesting possible vertical transmission.. · There were no detectable maternal antibodies for COVID-19 until after delivery..</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32305046</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1098-8785</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Apr</Month><Day>18</Day></PubDate></JournalIssue><Title>American journal of perinatology</Title><ISOAbbreviation>Am J Perinatol</ISOAbbreviation></Journal><ArticleTitle>Severe COVID-19 during Pregnancy and Possible Vertical Transmission.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1055/s-0040-1710050</ELocationID><Abstract><AbstractText>There are few cases of pregnant women with novel corona virus 2019 (COVID-19) in the literature, most of them with a mild illness course. There is limited evidence about in utero infection and early positive neonatal testing. A 41-year-old G3P2 with a history of previous cesarean deliveries and diabetes mellitus presented with a 4-day history of malaise, low-grade fever, and progressive shortness of breath. A nasopharyngeal swab was positive for COVID-19, COVID-19 serology was negative. The patient developed respiratory failure requiring mechanical ventilation on day 5 of disease onset. The patient underwent a cesarean delivery, and neonatal isolation was implemented immediately after birth, without delayed cord clamping or skin-to-skin contact. The neonatal nasopharyngeal swab, 16 hours after delivery, was positive for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) real-time polymerase chain reaction (RT-PCR), and immunoglobulin (Ig)-M and IgG for SARS-CoV-2 were negative. Maternal IgM and IgG were positive on postpartum day 4 (day 9 after symptom onset). We report a severe presentation of COVID-19 during pregnancy. To our knowledge, this is the earliest reported positive PCR in the neonate, raising the concern for vertical transmission. We suggest pregnant women should be considered as a high-risk group and minimize exposures for these reasons. KEY POINTS: · We report a severe presentation of COVID-19 in pregnancy requiring invasive ventilatory support.. · This is a case of positive RT-PCR in first day of life, suggesting possible vertical transmission.. · There were no detectable maternal antibodies for COVID-19 until after delivery..</AbstractText><CopyrightInformation>Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="N"><LastName>Alzamora</LastName><ForeName>Maria Claudia</ForeName><Initials>MC</Initials><Identifier Source="ORCID">0000-0002-0905-713X</Identifier><AffiliationInfo><Affiliation>Division of Maternal Fetal Medicine, British American Hospital, Lima, Peru.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="N"><LastName>Paredes</LastName><ForeName>Tania</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Division of Neonatology, British American Hospital, Lima, Peru.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="N"><LastName>Caceres</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Division of Pulmonary Medicine, British American Hospital, Lima, Peru.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="N"><LastName>Webb</LastName><ForeName>Camille M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Division of Infectious Disease, University of Texas Medical Branch, Texas.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Tropical Medicine Institute "Alexander von Humbolt," Universidad Peruana Cayetano Heredia, Lima, Peru.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="N"><LastName>Valdez</LastName><ForeName>Luis M</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>Tropical Medicine Institute "Alexander von Humbolt," Universidad Peruana Cayetano Heredia, Lima, Peru.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Infectious Disease, British American Hospital, Lima, Peru.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="N"><LastName>La Rosa</LastName><ForeName>Mauricio</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0003-0183-1706</Identifier><AffiliationInfo><Affiliation>Division of Maternal Fetal Medicine, British American Hospital, Lima, Peru.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Maternal Fetal Medicine, University of Texas Medical Branch, Texas.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Perinatol</MedlineTA><NlmUniqueID>8405212</NlmUniqueID><ISSNLinking>0735-1631</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CoiStatement>None declared.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>4</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32305046</ArticleId><ArticleId IdType="doi">10.1055/s-0040-1710050</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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